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  1. Article: C-

    Girish, T K / Kumar, K Anil / Prasada Rao, U J S

    Toxicology reports

    2016  Volume 3, Page(s) 652–663

    Abstract: C ...

    Abstract C
    Language English
    Publishing date 2016-08-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2016.08.006
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  2. Article: Klebsiella pneumoniae C

    Villalva, Crystal / Patil, Girish / Narayanan, Sai / Chanda, Debarati / Ghimire, Roshan / Snider, Timothy / Ramachandran, Akhilesh / Channappanavar, Rudragouda / More, Sunil

    bioRxiv : the preprint server for biology

    2023  

    Abstract: SARS-CoV-2 patients have been reported to have high rates of ... ...

    Abstract SARS-CoV-2 patients have been reported to have high rates of secondary
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.28.551035
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  3. Article ; Online: Trifluoroethylation and Pentafluoropropylation of C(sp

    Le, Thanh V / Ramachandru, Girish G / Daugulis, Olafs

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 17, Page(s) e202303190

    Abstract: ... the fluorinated scaffolds into organic molecules involves insertion of fluorine-containing carbenes into C(sp ...

    Abstract Polyfluorinated substituents often enhance effectiveness, improve the stability within metabolic processes, and boost the lipophilicity of biologically active compounds. However, methods for their introduction into aliphatic carbon chains remain very limited. A potentially general route to integrate the fluorinated scaffolds into organic molecules involves insertion of fluorine-containing carbenes into C(sp
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303190
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  4. Article ; Online: Extrinsic Pseudocapacitive NiSe/rGO/g-C

    Khaladkar, Somnath R / Maurya, Oshnik / Gund, Girish / Sinha, Bhavesh / Dubal, Deepak / Deshmukh, Rajendra / Kalekar, Archana

    ACS applied materials & interfaces

    2024  Volume 16, Issue 9, Page(s) 11408–11420

    Abstract: ... graphitic carbon nitride (g-C ...

    Abstract Battery-type materials with ultrahigh energy density show great potential for hybrid supercapacitors (HSCs). In this work, we have developed a nickel selenide (NiSe)/reduced graphene oxide (rGO)/graphitic carbon nitride (g-C
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c16010
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  5. Article ; Online: E3 ubiquitin ligase APC/C

    Colaco, Jencia Carminha / Chandrasekaran, Arun Pandian / Karapurkar, Janardhan Keshav / Gowda, D A Ayush / Birappa, Girish / Rajkumar, Sripriya / Suresh, Bharathi / Ko, Nare / Hong, Seok-Ho / Oh, Seung Jun / Kim, Kye-Seong / Ramakrishna, Suresh

    Biochimica et biophysica acta. General subjects

    2023  Volume 1867, Issue 11, Page(s) 130454

    Abstract: ... the interaction between APC/C: Results: Based on the E3 ligase screen and in vitro biochemical experiments ... we identified that APC/C: Conclusion: Our study highlights that APC/C ...

    Abstract Background: The solute carrier family 35 F2 (SLC35F2), belongs to membrane-bound carrier proteins that control various physiological functions and are activated in several cancers. However, the molecular mechanism regulating SLC35F2 protein turnover and its implication in cancer progression remains unexplored. Therefore, screening for E3 ligases that promote SLC35F2 protein degradation is essential during cancer progression.
    Methods: The immunoprecipitation and Duolink proximity ligation assays (PLA) were used to determine the interaction between APC/C
    Results: Based on the E3 ligase screen and in vitro biochemical experiments, we identified that APC/C
    Conclusion: Our study highlights that APC/C
    Language English
    Publishing date 2023-09-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2023.130454
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    Uc I Zs.247: Show issues Location:
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  6. Article ; Online: Modification of Association of Cystatin C With Kidney and Cardiovascular Outcomes by Obesity.

