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Article: Beyond PARP Inhibitors in Advanced Breast Cancer Patients with Germline

Nerone, Marta / Rossi, Lorenzo / Condorelli, Rosaria / Ratti, Vilma / Conforti, Fabio / Palazzo, Antonella / Graffeo, Rossella

Cancers

2023 Volume 15, Issue 13

Abstract: We explored the outcomes of ... ...

Abstract	We explored the outcomes of germline
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15133305
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-Cov-2 pneumonia and concurrent myelodysplasia complicated by Pseudomonas aeruginosa over-infection

Pezzuto, Aldo / Tammaro, Antonella / Tonini, Giuseppe / Conforti, Giulia / Falangone, Francesca / Spuntarelli, Valerio / Teggi, Antonella / Pennica, Alfredo

Journal of Virological Methods. 2022 Feb., v. 300 p.114419-

2022

Abstract: The new virus called severe acute respiratory syndrome coronavirus 2 (SARSCov-2) causing Coronavirus disease 2019 (COVID-19) has spread quickly in several countries and it has become pandemic. Different types of clinical manifestations are attributed to ... ...

Abstract	The new virus called severe acute respiratory syndrome coronavirus 2 (SARSCov-2) causing Coronavirus disease 2019 (COVID-19) has spread quickly in several countries and it has become pandemic. Different types of clinical manifestations are attributed to this infection. Some mechanisms related to the infection regarding the immune response are not still elucidated. Herein we reported a case of a 66-years-old patient affected by myelodysplasia who was referred to our hospital because of clinical and radiological manifestations of viral pneumonia. The clinical course has become complicated due to bacterial secondary over-infection by Pseudomonas aeruginosa during stay in internal medicine unit whilst a persistent positive oral and naso-pharyngeal swab test was reported up to 100 days of admission. The patient had a fast clinical and radiological worsening that led her to be admitted to an intensive care unit. Despite intubation and mechanical ventilation she died in a few days.
Keywords	COVID-19 infection ; Pseudomonas aeruginosa ; Severe acute respiratory syndrome coronavirus 2 ; disease course ; hospitals ; immune response ; medicine ; pandemic ; patients ; viral pneumonia ; viruses ; SARS-Cov-2 pneumonia ; Bacterial over-infection ; Myelodysplasia
Language	English
Dates of publication	2022-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2021.114419
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: SARS-Cov-2 pneumonia and concurrent myelodysplasia complicated by Pseudomonas aeruginosa over-infection.

Pezzuto, Aldo / Tammaro, Antonella / Tonini, Giuseppe / Conforti, Giulia / Falangone, Francesca / Spuntarelli, Valerio / Teggi, Antonella / Pennica, Alfredo

Journal of virological methods

2021 Volume 300, Page(s) 114419

Abstract	The new virus called severe acute respiratory syndrome coronavirus 2 (SARSCov-2) causing Coronavirus disease 2019 (COVID-19) has spread quickly in several countries and it has become pandemic. Different types of clinical manifestations are attributed to this infection. Some mechanisms related to the infection regarding the immune response are not still elucidated. Herein we reported a case of a 66-years-old patient affected by myelodysplasia who was referred to our hospital because of clinical and radiological manifestations of viral pneumonia. The clinical course has become complicated due to bacterial secondary over-infection by Pseudomonas aeruginosa during stay in internal medicine unit whilst a persistent positive oral and naso-pharyngeal swab test was reported up to 100 days of admission. The patient had a fast clinical and radiological worsening that led her to be admitted to an intensive care unit. Despite intubation and mechanical ventilation she died in a few days.
MeSH term(s)	Aged ; COVID-19 ; Female ; Humans ; Pandemics ; Pseudomonas aeruginosa ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-12-10
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2021.114419
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Article ; Online: Neoantigen cancer vaccine augments anti-CTLA-4 efficacy.

