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  1. Article ; Online: Reply to E. K. Bartlett et al and A. H. R. Varey et al.

    Bellomo, Domenico / Bridges, Alina G / Hieken, Tina J / Meves, Alexander

    JCO precision oncology

    2020  Volume 4, Page(s) 992–994

    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/po.20.00289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Neurosonographische und vollblutaggregometrische Untersuchungen zur Therapieoptimierung beim akuten ischämischen Hirninfarkt

    Meves, Saskia Hannah

    2013  

    Author's details vorgelegt von Saskia Meves
    Language German
    Size 129 Bl. : Ill., graph. Darst.
    Publishing place Bochum
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bochum, Univ., Kumulative Habil.-Schr., 2013
    Note Darin: 8 Aufsätze
    HBZ-ID HT018231049
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Antipsoriatic drug anthralin induces EGF receptor phosphorylation in keratinocytes: requirement for H(2)O(2) generation.

    Peus, Dominik / Beyerle, Astrid / Vasa, Mariuca / Pott, Markus / Meves, Alexander / Pittelkow, Mark R

    Experimental dermatology

    2004  Volume 13, Issue 2, Page(s) 78–85

    Abstract: ... by reactive oxygen species. First, we found that anthralin induces time-dependent generation of H(2)O(2). Second, there is ... phosphorylation and H(2)O(2) generation. Third, the structurally different antioxidants n-propyl gallate and N ... 1) H(2)O(2) generation, (2) epidermal growth factor receptor phosphorylation, and (3) extracellular ...

    Abstract Even though anthralin is a well-established topical therapeutic agent for psoriasis, little is known about its effects and biochemical mechanisms of signal transduction. In contrast to a previous report, we found that anthralin induced time- and concentration-dependent phosphorylation of epidermal growth factor receptor in primary human keratinocytes. Four lines of evidence show that this process is mediated by reactive oxygen species. First, we found that anthralin induces time-dependent generation of H(2)O(2). Second, there is a correlation between a time-dependent increase in anthralin-induced epidermal growth factor receptor phosphorylation and H(2)O(2) generation. Third, the structurally different antioxidants n-propyl gallate and N-acetylcysteine inhibited epidermal growth factor receptor phosphorylation induced by anthralin. Fourth, overexpression of catalase inhibited this process. The epidermal growth factor receptor-specific tyrosine kinase inhibitor PD153035 abrogated anthralin-induced epidermal growth factor receptor phosphorylation and activation of extracellular-regulated kinase 1/2. These findings establish the following sequence of events: (1) H(2)O(2) generation, (2) epidermal growth factor receptor phosphorylation, and (3) extracellular-regulated kinase activation. Our data identify anthralin-induced reactive oxygen species and, more specifically, H(2)O(2) as an important upstream mediator required for ligand-independent epidermal growth factor receptor phosphorylation and downstream signaling.
    MeSH term(s) Acetylcysteine/pharmacology ; Anthralin/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Catalase/genetics ; Catalase/metabolism ; Cells, Cultured ; Electroporation ; Humans ; Hydrogen Peroxide/metabolism ; Keratinocytes/drug effects ; Keratinocytes/physiology ; Kinetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3 ; Mitogen-Activated Protein Kinases/metabolism ; Phosphorylation ; Phosphotyrosine/metabolism ; Psoriasis/drug therapy ; Receptor, Epidermal Growth Factor/drug effects ; Receptor, Epidermal Growth Factor/metabolism ; Recombinant Proteins/metabolism ; Signal Transduction
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Recombinant Proteins ; Phosphotyrosine (21820-51-9) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Anthralin (U8CJK0JH5M) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2004-02
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/j.0906-6705.2004.00119.x
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  4. Article: H(2)O(2) mediates oxidative stress-induced epidermal growth factor receptor phosphorylation.

    Meves, A / Stock, S N / Beyerle, A / Pittelkow, M R / Peus, D

    Toxicology letters

    2001  Volume 122, Issue 3, Page(s) 205–214

    Abstract: ... with antioxidants or enhanced catalase activity in keratinocytes inhibited ROS/H(2)O(2) accumulation and EGFR ... phosphorylation, demonstrating that H(2)O(2) production is a mediator required for EGFR phosphorylation ... by oxidative stress-inducing agents, namely: (1) GSH depletion; (2) H(2)O(2) accumulation; and (3) EGFR ...

