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  1. Article: Searching for synergy. An interview with Erik De Clercq.

    De Clercq, E

    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies

    1997  Volume 11, Issue 2, Page(s) 14–16

    MeSH term(s) Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Cell Fusion/drug effects ; Drug Therapy, Combination ; HIV/drug effects ; HIV/physiology ; Herpesviridae/drug effects ; Herpesviridae/physiology ; Humans ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/therapeutic use
    Chemical Substances Anti-HIV Agents ; Reverse Transcriptase Inhibitors
    Language English
    Publishing date 1997-02
    Publishing country United States
    Document type Interview ; Newspaper Article
    ZDB-ID 2065360-8
    ISSN 1077-1824
    ISSN 1077-1824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Antiviral agents

    DeClercq, Erik

    (Advances in pharmacology ; 67)

    2013  

    Author's details ed. by Erik de Clercq
    Series title Advances in pharmacology ; 67
    Collection
    Language English
    Size XIV, 369 S.
    Edition 1. ed.
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017836258
    ISBN 978-0-12-405880-4 ; 0-12-405880-9
    Database Catalogue ZB MED Medicine, Health

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    Uf I Zs 171 -67- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Selected Milestones in Antiviral Drug Development.

    De Clercq, Erik

    Viruses

    2024  Volume 16, Issue 2

    Abstract: This review article will describe the (wide) variety of approaches that I envisaged to develop a specific therapy for viral infections: (i) interferon and its inducers, (ii) HSV, VZV and CMV inhibitors, (iii) NRTIs (nucleoside reverse transcriptase ... ...

    Abstract This review article will describe the (wide) variety of approaches that I envisaged to develop a specific therapy for viral infections: (i) interferon and its inducers, (ii) HSV, VZV and CMV inhibitors, (iii) NRTIs (nucleoside reverse transcriptase inhibitors), NtRTIs (nucleotide reverse transcriptase inhibitors) and NNRTIs (non-nucleoside reverse transcriptase inhibitors) as HIV inhibitors, (iv) NtRTIs as HBV inhibitors, and finally, (v) the transition of an HIV inhibitor to a stem cell mobilizer, as exemplified by AMD-3100 (Mozobil
    MeSH term(s) Humans ; Reverse Transcriptase Inhibitors/pharmacology ; Anti-HIV Agents/therapeutic use ; Virus Diseases/drug therapy ; HIV Infections/drug therapy ; Drug Development ; HIV Reverse Transcriptase
    Chemical Substances Reverse Transcriptase Inhibitors ; Anti-HIV Agents ; HIV Reverse Transcriptase (EC 2.7.7.49)
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16020169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A scientific career from the early 1960s till 2023: A tale of the various protagonists.

    De Clercq, Erik

    Biochemical pharmacology

    2024  , Page(s) 116248

    Abstract: ... of actors played a decisive role: Piet De Somer, Tom C. Merigan, Paul A. Janssen, Maurice Hilleman, and ...

    Abstract In this era spanning more than 60 years (from the early 1960s till today (2023), a broad variety of actors played a decisive role: Piet De Somer, Tom C. Merigan, Paul A. Janssen, Maurice Hilleman, and Georges Smets. Two protagonists (Antonín Holý and John C. Martin) formed with me a unique triangle (the Holý Trinity). Walter Fiers' group (with the help of Jean Content) contributed to the cloning of human β-interferon, and Piet Herdewijn accomplished the chemical synthesis of an array of anti-HIV 2',3'-dideoxynucleoside analogues. Rudi Pauwels, Masanori Baba, Dominique Schols, Johan Neyts, Lieve Naesens, Anita Van Lierde, Graciela Andrei, Robert Snoeck and Dirk Daelemans, as members of my team, helped me in achieving the intended goal, the development of a selective therapy for virus infections. The collaboration with "Lowie" (Guangdi Li) generated a new dimension for the future.
    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The development of BVDU: An odyssey.

    De Clercq, Erik

    Antiviral chemistry & chemotherapy

    2023  Volume 31, Page(s) 20402066231152971

    Abstract: Brivudin, (( ...

