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Article ; Online: The perceptions and attitudes of qualified dental therapists towards a diagnostic role in the provision of paediatric dental care.

Quach, Joshua D D / Wanyonyi-Kay, Kristina / Radford, David R / Louca, Chris

2022

Abstract: Objectives This study explored the perceptions and attitudes of qualified UK dental therapists (DTs) to act in a diagnostic role in the dental care of paediatric patients.Methods A mixed methods study. An electronic questionnaire was sent out to the ... ...

Abstract	Objectives This study explored the perceptions and attitudes of qualified UK dental therapists (DTs) to act in a diagnostic role in the dental care of paediatric patients.Methods A mixed methods study. An electronic questionnaire was sent out to the members of associations and closed social networking groups for qualified DTs across the UK. The questionnaire explored the training, clinical experience and working practices of the participants and measured their agreements with applicable statements using Likert scale scores. Semi-structured interviews were also undertaken to explore how UK DTs perceived a diagnostic role for them and what barriers and facilitators they experienced.Results A total of 155 questionnaire responses were returned and 11 interviews conducted. Participants were mostly women (94.8%) with a broad range of working experience, with a mean experience of 9.5 years (± 8.8 standard deviation [SD]) (range: 1-42 years). From the questionnaires, when asked to score agreement on a Likert scale from 0-5, DTs agreed that in a diagnostic role, they could increase access to dentistry for patients and a high proportion were in agreement that they had the knowledge to carry out examination (mean = 4.43 ± 0.87 SD), diagnosis (mean = 4.37 ± 0.90 SD) and care planning for paediatric patients (mean = 2.74 ± 1.32 SD). The interviews yielded three qualitative supra themes: 'working in the UK as a DT today'; 'the perceptions of dental therapists on acting in a diagnostic role in paediatric dental care'; and 'barriers and facilitators to acting in a diagnostic role' and within these, eight major themes were identified.Conclusion Within the limitations of a small sample who were representative of the workforce demographic and educational structures, we found that DTs felt that if they were to act in a diagnostic role, it would improve access to dental services benefitting patients, dentists and the DT profession. DTs identified and explored barriers and facilitators to a diagnostic role. Change is required to overcome these barriers in order to support DTs to act in a front-line diagnostic role.
Language	English
Publishing date	2022-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/s41415-022-4393-5
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Article ; Conference proceedings: Stereotactic Radiosurgery for Intracranial Solitary Fibrous Tumors: Systematic Review and Pooled Quantitative Analysis

Golub, Danielle / McBriar, Joshua D. / Wong, Taylor / Donaldson, Hayley / Unadkat, Prashin / White, Timothy G. / Quach, Eric T. / Chitti, Bhargava / Ziemba, Yonah / Goenka, Anuj / Schulder, Michael / Dehdashti, Amir R.

Journal of Neurological Surgery Part B: Skull Base

2024 Volume 85, Issue S 01

Event/congress	33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0044-1780178
Database	Thieme publisher's database

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Article ; Online: Are dental schools doing enough to prepare dental hygiene & therapy students for direct access?

D. D. Quach, Joshua / S. Davda, Latha / R. Radford, David / Louca, Chris

BDJ Team

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1038/s41407-020-0471-1
Database	COVID19

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Article ; Online: Postoperative stereotactic radiosurgery for intracranial solitary fibrous tumors: systematic review and pooled quantitative analysis.

Golub, Danielle / McBriar, Joshua D / Donaldson, Hayley / Wong, Taylor / Unadkat, Prashin / White, Timothy G / Quach, Eric T / Haddock, Sara / Chitti, Bhargava / Ziemba, Yonah / Goenka, Anuj / Singer, Samuel / Schulder, Michael / Dehdashti, Amir R

Journal of neuro-oncology

2023 Volume 165, Issue 2, Page(s) 229–239

Abstract: Background: Intracranial solitary fibrous tumors (SFTs), formerly hemangiopericytomas (HPCs), are rare, aggressive dural-based mesenchymal tumors. While adjuvant radiation therapy has been suggested to improve local tumor control (LTC), especially after ...

