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  1. Article ; Online: Molecular Research on Amyloidosis.

    Nakamura, Kazufumi

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: Amyloidosis is a large group of diseases that are caused by the deposition of insoluble amyloid fibrils formed by misfolded soluble proteins in organs or tissues [ ... ]. ...

    Abstract Amyloidosis is a large group of diseases that are caused by the deposition of insoluble amyloid fibrils formed by misfolded soluble proteins in organs or tissues [...].
    MeSH term(s) Humans ; Amyloidosis/metabolism ; Amyloid/metabolism
    Chemical Substances Amyloid
    Language English
    Publishing date 2023-04-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24086980
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  2. Article ; Online: Utility of angiopoietin-2 measured early after the Fontan operation.

    Toh, Norihisa / Akagi, Teiji / Nakamura, Kazufumi / Kasahara, Shingo

    The American journal of cardiology

    2023  Volume 205, Page(s) 516

    MeSH term(s) Humans ; Angiopoietin-2 ; Fontan Procedure
    Chemical Substances Angiopoietin-2
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.07.125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.73: Show issues Location:
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  3. Article ; Online: A variability of the QRS morphology during wide QRS tachycardia.

    Asada, Saori / Nakagawa, Koji / Nishii, Nobuhiro / Morita, Hiroshi / Nakamura, Kazufumi

    Pacing and clinical electrophysiology : PACE

    2023  Volume 46, Issue 12, Page(s) 1568–1571

    MeSH term(s) Humans ; Tachycardia, Supraventricular/diagnosis ; Electrocardiography ; Diagnosis, Differential
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/pace.14871
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    Zs.A 1466: Show issues Location:
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    Zs.MO 399: Show issues

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  4. Article: Mediastinal hematoma as an unusual intrathoracic manifestation of Boerhaave Syndrome: A case report.

    Nakano, Yusuke / Nakamura, Toru / Tomatsu, Makoto / Miyaki, Yuichiro / Suzuki, Kazufumi

    International journal of surgery case reports

    2024  Volume 116, Page(s) 109366

    Abstract: Introduction: Boerhaave Syndrome (BS) is rare but life-threatening condition caused by a sudden increase in the intraluminal pressure due to vomiting. We present a case of BS manifesting as a posterior mediastinal hematoma, indicative of a potentially ... ...

    Abstract Introduction: Boerhaave Syndrome (BS) is rare but life-threatening condition caused by a sudden increase in the intraluminal pressure due to vomiting. We present a case of BS manifesting as a posterior mediastinal hematoma, indicative of a potentially fatal condition.
    Presentation of case: A 51-year-old man presented with acute chest pain after vomiting. Enhanced Computed Tomography revealed mediastinal fluid with a left pleural effusion, leading to a diagnosis of BS. Emergency surgery revealed a posterior mediastinal hematoma with active bleeding due to a torn proper esophageal artery. Hemostasis and a wall repair were performed, and the patient was discharged uneventfully.
    Discussion: This case highlights two important aspects. Firstly, a spontaneous esophageal perforation can manifest as a mediastinal hematoma due to the subpleural arterial injury, delaying bacterial spillage. While preoperative thoracentesis may not always diagnose BS accurately, bloody thoracic drainage can serve as an alternative diagnostic sign. Secondly, the mediastinal hematoma itself poses a serious risk, as it can lead to a catastrophic outcome even before bacterial contamination occurs, emphasizing the necessity of a timely surgical intervention in BS cases.
    Conclusion: BS can manifest as a mediastinal hematoma, and the absence of gastrointestinal content in the thoracic drainage does not rule out the possibility of BS. Prompt surgical intervention remains essential, as a mediastinal hematoma alone can result in a catastrophic outcome. This case highlights the significance of a comprehensive diagnostic assessment for BS.
    Language English
    Publishing date 2024-02-12
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2024.109366
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  5. Article ; Online: Myocardial Late Iodine Enhancement Using Photon-Counting Computed Tomography in Patients With Hypertrophic Cardiomyopathy.

    Nishihara, Takahiro / Miyoshi, Toru / Akagi, Noriaki / Nakashima, Mitsutaka / Nakamura, Kazufumi / Ito, Hiroshi

    Circulation reports

    2023  Volume 5, Issue 6, Page(s) 269–270

    Language English
    Publishing date 2023-05-18
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-23-0034
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  6. Article ; Online: Treatment for pulmonary hypertension due to left heart diseases.

    Nakamura, Kazufumi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2016  Volume 39, Issue 1, Page(s) 6–7

    MeSH term(s) Heart Diseases ; Heart Failure ; Humans ; Hypertension, Pulmonary
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/hr.2015.116
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    Zs.A 3898: Show issues Location:
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  7. Article ; Online: Induced Pluripotent Stem Cell-Derived Cardiomyocytes Therapy for Ischemic Heart Disease in Animal Model: A Meta-Analysis.

