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Article ; Online: Induction of systemic resistance in Solanum lycopersicum and Capsicum annum seedlings against Fusarium wilt by Streptomyces bioformulations.

Devi, Sapna / Manhas, Rajesh Kumari

Environmental science and pollution research international

2023 Volume 30, Issue 50, Page(s) 109438–109452

Abstract: Plant diseases induced by various phytopathogens pose a significant threat to contemporary agricultural systems around the world. In modern agriculture, the use of pesticides is still a valuable and effective method to control plant diseases. However, ... ...

Abstract	Plant diseases induced by various phytopathogens pose a significant threat to contemporary agricultural systems around the world. In modern agriculture, the use of pesticides is still a valuable and effective method to control plant diseases. However, agrochemicals are becoming less popular because of the accretion of toxic compounds perilous and potentially hazardous to humans and the environment. Taking into consideration these aspects, the present study was conducted to explore the biocontrol potential of an endophytic Streptomyces sp. SP5 bioformulations against Fusarium wilt. Three bioformulations were prepared using cell biomass and different carriers, i.e., B1 (talc-kaolin), B2 (MgSO
MeSH term(s)	Humans ; Seedlings ; Streptomyces ; Solanum lycopersicum ; Fusarium ; Capsicum ; Talc/pharmacology ; Antioxidants/pharmacology ; Superoxide Dismutase ; Plant Diseases/prevention & control
Chemical Substances	Talc (14807-96-6) ; Antioxidants ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-09-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29973-w
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Article ; Online: Purification and biological analysis of antimicrobial compound produced by an endophytic Streptomyces sp.

Devi, Sapna / Sharma, Manish / Manhas, Rajesh Kumari

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15248

Abstract: Fungal phytopathogens and drug-resistant bacteria are two significant challenges in agriculture and public health, respectively. As a result, new sources of antimicrobial compounds are urgently needed. Taking into consideration these aspects, the present ...

Abstract	Fungal phytopathogens and drug-resistant bacteria are two significant challenges in agriculture and public health, respectively. As a result, new sources of antimicrobial compounds are urgently needed. Taking into consideration these aspects, the present study was carried out to explore the antimicrobial activity of Streptomyces sp. SP5 against drug-resistant bacteria, especially methicillin resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococcus and fungal phytopathogens. MRSA and VRE are both types of antibiotic-resistant bacteria that pose significant challenges to public health. In vitro analysis of the metabolites of Streptomyces sp. SP5 exhibited broad-spectrum antimicrobial activity against drug-resistant bacteria and phytopathogenic fungi. Further chemical investigation of the diethyl ether extract led to the isolation and purification of an antimicrobial compound. The structure of the purified compound was elucidated by performing detailed spectroscopic analysis including MS, IR, and NMR. The compound was identified as plicacetin. Plicacetin is a nucleoside antibiotic that has been reported for antibacterial activity against Gram-positive bacterium Mycobacterium tuberculosis. According to our knowledge, the present study is the first to demonstrate the antimicrobial properties of plicacetin against Fusarium oxysporum, Alternaria brassicicola, Fusarium solani, VRE and Bacillus subtilis. The outcome of the current study endorses that compound produced by Streptomyces sp. SP5 can be used as an antimicrobial agent against fungal phytopathogens and drug-resistant bacteria.
MeSH term(s)	Methicillin-Resistant Staphylococcus aureus ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Agriculture ; Bacillus subtilis
Chemical Substances	Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41296-x
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Article ; Online: Insecticidal potential of endophytic Streptomyces sp. against Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae) and biosafety evaluation.

Devi, Sapna / Diksha / Verma, Jaya / Sohal, Satwinder Kaur / Manhas, Rajesh Kumari

Toxicon : official journal of the International Society on Toxinology

2023 Volume 233, Page(s) 107246

Abstract: Fruit flies of Tephritidae family pose a serious threat to cultivation of fruits and vegetables across the world. Among them, melon fruit fly, Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae) is a devastating pest of plants from Cucurbitaceae ... ...

