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  1. Article ; Online: Response to "a fatal case of Guillain-Barré syndrome after infection with COVID-19".

    Nejad, Javad Hosseini / Heiat, Mohammad / Hosseini, Mohammad Javad / Allahyari, Fakhri / Torabi, Raheleh / Ranjbar, Reza

    Journal of neurovirology

    2022  

    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Letter
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    DOI 10.1007/s13365-022-01069-0
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  2. Article ; Online: Ultrasensitive nano-aptasensor for monitoring retinol binding protein 4 as a biomarker for diabetes prognosis at early stages.

    Torabi, Raheleh / Ghourchian, Hedayatollah

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 594

    Abstract: Prognosis of diabetes risk at early stages has become an important challenge due to the prevalence of this disease. Retinol binding protein 4 (RBP4), a recently identified adipokine, has been introduced as a predictor for the onset of diabetes type 2 in ... ...

    Abstract Prognosis of diabetes risk at early stages has become an important challenge due to the prevalence of this disease. Retinol binding protein 4 (RBP4), a recently identified adipokine, has been introduced as a predictor for the onset of diabetes type 2 in coming future. In the present report a sensitive aptasensor for detection of RBP4 is introduced. The immune sandwich was prepared by immobilizing biotinylated RBP4 aptamers on streptavidin coated polystyrene micro-wells and then incubation of RBP4 as target and finally addition of luminol-antibody bearing intercross-linked gold nanoparticles as reporter. The chemiluminescence intensity was recorded in the presence of hydrogen peroxide as oxidant agent and Au
    MeSH term(s) Age of Onset ; Aptamers, Nucleotide/chemistry ; Aptamers, Nucleotide/genetics ; Biomarkers/blood ; Biosensing Techniques/instrumentation ; Diabetes Mellitus, Type 2/metabolism ; Early Diagnosis ; Female ; Gold/chemistry ; Humans ; Hydrogen-Ion Concentration ; Male ; Metal Nanoparticles ; Prognosis ; Retinol-Binding Proteins, Plasma/analysis ; Retinol-Binding Proteins, Plasma/genetics ; Retinol-Binding Proteins, Plasma/metabolism
    Chemical Substances Aptamers, Nucleotide ; Biomarkers ; RBP4 protein, human ; Retinol-Binding Proteins, Plasma ; Gold (7440-57-5)
    Language English
    Publishing date 2020-01-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-57396-6
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  3. Article ; Online: Ultrasensitive nano-aptasensor for monitoring retinol binding protein 4 as a biomarker for diabetes prognosis at early stages

    Raheleh Torabi / Hedayatollah Ghourchian

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: Abstract Prognosis of diabetes risk at early stages has become an important challenge due to the prevalence of this disease. Retinol binding protein 4 (RBP4), a recently identified adipokine, has been introduced as a predictor for the onset of diabetes ... ...

    Abstract Abstract Prognosis of diabetes risk at early stages has become an important challenge due to the prevalence of this disease. Retinol binding protein 4 (RBP4), a recently identified adipokine, has been introduced as a predictor for the onset of diabetes type 2 in coming future. In the present report a sensitive aptasensor for detection of RBP4 is introduced. The immune sandwich was prepared by immobilizing biotinylated RBP4 aptamers on streptavidin coated polystyrene micro-wells and then incubation of RBP4 as target and finally addition of luminol-antibody bearing intercross-linked gold nanoparticles as reporter. The chemiluminescence intensity was recorded in the presence of hydrogen peroxide as oxidant agent and Au3+ as an efficient catalyst for luminol oxidation. The aptasensor responded to RBP4 in the linear concentration range from 0.001 to 2 ng/mL and detection limit was slightly less than 1 pg/mL. The proposed method has successfully applied to determine the RBP4 in patient real serums. By using the intercross-linked gold nanoparticles, it is possible to provide more accessible surface for immobilizing luminol and enhance the chemiluminescence signal. Therefore, the analytical parameters such as sensitivity, specificity, detection limit and linear range were improved in compare to the biosensors reported in the literature.
    Keywords Medicine ; R ; Science ; Q
    Subject code 500
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Impaired mental health status and uncivil workplace behaviours: An egg and chicken problem.