    Vo, Quan Duy / Saito, Yukihiro / Nakamura, Kazufumi / Iida, Toshihiro / Yuasa, Shinsuke

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Ischemic heart disease (IHD) poses a significant challenge in cardiovascular health, with current treatments showing limited success. Induced pluripotent derived-cardiomyocyte (iPSC-CM) therapy within regenerative medicine offers potential for IHD ... ...

    Abstract Ischemic heart disease (IHD) poses a significant challenge in cardiovascular health, with current treatments showing limited success. Induced pluripotent derived-cardiomyocyte (iPSC-CM) therapy within regenerative medicine offers potential for IHD patients, although its clinical impacts remain uncertain. This study utilizes meta-analysis to assess iPSC-CM outcomes in terms of efficacy and safety in IHD animal model studies. A meta-analysis encompassing PUBMED, ScienceDirect, Web of Science, and the Cochrane Library databases, from inception until October 2023, investigated iPSC therapy effects on cardiac function and safety outcomes. Among 51 eligible studies involving 1012 animals, despite substantial heterogeneity, the iPSC-CM transplantation improved left ventricular ejection fraction (LVEF) by 8.23% (95% CI, 7.15 to 9.32%;
    MeSH term(s) Humans ; Animals ; Myocytes, Cardiac ; Induced Pluripotent Stem Cells ; Stroke Volume ; Ventricular Function, Left ; Myocardial Ischemia/therapy ; Disease Models, Animal
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020987
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  8. Article ; Online: Catheter-directed thrombolysis for critical hand ischemia with failed distal venous arterialization.

    Nakashima, Mitsutaka / Toda, Hironobu / Ejiri, Kentaro / Ozawa, Susumu / Akagi, Satoshi / Nakamura, Kazufumi

    Cardiovascular intervention and therapeutics

    2023  Volume 39, Issue 1, Page(s) 95–96

    MeSH term(s) Humans ; Peripheral Vascular Diseases ; Ischemia/drug therapy ; Ischemia/etiology ; Catheters ; Thrombolytic Therapy ; Treatment Outcome
    Language English
    Publishing date 2023-08-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2581654-8
    ISSN 1868-4297 ; 1868-4300
    ISSN (online) 1868-4297
    ISSN 1868-4300
    DOI 10.1007/s12928-023-00956-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4771: Show issues Location:
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  9. Article ; Online: Molecular Mechanisms of Cardiac Amyloidosis

    Yukihiro Saito / Kazufumi Nakamura / Hiroshi Ito

    International Journal of Molecular Sciences, Vol 23, Iss 25, p

    2022  Volume 25

    Abstract: Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac ... ...

    Abstract Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved. However, a method for removing deposited amyloid has not been established. Methods for reducing cytotoxicity caused by amyloid deposition and amyloid precursor protein to protect cardiovascular cells are also needed. In this review, we outline the molecular mechanisms and treatments of cardiac amyloidosis.
    Keywords amyloid ; cytotoxicity ; transthyretin ; immunoglobulin light chain ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: [Staged Hybrid Repair of Extensive Thoracic Aortic Aneurysm with Right Aortic Arch and Isolated Left Subclavian Artery:Report of a Case].

    Niki, Taiki / Yoshida, Kazufumi / Nakamura, Ken / Kinoshita, Makoto / Koyama, Tadaaki

    Kyobu geka. The Japanese journal of thoracic surgery

    2023  Volume 76, Issue 2, Page(s) 132–135

    Abstract: A 69-year-old male was referred to our hospital due to extensive thoracic aortic aneurysm with right aortic arch and isolated left subclavian artery. We chose staged hybrid repair to avoid the risk of spinal cord injury and bilateral recurrent nerve ... ...

    Abstract A 69-year-old male was referred to our hospital due to extensive thoracic aortic aneurysm with right aortic arch and isolated left subclavian artery. We chose staged hybrid repair to avoid the risk of spinal cord injury and bilateral recurrent nerve paralysis. First, ascending aorta replacement with elephant trunk and reconstruction of the cervical branches were underwent. Second, we performed the thoracic endovascular aortic repair for aortic arch and descending aortic aneurysm. The postoperative course was satisfactory and, computed tomography (CT) showed successful aortic repair without any type of endoleak. He was discharged on the ninth day after the second operation. To our knowledge, this is the first report of surgical repair for an aortic aneurysm with right aortic arch and isolated subclavian artery.
    MeSH term(s) Male ; Humans ; Aged ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Subclavian Artery/diagnostic imaging ; Subclavian Artery/surgery ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/surgery ; Aortic Aneurysm/surgery ; Blood Vessel Prosthesis Implantation ; Treatment Outcome ; Stents ; Endovascular Procedures/methods
    Language Japanese
    Publishing date 2023-01-31
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 11: Show issues Location:
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