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Article: Editorial: Diabetic ketoacidosis in children and adolescents: From epidemiological data to clinical aspects.

Zucchini, Stefano / Bonfanti, Riccardo / Schiaffini, Riccardo / Passanisi, Stefano / Salzano, Giuseppina / Lombardo, Fortunato

Frontiers in pediatrics

2023 Volume 11, Page(s) 1164946

Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1164946
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of teplizumab in children and adolescents at risk of type 1 diabetes: perspectives of parents and caregivers from an Italian Pediatric Diabetes Center.

Bombaci, Bruno / Passanisi, Stefano / Pecoraro, Maria / Sorrenti, Lacrima / Papa, Mattia / Salzano, Giuseppina / Lombardo, Fortunato

Acta diabetologica

2024 Volume 61, Issue 5, Page(s) 635–642

Abstract: Aims: In view of the imminent introduction of a novel category of disease-modifying treatments for type 1 diabetes (T1D) in European countries, it becomes imperative to understand the existing awareness and viewpoints of parents and caregivers of ... ...

Abstract	Aims: In view of the imminent introduction of a novel category of disease-modifying treatments for type 1 diabetes (T1D) in European countries, it becomes imperative to understand the existing awareness and viewpoints of parents and caregivers of children and adolescents predisposed to T1D. This study aims to evaluate the perspectives of a cohort of parents and caregivers regarding using teplizumab to delay the onset of T1D in predisposed children and adolescents. Methods: This single-center study used a survey-based approach. Parents or caregivers of children and adolescents with T1D having at least one additional child without T1D answered 15 questions assessing their awareness about teplizumab, their potential willingness to provide consent for its administration in case of eligibility, and their expectations regarding potential outcomes. Results: Approximately half of the participants (52.6%) expressed readiness to consent to teplizumab administration for their child if the prescription criteria were met in the future. Only 6.3% of parents claimed detailed knowledge about this innovative medication. Notably, parents with prior experience of diabetic ketoacidosis (DKA) demonstrated a higher inclination to consent to teplizumab treatment (p = 0.018). Conclusions: Our findings underscore the necessity for comprehensive awareness campaigns spreading the current evidence concerning teplizumab in terms of both effectiveness and possible side effects. Additionally, our study reinforces the pivotal role of DKA prevention in successfully integrating disease-modifying treatments into clinical practice.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/drug therapy ; Adolescent ; Child ; Male ; Female ; Parents/psychology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Caregivers/psychology ; Caregivers/statistics & numerical data ; Italy/epidemiology ; Adult ; Surveys and Questionnaires ; Child, Preschool ; Health Knowledge, Attitudes, Practice
Chemical Substances	Antibodies, Monoclonal, Humanized ; teplizumab (S4M959U2IJ)
Language	English
Publishing date	2024-02-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-024-02245-w
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Article ; Online: Examining the associations between COVID-19 infection and pediatric type 1 diabetes.

Bombaci, Bruno / Passanisi, Stefano / Sorrenti, Lacrima / Salzano, Giuseppina / Lombardo, Fortunato

Expert review of clinical immunology

2023 Volume 19, Issue 5, Page(s) 489–497

Abstract: Introduction: The COVID-19 pandemic represents an unprecedented challenge for public health worldwide, not only for the very high number of cases and deaths but also due to a wide variety of indirect consequences. Among these, the possible relationship ... ...

