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Article ; Online: Factors Associated with Intention to Resign among Medical Residents during the COVID-19 Pandemic in Japan: A Cross-sectional Study.

Morita, Takako / Muroya, Saki / Takahashi, Osamu / Ohde, Sachiko

2023 Volume 6, Issue 3, Page(s) 292–299

Abstract: Introduction: The coronavirus disease 2019 (COVID-19) pandemic has significantly affected healthcare workers' mental health worldwide, leading to the intention to resign. Japanese medical residents were no exception to the impact of COVID-19. This study ...

Abstract	Introduction: The coronavirus disease 2019 (COVID-19) pandemic has significantly affected healthcare workers' mental health worldwide, leading to the intention to resign. Japanese medical residents were no exception to the impact of COVID-19. This study aimed to illustrate how the COVID-19 pandemic affected medical residents' intention to resign. Methods: A cross-sectional study was conducted for Postgraduate Year (PGY)1-5 medical residents in Japan using an internet survey from March 11 to March 18, 2021. During this survey, the Japanese government declared a second-time state of emergency on January 7, 2021, and all restrictions were expanded nationwide until March 21, 2021. Medical residents were categorized into two groups (intention to resign group [IR] or no intention to resign group [NIR]) based on their intention to resign. Multivariate logistic regression analysis was conducted to elucidate the risk factors for the intention to resign. Results: 354 medical residents were enrolled in this study (response rate: 40.2%). Ninety-two medical residents (26.0 %) were categorized into IR and 262 (74.0%) into NIR. According to multivariate logistic regression analysis, those who did not have mental support at their hospital had 2.95 times greater chance of intending to resign (Adjusted odds ratio [AOR] = 2.95, 95% confidence interval (CI) [1.42-6.15]). Medical residents who engaged in patients with COVID-19 (AOR = 2.13, 95% Cl [1.08-4.18]) and PGY5 (AOR = 3.38, 95% Cl [1.51-7.56]) had a higher likelihood of intending to resign among residents in all PGY. Conclusions: One in four medical residents intended to resign during the COVID-19 pandemic. Particularly, PGY5 and medical residents who treated patients with COVID-19 were found at risk of having the intention to resign. At times of crisis, such as the COVID-19 epidemic, establishing a mental health support system that targets high-risk residents is critical.
Language	English
Publishing date	2023-07-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2023-0004
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Article ; Online: A novel treatment strategy for bladder hypoplasia: A case of megaureter in a functional solitary kidney.

Sasaki, Yutaro / Takahashi, Masayuki / Nishiyama, Mitsuki / Kobayashi, Saki / Ueno, Yoshiteru / Furukawa, Junya / Shimada, Kenji

IJU case reports

2024 Volume 7, Issue 3, Page(s) 243–246

Abstract: Introduction: We report a case of megaureter in a functional solitary kidney in which surgery was performed after bladder capacity was increased by home bladder cycling.: Case presentation: A 6-day-old girl with a left megaureter, a right multicystic ...

Abstract	Introduction: We report a case of megaureter in a functional solitary kidney in which surgery was performed after bladder capacity was increased by home bladder cycling. Case presentation: A 6-day-old girl with a left megaureter, a right multicystic dysplastic kidney, and bladder hypoplasia underwent percutaneous left nephrostomy for obstructive renal failure. At 8 months, home bladder cycling was initiated to increase bladder capacity before the planned ureterocystoneostomy. Surgery was performed after bladder capacity increased. The left ureter was compressed by the left umbilical ligament, so ureteral end-to-end anastomosis was performed at 1 year and 4 months. At 2 years and 8 months, cystometry showed age-appropriate bladder capacity and improved bladder compliance. Conclusion: To the best of our knowledge, this is the first report of bladder hypoplasia treated by home bladder cycling.
Language	English
Publishing date	2024-02-25
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12713
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Article ; Online: Combined X-ray Reflectivity and Infrared Study of the Effect of Hydrogen Bonding of the OH Group on the Relaxation Behavior in Ultrathin Polyvinylphenol Films on SiO

Sharma, Tulika / Kashihara, Saki / Yamasaki, Yuta / Ozaki, Yukihiro / Takahashi, Isao / Sato, Harumi

The journal of physical chemistry. B

2023 Volume 127, Issue 35, Page(s) 7602–7614

Abstract: Utilizing X-ray reflectivity and infrared reflection absorption spectroscopy (IR-RAS), we have investigated the thermal expansion and contraction of ultrathin polyvinylphenol (PVPh) films supported on a silicon (100) substrate capped with an amorphous ... ...

