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  1. Article ; Online: Re: A prospective randomized trial of povidone-iodine prophylactic cleansing of the rectum before transrectal ultrasound guided prostate biopsy: Z. AbuGhosh, J. Margolick, S. L. Goldenberg, S. A. Taylor, K. Afshar, R. Bell, D. Lange, W. R. Bowie, D. Roscoe, L. Machan and P. C. Black J Urol 2013; 189: 1326-1331.

    Goh, Y S B / Law, Z W / Tiong, H Y

    The Journal of urology

    2013  Volume 190, Issue 6, Page(s) 2309–2310

    MeSH term(s) Anti-Infective Agents, Local/therapeutic use ; Bacterial Infections/prevention & control ; Humans ; Image-Guided Biopsy/adverse effects ; Male ; Povidone-Iodine/therapeutic use ; Preoperative Care/methods ; Prostate/pathology
    Chemical Substances Anti-Infective Agents, Local ; Povidone-Iodine (85H0HZU99M)
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2013.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.91: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 331: Show issues

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  2. Book ; Online: Healthy life expectancy in Hong Kong Special Administrative Region of China / C. K. Law and P. S. F. Yip ; Espérance de vie en bonne santé à Hong Kong (région administrative spéciale de Chine)

    Law, C. K / Yip, P. S. F

    résumé ; Esperanza de vida sana en Hong Kong (Región Administrativa Especial de China) : resumen

    2003  

    Abstract: Summaries in English, French and ... ...

    Abstract Summaries in English, French and Spanish
    Keywords Life expectancy ; Health status indicators ; Disability evaluation ; Quality-adjusted life years ; Sex factors ; Regression analysis ; Hong Kong ; Epidemiology and Statistics
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Book ; Online: Healthy life expectancy in Hong Kong Special Administrative Region of China / C. K. Law and P. S. F. Yip ; Espérance de vie en bonne santé à Hong Kong (région administrative spéciale de Chine)

    Law, C. K / Yip, P. S. F

    résumé ; Esperanza de vida sana en Hong Kong (Región Administrativa Especial de China) : resumen

    2003  

    Abstract: Summaries in English, French and ... ...

    Abstract Summaries in English, French and Spanish
    Keywords Life expectancy ; Health status indicators ; Disability evaluation ; Quality-adjusted life years ; Sex factors ; Regression analysis ; Hong Kong ; Epidemiology and Statistics
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Book ; Online: Sustainable Development Goal 3 : Health and Well-being of Ageing in Hong Kong

    Fong, Ben Y. F. / Law, Vincent T. S. / Leung, Tiffany C. H. / Lo, Man Fung / Ng, Tommy K. C. / Yee, Hilary H. L.

    2022  

    Keywords Development economics & emerging economies ; Public health & preventive medicine ; Child & developmental psychology ; Ageing and Diversity ; Healthy Ageing ; Health Equity ; Health Inequalities ; Sustainable Development Goals
    Size 1 electronic resource (104 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021232884
    ISBN 9781032115016 ; 1032115017
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Investigating the therapeutic potential of Allium cepa extract in combating pesticide exposure induced ocular damage.

    Sanyal, Shalini / Vemula, Praveen K / Law, Sujata

    Experimental eye research

    2024  Volume 240, Page(s) 109816

    Abstract: The ocular surface is subject to a range of potentially hazardous environmental factors and substances, owing to its anatomical location, sensitivity, and physiological makeup. Xenobiotic stress exerted by chronic pesticide exposure on the cornea is ... ...

    Abstract The ocular surface is subject to a range of potentially hazardous environmental factors and substances, owing to its anatomical location, sensitivity, and physiological makeup. Xenobiotic stress exerted by chronic pesticide exposure on the cornea is primarily responsible for ocular irritation, excessive tear production (hyper-lacrimation), corneal abrasions and decreased visual acuity. Traditional medicine hails the humble onion (Allium cepa) for its multi-faceted properties including but not limited to anti-microbial, antioxidant, anti-inflammatory and wound healing. However, there is a lacuna regarding its impact on the ocular surface. Thereby, the current study investigated whether topical application of crude extract of Allium cepa aided in mitigating pesticide-induced damage to the ocular surface. The deleterious effects of pesticide exposure and their mitigation through the topical application of herbal extract of Allium cepa were analysed initially through in vitro evaluation on cell lines and then on the ocular surface via various in-vivo and ex-vivo techniques. Pathophysiological alterations to the ocular surface that impacted vision were explored through detailed neurophysiological screening with special emphasis on visual acuity wherein it was observed that the murine group treated with topical application of Allium cepa extract had comparable visual capacity to the non-pesticide exposed group. Additionally, SOD2 was utilized as an oxidative stress marker along with the expression of cellular apoptotic markers such as Bcl-xL to analyse the impact of pesticide exposure and subsequent herbal intervention on oxidative stress-induced corneal damage. The impact on the corneal epithelial progenitor cell population (ABCG2 and TERT positive cells) was also flowcytometrically analysed. Therefore, from our observations, it can be postulated that the topical application of Allium cepa extract might serve as an effective strategy to alleviate pesticide exposure related ocular damage.
    MeSH term(s) Mice ; Animals ; Onions/physiology ; Pesticides/toxicity ; Cornea ; Antioxidants/pharmacology ; Oxidative Stress
    Chemical Substances Pesticides ; Antioxidants
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2024.109816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Activated STING in the thymus alters T cell development and selection leading to autoimmunity.