Abstract	Introduction: The COVID-19 pandemic represents an unprecedented challenge for public health worldwide, not only for the very high number of cases and deaths but also due to a wide variety of indirect consequences. Among these, the possible relationship between SARS-CoV-2 infection and type 1 diabetes (T1D) in pediatric age has aroused notable interest in the scientific community. Areas covered: This perspective article aims to focus on the epidemiological trend of T1D during the pandemic, the diabetogenic role of SARS-CoV-2, and the influence of preexisting T1D on COVID-19 outcomes. Expert opinion: The incidence of T1D has considerably changed during the COVID-19 pandemic, but any direct role of SARS-CoV-2 is uncertain. It is more likely that SARS-CoV-2 infection acts as an accelerator of pancreatic β-cell immunological destruction, which is activated by known viral triggers whose spread has been abnormal during these pandemic years. Another interesting aspect to consider is the role of immunization as a potential protective factor both for T1D development and the risk of severe outcomes in already diagnosed patients. Future studies are still required to address unmet needs, including the early use of antiviral drugs to reduce the risk of metabolic decompensation in children with T1D.
MeSH term(s)	Humans ; Child ; COVID-19 ; SARS-CoV-2/metabolism ; Diabetes Mellitus, Type 1 ; Pandemics ; Peptidyl-Dipeptidase A/metabolism
Chemical Substances	Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	English
Publishing date	2023-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2274260-8
ISSN	1744-8409 ; 1744-666X
ISSN (online)	1744-8409
ISSN	1744-666X
DOI	10.1080/1744666X.2023.2189587
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Article ; Online: Fake News and the Sleeper Effect in Social Media Posts: the Case of Perception of Safety in the Workplace.

Ruggieri, Stefano / Bonfanti, Rubinia C / Santoro, Gianluca / Passanisi, Alessia / Pace, Ugo

Cyberpsychology, behavior and social networking

2023 Volume 26, Issue 7, Page(s) 554–562

Abstract: Fake news and misinformation on social media platforms are two of the biggest problems of the last few years. Understanding the underlying mechanisms of memory is of fundamental importance to develop specific intervention programs. In this study, 324 ... ...

Abstract	Fake news and misinformation on social media platforms are two of the biggest problems of the last few years. Understanding the underlying mechanisms of memory is of fundamental importance to develop specific intervention programs. In this study, 324 white-collar workers viewed Facebook posts focused on coronavirus disease-2019 prevention norms in the workplace. In a within-participants design, we manipulated the message and the source to expose each participant to real news, real news presented by a discounting cue (sleeper effect condition), and fake news. The results show that participants were more susceptible to fake news during a 1-week delayed posttest following a memory recall process. Furthermore, they remembered the message easily, but not the source, which did not differ in the real-news conditions. We discuss the results, mentioning the sleeper effect and fake news theories.
MeSH term(s)	Humans ; Social Media ; COVID-19/prevention & control ; Disinformation ; Workplace ; Perception
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2545735-4
ISSN	2152-2723 ; 2152-2715
ISSN (online)	2152-2723
ISSN	2152-2715
DOI	10.1089/cyber.2022.0199
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Article: Early Assessment of Efficacy and Safety of Biologics in Pediatric Allergic Diseases: Preliminary Results from a Prospective Real-World Study.

Caminiti, Lucia / Galletta, Francesca / Foti Randazzese, Simone / Barraco, Paolo / Passanisi, Stefano / Gambadauro, Antonella / Crisafulli, Giuseppe / Valenzise, Mariella / Manti, Sara

Children (Basel, Switzerland)

2024 Volume 11, Issue 2

Abstract: Background: Despite the increasing interest in biologics for the management of allergic diseases, sparse real-world data are still available in the pediatric population. This study aimed to evaluate the early real-life efficacy and safety of omalizumab ... ...

Abstract	Background: Despite the increasing interest in biologics for the management of allergic diseases, sparse real-world data are still available in the pediatric population. This study aimed to evaluate the early real-life efficacy and safety of omalizumab for patients with moderate-to-severe asthma and chronic spontaneous urticaria (CSU), and Dupilumab for patients with moderate-to-severe atopic dermatitis (AD). Methods: A prospective study enrolling children aged 6-18 years was designed to assess the efficacy and safety of biologic drugs at 16 weeks of treatment (T1). The effectiveness was measured using validated questionnaires (ACQ-5 for asthma, UAS7 for CSU, and EASI score for AD). Secondary outcome measures included reductions in inhaled corticosteroid (ICS) dosages, asthma-related hospitalizations/exacerbations, and quality of life (QoL) indicators (iNRS, sNRS, DLQI/cDLQI) for CSU and AD. Safety was expressed according to the descriptions of adverse events provided by EMA and FDA. Results: The study cohort consisted of eighteen children (mean age 12.9 ± 3.4 years). The omalizumab treatment significantly reduced ACQ-5 and UAS7 scores ( Conclusions: Our findings validate omalizumab and dupilumab as effective and safe therapeutic options for managing moderate-to-severe allergic diseases in children and adolescents.
Language	English
Publishing date	2024-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children11020170
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Article ; Online: The Effects of Leader Self-Sacrifice in Virtual Teams on Prosocial Behavior