    Abstract Brivudin, ((
    MeSH term(s) Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Bromodeoxyuridine/metabolism ; Bromodeoxyuridine/pharmacology ; Herpesvirus 3, Human ; Herpes Zoster/drug therapy ; Herpesvirus 1, Human/metabolism ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Thymidine Kinase/genetics ; Thymidine Kinase/metabolism ; Thymidine Kinase/therapeutic use
    Chemical Substances brivudine (2M3055079H) ; Antiviral Agents ; Bromodeoxyuridine (G34N38R2N1) ; Fluorouracil (U3P01618RT) ; Thymidine Kinase (EC 2.7.1.21)
    Language English
    Publishing date 2023-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033586-9
    ISSN 2040-2066 ; 0956-3202
    ISSN (online) 2040-2066
    ISSN 0956-3202
    DOI 10.1177/20402066231152971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The magic of a methyl group: Biochemistry at the service of medicine.

    De Clercq, Erik

    Biochemical pharmacology

    2023  Volume 216, Page(s) 115786

    Abstract: A carbon-carbon linkage is created when a methyl group is implanted on dUMP, thus resulting in the formation of dTMP by thymidylate synthase. The methyl group is deleted by aromatase when androgens are converted to estrogens. The methyl group is ... ...

    Abstract A carbon-carbon linkage is created when a methyl group is implanted on dUMP, thus resulting in the formation of dTMP by thymidylate synthase. The methyl group is deleted by aromatase when androgens are converted to estrogens. The methyl group is rearranged with the help of vitamin B12 in the isomerization of methylmalonyl-CoA to succinyl-CoA. S-adenosylmethionine (SAM) serves as the universal methyl donor involved in the biosynthesis of adrenaline and creatine(phosphate). It also interferes with the 5'-mRNA capping and the degradation of catecholamines (i.e. adrenaline, noradrenaline). Cholesterol could be viewed as a conglomeration of methyl groups. Finally, as part of valine, two methyl functions participate in the origin of one of the most frequent hereditary diseases on earth, sickle cell anemia.
    MeSH term(s) Vitamin B 12/metabolism ; Cholesterol ; Epinephrine
    Chemical Substances Vitamin B 12 (P6YC3EG204) ; Cholesterol (97C5T2UQ7J) ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2023.115786
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  7. Book: Antiviral drug strategies

    DeClercq, Erik

    (Methods and principles in medicinal chemistry ; 50)

    2011  

    Author's details ed. by Erik DeClercq
    Series title Methods and principles in medicinal chemistry ; 50
    Collection
    Keywords Viruzid ; Virostatikum ; Arzneimittelentwicklung
    Subject Arzneimittel ; Drug Development ; Virustatikum ; Virostaticum ; Virustaticum ; Virenhemmendes Mittel ; Virushemmer ; Antiviraler Wirkstoff ; Antivirales Agens
    Subject code 615.19
    Language English
    Size XX, 406 S. zahlr. Ill., graph. Darst., 25 cm
    Publisher Wiley-VCH-Verl
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT017236847
    ISBN 978-3-527-32696-9 ; 3-527-32696-0 ; 9783527635955 ; 9783527635962 ; 9783527635979 ; 9783527635986 ; 3527635955 ; 3527635963 ; 3527635971 ; 352763598X
    Database Catalogue ZB MED Medicine, Health

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    2012 A 2171 order for loan Magazin

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  8. Article ; Online: Hydrogen Bonding (Base Pairing) in Antiviral Activity.

    De Clercq, Erik

    Viruses

    2023  Volume 15, Issue 5

    Abstract: Base pairing based on hydrogen bonding has, since its inception, been crucial in the antiviral activity of arabinosyladenine, 2'-deoxyuridines (i.e., IDU, TFT, BVDU), acyclic nucleoside analogues (i.e., acyclovir) and nucleoside reverse transcriptase ... ...