Abstract	Utilizing X-ray reflectivity and infrared reflection absorption spectroscopy (IR-RAS), we have investigated the thermal expansion and contraction of ultrathin polyvinylphenol (PVPh) films supported on a silicon (100) substrate capped with an amorphous SiO
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c01491
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Article ; Online: Biochemical Characterizations of the Putative Amidase Endolysin Ecd18980 Catalytic Domain from Clostridioides difficile.

Sekiya, Hiroshi / Kobayashi, Saki / Takahashi, Ikumi / Kamitori, Shigehiro / Tamai, Eiji

Biological & pharmaceutical bulletin

2023 Volume 46, Issue 11, Page(s) 1625–1629

Abstract: Clostridioides difficile is the major causative pathogen of pseudomembranous colitis, and novel antimicrobial agents are required for treatment. Phage-derived endolysins exhibiting species-specific lytic activity have potential as novel antimicrobial ... ...

Abstract	Clostridioides difficile is the major causative pathogen of pseudomembranous colitis, and novel antimicrobial agents are required for treatment. Phage-derived endolysins exhibiting species-specific lytic activity have potential as novel antimicrobial agents. We surveyed the genome of C. difficile strain 630 and identified a gene encoding an endolysin, Ecd18980, which has an amidase_3 domain at the N-terminus but unknown C-terminal domain. The genes encoding Ecd18980 and its catalytic domain (Ecd18980CD) were cloned and expressed in Escherichia coli as N-terminal histidine-tagged proteins. These purified proteins showed lytic activity against C. difficile. Ecd18980CD showed higher lytic activity than the wild-type enzyme and near-specific lytic activity against C. difficile. This species specificity is thought to depend on substrate cleavage activity rather than binding. We also characterized the biochemical properties of Ecd18980CD, including optimal pH, salt concentration, and thermal stability.
MeSH term(s)	Catalytic Domain ; Clostridioides difficile/genetics ; Clostridioides ; Bacteriophages/genetics ; Amidohydrolases ; Anti-Infective Agents
Chemical Substances	endolysin (EC 3.4.99.-) ; Amidohydrolases (EC 3.5.-) ; Anti-Infective Agents
Language	English
Publishing date	2023-11-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b23-00265
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Zs.A 1474: Show issues

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Article ; Online: L-type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids.

Akashi, Tomoya / Noguchi, Saki / Takahashi, Yu / Nishimura, Tomohiro / Tomi, Masatoshi

Journal of pharmaceutical sciences

2023 Volume 112, Issue 4, Page(s) 1137–1144

Abstract: Pregabalin is an anti-neuropathic pain drug inhibiting the α2δ subunit of the voltage-dependent calcium channel in the spinal cord. The aim of this study is to characterize the transport mechanism of pregabalin at the blood-spinal cord barrier (BSCB) by ... ...