Stefano Ruggieri / Melissa Gagliano / Rocco Servidio / Ugo Pace / Alessia Passanisi

Sustainability, Vol 15, Iss 6098, p

The Mediational Role of Team Identification and Self-Efficacy

2023 Volume 6098

Abstract: Leadership is one of the most studied features of virtual teams. Among the various characteristics analyzed by recent literature, leadership self-sacrifice is one of the most important, as it represents a predictor of many positive characteristics of ... ...

Abstract	Leadership is one of the most studied features of virtual teams. Among the various characteristics analyzed by recent literature, leadership self-sacrifice is one of the most important, as it represents a predictor of many positive characteristics of teams’ functioning. In this study, we (a) analyze the relationship between leader self-sacrifice and the prosocial behavior of followers in a work team and (b) observe the effects of leader self-sacrifice in virtual teams. A sample of 197 university students enrolled in a psychology course took part in a group electronic task of writing a detailed research plan for a scientific investigation. Participants collaborated in groups of five, led by a senior student for 30 days. Results showed the presence of an effect of e-leadership self-sacrifice on followers’ prosocial behavior. Another effect of e-leadership self-sacrifice was found via team identification and perceived self-efficacy. Findings are discussed on the basis of Social Identity Theory, showing the importance of self-sacrifice e-leaders to promote reciprocal prosocial behavior of the followers.
Keywords	e-leadership ; self-sacrifice ; virtual teams ; prosocial behavior ; team identification ; self-efficacy ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Skin Involvement in Paediatric Patients with Type 1 Diabetes.

Passanisi, Stefano / Salzano, Giuseppina / Lombardo, Fortunato

Current diabetes reviews

2021 Volume 18, Issue 4, Page(s) e030921196145

Abstract: Skin involvement is an overlooked aspect in the management of paediatric patients with type 1 diabetes. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: "children," "pediatric/ ... ...

Abstract	Skin involvement is an overlooked aspect in the management of paediatric patients with type 1 diabetes. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: "children," "pediatric/paediatric patients," "skin," "skin disorders," "type 1 diabetes." Dermatological side effects are frequently observed among diabetic children and adolescents. Insulin-induced lipodystrophies and allergic contact dermatitis caused by insulin pumps or glycaemic sensors are the most common skin reactions in these patients. Furthermore, several diabetes-associated skin diseases such as necrobiosis lipoidica, granuloma annulare, vitiligo, and bullosis diabeticorum may already be present in paediatric patients. Paediatric diabetes specialists should pay attention to their patients' skin to recognize these disorders, identify the potential causes, and choose the most suitable treatment. Finally, the evaluation of skin concentrations of advanced glycation end-products using non-invasive diagnostic techniques may be used to assess the risk of chronic complications of diabetes as early as adolescence.
MeSH term(s)	Adolescent ; Child ; Diabetes Complications ; Diabetes Mellitus, Type 1/complications ; Humans ; Insulin/adverse effects ; Necrobiosis Lipoidica ; Skin ; Skin Diseases
Chemical Substances	Insulin
Language	English
Publishing date	2021-09-02
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	1875-6417
ISSN (online)	1875-6417
DOI	10.2174/1573399817666210903153837
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Article: Clinical and genetic features of maturity-onset diabetes of the young in pediatric patients: a 12-year monocentric experience.

Passanisi, Stefano / Salzano, Giuseppina / Bombaci, Bruno / Lombardo, Fortunato

Diabetology & metabolic syndrome

2021 Volume 13, Issue 1, Page(s) 96

Abstract: Background: A retrospective observational study was conducted to assess the prevalence of maturity onset diabetes of the young (MODY) in a large paediatric population of Southern Italy newly diagnosed with diabetes. Clinical and genetic features of the ... ...