    Dini, Parisa / Shakiba, Behnam / Alimoradzadeh, Raheleh / Torabi, Nasim

    Journal of affective disorders

    2020  Volume 281, Page(s) 502

    MeSH term(s) Animals ; Chickens ; Health Status ; Humans ; Mental Health ; Sexual Harassment ; Students, Medical ; Workplace
    Language English
    Publishing date 2020-12-24
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2020.12.063
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    Zs.A 1485: Show issues Location:
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  5. Article: A challenging choice of aptamer for the selective enrichment of ochratoxin A

    Torabi, Raheleh / Rezvanipour, Abbas Ali / Heiat, Mohammad

    Journal of separation science. 2021 Feb., v. 44, no. 4

    2021  

    Abstract: In a recent study, the adenosine monophosphate‐specific aptamer has been applied for the rapid extraction of ochratoxin A. Although several publications have already reported the selection of adenosine monophosphate, adenosine triphosphate, and adenosine, ...

    Abstract In a recent study, the adenosine monophosphate‐specific aptamer has been applied for the rapid extraction of ochratoxin A. Although several publications have already reported the selection of adenosine monophosphate, adenosine triphosphate, and adenosine, there is no report on the detection of ochratoxin A using this aptamer. The data of the previous study are surprising since its aptamer‐based magnetic metal‐organic framework has shown a high selectivity with a very low detection limit for the selection of ochratoxin A. However, numerous studies have demonstrated that each aptamer can specifically bind to a target by folding into a unique structure and can differentiate molecules that differ by only one functional group. This study aimed to deal with the possibility of recognizing ochratoxin A and adenosine monophosphate by adenosine monophosphate‐specific aptamer. The procedure was performed by determining structural similarity and alignment, docking adenosine monophosphate and ochratoxin A on aptamer, and monitoring the interactions between ochratoxin A and adenosine monophosphate specific aptamer complex. The results indicated not only the lack of structural similarity between adenosine monophosphate and ochratoxin A but also the little possibility for strong bonds between the ochratoxin A and aptamer.
    Keywords adenosine ; adenosine monophosphate ; adenosine triphosphate ; coordination polymers ; detection limit ; magnetism ; ochratoxin A ; oligonucleotides ; separation
    Language English
    Dates of publication 2021-02
    Size p. 903-907.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-AP-2-clean ; JOURNAL ARTICLE
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.202001044
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review.

    Torabi, Raheleh / Ranjbar, Reza / Halaji, Mehrdad / Heiat, Mohammad

    Molecular and cellular probes

    2020  Volume 53, Page(s) 101636

    Abstract: The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts ... ...

    Abstract The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.
    MeSH term(s) Antiviral Agents/metabolism ; Antiviral Agents/therapeutic use ; Aptamers, Nucleotide/metabolism ; Aptamers, Nucleotide/therapeutic use ; Biosensing Techniques ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy
    Chemical Substances Antiviral Agents ; Aptamers, Nucleotide
    Keywords covid19
    Language English
    Publishing date 2020-07-04
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 639082-1
    ISSN 1096-1194 ; 0890-8508
    ISSN (online) 1096-1194
    ISSN 0890-8508
    DOI 10.1016/j.mcp.2020.101636
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    Zs.A 2230: Show issues Location:
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  7. Article ; Online: A challenging choice of aptamer for the selective enrichment of ochratoxin A.

    Torabi, Raheleh / Rezvanipour, Abbas Ali / Heiat, Mohammad

    Journal of separation science

    2020  Volume 44, Issue 4, Page(s) 903–907

    Abstract: In a recent study, the adenosine monophosphate-specific aptamer has been applied for the rapid extraction of ochratoxin A. Although several publications have already reported the selection of adenosine monophosphate, adenosine triphosphate, and adenosine, ...

