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  1. Book ; Online: Review for "Possible routes of SARS‐CoV‐2 invasion in brain

    Jerome Badaut

    In context of neurological symptoms in COVID‐19 patients"

    2020  

    Keywords covid19
    Publisher Wiley
    Publishing country us
    Document type Book ; Online
    DOI 10.1002/jnr.24717/v2/review2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Review for "Possible routes of SARS‐CoV‐2 invasion in brain

    Jerome Badaut

    In context of neurological symptoms in COVID‐19 patients"

    2020  

    Keywords covid19
    Publisher Wiley
    Publishing country us
    Document type Book ; Online
    DOI 10.1002/jnr.24717/v1/review2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: The non-invasive imaging techniques in understanding brain pathophysiology from preclinical to clinical studies.

    Chanraud, Sandra / Badaut, Jérôme

    Journal of neuroscience research

    2022  Volume 100, Issue 5, Page(s) 1125–1127

    MeSH term(s) Brain/diagnostic imaging ; Brain Diseases ; Humans ; Positron-Emission Tomography
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25043
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    Zs.A 1232: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Role of the non-invasive imaging techniques in monitoring and understanding the evolution of brain edema.

    Obenaus, Andre / Badaut, Jérôme

    Journal of neuroscience research

    2021  Volume 100, Issue 5, Page(s) 1191–1200

    Abstract: Human brain injury elicits accumulation of water within the brain due to a variety of pathophysiological processes. As our understanding of edema emerged two temporally (and cellular) distinct processes were identified, cytotoxic and vasogenic edema. The ...

    Abstract Human brain injury elicits accumulation of water within the brain due to a variety of pathophysiological processes. As our understanding of edema emerged two temporally (and cellular) distinct processes were identified, cytotoxic and vasogenic edema. The emergence of both types of edema is reflected by the temporal evolution and is influenced by the underlying pathology (type and extent). However, this two-edema compartment model does not adequately describe the transition between cytotoxic and vasogenic edema. Hence, a third category has been proposed, termed ionic edema, that is observed in the transition between cytotoxic and vasogenic edema. Magnetic resonance neuroimaging of edema today primarily utilizes T2-weighted (T2WI) and diffusion-weighted imaging (DWI). Clinical diagnostics and translational science studies have clearly demonstrated the temporal ability of both T2WI and DWI to monitor edema content and evolution. DWI measures water mobility within the brain reflecting cytotoxic edema. T2WI at later time points when vasogenic edema develops visualizes increased water content in the brain. Clinically relevant imaging modalities, including ultrasound and positron emission tomography, are not typically used to assess edema. In sum, edema imaging is an important cornerstone of clinical diagnostics and translational studies and can guide effective therapeutics manage edema and improve patient outcomes.
    MeSH term(s) Brain/diagnostic imaging ; Brain/pathology ; Brain Edema/diagnostic imaging ; Brain Edema/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Magnetic Resonance Imaging/methods ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.24837
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    Zs.A 1232: Show issues Location:
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  5. Article ; Online: From land to ocean: One month for southern elephant seal pups to acquire aquatic skills prior to their first departure to sea.

    Piot, Erwan / Hippauf, Lea / Charlanne, Laura / Picard, Baptiste / Badaut, Jérôme / Gilbert, Caroline / Guinet, Christophe

    Physiology & behavior

    2024  Volume 279, Page(s) 114525

    Abstract: Weaned southern elephant seals (SES) quickly transition from terrestrial to aquatic life after a 5- to 6-week post-weaning period. At sea, juveniles and adult elephant seals present extreme, continuous diving behaviour. Previous studies have highlighted ... ...