Abstract	Background: A retrospective observational study was conducted to assess the prevalence of maturity onset diabetes of the young (MODY) in a large paediatric population of Southern Italy newly diagnosed with diabetes. Clinical and genetic features of the identified MODY patients were also described. Methods: Genetic testing was performed in children and adolescents newly diagnosed with diabetes who presented autoantibody negativity and fasting C-peptide levels ≥ 0.8 ng/mL. Patients with a low insulin daily dose and optimal glycaemic control after two years from diabetes onset were also investigated for monogenic diabetes, regardless of their autoimmunity status and/or C-peptide levels. Results: A prevalence of 6.5% of MODY was found. In particular, glucokinase-MODY was the most common type of MODY. The mean age at diagnosis was 9.1 years. Clinical presentation and biochemical data were heterogeneous also among patients belonging to the same MODY group. Conclusions: We found a relatively high prevalence of MODY among paediatric patients with a new diagnosis of diabetes in comparison to literature data. Our findings highlight that a more detailed clinical evaluation along with easier and less expensive approachability to genetic testing may allow diagnosing an increasing number of MODY cases. A correct, prompt diagnosis is crucial to choose the most appropriate treatment and offer adequate genetic counselling.
Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-021-00716-6
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Article ; Online: Aiming for the Best Glycemic Control Beyond Time in Range: Time in Tight Range as a New Continuous Glucose Monitoring Metric in Children and Adolescents with Type 1 Diabetes Using Different Treatment Modalities.

Passanisi, Stefano / Piona, Claudia / Salzano, Giuseppina / Marigliano, Marco / Bombaci, Bruno / Morandi, Anita / Alibrandi, Angela / Maffeis, Claudio / Lombardo, Fortunato

Diabetes technology & therapeutics

2023 Volume 26, Issue 3, Page(s) 161–166

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Child ; Adolescent ; Diabetes Mellitus, Type 1/drug therapy ; Hypoglycemic Agents/therapeutic use ; Blood Glucose ; Glycemic Control ; Blood Glucose Self-Monitoring ; Continuous Glucose Monitoring ; Cross-Sectional Studies ; Insulin/therapeutic use
Chemical Substances	Hypoglycemic Agents ; Blood Glucose ; Insulin
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1452816-2
ISSN	1557-8593 ; 1520-9156
ISSN (online)	1557-8593
ISSN	1520-9156
DOI	10.1089/dia.2023.0373
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Article: Vaccinations and Immune Response in Celiac Disease.

Passanisi, Stefano / Dipasquale, Valeria / Romano, Claudio

Vaccines

2020 Volume 8, Issue 2

Abstract: Immune response to vaccinations in celiac patients is of growing scientific interest. However, some aspects of the relationship between celiac disease (CD) and vaccines are still unclear. A comprehensive search of published literature using the PubMed ... ...

Abstract	Immune response to vaccinations in celiac patients is of growing scientific interest. However, some aspects of the relationship between celiac disease (CD) and vaccines are still unclear. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: "adaptive immunity", "celiac disease", "humoral immune response", "immunization", and "vaccination". To date, there is no evidence showing any causative association between vaccines and CD development. Therefore, vaccinations may be administered according to the modalities and timing of the National Immunization Schedule for each country. The rotavirus vaccine is currently recommended for the general population, and according to some data, it appears to reduce the risk for the development of CD autoimmunity in the early years of life. Regarding the hepatitis B virus, a booster dose of the vaccine is often required due to the low or the lost immune response rate in CD. Furthermore, determination of hepatitis B antibody titers could be useful in newly diagnosed CD subjects regardless of age at diagnosis. Finally, pneumococcal vaccines may be administered in patients with advancing age at diagnosis and concomitant risk factors. Future clinical practice guidelines for vaccination and monitoring programs in celiac patients could be recommended.
Language	English
Publishing date	2020-06-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines8020278
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