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  1. Book: Handbook of antimicrobial resistance

    Gotte, Matthias / Berghuis, Albert / Matlashewski, Greg / Wainberg, Mark A. / Sheppard, Donald

    (Springer reference)

    2017  

    Author's details Matthias Gotte, Albert Berghuis, Greg Matlashewski, Mark A. Wainberg, Donald Sheppard
    Series title Springer reference
    Language English
    Size xvii, 606 Seiten, Illustrationen
    Publisher Springer
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT019346483
    ISBN 978-1-4939-0693-2 ; 9781493906949 ; 1-4939-0693-3 ; 1493906941
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 1129 available for loan (reading room) Lesesaal EG

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  2. Article: Global perspective from International AIDS Society president Mark Wainberg. Interview by Dennis Blakesley.

    Wainberg, M A

    JAMA

    1998  Volume 280, Issue 21, Page(s) 1811, 1813–4

    MeSH term(s) Acquired Immunodeficiency Syndrome/prevention & control ; Global Health ; Humans ; Societies, Medical
    Language English
    Publishing date 1998-12-02
    Publishing country United States
    Document type Interview
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
    ISSN (online) 1538-3598
    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
    DOI 10.1001/jama.280.21.1811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Early HIV treatment to forestall drug resistance.

    Wainberg, Mark A

    The Lancet. Infectious diseases

    2016  Volume 16, Issue 5, Page(s) 512–513

    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(16)00013-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: landmark HIV-1 research honoured.

    Berkhout, Ben / Lever, Andrew / Wainberg, Mark / Fassati, Ariberto / Borrow, Persephone / Fujii, Masahiro

    Retrovirology

    2013  Volume 10, Page(s) 38

    MeSH term(s) Awards and Prizes ; Biomedical Research/trends ; France ; HIV Infections/virology ; HIV-1/physiology ; History, 20th Century ; History, 21st Century ; Humans ; Proviruses/physiology ; Virology/trends ; Virus Latency
    Language English
    Publishing date 2013-04-05
    Publishing country England
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 2142602-8
    ISSN 1742-4690 ; 1742-4690
    ISSN (online) 1742-4690
    ISSN 1742-4690
    DOI 10.1186/1742-4690-10-38
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Rôle de la pharmacogénétique dans le métabolisme et le transport des antirétroviraux.

    Michaud, Véronique / Turgeon, Jacques / Flockhart, David / Wainberg, Mark A

    Virologie (Montrouge, France)

    2022  Volume 15, Issue 3, Page(s) 157–174

    Abstract: Wide intra- and inter-subject variability in antiretroviral drug response is observed. Pharmacotherapy of HIV-infected patients is challenging considering the great numbers of co-morbidities increasing the risk of drug-drug interactions. Drug-metabolism ... ...

    Title translation Importance of pharmacogenetics in antiretroviral metabolism and drug-transporters.
    Abstract Wide intra- and inter-subject variability in antiretroviral drug response is observed. Pharmacotherapy of HIV-infected patients is challenging considering the great numbers of co-morbidities increasing the risk of drug-drug interactions. Drug-metabolism enzymes and drug-transporters regulate drug access to the systemic circulation, target cells and sanctuary sites; these factors determine pharmacokinetics and could explain variability in efficacy and adverse drug reactions associated with antiretroviral drugs. Notions related to the major enzymes (CYP450s and UGTs) involved in antiretroviral metabolism and drugtransporters are reviewed with an attention paid on genetic polymorphisms. Genetic polymorphisms affecting the activity or the expression of membrane proteins in the transport of drugs would be highlighted with examples such as neurotoxicity with efavirenz, nephrotoxicity with tenofovir, hepatotoxicity with nevirapine and hyperlibirubinemia associated with indinavir and atazanavir. The objective is to provide a better understanding on mechanisms involved in drugdisposition of antiretroviral helping out health care providers in the management of pharmacotherapy of HIV-infected patients.
    Language French
    Publishing date 2022-09-19
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2011.17135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial Commentary: Clinical Significance of HIV Subtype Variability in Regard to Treatment Outcome.

    Wainberg, Mark A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2015  Volume 60, Issue 10, Page(s) 1550–1551

    MeSH term(s) Drug Resistance, Viral ; Female ; Genotype ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV-1/classification ; HIV-1/drug effects ; Humans ; Male
    Language English
    Publishing date 2015-05-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/civ107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  7. Article: Antiretroviral therapy with integrase inhibitors: more options.

    Raffi, François / Wainberg, Mark A

    Virologie (Montrouge, France)

    2019  Volume 17, Issue 2, Page(s) 54–60

    Abstract: Strand transfer inhibitors of HIV-1 integrase represent a new and very potent class of compounds, besides reverse transcriptase and protease inhibitors. The first integrase inhibitor, raltegravir, was made available in 2007. Recently, phase 3 studies of ... ...