Salvatori, Erika / Lione, Lucia / Compagnone, Mirco / Pinto, Eleonora / Conforti, Antonella / Ciliberto, Gennaro / Aurisicchio, Luigi / Palombo, Fabio

NPJ vaccines

2022 Volume 7, Issue 1, Page(s) 15

Abstract: Immune checkpoint inhibitors (ICI) based on anti-CTLA-4 (αCTLA-4) and anti-PD1 (αPD1) are being tested in combination with different therapeutic approaches including other immunotherapies such as neoantigen cancer vaccines (NCV). Here we explored, in two ...

Abstract	Immune checkpoint inhibitors (ICI) based on anti-CTLA-4 (αCTLA-4) and anti-PD1 (αPD1) are being tested in combination with different therapeutic approaches including other immunotherapies such as neoantigen cancer vaccines (NCV). Here we explored, in two cancer murine models, different therapeutic combinations of ICI with personalized DNA vaccines expressing neoantigens and delivered by electroporation (EP). Anti-cancer efficacy was evaluated using vaccines with or without CD4 epitopes. Therapeutic DNA vaccines showed synergistic effects in different therapeutic protocols including established large tumors. Flow cytometry (FC) was utilized to measure CD8, CD4, Treg, and switched B cells as well as neoantigen-specific immune responses, which were also measured by IFN-γ ELIspot. Immune responses were augmented in combination with αCTLA4 but not with αPD1 in the MC38 tumor-bearing mice, significantly impacting tumor growth. Similarly, neoantigen-specific T cell immune responses were enhanced in combined treatment with αCTLA-4 in the CT26 tumor model where large tumors regressed in all mice, while monotherapy with αCTLA-4 was less efficacious. In line with previous evidence, we observed an increased switched B cells in the spleen of mice treated with αCTLA-4 alone or in combination with NCV. These results support the use of NCV delivered by DNA-EP with αCTLA-4 and suggest a new combined therapy for clinical testing.
Language	English
Publishing date	2022-02-02
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-022-00433-9
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Article: Immunogenicity of COVID-eVax Delivered by Electroporation Is Moderately Impacted by Temperature and Molecular Isoforms.

D'Alessio, Federico / Lione, Lucia / Salvatori, Erika / Bucci, Federica / Muzi, Alessia / Roscilli, Giuseppe / Compagnone, Mirco / Pinto, Eleonora / Battistuzzi, Gianfranco / Conforti, Antonella / Aurisicchio, Luigi / Palombo, Fabio

Vaccines

2023 Volume 11, Issue 3

Abstract: DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy, DNA molecules are considered to be more stable. In this study, we ... ...

Abstract	DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy, DNA molecules are considered to be more stable. In this study, we challenged this concept by characterizing the immunological response induced by a plasmid DNA vaccine delivered using electroporation. As a model, we used COVID-eVax, a plasmid DNA-based vaccine that targets the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Increased nicked DNA was produced by using either an accelerated stability protocol or a lyophilization protocol. Surprisingly, the immune response induced in vivo was only minimally affected by the percentage of open circular DNA. This result suggests that plasmid DNA vaccines, such as COVID-eVax that have recently completed a phase I clinical trial, retain their efficacy upon storage at higher temperatures, and this feature may facilitate their use in low-/middle-income countries.
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11030678
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Article ; Online: Are Genetic Vaccines the Right Weapon against COVID-19?

Conforti, Antonella / Marra, Emanuele / Roscilli, Giuseppe / Palombo, Fabio / Ciliberto, Gennaro / Aurisicchio, Luigi

Molecular therapy : the journal of the American Society of Gene Therapy

2020 Volume 28, Issue 7, Page(s) 1555–1556

MeSH term(s)	Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; DNA, Viral/genetics ; Humans ; Immunogenicity, Vaccine ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Polymerase Chain Reaction/methods ; SARS-CoV-2 ; Vaccination ; Vaccines, DNA/adverse effects ; Vaccines, DNA/economics ; Vaccines, DNA/immunology ; Viral Vaccines/immunology ; Viral Vaccines/therapeutic use
Chemical Substances	DNA, Viral ; Vaccines, DNA ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	United States
Document type	Letter
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2020.06.007
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Article ; Online: Use of Iron and Steel Slags in Concrete

Alan Piemonti / Antonio Conforti / Luca Cominoli / Sabrina Sorlini / Antonella Luciano / Giovanni Plizzari

Sustainability, Vol 13, Iss 2, p

State of the Art and Future Perspectives

2021 Volume 556

Abstract: In the two last decades, world production of pig iron and steel has undergone a significant increase. In 2018, 1252.87 and 1806.46 million tons of pig iron and steel, respectively, were produced as compared to the 575.78 and 809.94 million tons of 2000. ... ...