Abstract	Background: Intracranial solitary fibrous tumors (SFTs), formerly hemangiopericytomas (HPCs), are rare, aggressive dural-based mesenchymal tumors. While adjuvant radiation therapy has been suggested to improve local tumor control (LTC), especially after subtotal resection, the role of postoperative stereotactic radiosurgery (SRS) and the optimal SRS dosing strategy remain poorly defined. Methods: PubMed, EMBASE, and Web of Science were systematically searched according to PRISMA guidelines for studies describing postoperative SRS for intracranial SFTs. The search strategy was defined in the authors' PROSPERO protocol (CRD42023454258). Results: 15 studies were included describing 293 patients harboring 476 intracranial residual or recurrent SFTs treated with postoperative SRS. At a mean follow-up of 21-77 months, LTC rate after SRS was 46.4-93% with a mean margin SRS dose of 13.5-21.7 Gy, mean maximum dose of 27-39.6 Gy, and mean isodose at the 42.5-77% line. In pooled analysis of individual tumor outcomes, 18.7% of SFTs demonstrated a complete SRS response, 31.7% had a partial response, 18.9% remained stable (overall LTC rate of 69.3%), and 30.7% progressed. When studies were stratified by margin dose, a mean margin dose > 15 Gy showed an improvement in LTC rate (74.7% versus 65.7%). Conclusions: SRS is a safe and effective treatment for intracranial SFTs. In the setting of measurable disease, our pooled data suggests a potential dose response of improving LTC with increasing SRS margin dose. Our improved understanding of the aggressive biology of SFTs and the tolerated adjuvant SRS parameters supports potentially earlier use of SRS in the postoperative treatment paradigm for intracranial SFTs.
MeSH term(s)	Humans ; Radiosurgery/methods ; Follow-Up Studies ; Severe Fever with Thrombocytopenia Syndrome ; Retrospective Studies ; Treatment Outcome ; Solitary Fibrous Tumors/radiotherapy ; Solitary Fibrous Tumors/surgery
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-023-04499-w
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Article: A Phase II, Open-Label Clinical Trial of Intranasal Ketamine for Depression in Patients with Cancer Receiving Palliative Care (INKeD-PC Study).

Rosenblat, Joshua D / deVries, Froukje E / Doyle, Zoe / McIntyre, Roger S / Rodin, Gary / Zimmermann, Camilla / Mak, Ernie / Hannon, Breffni / Schulz-Quach, Christian / Kindy, Aida Al / Patel, Zeal / Li, Madeline

Cancers

2023 Volume 15, Issue 2

Abstract: Antidepressants require several weeks for the onset of action, a lag time that may exceed life expectancy in palliative care. Ketamine has demonstrated rapid antidepressant effects, but has been minimally studied in cancer and palliative care populations. ...

Abstract	Antidepressants require several weeks for the onset of action, a lag time that may exceed life expectancy in palliative care. Ketamine has demonstrated rapid antidepressant effects, but has been minimally studied in cancer and palliative care populations. Herein, the objective was to determine the feasibility, safety, tolerability and preliminary efficacy of intranasal racemic ketamine for major depressive disorder (MDD) in patients with advanced cancer. We conducted a single-arm, open-label phase II trial at the Princess Margaret Cancer Centre in Toronto, ON, Canada. Participants with advanced cancer with moderate to severe MDD received three flexible doses of intranasal (IN) ketamine (50−150 mg) over a one-week period. The primary efficacy outcome was an antidepressant response and remission rates as determined by the Montgomery−Åsberg Depression Rating Scale (MADRS) from baseline to the Day 8 primary endpoint. Twenty participants were enrolled in the trial, receiving at least one dose of IN ketamine, with fifteen participants receiving all three doses. The Day 8 antidepressant response (MADRS decreased by >50%) and remission (MADRS < 10 on Day 8) rates were high at 70% and 45%, respectively. Mean MADRS scores decreased significantly from baseline (mean MADRS of 31, standard deviation 7.6) to Day 8 (11 +/− 7.4) with an overall decrease of 20 points (p < 0.001). Antidepressant effects were partially sustained in the second week in the absence of additional ketamine doses, with a Day 14 mean MADRS score of 14 +/− 9.9. Common adverse effects included fatigue, dissociation, nausea, dysgeusia and headaches; almost all adverse effects were mild and transient, resolving within 2 h of each ketamine dose with one dropout related to adverse effects (negative dissociative episode). Given these promising findings, larger, controlled trials are merited.
Language	English
Publishing date	2023-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020400
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Article ; Online: Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin.