Abstract	Fruit flies of Tephritidae family pose a serious threat to cultivation of fruits and vegetables across the world. Among them, melon fruit fly, Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae) is a devastating pest of plants from Cucurbitaceae family. In a rising concern about the harmful effects associated with the use of chemical insecticides and development of resistance in pest insects, safer pest management strategies such as, use of biopesticides of microbial origin are being contemplated. Therefore, the present study aimed to evaluate the insecticidal potential of Streptomyces sp. SP5 protein extract against Z. cucurbitae. MTT assay, Ames mutagenicity, DNA nicking, and comet assay were conducted to determine the biosafety of protein extract. Second instar larvae of Z. cucurbitae were treated with various concentrations (1, 100, 200, 300, 400, and 500 μg/ml) of Streptomyces sp. SP5 protein extract. The protein extract showed significant larvicidal effects with LC
MeSH term(s)	Animals ; Tephritidae ; Insecticides/toxicity ; Streptomyces ; Containment of Biohazards ; Larva ; Drosophila
Chemical Substances	Insecticides
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2023.107246
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Article ; Online: Impacts of lockdown on the dynamics of forestry biomass, wildlife species and control of atmospheric pollution.

Devi, Sapna / Fatma, Reda / Verma, Vinay

International journal of dynamics and control

2022 Volume 11, Issue 3, Page(s) 1415–1431

Abstract: In this paper, we have formulated and analysed a mathematical model to investigate the impacts of lockdown on the dynamics of forestry biomass, wildlife species and pollution. For this purpose, we have considered a nonlinear system of four ordinary ... ...

Abstract	In this paper, we have formulated and analysed a mathematical model to investigate the impacts of lockdown on the dynamics of forestry biomass, wildlife species and pollution. For this purpose, we have considered a nonlinear system of four ordinary differential equations representing rates of change of the density of forestry biomass, the density of wildlife species, the concentration of pollutants and lockdown. Conditions for the existence, uniqueness and local stability of all equilibria along with the global stability of the interior equilibrium point are derived. Furthermore, conditions that influence the persistence of the system are obtained. By formulating an optimal control problem, the optimal strategies for minimizing the cost of implementation of lockdown as well as the concentration of pollutants are also studied. Numerical simulations are carried out to verify and validate our analytical findings. By this study, we have observed that implementation of lockdown for a sufficient period of time minimizes excessive harvesting of both forestry biomass and wildlife species and the concentration of pollutants in the environment. It is also found that lockdown policy is effective in the optimal control of atmospheric pollution. Therefore, lockdown plays a significant role in the dynamics of forestry biomass, wildlife species and control of pollution in the environment.
Language	English
Publishing date	2022-10-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2714518-9
ISSN	2195-2698 ; 2195-268X
ISSN (online)	2195-2698
ISSN	2195-268X
DOI	10.1007/s40435-022-01053-w
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Article ; Online: Investigating the plant growth promoting and biocontrol potentiality of endophytic Streptomyces SP. SP5 against early blight in Solanum lycopersicum seedlings.

Devi, Sapna / Sharma, Manish / Manhas, Rajesh Kumari

BMC microbiology

2022 Volume 22, Issue 1, Page(s) 285

Abstract: Background: Early blight (EB), caused by Alternaria solani, is one of the alarming diseases that restrict tomato production globally. Existing cultural practices and fungicide applications are not enough to control early blight diseases. Therefore, the ... ...

Abstract	Background: Early blight (EB), caused by Alternaria solani, is one of the alarming diseases that restrict tomato production globally. Existing cultural practices and fungicide applications are not enough to control early blight diseases. Therefore, the study aimed to isolate, identify, and characterize an endophytic Streptomyces exhibiting the potential to control early blight in tomato and also promote plant growth. Results: From a Citrus jambhiri leaf, an endophytic Streptomyces sp. with antagonistic activity against Alternaria solani, Colletotrichum acutatum, Cladosporium herbarum, Alternaria brassicicola, Alternaria sp., Fusarium oxysporum and Fusarium sp. was isolated. It was identified as a Streptomyces sp. through 16S ribosomal DNA sequence analysis and designated as SP5. It also produced indole acetic acid which was confirmed by Salkowski reagent assay, TLC and HPLC analysis. Treatment of pathogen infected plants with Streptomyces sp. SP5 antagonists (culture cells/culture supernatant/solvent extract/ acetone precipitates) decreased the early blight disease incidence and significantly increased the various agronomic traits. Conclusion: The present study concluded that Streptomyces sp. SP5 possessed antifungal activity against different fungal phytopathogens and had significant potential to control early blight disease and promote plant growth.
MeSH term(s)	Seedlings ; Lycopersicon esculentum ; Streptomyces/genetics ; Moraxellaceae Infections
Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041505-9
ISSN	1471-2180 ; 1471-2180
ISSN (online)	1471-2180
ISSN	1471-2180
DOI	10.1186/s12866-022-02695-8
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Article: Eosinophilic Enteritis Flare-Up Mimicking Acute Gastroenteritis: A Rare Case.