Abstract	In the two last decades, world production of pig iron and steel has undergone a significant increase. In 2018, 1252.87 and 1806.46 million tons of pig iron and steel, respectively, were produced as compared to the 575.78 and 809.94 million tons of 2000. Consequently, the amount of the different types of slags deriving from these production processes has also increased considerably. In relation to the principles of sustainability and circular economy, the available literature suggests several possible reuses for these slags (bituminous conglomerates, hydraulic engineering, metallurgy, fertilizers, etc.). This paper aims to provide an overview of the iron and steel slags production and their reuse in concrete (for example as replacement of cement, fine or coarse aggregates). The characteristics of slags are analyzed in terms of chemical, physical, and mechanical properties. Mechanical and durability tests (both from material and structures point of view) carried out in the different studies and research are shown as well. Particular attention was devoted to electric arc furnace slags (EAF) since they are the most produced in Italy. Based on this deep literature review, the gaps that still require further studies have been identified and discussed.
Keywords	concrete ; iron ; slag ; steel ; sustainability ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The rare entity of gastrointestinal leiomyosarcomas: An Italian multicenter retrospective study in high-volume referral centers.

Zagami, Paola / Comandone, Alessandro / Fiore, Marco / Baldi, Giacomo Giulio / Grignani, Giovanni / Vincenzi, Bruno / Gronchi, Alessandro / Antonarelli, Gabriele / Boglione, Antonella / Pennacchioli, Elisabetta / Curigliano, Giuseppe / Conforti, Fabio / De Pas, Tommaso Martino

Cancer medicine

2023 Volume 12, Issue 16, Page(s) 17047–17055

Abstract: Background: After a huge efficacy of imatinib in treating patients with gastrointestinal stromal tumors (GISTs) was proven, a maximum effort was made to make a differential diagnosis between GISTs and gastrointestinal leiomyosarcomas (GI-LMS), showing ... ...

Abstract	Background: After a huge efficacy of imatinib in treating patients with gastrointestinal stromal tumors (GISTs) was proven, a maximum effort was made to make a differential diagnosis between GISTs and gastrointestinal leiomyosarcomas (GI-LMS), showing the latter to be an extremely rare tumor entity. Limited data on GI-LMS biology, clinical behavior and drug-sensibility are available, and the clinical decision-making in this subgroup of patients is usually challenging. Methods: We conducted a multicenter, retrospective observational study on patients with diagnosed GI-LMS from 2004 to 2020 within six high-volume referral centers in Italy. Results: Thirty-three patients had diagnosis of KIT-negative GI-LMS confirmed by sarcoma-expert pathologist. The most common site of origin was the intestine. Twenty-two patients had localized disease and underwent surgery: with a median follow-up of 72 months, median disease-free survival was 42 months. Overall survival (OS)-rate at 5 years was 73% and median OS was 193 months. Five out of 10 patients with local relapse received a salvage surgery, and 2/5 remained with no evidence of disease. Thirteen patients received neoadjuvant (6) or adjuvant (7) chemotherapy, and 2/13 patients remained free from relapse. The median OS for patients with metastatic LMS was 16.4 months. Conclusion: GI-LMS is very rare and extremely aggressive subgroup of sarcomas with a high tendency to systemic spread. Localized GI-LMS at diagnosis may be cured if treated with adequate surgery with or without (neo) adjuvant chemotherapy, while de-novo metastatic disease appeared to have a poor prognosis. Clinical effort to understand GI-LMS biology and clinical behavior and to develop active treatment strategy, especially for metastatic-disease, is warranted.
MeSH term(s)	Humans ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/therapy ; Leiomyosarcoma/pathology ; Retrospective Studies ; Neoplasm Recurrence, Local/therapy ; Sarcoma ; Gastrointestinal Stromal Tumors/therapy ; Gastrointestinal Stromal Tumors/drug therapy ; Italy/epidemiology
Language	English
Publishing date	2023-07-16
Publishing country	United States
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6340
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunogenicity of COVID-eVax Delivered by Electroporation Is Moderately Impacted by Temperature and Molecular Isoforms