Rosenblat, Joshua D / Meshkat, Shakila / Doyle, Zoe / Kaczmarek, Erica / Brudner, Ryan M / Kratiuk, Kevin / Mansur, Rodrigo B / Schulz-Quach, Christian / Sethi, Rickinder / Abate, Amanda / Ali, Shaun / Bawks, Jordan / Blainey, Marc G / Brietzke, Elisa / Cronin, Victoria / Danilewitz, Jessica / Dhawan, Shalini / Di Fonzo, Anthony / Di Fonzo, Melissa /

Drzadzewski, Pawel / Dunlop, William / Fiszter, Hajnalka / Gomes, Fabiano A / Grewal, Smrita / Leon-Carlyle, Marisa / McCallum, Marilyn / Mofidi, Niki / Offman, Hilary / Riva-Cambrin, Jeremy / Schmidt, Joel / Smolkin, Mark / Quinn, Joan M / Zumrova, Andrea / Marlborough, Michelle / McIntyre, Roger S

Med (New York, N.Y.)

2024 Volume 5, Issue 3, Page(s) 190–200.e5

Abstract: Background: Psilocybin-assisted psychotherapy (PAP) has been associated with antidepressant effects. Trials to date have typically excluded participants with complex presentations. Our aim was to determine the feasibility of PAP in a complex population, ...

Abstract	Background: Psilocybin-assisted psychotherapy (PAP) has been associated with antidepressant effects. Trials to date have typically excluded participants with complex presentations. Our aim was to determine the feasibility of PAP in a complex population, including high levels of treatment resistance in major depressive and bipolar disorder and patients with baseline suicidality and significant comorbidity. We also evaluated flexible repeated doses over a 6-month period. Methods: Adults with treatment-resistant depression as part of major depressive or bipolar II disorder without psychosis or a substance use disorder were eligible to participate. Subjects were randomized to immediate treatment or waitlist control, with all eventually receiving PAP. Participants had one, two, or three psilocybin sessions with a fixed dose of 25 mg. Each dose was accompanied by preparation and integration psychotherapy sessions. Acceptability, safety, tolerability, and efficacy were evaluated (this study was registered at ClinicalTrials.gov: NCT05029466). Findings: Participants were randomized to immediate treatment (n = 16) or delayed treatment (n = 14). 29/30 were retained to the week-2 primary endpoint. Adverse events were transient, with no serious adverse events. Greater reductions in depression severity as measured by the Montgomery-Åsberg Depression Rating Scale (MADRS) were observed in the immediate treatment arm compared to the waitlist period arm with a large hedge's g effect size of 1.07 (p < 0.01). Repeated doses were associated with further reductions in MADRS scores compared to baseline. Conclusions: PAP was feasible in complex patients with preliminary antidepressant efficacy and adequate safety and tolerability. Repeated doses were associated with greater reductions in depression severity. Funding: This work was funded by Brain and Cognition Discovery Foundation (BCDF), Usona, and Braxia Scientific.
MeSH term(s)	Adult ; Humans ; Psilocybin/adverse effects ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/chemically induced ; Depressive Disorder, Treatment-Resistant/drug therapy ; Antidepressive Agents/adverse effects ; Psychotherapy
Chemical Substances	Psilocybin (2RV7212BP0) ; Antidepressive Agents
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2024.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relationship between coliphage and Enterococcus at southern California beaches and implications for beach water quality management.

Zimmer-Faust, Amity G / Griffith, John F / Steele, Joshua A / Santos, Bryan / Cao, Yiping / Asato, Laralyn / Chiem, Tania / Choi, Samuel / Diaz, Arturo / Guzman, Joe / Laak, David / Padilla, Michele / Quach-Cu, Jennifer / Ruiz, Victor / Woo, Mary / Weisberg, Stephen B

Water research

2022 Volume 230, Page(s) 119383

Abstract: ... somatic coliphage by the new EPA dead-end hollow fiber ultrafiltration (D-HFUF-SAL) method and ...

