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  1. Article ; Online: Letter to the Editor - responses to Weisntein D, Simon M, Yehezkel E, Laron Z, Werner H. Insulin analogues display IGF-I-like mitogenic and antiactivity in cultured cancer cells.

    Weinstein, Doron / Simon, Meital / Yehezkel, Einat / Laron, Zvi / Werner, Haim

    Diabetes/metabolism research and reviews

    2013  

    Abstract: We thank the team of Eli Lilly and Company for their critical appraisal of our study and for giving us the opportunity to clarify a number of points [1]. We agree with Kazda et al. that randomized clinical trials will best address any direct relationship ...

    Abstract We thank the team of Eli Lilly and Company for their critical appraisal of our study and for giving us the opportunity to clarify a number of points [1]. We agree with Kazda et al. that randomized clinical trials will best address any direct relationship between insulin analogues and cancer in man. We do not question the fact that tight control of blood glucose has dramatically advanced the lives of patients with diabetes. This article is protected by copyright. All rights reserved.
    Language English
    Publishing date 2013-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.2447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A P-H functionalized Al/P-based frustrated Lewis pair - hydrophosphination of nitriles, ring opening with cyclopropenones and evidence of P[double bond, length as m-dash]C double bond formation.

    Keweloh, Lukas / Aders, Niklas / Hepp, Alexander / Pleschka, Damian / Würthwein, Ernst-Ulrich / Uhl, Werner

    Dalton transactions (Cambridge, England : 2003)

    2018  Volume 47, Issue 25, Page(s) 8402–8417

    Abstract: Hydroalumination of R-P(H)-C[triple bond, length as m-dash]C-tBu with bulky H-Al[CH(SiMe3)2]2 ... afforded the new P-H functionalized Al/P-based frustrated Lewis pair R-P(H)-C[[double bond, length as m ... dash]C(H)-tBu]-AlR2 [R = CH(SiMe3)2; FLP 7]. A weak adduct of 7 with benzonitrile (8) was detected ...

    Abstract Hydroalumination of R-P(H)-C[triple bond, length as m-dash]C-tBu with bulky H-Al[CH(SiMe3)2]2 afforded the new P-H functionalized Al/P-based frustrated Lewis pair R-P(H)-C[[double bond, length as m-dash]C(H)-tBu]-AlR2 [R = CH(SiMe3)2; FLP 7]. A weak adduct of 7 with benzonitrile (8) was detected by NMR spectroscopy, but could not be isolated. tert-Butyl isocyanide afforded a similar, but isolable adduct (9), in which the isocyanide C atom was coordinated to aluminium. The unique reactivity of 7 became evident from its reactions with the heteroatom substituted nitriles PhO-C[triple bond, length as m-dash]N, PhCH2S-C[triple bond, length as m-dash]N and H8C4N-C[triple bond, length as m-dash]N. Hydrophosphination of the C[triple bond, length as m-dash]N triple bonds afforded imines at room temperature which were coordinated to the FLP by Al-N and P-C bonds to yield AlCPCN heterocycles (10 to 12). These processes depend on substrate activation by the FLP. Diphenylcyclopropenone and its sulphur derivative reacted with 7 by addition of the P-H bond to a C-C bond of the strained C3 ring and ring opening to afford the fragment (Z)-Ph-C(H)[double bond, length as m-dash]C(Ph)-C-X-Al (X = O, S). The C-O or C-S groups were coordinated to the FLP to yield AlCPCX heterocycles (13 and 14). The thiocarbonyl derived compound 14 contains an internally stabilized phosphenium cation with a localized P[double bond, length as m-dash]C bond, a trigonal planar coordinated P atom and a short P[double bond, length as m-dash]C distance (168.9 pm). Insight into formation mechanisms, the structural and energetic properties of FLP 7 and compounds 13 and 14 was gained by quantum chemical DFT calculations.
    Language English
    Publishing date 2018-06-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c8dt01836g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Das biomechanische Okklusionskonzept nach M. H. Polz in der interdisziplinären Funktionstherapie

    Boisserée, Wolfgang / Schupp, Werner / Läkamp, Manfred

    Quintessenz Zahntechnik

    2010  Volume 36, Issue 8, Page(s) 1048

    Language German
    Document type Article
    ZDB-ID 7993-5
    ISSN 0340-4641
    Database Current Contents Medicine

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  4. Article: [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.