Federico D’Alessio / Lucia Lione / Erika Salvatori / Federica Bucci / Alessia Muzi / Giuseppe Roscilli / Mirco Compagnone / Eleonora Pinto / Gianfranco Battistuzzi / Antonella Conforti / Luigi Aurisicchio / Fabio Palombo

Vaccines, Vol 11, Iss 678, p

2023 Volume 678

Abstract	DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy, DNA molecules are considered to be more stable. In this study, we challenged this concept by characterizing the immunological response induced by a plasmid DNA vaccine delivered using electroporation. As a model, we used COVID-eVax, a plasmid DNA-based vaccine that targets the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Increased nicked DNA was produced by using either an accelerated stability protocol or a lyophilization protocol. Surprisingly, the immune response induced in vivo was only minimally affected by the percentage of open circular DNA. This result suggests that plasmid DNA vaccines, such as COVID-eVax that have recently completed a phase I clinical trial, retain their efficacy upon storage at higher temperatures, and this feature may facilitate their use in low-/middle-income countries.
Keywords	COVID-19 ; DNA stability ; immune responses ; vaccines ; Medicine ; R
Subject code	612
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fourteen years' clinical experience and the first million babies protected with human live-attenuated vaccine against rotavirus disease in Italy.

Bonanni, Paolo / Conforti, Giorgio / Franco, Elisabetta / Gabutti, Giovanni / Marchetti, Federico / Mattei, Antonella / Prato, Rosa / Vitali Rosati, Giovanni / Vitale, Francesco

Human vaccines & immunotherapeutics

2021 Volume 17, Issue 11, Page(s) 4636–4645

Abstract: Rotavirus (RV) causes up to half of hospital and community acute gastroenteritis (AGE) cases in young children in Italy. Two RV vaccines, available since 2006, are human RV (HRV) and human bovine RV (HBRV). This report looks back at the implementation of ...

Abstract	Rotavirus (RV) causes up to half of hospital and community acute gastroenteritis (AGE) cases in young children in Italy. Two RV vaccines, available since 2006, are human RV (HRV) and human bovine RV (HBRV). This report looks back at the implementation of RV vaccination with HRV in Italy, and at HRV current and future perspectives. Initial regional policies led to national implementation by 2018, after scientific societies' disease awareness efforts. Following vaccination, RV hospitalizations declined significantly, and cost savings were observed. The two-dose HRV vaccine is easily administered during compulsory vaccine visits, helping increase coverage. Intussusception, a serious event in children <1 year, was reported in Italy with a rate of 33-40 per 100,000 infants. RV vaccination presents a low increased risk of intussusception after the first dose, estimated at 0.6 cases per 100,000 doses in Italy in 2019. Parents should be aware of the intussusception risk and symptoms to ensure prompt treatment. It is widely recognized that the vaccination benefits (large numbers of RV hospitalizations prevented) outweigh the risk. HRV introduction in Italy was supported by epidemiologic burden studies, healthcare provider opinions, and congress debates, which significantly contributed to implementation of RV universal routine infant vaccination in Italy.
MeSH term(s)	Animals ; Cattle ; Child ; Child, Preschool ; Humans ; Infant ; Italy/epidemiology ; Rotavirus ; Rotavirus Infections/epidemiology ; Rotavirus Infections/prevention & control ; Rotavirus Vaccines ; Vaccination ; Vaccines, Attenuated
Chemical Substances	Rotavirus Vaccines ; Vaccines, Attenuated
Language	English
Publishing date	2021-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.1955611
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