Abstract	Coliphage have been suggested as an alternative to fecal indicator bacteria for assessing recreational beach water quality, but it is unclear how frequently and at what types of beaches coliphage produces a different management outcome. Here we conducted side-by-side sampling of male-specific and somatic coliphage by the new EPA dead-end hollow fiber ultrafiltration (D-HFUF-SAL) method and Enterococcus at southern California beaches over two years. When samples were combined for all beach sites, somatic and male-specific coliphage both correlated with Enterococcus. When examined categorically, Enterococcus would have resulted in approximately two times the number of health advisories as somatic coliphage and four times that of male-specific coliphage,using recently proposed thresholds of 60 PFU/100 mL for somatic and 30 PFU/100 mL for male-specific coliphage. Overall, only 12% of total exceedances would have been for coliphage alone. Somatic coliphage exceedances that occurred in the absence of an Enterococcus exceedance were limited to a single site during south swell events, when this beach is known to be affected by nearby minimally treated sewage. Thus, somatic coliphage provided additional valuable health protection information, but may be more appropriate as a supplement to FIB measurements rather than as replacement because: (a) EPA-approved PCR methods for Enterococcus allow a more rapid response, (b) coliphage is more challenging owing to its greater sampling volume and laboratory time requirements, and (c) Enterococcus' long data history has yielded predictive management models that would need to be recreated for coliphage.
MeSH term(s)	Male ; Humans ; Water Quality ; Enterococcus ; Bathing Beaches ; California ; Coliphages ; Feces/microbiology ; Water Microbiology ; Environmental Monitoring/methods
Language	English
Publishing date	2022-11-19
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2022.119383
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Article ; Online: Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing.

Chen, Fang / Wang, Xingyan / Jang, Seon-Kyeong / Quach, Bryan C / Weissenkampen, J Dylan / Khunsriraksakul, Chachrit / Yang, Lina / Sauteraud, Renan / Albert, Christine M / Allred, Nicholette D D / Arnett, Donna K / Ashley-Koch, Allison E / Barnes, Kathleen C / Barr, R Graham / Becker, Diane M / Bielak, Lawrence F / Bis, Joshua C / Blangero, John / Boorgula, Meher Preethi /

Chasman, Daniel I / Chavan, Sameer / Chen, Yii-Der I / Chuang, Lee-Ming / Correa, Adolfo / Curran, Joanne E / David, Sean P / Fuentes, Lisa de Las / Deka, Ranjan / Duggirala, Ravindranath / Faul, Jessica D / Garrett, Melanie E / Gharib, Sina A / Guo, Xiuqing / Hall, Michael E / Hawley, Nicola L / He, Jiang / Hobbs, Brian D / Hokanson, John E / Hsiung, Chao A / Hwang, Shih-Jen / Hyde, Thomas M / Irvin, Marguerite R / Jaffe, Andrew E / Johnson, Eric O / Kaplan, Robert / Kardia, Sharon L R / Kaufman, Joel D / Kelly, Tanika N / Kleinman, Joel E / Kooperberg, Charles / Lee, I-Te / Levy, Daniel / Lutz, Sharon M / Manichaikul, Ani W / Martin, Lisa W / Marx, Olivia / McGarvey, Stephen T / Minster, Ryan L / Moll, Matthew / Moussa, Karine A / Naseri, Take / North, Kari E / Oelsner, Elizabeth C / Peralta, Juan M / Peyser, Patricia A / Psaty, Bruce M / Rafaels, Nicholas / Raffield, Laura M / Reupena, Muagututi'a Sefuiva / Rich, Stephen S / Rotter, Jerome I / Schwartz, David A / Shadyab, Aladdin H / Sheu, Wayne H-H / Sims, Mario / Smith, Jennifer A / Sun, Xiao / Taylor, Kent D / Telen, Marilyn J / Watson, Harold / Weeks, Daniel E / Weir, David R / Yanek, Lisa R / Young, Kendra A / Young, Kristin L / Zhao, Wei / Hancock, Dana B / Jiang, Bibo / Vrieze, Scott / Liu, Dajiang J

Nature genetics

2023 Volume 55, Issue 2, Page(s) 291–300

Abstract: Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression ... ...

