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  1. Book: Inherited kidney diseases

    Devuyst, Olivier

    (Nephrology, dialysis, transplantation ; 29,S4)

    2014  

    Author's details guest ed. by Olivier Devuyst
    Series title Nephrology, dialysis, transplantation ; 29,S4
    Collection
    Language English
    Size 53 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018400866
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2198 -29,S4- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Assessing transport across the peritoneal membrane: Precision medicine in dialysis.

    Devuyst, Olivier

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2021  Volume 41, Issue 4, Page(s) 349–351

    MeSH term(s) Dialysis Solutions ; Humans ; Peritoneal Dialysis ; Peritoneum ; Precision Medicine ; Renal Dialysis
    Chemical Substances Dialysis Solutions
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608211022236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tubular handling of filtered albumin.

    Devuyst, Olivier / Ronco, Pierre

    Kidney international

    2023  Volume 104, Issue 6, Page(s) 1073–1075

    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The first decade of Kidney International: treasure hunt for the kidney tubule.

    Devuyst, Olivier

    Kidney international

    2020  Volume 97, Issue 5, Page(s) 818–822

    MeSH term(s) Bartter Syndrome ; Humans ; Kidney ; Kidney Tubules
    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.02.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The CTNS-MTORC1 axis couples lysosomal cystine to epithelial cell fate decisions and is a targetable pathway in cystinosis.

    Luciani, Alessandro / Devuyst, Olivier

    Autophagy

    2023  Volume 20, Issue 1, Page(s) 202–204

    Abstract: Differentiation and fate decisions are critical for the epithelial cells lining the proximal tubule (PT) of the kidney, but the signals involved remain unknown. Defective cystine mobilization from lysosomes through CTNS (cystinosin, lysosomal cystine ... ...

    Abstract Differentiation and fate decisions are critical for the epithelial cells lining the proximal tubule (PT) of the kidney, but the signals involved remain unknown. Defective cystine mobilization from lysosomes through CTNS (cystinosin, lysosomal cystine transporter), which is mutated in cystinosis, triggers the dedifferentiation and dysfunction of the PT cells, causing kidney disease and severe metabolic complications. Using preclinical models and physiologically relevant cellular systems, along with functional assays and a generative artificial intelligence (AI)-powered engine, we found that cystine storage imparted by CTNS deficiency stimulates Ragulator-RRAG GTPase-dependent recruitment of MTORC1 and its constitutive activation. In turn, this diverts the catabolic trajectories and differentiating states of PT cells toward growth and proliferation, disrupting homeostasis and their specialized functions. Therapeutic MTORC1 inhibition by using low doses of rapamycin corrects lysosome function and differentiation downstream of cystine storage and ameliorates PT dysfunction in preclinical models of cystinosis. These discoveries suggest that cystine may act as a lysosomal fasting signal that tailors MTORC1 signaling to direct fate decisions in the kidney PT epithelium, highlighting novel therapeutic paradigms for cystinosis and other lysosome-related disorders.
    MeSH term(s) Amino Acid Transport Systems, Neutral/metabolism ; Artificial Intelligence ; Autophagy ; Cystine/metabolism ; Cystinosis/metabolism ; Epithelial Cells/metabolism ; Lysosomes/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism
    Chemical Substances Amino Acid Transport Systems, Neutral ; Cystine (48TCX9A1VT) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2250165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Urine: from waste to fertilizer.

    Govers, Larissa P / Devuyst, Olivier

    Kidney international

    2022  Volume 102, Issue 6, Page(s) 1206–1208

    MeSH term(s) Fertilizers/adverse effects ; Body Fluids
    Chemical Substances Fertilizers
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.08.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gout.

    Devuyst, Olivier / Olinger, Eric / Köttgen, Anna

    The New England journal of medicine

    2023  Volume 388, Issue 13, Page(s) e47

    MeSH term(s) Humans ; Gout
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2216467
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  8. Article ; Online: On the way to translate GWAS into kidney disease mechanisms.

    Devuyst, Olivier / Kiryluk, Krzysztof

    Kidney international

    2022  Volume 103, Issue 1, Page(s) 16–18

    MeSH term(s) Humans ; Genome-Wide Association Study ; Kidney ; Kidney Tubules, Proximal ; Kidney Diseases/genetics
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.10.004
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  9. Article ; Online: Tubular cell plasticity-new hope for autosomal dominant polycystic kidney disease?

    Berquez, Marine / Devuyst, Olivier

    Kidney international

    2022  Volume 102, Issue 1, Page(s) 6–8

    MeSH term(s) Cell Plasticity ; Epithelial Cells ; Humans ; Polycystic Kidney, Autosomal Dominant/genetics
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.03.015
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  10. Article ; Online: Series introduction: drug repurposing for kidney diseases.

    Drummond, Iain A / Rovin, Brad H / Devuyst, Olivier

    Kidney international

    2023  Volume 103, Issue 5, Page(s) 812

    MeSH term(s) Humans ; Drug Repositioning ; Kidney Diseases/drug therapy
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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