    Chen, Debbie C / Scherzer, Rebecca / Ix, Joachim H / Kramer, Holly J / Crews, Deidra C / Nadkarni, Girish / Gutierrez, Orlando / Bullen, Alexander L / Ilori, Titilayo / Garimella, Pranav S / Shlipak, Michael G / Estrella, Michelle M

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2023  Volume 83, Issue 4, Page(s) 489–496.e1

    Abstract: Rationale & objective: Cystatin C-based estimated glomerular filtration rate (eGFR: Study design ... Plain-language summary: Cystatin C is increasingly used in clinical practice to estimate kidney ... function, and cystatin C-based eGFR (eGFR ...

    Abstract Rationale & objective: Cystatin C-based estimated glomerular filtration rate (eGFR
    Study design: Cohort study.
    Setting & participants: 27,249 US adults in the Reasons for Geographic and Racial Differences in Stroke Study.
    Predictors: eGFR
    Outcome: All-cause mortality, kidney failure, incident atherosclerotic cardiovascular disease (ASCVD), and incident heart failure (HF).
    Analytical approach: Multivariable Cox and Fine-Gray models with multiplicative interaction terms were constructed to investigate whether waist circumference quartiles or BMI categories modified associations of eGFR
    Results: Participants had a mean age of 65 years; 54% were women, 41% were Black, and 21% had an eGFR
    Limitations: Included only Black and White persons in the United States.
    Conclusion: Obesity did not modify the association of eGFR
    Plain-language summary: Cystatin C is increasingly used in clinical practice to estimate kidney function, and cystatin C-based eGFR (eGFR
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Atherosclerosis ; Cohort Studies ; Creatinine ; Cystatin C/metabolism ; Glomerular Filtration Rate ; Kidney ; Obesity/epidemiology ; Obesity/complications ; Renal Insufficiency ; Renal Insufficiency, Chronic/epidemiology ; United States/epidemiology
    Chemical Substances Creatinine (AYI8EX34EU) ; Cystatin C ; CST3 protein, human
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2023.08.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
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    Zs.MO 468: Show issues

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  7. Article ; Online: Visible-Light Enabled C(s

    Yedase, Girish Suresh / Jha, Avishek Kumar / Yatham, Veera Reddy

    The Journal of organic chemistry

    2022  Volume 87, Issue 8, Page(s) 5442–5450

    Abstract: ... operates under mild reaction conditions and tolerates a variety of functional groups affording C(s ...

    Abstract We herein report the first visible-light-mediated cross-coupling of unactivated alkyl iodides with aryl bromides through synergistic halogen atom transfer (XAT) and nickel catalysis. This simple protocol operates under mild reaction conditions and tolerates a variety of functional groups affording C(s
    MeSH term(s) Bromides ; Catalysis ; Halogens ; Nickel ; Oxidation-Reduction
    Chemical Substances Bromides ; Halogens ; Nickel (7OV03QG267)
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c00251
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  8. Article ; Online: Sofosbuvir-velpatasvir in children 3-17 years old with hepatitis C virus infection.

    Jonas, Maureen M / Romero, Rene / Rosenthal, Philip / Lin, Chuan-Hao / Verucchi, Gabriella / Wen, Jessica / Balistreri, William F / Whitworth, Suzanne / Bansal, Sanjay / Leung, Daniel H / Narkewicz, Michael R / Gonzalez-Peralta, Regino P / Mangia, Alessandra / Karnsakul, Wikrom / Rao, Girish S / Shao, Jiang / de Jong, Jan / Parhy, Bandita / Osinusi, Anu /
    Kersey, Kathryn / Murray, Karen F / Sokal, Etienne M / Schwarz, Kathleen B

    Journal of pediatric gastroenterology and nutrition

    2024  

    Abstract: ... with chronic hepatitis C virus (HCV) infection of any genotype were evaluated.: Methods: In this Phase 2 ...