    Abstract Weaned southern elephant seals (SES) quickly transition from terrestrial to aquatic life after a 5- to 6-week post-weaning period. At sea, juveniles and adult elephant seals present extreme, continuous diving behaviour. Previous studies have highlighted the importance of the post-weaning period for weanlings to prepare for the physiological challenges of their future sea life. However, very little is known about how their body condition during this period may influence the development of their behaviour and brain activities. To characterise changes in the behavioural and brain activity of weanlings prior to ocean departure, we implemented a multi-logger approach combining measurements of movements (related to behaviour), pressure (related to diving), and brain electrical activity. As pups age, the amount of time allocated to resting decreases in favour of physical activity. Most resting (9.6 ± 1.2 h/day) takes place during daytime, with periods of slow-wave sleep representing 4.9 ± 0.9 h/day during the first 2 weeks. Furthermore, an increasing proportion of physical activity transitions from land to shore. Additionally, pups in poorer condition (lean group) are more active earlier than those in better condition (corpulent group). Finally, at weaning, clear circadian activity with two peaks at dawn and dusk is observed, and this pattern remains unchanged during the 4 weeks on land. This circadian pattern matches the one observed in adults at sea, with more prey catches at dawn and dusk, raising the question of whether it is endogenous or triggered by the mother during lactation.
    MeSH term(s) Female ; Animals ; Humans ; Mothers ; Seals, Earless/physiology ; Oceans and Seas
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2024.114525
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    Zs.A 747: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Diving behaviour of southern elephant seals: new models of behavioural and ecophysiological adjustments of oxygen store management.

    Piot, Erwan / Picard, Baptiste / Badaut, Jérôme / Gilbert, Caroline / Guinet, Christophe

    The Journal of experimental biology

    2023  Volume 226, Issue 13

    Abstract: Among pinnipeds, southern elephant seals (SESs, Mirounga leonina) are extreme divers that dive deeply and continuously along foraging trips to restore their body stores after fasting on land during breeding or moulting. Their replenishment of body stores ...

    Abstract Among pinnipeds, southern elephant seals (SESs, Mirounga leonina) are extreme divers that dive deeply and continuously along foraging trips to restore their body stores after fasting on land during breeding or moulting. Their replenishment of body stores influences their energy expenditure during dives and their oxygen (O2) reserves (via muscular mass), yet how they manage their O2 stores during their dives is not fully understood. In this study, 63 female SESs from Kerguelen Island were equipped with accelerometers and time-depth recorders to investigate changes in diving parameters through their foraging trips. Two categories of dive behaviour were identified and related to the body size of individuals, with smaller SESs performing shallower and shorter dives requiring greater mean stroke amplitude compared with larger individuals. In relation to body size, the larger seals had lower estimated oxygen consumption levels for a given buoyancy (i.e. body density) compared with smaller individuals. However, both groups were estimated to have the same oxygen consumption of 0.079±0.001 ml O2 stroke-1 kg-1 for a given dive duration and at neutral buoyancy when the cost of transport was minimal. Based on these relationships, we built two models that estimate changes in oxygen consumption according to dive duration and body density. The study highlights that replenishing body stores improves SES foraging efficiency, as indicated by increased time spent at the bottom of the ocean. Thus, prey-capture attempts increase as SES buoyancy approaches the neutral buoyancy point.
    MeSH term(s) Animals ; Female ; Diving/physiology ; Oxygen Consumption/physiology ; Energy Metabolism ; Seals, Earless/physiology ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.245157
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    Zs.A 2629: Show issues Location:
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  7. Article ; Online: Blood-brain borders: a proposal to address limitations of historical blood-brain barrier terminology.

    Badaut, Jerome / Ghersi-Egea, Jean-François / Thorne, Robert G / Konsman, Jan Pieter

    Fluids and barriers of the CNS

    2024  Volume 21, Issue 1, Page(s) 3

    Abstract: Many neuroscientists use the term Blood-Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to tight junction molecules physically sealing cerebral endothelial cells, rather than pointing out the ... ...