    Abstract We used a well-established thiol-alkylating agent, N-ethylmaleimide (NEM), to oxidatively stress human keratinocytes. Time course studies revealed that NEM rapidly depleted keratinocytes of reduced glutathione (GSH), which was followed by rapidly increasing levels of intracellular reactive oxygen species (ROS) and subsequently by phosphorylation of epidermal growth factor receptor (EGFR). Pretreatment with antioxidants or enhanced catalase activity in keratinocytes inhibited ROS/H(2)O(2) accumulation and EGFR phosphorylation, demonstrating that H(2)O(2) production is a mediator required for EGFR phosphorylation. Collectively, these results suggest a sequence of events leading to EGFR phosphorylation which is likely shared by oxidative stress-inducing agents, namely: (1) GSH depletion; (2) H(2)O(2) accumulation; and (3) EGFR phosphorylation. We propose that depletion of GSH and accumulation of H(2)O(2) are upstream events and critical mediators required for ligand-independent phosphorylation of growth factor receptors in response to oxidative stress.
    MeSH term(s) Ascorbic Acid/analogs & derivatives ; Ascorbic Acid/pharmacology ; Catalase/metabolism ; Cells, Cultured ; Electroporation ; ErbB Receptors/metabolism ; Ethylmaleimide/toxicity ; Glutathione/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Oxidative Stress ; Phosphorylation ; Propyl Gallate/pharmacology ; Reactive Oxygen Species ; Tyrosine/metabolism ; Ultraviolet Rays
    Chemical Substances Reactive Oxygen Species ; Tyrosine (42HK56048U) ; Propyl Gallate (8D4SNN7V92) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6) ; ErbB Receptors (EC 2.7.10.1) ; Glutathione (GAN16C9B8O) ; Ethylmaleimide (O3C74ACM9V) ; Ascorbic Acid (PQ6CK8PD0R) ; 6-O-palmitoylascorbic acid (QN83US2B0N)
    Language English
    Publishing date 2001-07-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/s0378-4274(01)00359-9
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  5. Book ; Thesis: Hauptkrankheiten und Todesursachen bei 32 querschnittsgelähmten Patienten

    Meves, Saskia Hannah

    eine Analyse des Obduktionsgutes

    1995  

    Author's details vorgelegt von Saskia Hannah Meves
    Language German
    Size III, 78 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bochum, Univ., Diss., 1996
    HBZ-ID HT007175831
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: β3 integrin immunohistochemistry as a method to predict sentinel lymph node status in patients with primary cutaneous melanoma.

    Quattrocchi, Enrica / Sominidi-Damodaran, Sindhuja / Murphree, Dennis H / Meves, Alexander

    International journal of dermatology

    2020  Volume 59, Issue 10, Page(s) 1241–1248

    Abstract: ... in a subset of 271 patients by H score. Outcome of interest was SLN biopsy metastasis within 90 days ... integrin H score does not significantly improve models for the likelihood of SLN metastasis over Breslow ...

    Abstract Background: Integrins are heterodimeric proteins composed of noncovalently linked ɑ and β subunits which are essential for a wide range of normal physiology and also play prominent roles in cancer. Here we tested whether integrin expression in diagnostic skin biopsies is associated with sentinel lymph node (SLN) metastasis.
    Methods: We utilized a cohort of 854 consecutive patients with primary cutaneous melanoma to quantify the expression of β integrin subunits by reverse transcriptase quantitative PCR (RT-qPCR). In addition, we quantified the expression of β3 integrin by immunohistochemistry (IHC) in a subset of 271 patients by H score. Outcome of interest was SLN biopsy metastasis within 90 days of melanoma diagnosis. Logistic regression analyses were used to develop models for the likelihood of SLN metastasis from molecular, clinical, and histologic variables.
    Results: β3 integrin expression quantified by IHC or RT-qPCR was associated with SLN metastasis. β1, β5, β6, and β8 integrin expression was not associated with SLN metastasis. The incremental gain in performance of a predictive model which included β3 integrin expression as quantified by IHC in combination with established clinicopathologic variables (Breslow depth and patient age) was limited.
    Conclusions: β3 integrin is the principal integrin subunit associated with sentinel lymph node biopsy (SLNb) metastasis in primary cutaneous melanoma. However, β3 integrin H score does not significantly improve models for the likelihood of SLN metastasis over Breslow depth and patient age.
    MeSH term(s) Humans ; Immunohistochemistry ; Integrin beta3/genetics ; Lymph Nodes ; Melanoma/surgery ; Prognosis ; Sentinel Lymph Node ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/surgery
    Chemical Substances Integrin beta3
    Language English
    Publishing date 2020-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15125
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  7. Article: Arachidonic acid and ion channels: an update.

    Meves, H

    British journal of pharmacology

    2008  Volume 155, Issue 1, Page(s) 4–16

    Abstract: Arachidonic acid (AA), a polyunsaturated fatty acid with four double bonds, has multiple actions on living cells. Many of these effects are mediated by an action of AA or its metabolites on ion channels. During the last 10 years, new types of ion ... ...