    Gasparini, Fabrizio / Andres, Hendrik / Flor, Peter Josef / Heinrich, Micheline / Inderbitzin, Werner / Lingenhöhl, Kurt / Müller, Hanspeter / Munk, Veronica Cecilia / Omilusik, Kyla / Stierlin, Christine / Stoehr, Natacha / Vranesic, Ivo / Kuhn, Rainer

    Bioorganic & medicinal chemistry letters

    2002  Volume 12, Issue 3, Page(s) 407–409

    Abstract: The synthesis of a new potent, subtype-selective radioligand [(3)H]-M-MPEP (2-methyl-6-((3 ...

    Abstract The synthesis of a new potent, subtype-selective radioligand [(3)H]-M-MPEP (2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine) and its in vitro pharmacological characteristics are described. Science Ltd.
    MeSH term(s) Binding Sites ; Binding, Competitive/drug effects ; Humans ; Kinetics ; Ligands ; Pyridines/pharmacology ; Radiopharmaceuticals/chemical synthesis ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate/antagonists & inhibitors ; Receptors, Metabotropic Glutamate/metabolism ; Recombinant Proteins/metabolism
    Chemical Substances Ligands ; Pyridines ; Radiopharmaceuticals ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate ; Recombinant Proteins ; SIB 1893 ; 6-methyl-2-(phenylethynyl)pyridine (7VC0YVI27Y)
    Language English
    Publishing date 2002-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/s0960-894x(01)00767-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Formation of (bn-1 + H2O) ions by collisional activation of MALDI-formed peptide [M + H]+ ions in a QqTOF mass spectrometer.

    She, Yi-Min / Krokhin, Oleg / Spicer, Victor / Loboda, Alexandre / Garland, Gideon / Ens, Werner / Standing, Kenneth G / Westmore, John B

    Journal of the American Society for Mass Spectrometry

    2007  Volume 18, Issue 6, Page(s) 1024–1037

    Abstract: Collisional activation of [M + H](+) parent ions from peptides of n amino acid residues may yield ... a rearrangement that involves loss of the C-terminal amino acid residue to produce (b(n-1) + H(2)O) daughters ... We have studied this reaction by a retrospective examination of the m/z spectra of two collections of data ...

    Abstract Collisional activation of [M + H](+) parent ions from peptides of n amino acid residues may yield a rearrangement that involves loss of the C-terminal amino acid residue to produce (b(n-1) + H(2)O) daughters. We have studied this reaction by a retrospective examination of the m/z spectra of two collections of data. The first set comprised 398 peptides from coat protein digests of a number of plant viruses by various enzymes, where conditions in the tryptic digests were chosen so as to produce many missed cleavages. In this case, a large effect was observed-323 (b(n-1) + H(2)O) daughter ions (approximately 81%), including 185 (approximately 46%) "strong" decays with ratios (b(n-1) + H(2)O)/(b(n-1)) > 1. The second set comprised 1200 peptides, all from tryptic digests, which were carried out under more stringent conditions, resulting in relatively few missed cleavages. Even here, 190 (b(n-1) + H(2)O) ions (approximately 16%) were observed, including 87 (> 7%) "strong" decays, so the effect is still appreciable. The results suggest that the tendency for (b(n-1) + H(2)O) ion formation is promoted by the protonated side chain of a non-C-terminal basic amino acid residue, in the order arginine >> lysine > or = histidine, and that its (non-C-terminal) position is not critical. The results can be interpreted by a mechanism in which hydrogen bonding between the protonated side chain and the (n - 1) carbonyl oxygen facilitates loss of the C-terminal amino acid residue to give a product ion having a carboxyl group at the new C-terminus.
    MeSH term(s) Amino Acids/chemistry ; Capsid Proteins/chemistry ; Hydrogen Bonding ; Ions ; Solutions ; Spectrometry, Mass, Electrospray Ionization/methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Water/chemistry
    Chemical Substances Amino Acids ; Capsid Proteins ; Ions ; Solutions ; Water (059QF0KO0R)
    Language English
    Publishing date 2007-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1073671-2
    ISSN 1044-0305
    ISSN 1044-0305
    DOI 10.1016/j.jasms.2007.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4618: Show issues Location:
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    Zs.MO 241: Show issues

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  6. Article: [Rezension von: Global environmental economics, equity and the limits to markets, M. H. I. Dore .̤ (eds.)]