    Abstract Many neuroscientists use the term Blood-Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to tight junction molecules physically sealing cerebral endothelial cells, rather than pointing out the complexity of this biological interface with respect to its selectivity and variety of exchange between the general blood circulation and the central nervous tissue. Several authors in the field find it unfortunate that the exquisitely dynamic interfaces between blood and brain continue to be viewed primarily as obstructive barriers to transport. Although the term blood-brain interface is an excellent descriptor that does not convey the idea of a barrier, it is important and preferable for the spreading of an idea beyond specialist communities to try to appeal to well-chosen metaphors. Recent evidence reviewed here indicates that blood-brain interfaces are more than selective semi-permeable membranes in that they display many dynamic processes and complex mechanisms for communication. They are thus more like 'geopolitical borders'. Furthermore, some authors working on blood-brain interface-relevant issues have started to use the word border, for example in border-associated macrophages. Therefore, we suggest adopting the term Blood-Brain Border to better communicate the flexibility of and movement across blood-brain interfaces.
    MeSH term(s) Blood-Brain Barrier ; Endothelial Cells ; Cardiovascular System ; Brain ; Tight Junctions
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-023-00478-5
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  8. Article ; Online: Do astrocytes act as immune cells after pediatric TBI?

    Panchenko, Polina E / Hippauf, Lea / Konsman, Jan Pieter / Badaut, Jerome

    Neurobiology of disease

    2023  Volume 185, Page(s) 106231

    Abstract: Astrocytes are in contact with the vasculature, neurons, oligodendrocytes and microglia, forming a local network with various functions critical for brain homeostasis. One of the primary responders to brain injury are astrocytes as they detect neuronal ... ...

    Abstract Astrocytes are in contact with the vasculature, neurons, oligodendrocytes and microglia, forming a local network with various functions critical for brain homeostasis. One of the primary responders to brain injury are astrocytes as they detect neuronal and vascular damage, change their phenotype with morphological, proteomic and transcriptomic transformations for an adaptive response. The role of astrocytic responses in brain dysfunction is not fully elucidated in adult, and even less described in the developing brain. Children are vulnerable to traumatic brain injury (TBI), which represents a leading cause of death and disability in the pediatric population. Pediatric brain trauma, even with mild severity, can lead to long-term health complications, such as cognitive impairments, emotional disorders and social dysfunction later in life. To date, the underlying pathophysiology is still not fully understood. In this review, we focus on the astrocytic response in pediatric TBI and propose a potential immune role of the astrocyte in response to trauma. We discuss the contribution of astrocytes in the local inflammatory cascades and secretion of various immunomodulatory factors involved in the recruitment of local microglial cells and peripheral immune cells through cerebral blood vessels. Taken together, we propose that early changes in the astrocytic phenotype can alter normal development of the brain, with long-term consequences on neurological outcomes, as described in preclinical models and patients.
    MeSH term(s) Child ; Humans ; Astrocytes ; Proteomics ; Brain Injuries, Traumatic/complications ; Brain ; Brain Injuries/complications ; Microglia
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2023.106231
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    Zs.A 4444: Show issues Location:
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  9. Article ; Online: 17th international conference on Brain Edema and Cellular Injury.

    Badaut, Jerome / Zhang, John

    Journal of neuroscience research

    2019  Volume 98, Issue 1, Page(s) 5–8

    MeSH term(s) Brain Edema/drug therapy ; Brain Edema/metabolism ; Brain Edema/physiopathology ; Humans
    Language English
    Publishing date 2019-12-01
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.24540
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  10. Article ; Online: Aquaporins through the brain in health and disease: From water to gas movements.

    Friscourt, Frédéric / Badaut, Jerome

    Journal of neuroscience research

    2017  Volume 96, Issue 2, Page(s) 177–179

    MeSH term(s) Aquaporins/genetics ; Brain ; Dystrophin ; Humans ; Transcriptome ; Water
    Chemical Substances Aquaporins ; Dystrophin ; Water (059QF0KO0R)
    Language English
    Publishing date 2017-09-27
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.24155
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