Abstract	Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quantitative trait locus (eQTL) data from diverse ancestries. We developed a new approach, TESLA (multi-ancestry integrative study using an optimal linear combination of association statistics), to integrate an eQTL dataset with a multi-ancestry GWAS. By exploiting shared phenotypic effects between ancestries and accommodating potential effect heterogeneities, TESLA improves power over other TWAS methods. When applied to tobacco use phenotypes, TESLA identified 273 new genes, up to 55% more compared with alternative TWAS methods. These hits and subsequent fine mapping using TESLA point to target genes with biological relevance. In silico drug-repurposing analyses highlight several drugs with known efficacy, including dextromethorphan and galantamine, and new drugs such as muscle relaxants that may be repurposed for treating nicotine addiction.
MeSH term(s)	Humans ; Transcriptome/genetics ; Drug Repositioning ; Genome-Wide Association Study/methods ; Tobacco Use ; Biology ; Polymorphism, Single Nucleotide/genetics ; Genetic Predisposition to Disease
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/s41588-022-01282-x
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Article ; Online: Treatment of patients with multiple myeloma who are eligible for stem cell transplantation: position statement of the Myeloma Foundation of Australia Medical and Scientific Advisory Group.

Quach, H / Joshua, D / Ho, J / Szer, J / Spencer, A / Harrison, S J / Mollee, P / Roberts, A W / Horvath, N / Talaulikar, D / To, B / Zannettino, A / Brown, R / Catley, L / Augustson, B / Jaksic, W / Gibson, J / Prince, H M

Internal medicine journal

2015 Volume 45, Issue 1, Page(s) 94–105

Abstract: The survival of patients with multiple myeloma (MM) has improved substantially since the introduction in the late 1980s of high-dose chemotherapy (HDT) supported by autologous stem cell transplantation (ASCT). Further improvements have been observed ... ...

Abstract	The survival of patients with multiple myeloma (MM) has improved substantially since the introduction in the late 1980s of high-dose chemotherapy (HDT) supported by autologous stem cell transplantation (ASCT). Further improvements have been observed following the availability of immunomodulatory drugs (IMiD) such as thalidomide and lenalidomide, and the proteasome inhibitor, bortezomib. Here, we summarise the recommendations of the Medical Scientific Advisory Group to the Myeloma Foundation of Australia for patients considered suitable for HDT + ASCT as part of initial therapy. These recommendations incorporate the various phases of treatment: induction, HDT conditioning and maintenance therapy.
MeSH term(s)	Advisory Committees ; Australia/epidemiology ; Disease-Free Survival ; Hematopoietic Stem Cell Transplantation/standards ; Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/epidemiology ; Practice Guidelines as Topic ; Societies, Scientific ; Survival Rate/trends ; Transplantation, Autologous ; Treatment Outcome
Language	English
Publishing date	2015
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.12640
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Article ; Online: Treatment of patients with Waldenström macroglobulinaemia: clinical practice update from the Myeloma Foundation of Australia Medical and Scientific Advisory Group.

Talaulikar, Dipti / Joshua, Douglas / Ho, Phoebe Joy / Gibson, John / Quach, Hang / Gibbs, Simon / Ling, Silvia / Ward, Christopher / Augustson, Bradley M / Trotman, Judith / Harrison, Simon J / Tam, Constantine S

Internal medicine journal

2023 Volume 53, Issue 4, Page(s) 599–609

Abstract: Waldenström macroglobulinaemia (WM) is an indolent B-cell malignancy characterised by the presence of IgM paraprotein, bone marrow infiltration by clonal small B lymphocytes with plasmacytic differentiation and the MYD88 L265P mutation in >90% of cases. ... ...

Abstract	Waldenström macroglobulinaemia (WM) is an indolent B-cell malignancy characterised by the presence of IgM paraprotein, bone marrow infiltration by clonal small B lymphocytes with plasmacytic differentiation and the MYD88 L265P mutation in >90% of cases. Traditionally, WM has been treated with chemoimmunotherapy. Recent trials have demonstrated the efficacy and safety of Bruton tyrosine kinase inhibitors in WM, both as monotherapy and in combination with other drugs. There is emerging evidence on the use of other agents including B-cell lymphoma 2 inhibitors and on the treatment of rare presentations of WM. In this update, the Medical and Scientific Advisory Group of Myeloma Australia reviews the available evidence on the treatment of WM since the last publication in 2017 and provides specific recommendations to assist Australian clinicians in the management of this disease.
MeSH term(s)	Humans ; Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/drug therapy ; Waldenstrom Macroglobulinemia/genetics ; Multiple Myeloma/drug therapy ; Australia/epidemiology ; Antineoplastic Agents/therapeutic use ; Bone Marrow/pathology ; Mutation ; Myeloid Differentiation Factor 88/genetics
Chemical Substances	Antineoplastic Agents ; Myeloid Differentiation Factor 88
Language	English
Publishing date	2023-04-05
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.15980
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