Abstract	Pregabalin is an anti-neuropathic pain drug inhibiting the α2δ subunit of the voltage-dependent calcium channel in the spinal cord. The aim of this study is to characterize the transport mechanism of pregabalin at the blood-spinal cord barrier (BSCB) by means of in vivo experiments in rats and in vitro studies using primary-cultured rat spinal cord endothelial cells. We isolated endothelial cells by culturing rat spinal cord tissue in the presence of puromycin, and confirmed the expression of BSCB markers such as Cd31, Mdr1a, and Claudin-5. The uptake of pregabalin by primary-cultured rat spinal cord endothelial cells was sodium-independent and was significantly inhibited by L-leucine, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, and JPH203. These results suggest the involvement of L-type amino acid transporter (LAT) 1. LAT1 mRNA and protein was expressed in primary-cultured rat spinal cord endothelial cells, which is consistent with LAT1 expression at the BSCB. In the in vivo study, the transfer of pregabalin to rat spinal cord and brain was significantly decreased by the pre-administration of branched chain amino acids (BCAAs), which are endogenous substrates of LAT1. Our results indicate that pregabalin transport across the BSCB is mediated at least in part by LAT1 and is inhibited by plasma BCAAs.
MeSH term(s)	Rats ; Animals ; Pregabalin ; Large Neutral Amino Acid-Transporter 1/genetics ; Large Neutral Amino Acid-Transporter 1/metabolism ; Amino Acids, Branched-Chain/metabolism ; Endothelial Cells/metabolism ; Spinal Cord/metabolism
Chemical Substances	Pregabalin (55JG375S6M) ; Large Neutral Amino Acid-Transporter 1 ; Amino Acids, Branched-Chain
Language	English
Publishing date	2023-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1016/j.xphs.2022.12.028
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Article: Imbalance of glutamatergic and GABAergic neurotransmission in audiogenic seizure-susceptible L

Kinboshi, Masato / Shimizu, Saki / Tokudome, Kentaro / Mashimo, Tomoji / Serikawa, Tadao / Ito, Hidefumi / Takahashi, Ryosuke / Ikeda, Akio / Ohno, Yukihiro

Heliyon

2023 Volume 9, Issue 7, Page(s) e17984

Abstract: Leucine-rich glioma-inactivated ... ...

Abstract	Leucine-rich glioma-inactivated 1
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e17984
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Article ; Online: Antimicrobial resistance patterns of Streptococcus uberis isolates from bovine milk in Chiba prefecture, Japan: association between multidrug resistance and clonal complex 996.

Tsuyuki, Yuzo / Maeda, Takahiro / Torii, Kae / Yoshida, Haruno / Ikeda, Noriaki / Yoshida, Saki / Ito, Masahiko / Goto, Mieko / Takahashi, Takashi

The Journal of veterinary medical science

2024

Abstract: Streptococcus uberis is one of major pathogens causing bovine mastitis. However, there is poor information on antimicrobial resistance (AMR) among the Japanese isolates. To provide treatment information for the mastitis caused by S. uberis in Japan, we ... ...

Abstract	Streptococcus uberis is one of major pathogens causing bovine mastitis. However, there is poor information on antimicrobial resistance (AMR) among the Japanese isolates. To provide treatment information for the mastitis caused by S. uberis in Japan, we aimed to clarify AMR patterns of the isolates from bovine milk mainly in Chiba. AMR phenotyping/genotyping [blaZ-erm(A)-erm(B)-mef(A)-linB-lnuD-tet(M)-tet(O)-tet(K)-tet(L)-tet(S)] and multilocus sequence typing were performed to analyze relationships between AMR patterns and clonal complexes (CCs). Resistance to tetracycline-, macrolide-, and lincosamide-classes was mainly associated with possession of tet(O), tet(S), erm(B), linB, and lnuD genes. CC996 was significantly associated with multidrug resistance (P<0.0001). These findings will aid Chiba farm animal clinics in treating bovine mastitis.
Language	English
Publishing date	2024-04-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.23-0526
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Zs.B 579: Show issues

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Article: A case of laparoscopically assisted transperineal repair of anterior enterocele dehiscence with small bowel evisceration after robot-assisted radical cystectomy.

Sasaki, Yutaro / Yamamoto, Yasuyo / Kobayashi, Saki / Nishi, Masaaki / Takahashi, Masayuki / Furukawa, Junya

Urology case reports

2023 Volume 52, Page(s) 102629

Abstract: We herein report a case of successful laparoscopically assisted transperineal repair of anterior enterocele dehiscence with small bowel evisceration after robot-assisted radical cystectomy. A 75-year-old woman underwent robot-assisted radical cystectomy ... ...