    Abstract Arachidonic acid (AA), a polyunsaturated fatty acid with four double bonds, has multiple actions on living cells. Many of these effects are mediated by an action of AA or its metabolites on ion channels. During the last 10 years, new types of ion channels, transient receptor potential (TRP) channels, store-operated calcium entry (SOCE) channels and non-SOCE channels have been studied. This review summarizes our current knowledge about the effects of AA on TRP and non-SOCE channels as well as classical ion channels. It aims to distinguish between effects of AA itself and effects of AA metabolites. Lipid mediators are of clinical interest because some of them (for example, leukotrienes) play a role in various diseases, others (such as prostaglandins) are targets for pharmacological therapeutic intervention.
    MeSH term(s) Animals ; Arachidonic Acid/metabolism ; Calcium Channels/metabolism ; Cell Membrane/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Humans ; Ion Channels/metabolism ; Lipoxygenase/metabolism ; Membrane Potentials ; Potassium Channels/metabolism ; Prostaglandin-Endoperoxide Synthases/metabolism ; Protein Subunits ; TRPC Cation Channels/metabolism
    Chemical Substances Calcium Channels ; Ion Channels ; Potassium Channels ; Protein Subunits ; TRPC Cation Channels ; Arachidonic Acid (27YG812J1I) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Lipoxygenase (EC 1.13.11.12) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1)
    Language English
    Publishing date 2008-06-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1038/bjp.2008.216
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  8. Article ; Conference proceedings: Endoskopische Therapie der akuten nekrotisierenden Pankreatitis – Ist der Beginn so spät wie möglich noch zeitgemäß?

    Meinhardt, C. / Dahl, B. / Chamieh, A. E. / Fehrendt, H. / Meves, V. / Schäfer, N. / Geismann, C. / Seifert, H. / Arlt, A.

    Zeitschrift für Gastroenterologie

    2023  Volume 61, Issue 08

    Event/congress Viszeralmedizin 2023 77. Jahrestagung der DGVS mit Sektion Endoskopie Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie mit den Arbeitsgemeinschaften der DGAV und Jahrestagung der CACP, Erst online. Dann Hamburg., 2023-09-11
    Language German
    Publishing date 2023-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0043-1772007
    Database Thieme publisher's database

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  9. Article: The action of prostaglandins on ion channels.

    Meves, Hans

    Current neuropharmacology

    2008  Volume 4, Issue 1, Page(s) 41–57

    Abstract: Prostaglandins, in particular PGE(2) and prostacyclin PGI(2) have diverse biological effects. Most importantly, they are involved in inflammation and pain. Prostaglandins in nano- and micromolar concentrations sensitize nerve cells, i.e. make them more ... ...

    Abstract Prostaglandins, in particular PGE(2) and prostacyclin PGI(2) have diverse biological effects. Most importantly, they are involved in inflammation and pain. Prostaglandins in nano- and micromolar concentrations sensitize nerve cells, i.e. make them more sensitive to electrical or chemical stimuli. Sensitization arises from the effect of prostaglandins on ion channels and occurs both at the peripheral terminal of nociceptors at the site of tissue injury (peripheral sensitization) and at the synapses in the spinal cord (central sensitization). The first step is the binding of prostaglandins to receptors in the cell membrane, mainly EP and IP receptors. The receptors couple via G proteins to enzymes such as adenylate cyclase and phospholipase C (PLC). Activation of adenylate cyclase leads to increase of cAMP and subsequent activation of protein kinase A (PKA) or PKA-independent effects of cAMP, e.g. mediated by Epac (=exchange protein activated by cAMP). Activation of PLC causes increase of inositol phosphates and increase of cytosolic calcium. This article summarizes the effects of PGE(2), PGE(1), PGI2 and its stable analogues on non-selective cation channels and sodium, potassium, calcium and chloride channels. It describes the mechanism responsible for the facilitatory or inhibitory prostaglandin effects on ion channels. Understanding these mechanisms is essential for the development of useful new analgesics.
    Language English
    Publishing date 2008-07-10
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/157015906775203048
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  10. Article ; Online: [No title information]

    Hummel, T / Meves, S H / Breuer-Kaiser, A / Düsterwald, J O / Mühlberger, D / Mumme, A / Neubauer, H

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2021  Volume 92, Issue 11, Page(s) 1050

    Title translation Erratum zu: Evaluation einer Therapieanpassung bei ASS-Low-Response in der Gefäßchirurgie.
    Language German
    Publishing date 2021-10-06
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-021-01526-2
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