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Book ; Online: Geochemistry of ODP Hole 108-658C sediments, supplementary data to: Cole, Jennifer M; Goldstein, Steven L; deMenocal, Peter B; Hemming, Sidney R; Grousset, Francis E (2009): Contrasting compositions of Saharan dust in the eastern Atlantic Ocean during the last deglaciation and African Humid Period. Earth and Planetary Science Letters, 278(3-4), 257-266

Cole, Jennifer M / Goldstein, Steven L / Grousset, Francis E / Hemming, Sidney R / deMenocal, Peter B

2009

Abstract: During the African Humid Period (AHP), much of the modern hyperarid Saharan desert was vegetated and covered with numerous lakes. In marine sediments off northwestern Africa, the AHP is represented by markedly reduced siliciclastic sediment flux between ~ ...

Abstract	During the African Humid Period (AHP), much of the modern hyperarid Saharan desert was vegetated and covered with numerous lakes. In marine sediments off northwestern Africa, the AHP is represented by markedly reduced siliciclastic sediment flux between ~ 12.3 and 5.5 ka. Changes in the origin of this terrigenous sediment fraction can be constrained by sediment chemistry and radiogenic isotope tracers. At Ocean Drilling Program (ODP) Site 658, Hole C (20°44.95'N, 18°34.85'W, 2263 mbsl), the neodymium (Nd) isotope composition of terrigenous detritus shows little variability throughout the last 25 kyr, indicating that the contributing geological terranes have not changed appreciably since the last glacial period. In contrast, there were large and abrupt changes in strontium (Sr) isotope ratios and chemical compositions associated with the AHP, during which 87Sr/86Sr ratios were markedly less radiogenic, and sediments show higher chemical indices of alteration. We show that sediment geochemical changes during the AHP cannot be attributed to changes in the source terranes, physical sorting, or intensity of chemical weathering. The low 87Sr/86Sr and high Sr concentrations of AHP-age samples also conflict with the interpretation of increased fine-grained, fluvially derived sediments. We propose that the most significant compositional changes at ODP 658C are due to the addition of an aluminosilicate component that has a highly altered major element signature but is enriched in soluble elements like Sr and magnesium (Mg) compared to aluminum (Al) and has low 87Sr/86Sr relative to local terrigenous source areas. We interpret these characteristics to reflect authigenic sediment supply from extensive North African paleolake basins that were prevalent during the AHP.
Language	English
Dates of publication	2009-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1016/j.epsl.2008.12.011
DOI	10.1594/PANGAEA.785479
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Identification of an M(r) 60,000 polypeptide unique to the meiotic spindle of the mouse oocyte.

Sobel, J S / Pinto-Correia, C / Goldstein, E G

Molecular reproduction and development

1995 Volume 40, Issue 4, Page(s) 467–480

Abstract: The mouse oocyte expresses an M(r) 60,000 (p60) polypeptide that is associated with the first and ...

Abstract	The mouse oocyte expresses an M(r) 60,000 (p60) polypeptide that is associated with the first and second meiotic spindles. Immunoreactive p60 was not detectable in the meiotic spindles of male germ cells or in mitotic spindles. P60 was identified with a polyclonal antibody whose predominant activity is directed against ankyrin. However, immunoadsorption experiments demonstrated that p60 is not an ankyrin isoform and represents a secondary activity of the polyclonal antibody. Circumstantial evidence suggest that p60 may be a microtubule-associated protein. Since the most obvious difference between the female meiotic spindle and other spindles is the long half-life of the former, we hypothesize that p60 may function in the maintenance of the long-lived female meiotic apparatus.
MeSH term(s)	Animals ; Ankyrins/immunology ; Antibodies, Monoclonal ; Female ; Fluorescent Antibody Technique ; Male ; Meiosis ; Mice ; Mice, Inbred ICR ; Microtubule Proteins/isolation & purification ; Microtubule Proteins/metabolism ; Molecular Weight ; Oocytes/cytology ; Oocytes/metabolism
Chemical Substances	Ankyrins ; Antibodies, Monoclonal ; Microtubule Proteins
Language	English
Publishing date	1995-04
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.1080400411
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Article: Analysis of carrageenan from Hypnea musciformis by using k- and i- carrageenanases and 13C-N.M.R. spectroscopy

Greer, C.W / Shomer, I / Goldstein, M.E / Yaphe, W

Carbohydrate research. July 1, 1984. v. 129

1984

Title variant	Analysis of carrageenan from Hypnea musciformis by using k- [kappa] and i- [iota] carrageenanases and 13C-N.M.R. spectroscopy
Keywords	plant physiology ; plant biochemistry
Language	English
Dates of publication	1984-0701
Size	p. 189-196., ill.
Document type	Article
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Early clinical staging: Why does it matter, and what do we know?

