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  1. Article: Eugene V. Koonin.

    Koonin, Eugene V

    Current biology : CB

    2004  Volume 14, Issue 3, Page(s) R96–7

    MeSH term(s) Evolution, Molecular ; Genomics ; Peer Review, Research ; Research/trends
    Language English
    Publishing date 2004-02-03
    Publishing country England
    Document type Interview
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3208: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Circular RNAs from linear viral RNA genomes: A distinct dimension in the virus world.

    Koonin, Eugene V

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 8, Page(s) e2401335121

    MeSH term(s) Humans ; RNA/genetics ; RNA, Viral/genetics ; RNA, Circular/genetics ; Hepacivirus/genetics ; Genome, Viral/genetics ; Hepatitis C/genetics
    Chemical Substances RNA (63231-63-0) ; RNA, Viral ; RNA, Circular
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2401335121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antitoxins within toxins: A new theme in bacterial antivirus defense.

    Koonin, Eugene V

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 31, Page(s) e2311001120

    MeSH term(s) Antitoxins ; Toxins, Biological
    Chemical Substances Antitoxins ; Toxins, Biological
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2311001120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Science in times of war: oppose Russian aggression but support Russian scientists.

    Koonin, Eugene V

    EMBO reports

    2022  Volume 23, Issue 4, Page(s) e54988

    Abstract: In the face of Russia's invasion of the Ukraine, the global scientific community must continue to support their Russian colleagues without endorsing their government. ...

    Abstract In the face of Russia's invasion of the Ukraine, the global scientific community must continue to support their Russian colleagues without endorsing their government.
    MeSH term(s) Aggression ; Russia
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202254988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Learn from the past to predict viral pandemics.

    Rochman, Nash D / Koonin, Eugene V

    Nature

    2023  Volume 622, Issue 7984, Page(s) 700–702

    MeSH term(s) Humans ; Pandemics/prevention & control ; COVID-19/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-02931-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  6. Book: Power laws, scale-free networks and genome biology

    Koonin, Eugene V.

    (Molecular biology intelligence unit)

    2006  

    Title variant Power laws, scale free networks and genome biology
    Author's details Eugene V. Koonin
    Series title Molecular biology intelligence unit
    Keywords Genomics ; Algorithms ; Computional Biology ; Models, Biology ; Molekularbiologie ; Biomathematik ; Molekulargenetik
    Subject Biowissenschaften ; Biometrie ; Molekulare Genetik ; Biochemische Genetik ; Molekulare Biologie
    Language English
    Size [XX], 257 S. : zahlr. Ill. und graph. Darst., 24cm
    Publisher Landes Bioscience / Eurekah.com ; Springer Science+Business Media
    Publishing place Georgetown, Tex ; New York, NY
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT014768296
    ISBN 0-387-25883-3 ; 978-0-387-25883-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 5656 order for loan Magazin

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  7. Article: Mriyaviruses: Small Relatives of Giant Viruses.

    Yutin, Natalya / Mutz, Pascal / Krupovic, Mart / Koonin, Eugene V

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... The ... ...

    Abstract The phylum
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.29.582850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: New faces of prokaryotic mobile genetic elements: guide RNAs link transposition with host defense mechanisms.

    Koonin, Eugene V / Krupovic, Mart

    Current opinion in systems biology

    2023  Volume 36

    Abstract: Most life forms harbor multiple, diverse mobile genetic elements (MGE) that widely differ in their rates and mechanisms of mobility. Recent findings on two classes of MGE in prokaryotes revealed a novel mechanism, RNA-guided transposition, where a ... ...

    Abstract Most life forms harbor multiple, diverse mobile genetic elements (MGE) that widely differ in their rates and mechanisms of mobility. Recent findings on two classes of MGE in prokaryotes revealed a novel mechanism, RNA-guided transposition, where a transposon-encoded guide RNA directs the transposase to a unique site in the host genome. Tn7-like transposons, on multiple occasions, recruited CRISPR systems that lost the capacity to cleave target DNA and instead mediate RNA-guided transposition via CRISPR RNA. Conversely, the abundant transposon-associated, RNA-guided nucleases IscB and TnpB that appear to promote proliferation of IS
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article
    ISSN 2452-3100
    ISSN 2452-3100
    DOI 10.1016/j.coisb.2023.100473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Viriforms-A New Category of Classifiable Virus-Derived Genetic Elements.

    Kuhn, Jens H / Koonin, Eugene V

    Biomolecules

    2023  Volume 13, Issue 2

    Abstract: The International Committee on Taxonomy of Viruses (ICTV) recently accepted viriforms as a new polyphyletic category of classifiable virus-derived genetic elements, juxtaposed to the polyphyletic virus, viroid, and satellite nucleic acid categories. ... ...

    Abstract The International Committee on Taxonomy of Viruses (ICTV) recently accepted viriforms as a new polyphyletic category of classifiable virus-derived genetic elements, juxtaposed to the polyphyletic virus, viroid, and satellite nucleic acid categories. Viriforms are endogenized former viruses that have been exapted by their cellular hosts to fulfill functions important for the host's life cycle. While morphologically resembling virions, particles made by viriforms do not package the viriform genomes but instead transport host genetic material. Known viriforms are highly diverse: members of family
    MeSH term(s) Animals ; Genome, Viral ; Polydnaviridae/genetics ; Wasps ; Mammals/genetics
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13020289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Defense systems and horizontal gene transfer in bacteria.

    Kogay, Roman / Wolf, Yuri I / Koonin, Eugene V

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Horizontal gene transfer (HGT) is a fundamental process in the evolution of prokaryotes, making major contributions to diversification and adaptation. Typically, HGT is facilitated by mobile genetic elements (MGEs), such as conjugative plasmids and ... ...

    Abstract Horizontal gene transfer (HGT) is a fundamental process in the evolution of prokaryotes, making major contributions to diversification and adaptation. Typically, HGT is facilitated by mobile genetic elements (MGEs), such as conjugative plasmids and phages that generally impose fitness costs on their hosts. However, a substantial fraction of bacterial genes is involved in defense mechanisms that limit the propagation of MGEs, raising the possibility that they can actively restrict HGT. Here we examine whether defense systems curb HGT by exploring the connections between HGT rate and the presence of 73 defense systems in 12 bacterial species. We found that only 6 defense systems, 3 of which are different CRISPR-Cas subtypes, are associated with the reduced gene gain rate on the scale of species evolution. The hosts of such defense systems tend to have a smaller pangenome size and harbor fewer phage-related genes compared to genomes lacking these systems, suggesting that these defense mechanisms inhibit HGT by limiting the integration of prophages. We hypothesize that restriction of HGT by defense systems is species-specific and depends on various ecological and genetic factors, including the burden of MGEs and fitness effect of HGT in bacterial populations.
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.09.579689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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