    Abstract Base pairing based on hydrogen bonding has, since its inception, been crucial in the antiviral activity of arabinosyladenine, 2'-deoxyuridines (i.e., IDU, TFT, BVDU), acyclic nucleoside analogues (i.e., acyclovir) and nucleoside reverse transcriptase inhibitors (NRTIs). Base pairing based on hydrogen bonding also plays a key role in the mechanism of action of various acyclic nucleoside phosphonates (ANPs) such as adefovir, tenofovir, cidofovir and O-DAPYs, thus explaining their activity against a wide array of DNA viruses (human hepatitis B virus (HBV), human immunodeficiency (HIV) and human herpes viruses (i.e., human cytomegalovirus)). Hydrogen bonding (base pairing) also seems to be involved in the inhibitory activity of Cf1743 (and its prodrug FV-100) against varicella-zoster virus (VZV) and in the activity of sofosbuvir against hepatitis C virus and that of remdesivir against SARS-CoV-2 (COVID-19). Hydrogen bonding (base pairing) may also explain the broad-spectrum antiviral effects of ribavirin and favipiravir. This may lead to lethal mutagenesis (error catastrophe), as has been demonstrated with molnutegravir in its activity against SARS-CoV-2.
    MeSH term(s) Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Nucleosides/pharmacology ; Base Pairing ; Hydrogen Bonding ; COVID-19 ; SARS-CoV-2 ; Viruses
    Chemical Substances Antiviral Agents ; Nucleosides
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15051145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reflections on the Rega Institute for Medical Research, at the fiftieth anniversary of the Rega Stichting vzw (Rega Instituut vzw, Rega Foundation).

    Clercq, Erik De

    Antiviral chemistry & chemotherapy

    2022  Volume 30, Page(s) 20402066221129979

    Abstract: ... by Prof. Piet De Somer (where Prof. Alfons Billiau, Prof. André Vlerick and I were also present ...

    Abstract The idea to start the Rega Foundation was conceived in 1971 at an informal meeting organized by Prof. Piet De Somer (where Prof. Alfons Billiau, Prof. André Vlerick and I were also present), before the Foundation was formally created in 1972. From the early years some antiviral compounds, such as BVDU and the aminoacyl esters of acyclovir (from which ultimately valacyclovir evolved) originated. The advent of AIDS in 1981 and the discovery of the etiologic agent (HIV) thereof in 1983 have led to the identification of an avalanche of anti-HIV compounds in which the Rega Institute has played a primordial role. Foremost among these compounds was tenofovir, discovered in collaboration with Antonín Holý from the IOCB (Institute of Organic Chemistry and Biochemistry) in Prague. Tenofovir laid the basis for the treatment of HIV (AIDS) and hepatitis B virus (HBV) infections, and in combination with emtricitabine it was the first chemical ever approved by the US FDA (Food and Drug Administration) for the prophylaxis of HIV infections.
    MeSH term(s) Humans ; HIV Infections/drug therapy ; Acquired Immunodeficiency Syndrome/drug therapy ; Anniversaries and Special Events ; Tenofovir ; Antiviral Agents/chemistry ; Hepatitis B virus ; Biomedical Research ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use
    Chemical Substances Tenofovir (99YXE507IL) ; Antiviral Agents ; Anti-HIV Agents
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033586-9
    ISSN 2040-2066 ; 0956-3202
    ISSN (online) 2040-2066
    ISSN 0956-3202
    DOI 10.1177/20402066221129979
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  10. Article ; Online: Cidofovir for the Treatment of Molluscum Contagiosum Virus.

    De Clercq, Erik

    Viruses

    2022  Volume 14, Issue 11

    Abstract: ... of poxviruses was first demonstrated by De Clercq et al.. That its active metabolite, the diphosphate, was found ...

    Abstract That cidofovir, an acyclic nucleoside phosphonate (ANP), was inhibitory to the replication of poxviruses was first demonstrated by De Clercq et al.. That its active metabolite, the diphosphate, was found to be inhibitory to the molluscum contagiosum (
    MeSH term(s) Humans ; Cidofovir/therapeutic use ; Molluscum contagiosum virus ; Cytosine ; Organophosphonates/therapeutic use ; Molluscum Contagiosum/drug therapy
    Chemical Substances Cidofovir (JIL713Q00N) ; Cytosine (8J337D1HZY) ; Organophosphonates
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14112484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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