Hafeman, Danella M / Goldstein, Tina R / Birmaher, Boris

Bipolar disorders

2023 Volume 25, Issue 1, Page(s) 79–81

MeSH term(s)	Humans ; Bipolar Disorder/diagnosis
Language	English
Publishing date	2023-01-26
Publishing country	Denmark
Document type	Journal Article ; Comment
ZDB-ID	1472242-2
ISSN	1399-5618 ; 1398-5647
ISSN (online)	1399-5618
ISSN	1398-5647
DOI	10.1111/bdi.13290
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Article ; Online: Characterization of African-American Super-Agers in the National Alzheimer's Coordinating Center cohort.

Trammell, Antoine R / Goldstein, Felicia C / Parker, Monica W / Hajjar, Ihab M

Journal of the American Geriatrics Society

2024

Abstract: Background: "Super-agers" are adults aged ≥80 with cognitive performance similar to persons two to three decades younger. Characteristics such as larger hippocampal volume, APOE-ε4 allele absence, higher educational attainment, female sex, and lifelong ... ...

Abstract	Background: "Super-agers" are adults aged ≥80 with cognitive performance similar to persons two to three decades younger. Characteristics such as larger hippocampal volume, APOE-ε4 allele absence, higher educational attainment, female sex, and lifelong cognitive stimulation are associated with cognitive performance compatible with super-aging. These findings are based on predominantly white research samples. Limited data are available on African-American super-agers. To fill this gap, we explored potential factors associated with super-aging in older African-American adults. Methods: Data from African-American participants aged ≥80 in the National Alzheimer's Coordinating Center (NACC) dataset were analyzed. Using global Clinical Dementia Rating (CDR) scores, participants were first categorized as impaired (score ≥0.5) or non-impaired/normal cognition (NC) (score = 0). From the NC group, super-agers were identified using NACC-data-driven cutoffs. Participants were considered super-agers if their memory performance was similar to persons aged 50-60 with NC, and their performance on other domains was within one standard deviation of the mean for persons aged ≥80. We examined group characteristics (NC, super-ager, impaired) using chi-square and ANOVA with pairwise comparisons. Multinomial logistic regression, adjusted for sex and education, evaluated correlates of super-ager group assignment. Results: Data for 1285 African-American participants aged ≥80 were analyzed. We identified 24.7% (n = 316) NC, 4.8% (n = 61) super-agers, and 70.6% (n = 905) impaired. Super-agers were mostly female and more educated, had similar vascular comorbidities as the other groups, and had less sleep disorders, depression, and alcohol use. After adjusting for sex and education, super-ager group assignment was associated with less sleep disorders, less depression, and moderate alcohol use. Conclusions: Participants with controlled vascular risk, mental health, alcohol use, and sleep disorders tended to be in the super-ager group. These factors may be important focus areas in clinical practice to support cognitive resilience with aging in older African-American adults.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.18882
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Article ; Online: Variation in second cancer risk by melanoma subtype among survivors.

Luu, Yen T / Goldstein, Alisa M / Sargen, Michael R

Journal of the American Academy of Dermatology

2022 Volume 88, Issue 2, Page(s) 433–434

MeSH term(s)	Humans ; Neoplasms, Second Primary/epidemiology ; Melanoma/epidemiology ; Skin Neoplasms/epidemiology ; Survivors
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2022.05.022
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Article ; Online: Beyond Efficacy and Toward Dissemination and Personalization of Psychotherapy for Bipolar Disorder.

Goldstein, Tina R / Hafeman, Danella M

JAMA psychiatry

2020 Volume 78, Issue 2, Page(s) 131–132

MeSH term(s)	Bipolar Disorder/psychology ; Bipolar Disorder/therapy ; Humans ; Psychotherapy/methods ; Treatment Outcome
Language	English
Publishing date	2020-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701203-7
ISSN	2168-6238 ; 2168-622X
ISSN (online)	2168-6238
ISSN	2168-622X
DOI	10.1001/jamapsychiatry.2020.2980
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Article ; Online: CenSoc: Public Linked Administrative Mortality Records for Individual-level Research.