    Gottinger, Hans Werner / Dore, M. H. I

    Journal of economics Vol. 72, No. 3 , p. 321-322

    2000  Volume 72, Issue 3, Page(s) 321–322

    Author's details H. W. Gottinger
    Keywords 40#49
    Language English
    Publisher Springer
    Publishing place Wien [u.a.]
    Document type Article
    ZDB-ID 635037-9 ; 1476543-3
    ISSN 1617-7134 ; 0931-8658
    ISSN (online) 1617-7134
    ISSN 0931-8658
    Database ECONomics Information System

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  7. Book: Ausschuß für G.m.b.H.-Recht

    Schubert, Werner

    (Akademie für Deutsches Recht, 1933 - 1945 ; : Protokolle der Ausschüsse / hrsg. von Werner Schubert .. ; Bd. 2)

    1986  

    Institution Akademie für Deutsches Recht
    Author's details hrsg. u. mit e. Einl. vers. von Werner Schubert
    Series title Akademie für Deutsches Recht, 1933 - 1945
    : Protokolle der Ausschüsse / hrsg. von Werner Schubert .. ; Bd. 2
    Language German
    Size XXIX, 625 S
    Publisher de Gruyter
    Publishing place Berlin u.a.
    Document type Book
    ISBN 3110111365 ; 9783110111361
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Ausschuß für G.m.b.H.-Recht

    Schubert, Werner

    (Akademie für Deutsches Recht, 1933 - 1945 ; : Protokolle der Ausschüsse / hrsg. von Werner Schubert .. ; Bd. 2)

    1986  

    Institution Akademie für Deutsches Recht
    Author's details hrsg. u. mit e. Einl. vers. von Werner Schubert
    Series title Akademie für Deutsches Recht, 1933 - 1945
    : Protokolle der Ausschüsse / hrsg. von Werner Schubert .. ; Bd. 2
    Language German
    Size XXIX, 625 S
    Publisher de Gruyter
    Publishing place Berlin u.a.
    Document type Book
    ISBN 3110111365 ; 9783110111361
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Online: Terrain model of the H?kon Mosby Mud Volcano (10 m grid size), supplementary data to: Beyer, Andreas; Rathlau, Rike; Schenke, Hans Werner (2005): Multibeam bathymetry of the H?kon Mosby Mud Volcano. Marine Geophysical Researches, 26, 61-75

    Beyer, Andreas / Rathlau, Rike / Schenke, Hans Werner

    2005  

    Abstract: The H?kon Mosby Mud Volcano is a natural laboratory to study geological, geochemical, and ... ecological processes related to deep-water mud volcanism. High resolution bathymetry of the H?kon Mosby Mud ... density to generate a regular 10 m grid. Generalization was applied to preserve and represent ...

    Abstract The H?kon Mosby Mud Volcano is a natural laboratory to study geological, geochemical, and ecological processes related to deep-water mud volcanism. High resolution bathymetry of the H?kon Mosby Mud Volcano was recorded during RV Polarstern expedition ARK-XIX/3 utilizing the multibeam system Hydrosweep DS-2. Dense spacing of the survey lines and slow ship speed (5 knots) provided necessary point density to generate a regular 10 m grid. Generalization was applied to preserve and represent morphological structures appropriately. Contour lines were derived showing detailed topography at the centre of the H?kon Mosby Mud Volcano and generalized contours in the vicinity. We provide a brief introduction to the H?kon Mosby Mud Volcano area and describe in detail data recording and processing methods, as well as the morphology of the area. Accuracy assessment was made to evaluate the reliability of a 10 m resolution terrain model. Multibeam sidescan data were recorded along with depth measurements and show reflectivity variations from light grey values at the centre of the H?kon Mosby Mud Volcano to dark grey values (less reflective) at the surrounding moat.
    Language English
    Dates of publication 2005-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1007/s11001-005-1131-8
    DOI 10.1594/PANGAEA.370797
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Physically Cross-Linked Ultrathin Elastomeric Membranes This work was supported by the Max-Planck Gesellschaft, the Deutsche Forschungsgemeinschaft (project Gö 693/2), and the Kalhof-Rose Stiftung. The experiments were conducted at the Max-Planck-Institut für Kolloid- & Grenzflächenforschung, Berlin. We thank H. Möhwald (MPI-KGF), M. Antonietti (MPI-KGF), M. Möller (Universität Ulm), and J. Rabe (Humboldt Universität Berlin) for support and fruitful discussions.

    Mallwitz, Frank / Goedel, Werner A.

    Angewandte Chemie (International ed. in English)

    2001  Volume 40, Issue 14, Page(s) 2645–2647

    Language English
    Publishing date 2001-07-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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