    Abstract Background: The safety and efficacy of sofosbuvir-velpatasvir in children aged 3-17 years with chronic hepatitis C virus (HCV) infection of any genotype were evaluated.
    Methods: In this Phase 2, multicenter, open-label study, patients received once daily for 12 weeks either sofosbuvir-velpatasvir 400/100 mg tablet (12-17 years), 200/50 mg low dose tablet or oral granules (3-11 years and ≥17 kg), or 150/37.5 mg oral granules (3-5 years and <17 kg). The efficacy endpoint was sustained virologic response 12 weeks after therapy (SVR12). Dose appropriateness was confirmed by intensive pharmacokinetics in each age group.
    Findings: Among 216 patients treated, 76% had HCV genotype 1% and 12% had genotype 3. Rates of SVR12 were 83% (34/41) among 3-5-year-olds, 93% (68/73) among 6-11-year-olds, and 95% (97/102) among 12-17-year-olds. Only two patients experienced virologic failure. The most common adverse events were headache, fatigue, and nausea in 12-17-year-olds; vomiting, cough, and headache in 6-11-year-olds; and vomiting in 3-5-year-olds. Three patients discontinued treatment because of adverse events. Four patients had serious adverse events; all except auditory hallucination (n = 1) were considered unrelated to study drug. Exposures of sofosbuvir, its metabolite GS-331007, and velpatasvir were comparable to those in adults in prior Phase 2/3 studies. Population pharmacokinetic simulations supported weight-based dosing for children in this age range.
    Interpretation: The pangenotypic regimen of sofosbuvir-velpatasvir is highly effective and safe in treating children 3-17 years with chronic HCV infection.
    Language English
    Publishing date 2024-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1002/jpn3.12045
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    Zs.A 1728: Show issues Location:
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  9. Article ; Online: Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review.

    Kumar, Prabal / Nayak, Kusumakshi / Umakanth, Shashikiran / Girish, N

    Aging clinical and experimental research

    2023  Volume 35, Issue 6, Page(s) 1161–1186

    Abstract: Background: C-terminal Agrin Fragment (CAF) has emerged as a potent biomarker for identifying ...

    Abstract Background: C-terminal Agrin Fragment (CAF) has emerged as a potent biomarker for identifying sarcopenia. However, the effect of interventions on CAF concentration and the association of CAF with sarcopenia components are unclear.
    Objective: To review the association between CAF concentration and muscle mass, muscle strength, and physical performance among individuals with primary and secondary sarcopenia and to synthesize the effect of interventions on the change in the level of CAF concentration.
    Methods: A systematic literature search was conducted in six electronic databases, and studies were included if they met the selection criteria decided a priori. The data extraction sheet was prepared, validated, and extracted relevant data.
    Results: A total of 5,158 records were found, of which 16 were included. Among studies conducted on individuals with primary sarcopenia, muscle mass was significantly associated with CAF levels, followed by hand grip strength (HGS) and physical performance, with more consistent findings in males. While in secondary sarcopenics, the strongest association was found for HGS and CAF levels, followed by physical performance and muscle mass. CAF concentration was reduced in trials that used functional, dual task, and power training, whereas resistance training and physical activity raised CAF levels. Hormonal therapy did not affect serum CAF concentration.
    Conclusion(s): The association between CAF and sarcopenic assessment parameters varies in primary and secondary sarcopenics. The findings would help practitioners and researchers choose the best training mode/parameters/exercises to reduce CAF levels and, eventually, manage sarcopenia.
    MeSH term(s) Humans ; Male ; Agrin ; Hand Strength/physiology ; Muscle Strength ; Sarcopenia
    Chemical Substances Agrin ; C-terminal agrin fragment
    Language English
    Publishing date 2023-03-28
    Publishing country Germany
    Document type Journal Article ; Systematic Review
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-023-02396-w
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    Zs.A 3343: Show issues Location:
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  10. Article: COVID-19-associated acute respiratory distress syndrome (C-ARDS): Inhaled nitroglycerin could be an efficient pulmonary vasodilator.

    Daunaria, Deepak K / Singh, Girish K / Agarwal, Ankit / Mishra, Priyanka

    Indian journal of anaesthesia

    2023  Volume 67, Issue 4, Page(s) 403–405

    Language English
    Publishing date 2023-04-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0019-5049
    ISSN 0019-5049
    DOI 10.4103/ija.ija_635_22
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