Abstract	We herein report a case of successful laparoscopically assisted transperineal repair of anterior enterocele dehiscence with small bowel evisceration after robot-assisted radical cystectomy. A 75-year-old woman underwent robot-assisted radical cystectomy with anterior vaginectomy and urethrectomy for bladder cancer (pTisN0M0). Vaginal reconstruction was performed using the posterior vaginal wall. Four months after surgery, she presented with small bowel evisceration due to anterior enterocele dehiscence. She underwent laparoscopically assisted transperineal repair. The anterior enterocele dehiscence did not occur at the vaginal closure site but instead between the vaginal wall and posterior pubic bone. No recurrence had developed at 2 months postoperatively.
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2023.102629
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Article: Bacterial meningitis caused by nontraumatic cerebrospinal fluid rhinorrhea with aqueductal stenosis: A case report.

Kotani, Saki / Takahashi, Yoshinobu / Morisako, Tamaki / Yamanaka, Takumi / Hashimoito, Naoya

Surgical neurology international

2022 Volume 13, Page(s) 439

Abstract: Background: Nontraumatic cerebrospinal fluid (CSF) rhinorrhea associated with aqueductal stenosis is rare. The resulting CSF leakage may cause bacterial meningitis, and appropriately timed surgical treatment should be considered.: Case description: A ...

Abstract	Background: Nontraumatic cerebrospinal fluid (CSF) rhinorrhea associated with aqueductal stenosis is rare. The resulting CSF leakage may cause bacterial meningitis, and appropriately timed surgical treatment should be considered. Case description: A 28-year-old woman with obstructive hydrocephalus secondary to aqueductal stenosis presented with intermittent nasal discharge. CSF rhinorrhea was suspected, but she refused surgery. During the course of conservative treatment, she developed meningitis. Exacerbation of hydrocephalus and CSF rhinorrhea was suspected, and the patient underwent endoscopic third ventriculostomy after recovery from meningitis. Postoperatively, ventricular size decreased and CSF leakage completely resolved. There was no recurrence of hydrocephalus or rhinorrhea. Conclusion: Patients with intermittent CSF rhinorrhea due to exacerbation of hydrocephalus are at high risk for bacterial meningitis. Appropriately timed surgical treatment results in a favorable outcome.
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Case Reports
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_610_2022
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Article ; Online: Volumetric Strategy for Quantitatively Elucidating a Local Hydration Network around a G-Quadruplex.

Matsumoto, Saki / Takahashi, Shuntaro / Bhowmik, Sudipta / Ohyama, Tatsuya / Sugimoto, Naoki

Analytical chemistry

2022 Volume 94, Issue 20, Page(s) 7400–7407

Abstract: Hydration around nucleic acids, such as DNA and RNA, is an important factor not only for the stability of nucleic acids but also for their interaction with binding molecules. Thus, it is necessary to quantitatively elucidate the hydration properties of ... ...

Abstract	Hydration around nucleic acids, such as DNA and RNA, is an important factor not only for the stability of nucleic acids but also for their interaction with binding molecules. Thus, it is necessary to quantitatively elucidate the hydration properties of nucleic acids around a certain structure. In this study, volumetric changes in G-quadruplex (G4) RNA formation were investigated by systematically changing the number of G-quartet stacks under high pressure. The volumetric contribution at the level of each G4 structural unit revealed that the core G4 helix was significantly more dehydrated than the other parts, including the edges of G-quartets and loops. These findings will help in predicting the binding of G4 ligands on the surface of G4, depending on the chemical structure of the ligand and solution environment. Therefore, the preset volumetric parameter provides information that can predict molecular interactions in G4 formations during molecular crowding in cells.
MeSH term(s)	DNA/chemistry ; G-Quadruplexes ; Ligands ; RNA
Chemical Substances	Ligands ; RNA (63231-63-0) ; DNA (9007-49-2)
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c01075
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Zs.A 4033: Show issues

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