Veer, Maha / Devi, Sapna / Sonia, Fnu / Khenhrani, Raja Ram / Kumar, Mukesh

Cureus

2023 Volume 15, Issue 8, Page(s) e44199

Abstract: Eosinophilic enteritis is a rare subset of eosinophilic gastrointestinal disorders. It typically presents with chronic symptoms of abdominal pain, nausea, vomiting, diarrhea, and ascites. However, the clinical presentation can vary due to acute flare-ups. ...

Abstract	Eosinophilic enteritis is a rare subset of eosinophilic gastrointestinal disorders. It typically presents with chronic symptoms of abdominal pain, nausea, vomiting, diarrhea, and ascites. However, the clinical presentation can vary due to acute flare-ups. Here, we present a case of eosinophilic enteritis in a young female patient with intractable vomiting and diarrhea, mimicking acute gastroenteritis in the absence of other gastrointestinal symptoms. This case illustrates the challenge of diagnosing acute and diverse presentations of eosinophilic enteritis. It also highlights the importance of promptly treating and confirming the diagnosis through urgent tissue histopathology in adolescents with unexplained vomiting and diarrhea.
Language	English
Publishing date	2023-08-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44199
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Article ; Online: Residue estimation and dietary risk assessment of fenvalerate, novaluron, and profenofos in bell pepper grown under protected and open field conditions.

Gautam, Himani / Katna, Sapna / Dubey, Jatiender Kumar / Sharma, Ajay / Brar, Gaganpreet Singh / Singh, Shubhra / Devi, Nisha / Kumar, Arvind / Prashad, Hema

Environmental science and pollution research international

2024 Volume 31, Issue 7, Page(s) 10934–10949

Abstract: Residue studies were conducted in bell pepper crops (green and yellow bell pepper) to ensure the safe use of fenvalerate, profenofos, and novaluron (under open field and protected conditions) in randomized block design (RBD) following three applications ... ...

Abstract	Residue studies were conducted in bell pepper crops (green and yellow bell pepper) to ensure the safe use of fenvalerate, profenofos, and novaluron (under open field and protected conditions) in randomized block design (RBD) following three applications at a 10-day interval over two consecutive years, 2021 and 2022. A robust analytical method was developed using quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction and gas chromatography-tandem mass spectrometry (GC-MS/MS) for the determination of pesticide residues in bell pepper samples. The half-lives for fenvalerate were 2.47-2.87 and 2.50-3.03 days on bell pepper under open field conditions, whereas the corresponding values for bell pepper under protected conditions were 3.84-4.58 and 4.17-4.71 days, during 2021 and 2022, respectively. Profenofos displayed half-lives of 2.03-2.65 and 2.15-2.77 days in open field conditions and 3.05-3.89 and 3.16-3.78 days in protected conditions during 2021 and 2022, respectively. Similarly, novaluron had half-lives of 2.87-3.49 and 3.24-3.75 days under protected conditions in 2021 and 2022, respectively. The maximum residue limits (MRLs) were calculated to be 0.6 mg/kg for fenvalerate, while for profenofos it was 0.7 mg/kg on bell pepper under open field conditions at double doses, at the proposed pre-harvest interval (PHI) of 3 days. Likewise, for bell peppers grown under protected conditions, MRLs at the PHI of 3 days were determined to be 0.8 mg/kg for fenvalerate, 0.3 mg/kg for novaluron, and 1.5 mg/kg for profenofos. A dietary risk assessment study indicated that the percentage of acute hazard index (% aHI) was significantly lower than 100, and hazard quotient (HQ) values were below 1, signifying no acute or chronic risk to consumers. These findings underscore the safety of consuming bell peppers treated with fenvalerate, profenofos, and novaluron under the protected and open field conditions.
MeSH term(s)	Tandem Mass Spectrometry/methods ; Capsicum/chemistry ; Gas Chromatography-Mass Spectrometry/methods ; Pesticide Residues/analysis ; Risk Assessment ; Nitriles ; Phenylurea Compounds ; Pyrethrins ; Organothiophosphates
Chemical Substances	fenvalerate (Z6MXZ39302) ; profenofos (7J04O7BS4W) ; novaluron (Z8H1B3CW0B) ; Pesticide Residues ; Nitriles ; Phenylurea Compounds ; Pyrethrins ; Organothiophosphates
Language	English
Publishing date	2024-01-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-31846-9
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Article: Modelling and analysis of a SEIQR model on COVID-19 pandemic with delay.