Breen, Casey F / Osborne, Maria / Goldstein, Joshua R

Scientific data

2023 Volume 10, Issue 1, Page(s) 802

Abstract: In the United States, much has been learned about the determinants of longevity from survey data and aggregated tabulations. However, the lack of large-scale, individual-level administrative mortality records has proven to be a barrier to further ... ...

Abstract	In the United States, much has been learned about the determinants of longevity from survey data and aggregated tabulations. However, the lack of large-scale, individual-level administrative mortality records has proven to be a barrier to further progress. We introduce the CenSoc datasets, which link the complete-count 1940 U.S. Census to Social Security mortality records. These datasets-CenSoc-DMF (N = 4.7 million) and CenSoc-Numident (N = 7.0 million)-primarily cover deaths among individuals aged 65 and older. The size and richness of CenSoc allows investigators to make new discoveries into geographic, racial, and class-based disparities in old-age mortality in the United States. This article gives an overview of the technical steps taken to construct these datasets, validates them using external aggregate mortality data, and discusses best practices for working with these datasets. The CenSoc datasets are publicly available, enabling new avenues of research into the determinants of mortality disparities in the United States.
MeSH term(s)	Humans ; Racial Groups ; Surveys and Questionnaires ; United States ; Mortality
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02713-y
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Article ; Online: Eurasian back-migration into Northeast Africa was a complex and multifaceted process.

Hammarén, Rickard / Goldstein, Steven T / Schlebusch, Carina M

PloS one

2023 Volume 18, Issue 11, Page(s) e0290423

Abstract: Recent studies have identified Northeast Africa as an important area for human movements during the Holocene. Eurasian populations have moved back into Northeastern Africa and contributed to the genetic composition of its people. By gathering the largest ...

Abstract	Recent studies have identified Northeast Africa as an important area for human movements during the Holocene. Eurasian populations have moved back into Northeastern Africa and contributed to the genetic composition of its people. By gathering the largest reference dataset to date of Northeast, North, and East African as well as Middle Eastern populations, we give new depth to our knowledge of Northeast African demographic history. By employing local ancestry methods, we isolated the Non-African parts of modern-day Northeast African genomes and identified the best putative source populations. Egyptians and Sudanese Copts bore most similarities to Levantine populations whilst other populations in the region generally had predominantly genetic contributions from the Arabian peninsula rather than Levantine populations for their Non-African genetic component. We also date admixture events and investigated which factors influenced the date of admixture and find that major linguistic families were associated with the date of Eurasian admixture. Taken as a whole we detect complex patterns of admixture and diverse origins of Eurasian admixture in Northeast African populations of today.
MeSH term(s)	Humans ; Africa ; Arabia ; Black People/genetics ; Egypt ; Genetics, Population ; White People/genetics ; Human Migration
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0290423
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Article ; Online: Survival Mixture Density Networks.

Han, Xintian / Goldstein, Mark / Ranganath, Rajesh

Proceedings of machine learning research

2023 Volume 182, Page(s) 224–248

Abstract: Survival analysis, the art of time-to-event modeling, plays an important role in clinical treatment decisions. Recently, continuous time models built from neural ODEs have been proposed for survival analysis. However, the training of neural ODEs is slow ... ...

Abstract	Survival analysis, the art of time-to-event modeling, plays an important role in clinical treatment decisions. Recently, continuous time models built from neural ODEs have been proposed for survival analysis. However, the training of neural ODEs is slow due to the high computational complexity of neural ODE solvers. Here, we propose an efficient alternative for flexible continuous time models, called Survival Mixture Density Networks (Survival MDNs). Survival MDN applies an invertible positive function to the output of Mixture Density Networks (MDNs). While MDNs produce flexible real-valued distributions, the invertible positive function maps the model into the time-domain while preserving a tractable density. Using four datasets, we show that Survival MDN performs better than, or similarly to continuous and discrete time baselines on concordance, integrated Brier score and integrated binomial log-likelihood. Meanwhile, Survival MDNs are also faster than ODE-based models and circumvent binning issues in discrete models.
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article
ISSN	2640-3498
ISSN (online)	2640-3498
Database	MEDical Literature Analysis and Retrieval System OnLINE

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