    Title translation Traitement de l’infection VIH par inhibiteurs d’intégrase : plus d’options.
    Abstract Strand transfer inhibitors of HIV-1 integrase represent a new and very potent class of compounds, besides reverse transcriptase and protease inhibitors. The first integrase inhibitor, raltegravir, was made available in 2007. Recently, phase 3 studies of two new compounds - elvitegravir which needs pharmacological boosting with either ritonavir or cobicistat, and dolutegravir - have been presented, showing high virologic success rates, over 48-96 weeks, both in first-line antiretroviral therapy and in the treatment of experienced patients. The clinical tolerance of the three inhibitors is good, and they have globally a good safety profile. Dolutegravir and cobicistat exerts a blockade of the renal tubular secretion of creatinine, leading to a decrease in estimated creatinine clearance, which does not reflect renal toxicity, i.e. decrease in glomerular filtration. Both dolutegravir and elvitegravir (within the fixed dose combination of TDF/FTC/elvitegravir/cobicistat) should be available in clinical practice soon, which will offer more options for the strategic use of integrase inhibitors to treat both HIV-1 and possibly HIV-2 infections.
    Language English
    Publishing date 2019-12-10
    Publishing country France
    Document type Journal Article
    ISSN 1267-8694
    ISSN 1267-8694
    DOI 10.1684/vir.2013.0479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Combination therapies, effectiveness, and adherence in patients with HIV infection: clinical utility of a single tablet of emtricitabine, rilpivirine, and tenofovir.

    Wainberg, Mark A

    HIV/AIDS (Auckland, N.Z.)

    2013  Volume 5, Page(s) 41–49

    Abstract: A recent addition to the anti-human immunodeficiency virus armamentarium of drugs is rilpivirine, which is a potent non-nucleoside reverse transcriptase inhibitor. This review focuses on the clinical utility of rilpivirine in terms of efficacy and ... ...

    Abstract A recent addition to the anti-human immunodeficiency virus armamentarium of drugs is rilpivirine, which is a potent non-nucleoside reverse transcriptase inhibitor. This review focuses on the clinical utility of rilpivirine in terms of efficacy and virologic suppression, drug resistance, drug-drug interactions, and safety. The rilpivirine-tenofovir-emtricitabine combination is a safe and effective regimen for use in most patients who are ready to start first-line anti-human immunodeficiency virus therapy. Although drug resistance can be a problem in patients who initiate therapy on rilpivirine-based regimens with viral loads > 100,000 copies of viral RNA/mL, this problem can be alleviated by first starting therapy with efavirenz-tenofovir-emtricitabine for several months to suppress viral load to <50 copies/mL before switching to rilpivirine-based therapy. E138K is the most important mutation associated with resistance against rilpivirine and its development must be avoided whenever possible, because this mutation confers broad cross-resistance against all approved members of the non-nucleoside reverse transcriptase inhibitor family of drugs.
    Language English
    Publishing date 2013-02-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520734-9
    ISSN 1179-1373
    ISSN 1179-1373
    DOI 10.2147/HIV.S32377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Will LEDGIN molecules be able to play a role in a cure for HIV infection?

    Mesplède, Thibault / Wainberg, Mark A

    EBioMedicine

    2016  Volume 8, Page(s) 14–15

    Language English
    Publishing date 2016-05-07
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2016.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  10. Article: Results of a Randomized, Double-Blind, Placebo-Controlled, Phase 1b/2 Trial of Nabpaclitaxel + Gemcitabine ± Olaratumab in Treatment-Naïve Participants with Metastatic Pancreatic Cancer.

    Gardner, Faithlore P / Wainberg, Zev A / Fountzilas, Christos / Bahary, Nathan / Womack, Mark S / Macarulla, Teresa / Garrido-Laguna, Ignacio / Peterson, Patrick M / Borazanci, Erkut / Johnson, Melissa / Ceccarelli, Matteo / Pelzer, Uwe

    Cancers

    2024  Volume 16, Issue 7

    Abstract: The efficacy and safety of olaratumab plus nabpaclitaxel and gemcitabine in treatment-naïve participants with metastatic pancreatic ductal adenocarcinoma was evaluated. An initial phase 1b dose-escalation trial was conducted to determine the olaratumab ... ...

    Abstract The efficacy and safety of olaratumab plus nabpaclitaxel and gemcitabine in treatment-naïve participants with metastatic pancreatic ductal adenocarcinoma was evaluated. An initial phase 1b dose-escalation trial was conducted to determine the olaratumab dose for the phase 2 trial, a randomized, double-blind, placebo-controlled trial to compare overall survival (OS) in the olaratumab arm vs. placebo arms. In phase 1b, 22 participants received olaratumab at doses of 15 and 20 mg/kg with a fixed dose of nabpaclitaxel and gemcitabine. In phase 2, 159 participants were randomized to receive olaratumab 20 mg/kg in cycle 1 followed by 15 mg/kg in the subsequent cycles (n = 81) or the placebo (n = 78) on days 1, 8, and 15 of a 28-day cycle, plus nabpaclitaxel and gemcitabine. The primary objective of the trial was not met, with a median OS of 9.1 vs. 10.8 months (hazard ratio [HR] = 1.05; 95% confidence interval [CI]: 0.728, 1.527;
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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