Bhadauria, Archana Singh / Devi, Sapna / Gupta, Nivedita

Modeling earth systems and environment

2021 Volume 8, Issue 3, Page(s) 3201–3214

Abstract: This paper deals with mathematical modelling and analysis of a SEIQR model to study the dynamics of COVID-19 considering delay in conversion of exposed population to the infected population. The model is analysed for local and global stability using ... ...

Abstract	This paper deals with mathematical modelling and analysis of a SEIQR model to study the dynamics of COVID-19 considering delay in conversion of exposed population to the infected population. The model is analysed for local and global stability using Lyapunov method of stability followed by Hopf bifurcation analysis. Basic reproduction number is determined, and it is observed that local and global stability conditions are dependent on the number of secondary infections due to exposed as well as infected population. Our study reveals that asymptomatic cases due to exposed population play a vital role in increasing the COVID-19 infection among the population.
Language	English
Publishing date	2021-09-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2821317-8
ISSN	2363-6211 ; 2363-6203
ISSN (online)	2363-6211
ISSN	2363-6203
DOI	10.1007/s40808-021-01279-1
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Article ; Online: Association of Deja vu With Cardiovascular Diseases.

Rashid, Sarim / Khenhrani, Raja Ram / Devi, Sapna / Veer, Maha / Malik, Maria / Malik, Jahanzeb

Current problems in cardiology

2023 Volume 48, Issue 9, Page(s) 101793

Abstract: Recent studies have suggested a link between déjà vu and cardiovascular diseases (CVDs). While the mechanism for this association is not fully understood, 1 theory suggests that déjà vu may be a result of a disruption in the temporal lobe, which is also ... ...

Abstract	Recent studies have suggested a link between déjà vu and cardiovascular diseases (CVDs). While the mechanism for this association is not fully understood, 1 theory suggests that déjà vu may be a result of a disruption in the temporal lobe, which is also responsible for regulating blood pressure and heart rate. Another theory suggests that there may be a shared genetic factor between the 2 conditions, with certain individuals being predisposed to experiencing both. The Apolipoprotein E (APOE) gene, in particular, has been associated with memory processing, Alzheimer's disease, and an increased risk of CVD. The protein encoded by this gene is involved in the metabolism of lipoproteins, including cholesterol and triglycerides, and is also involved in the development of atherosclerosis, which is a key risk factor for CVD. Several hypotheses have been proposed to explain how the APOE4 isoform contributes to CVD, including impairing the clearance of lipoproteins, promoting inflammation, and causing endothelial dysfunction. Psychological factors such as stress may also contribute to the development of CVD, and déjà vu may be associated with emotional arousal and stress. Further research is needed to fully understand the link between déjà vu and CVDs and to explore potential treatment options for individuals who experience both conditions.
MeSH term(s)	Humans ; Deja Vu/psychology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Temporal Lobe/physiology
Language	English
Publishing date	2023-05-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2023.101793
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Article ; Online: Residue behavior and consumer risk assessment of spirotetramat and chlorpyrifos on cabbage heads and cropped soil.

Istatu, Pankaj Sharma / Dubey, Jatiender Kumar / Katna, Sapna / Sharma, Ajay / Sharma, Sakshi / Shandil, Deepika / Devi, Nisha / Kumar, Arvind / Singh, Shubhra / Thakur, Nimisha

Environmental science and pollution research international

2024 Volume 31, Issue 17, Page(s) 25736–25750

Abstract: A field experiment following good agricultural practices was laid out to study the dissipation of spirotetramat (90 g a.i. ... ...

Abstract	A field experiment following good agricultural practices was laid out to study the dissipation of spirotetramat (90 g a.i. ha
MeSH term(s)	Chlorpyrifos ; Soil/chemistry ; Brassica/chemistry ; Pesticide Residues/analysis ; Soil Pollutants/analysis ; Pesticides/analysis ; Risk Assessment ; Half-Life ; Aza Compounds ; Spiro Compounds
Chemical Substances	Chlorpyrifos (JCS58I644W) ; Soil ; spirotetramat (4G7KR034OX) ; Pesticide Residues ; Soil Pollutants ; Pesticides ; Aza Compounds ; Spiro Compounds
Language	English
Publishing date	2024-03-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32854-5
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