    Abstract In a recent study, the adenosine monophosphate-specific aptamer has been applied for the rapid extraction of ochratoxin A. Although several publications have already reported the selection of adenosine monophosphate, adenosine triphosphate, and adenosine, there is no report on the detection of ochratoxin A using this aptamer. The data of the previous study are surprising since its aptamer-based magnetic metal-organic framework has shown a high selectivity with a very low detection limit for the selection of ochratoxin A. However, numerous studies have demonstrated that each aptamer can specifically bind to a target by folding into a unique structure and can differentiate molecules that differ by only one functional group. This study aimed to deal with the possibility of recognizing ochratoxin A and adenosine monophosphate by adenosine monophosphate-specific aptamer. The procedure was performed by determining structural similarity and alignment, docking adenosine monophosphate and ochratoxin A on aptamer, and monitoring the interactions between ochratoxin A and adenosine monophosphate specific aptamer complex. The results indicated not only the lack of structural similarity between adenosine monophosphate and ochratoxin A but also the little possibility for strong bonds between the ochratoxin A and aptamer.
    MeSH term(s) Aptamers, Nucleotide/chemistry ; Food Contamination/analysis ; Ochratoxins/analysis
    Chemical Substances Aptamers, Nucleotide ; Ochratoxins ; ochratoxin A (1779SX6LUY)
    Language English
    Publishing date 2020-12-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.202001044
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  8. Article: Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review

    Torabi, Raheleh / Ranjbar, Reza / Halaji, Mehrdad / Heiat, Mohammad

    Mol Cell Probes

    Abstract: The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts ... ...

    Abstract The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #621879
    Database COVID19

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  9. Article ; Online: Guillain-Barré syndrome associated with COVID-19: a case report study.

    Nejad, Javad Hosseini / Heiat, Mohammad / Hosseini, Mohammad Javad / Allahyari, Fakhri / Lashkari, Ali / Torabi, Raheleh / Ranjbar, Reza

    Journal of neurovirology

    2021  Volume 27, Issue 5, Page(s) 802–805

    Abstract: Acute respiratory distress syndrome (ARDS) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is spreading around the world. Patients with coronavirus disease 2019 (COVID-19) typically present fever, cough, and respiratory illnesses. ... ...

    Abstract Acute respiratory distress syndrome (ARDS) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is spreading around the world. Patients with coronavirus disease 2019 (COVID-19) typically present fever, cough, and respiratory illnesses. It has been revealed that the comorbidities can turn it into severe types, and the managements meet unpredicted complications. Here, we report a case of coronavirus disease 2019 (COVID-19) coincidence with confirmed acute Guillain-Barré syndrome (GBS). Ten days after admission and therapeutic process, the patient developed autonomic dysfunction. Despite respiratory support and receiving intravenous immunoglobulin, the patient died due to cardiac arrest. Albeit it is yet scientifically doubtful, there are raising concerns toward a possible association between GBS and SARS-CoV-2 infection, demonstrating potential neurological symptoms of COVID-19.
    MeSH term(s) Aged ; COVID-19/complications ; Fatal Outcome ; Guillain-Barre Syndrome/virology ; Humans ; Male ; SARS-CoV-2
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    DOI 10.1007/s13365-021-00984-y
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    Zs.A 4426: Show issues Location:
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  10. Article ; Online: Aptamer-Conjugated Calcium Phosphate Nanoparticles for Reducing Diabetes Risk via Retinol Binding Protein 4 Inhibition.

    Torabi, Raheleh / Ghourchian, Hedayatollah / Amanlou, Massoud / Pasalar, Parvin

    Canadian journal of diabetes

    2017  Volume 41, Issue 3, Page(s) 305–311

    Abstract: Objectives: Inhibition of the binding of retinol to its carrier, retinol binding protein 4, is a new strategy for treating type 2 diabetes; for this purpose, we have provided an aptamer-functionalized multishell calcium phosphate nanoparticle.: ... ...

    Abstract Objectives: Inhibition of the binding of retinol to its carrier, retinol binding protein 4, is a new strategy for treating type 2 diabetes; for this purpose, we have provided an aptamer-functionalized multishell calcium phosphate nanoparticle.
    Methods: First, calcium phosphate nanoparticles were synthesized and conjugated to the aptamer. The cytotoxicity of nanoparticles releases the process of aptamer from nanoparticles and their inhibition function of binding retinol to retinol binding protein 4.
    Results: After synthesizing and characterizing the multishell calcium phosphate nanoparticles and observing the noncytotoxicity of conjugate, the optimum time (48 hours) and the pH (7.4) for releasing the aptamer from the nanoparticles was determined. The half-maximum inhibitory concentration (IC
    Conclusions: The results revealed that the aptamer could prevent connection between retinol and retinol binding protein 4 at a very low IC
    Language English
    Publishing date 2017-06
    Publishing country Canada
    Document type Journal Article
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2016.11.001
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