    Deng, Zimu / Law, Christopher S / Kurra, Santosh / Simchoni, Noa / Shum, Anthony K

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Classifying systemic inflammatory disorders as autoinflammatory or autoimmune provides insight into disease pathogenesis and whether treatment should target innate molecules and their signaling pathways or the adaptive immune response. COPA syndrome is a ...

    Abstract Classifying systemic inflammatory disorders as autoinflammatory or autoimmune provides insight into disease pathogenesis and whether treatment should target innate molecules and their signaling pathways or the adaptive immune response. COPA syndrome is a monogenic disorder of immune dysregulation that leads to interstitial lung disease and high-titer autoantibodies. Studies show constitutive activation of the innate immune molecule STING is centrally involved in disease. However, the mechanisms by which STING results in loss of T cell tolerance and autoimmunity in COPA syndrome or more common autoimmune diseases is not understood. Using
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.17.580803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Optimising the discharge process in internal medicine in Québec: A qualitative interpretive descriptive study to understand the challenges faced by healthcare professionals.

    Charlebois, Kathleen / Law, Susan

    Health & social care in the community

    2022  Volume 30, Issue 6, Page(s) e5916–e5925

    Abstract: Optimising the discharge process for internal medicine programs is a challenge given multiple social and practical constraints in transitions from hospital to home. The objective of this study is to explore healthcare professionals' perspectives on ... ...

    Abstract Optimising the discharge process for internal medicine programs is a challenge given multiple social and practical constraints in transitions from hospital to home. The objective of this study is to explore healthcare professionals' perspectives on discharge processes in internal medicine within a context of organisational reform. This is an interpretive descriptive qualitative study using in-depth individual interviews with healthcare providers. Seventeen semi-structured interviews were conducted. The study comprised a sample of 18 healthcare professionals working on two internal medicine wards in an acute care teaching hospital in Quebec. A conceptual framework comprising core aspects of the discharge process (planning, coordination, teaching and outcomes) guided data collection and analysis. Thematic analysis was applied to analyse the data. Major themes were developed by contrasting empirical data and the conceptual framework. Five themes were developed (1) Iterative discharge planning; (2) Patient and family engagement in discharge planning and discharge readiness, (3) Lack of time for discharge teaching, (4) Discharge coordination and the placement of patients and (5) Inequitable social support and resources and risk of readmission. This study highlights the inter-relationship between discharge readiness and phases of the discharge process, in particular planning and coordination. Iterative planning along with strategies to coordinate discharge constitute efforts to ensure flexible processes that respond to patients' needs and preferences. Challenges persist for healthcare professionals regarding autonomy and resources, along with reduced opportunities for patient and family engagement in decision-making.
    MeSH term(s) Humans ; Patient Discharge ; Quebec ; Qualitative Research ; Health Personnel ; Internal Medicine ; Delivery of Health Care
    Language English
    Publishing date 2022-09-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1155902-0
    ISSN 1365-2524 ; 0966-0410
    ISSN (online) 1365-2524
    ISSN 0966-0410
    DOI 10.1111/hsc.14023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3728: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Facilitators and barriers for implementing screening brief intervention and referral for health promotion in a rural hospital in Alberta: using consolidated framework for implementation research.

    Mah, Sharon S / Teare, Gary F / Law, Jessica / Adhikari, Kamala

    BMC health services research

    2024  Volume 24, Issue 1, Page(s) 228

    Abstract: Background: Screening, brief intervention, and referral (SBIR) is an evidence-based, comprehensive health promotion approach commonly implemented to reduce alcohol and substance use. Implementation research on SBIR demonstrate that patients find it ... ...

    Abstract Background: Screening, brief intervention, and referral (SBIR) is an evidence-based, comprehensive health promotion approach commonly implemented to reduce alcohol and substance use. Implementation research on SBIR demonstrate that patients find it acceptable, reduces hospital costs, and it is effective. However, SBIR implementation in hospital settings for multiple risk factors (fruit and vegetable consumption, physical activity, alcohol and tobacco use) is still emergent. More evidence is needed to guide SBIR implementation for multiple risk factors in hospital settings.
    Objective: To explore the facilitators and barriers of SBIR implementation in a rural hospital using the Consolidated Framework for Implementation Research (CFIR).
    Methods: We conducted a descriptive qualitative investigation consisting of both inductive and deductive analyses. We conducted virtual, semi-structured interviews, guided by the CFIR framework. All interviews were audio-recorded, and transcribed verbatim. NVivo 12 Pro was used to organize and code the raw data.
    Results: A total of six key informant semi-structured interviews, ranging from 45 to 60 min, were carried out with members of the implementation support team and clinical implementers. Implementation support members reported that collaborating with health departments facilitated SBIR implementation by helping (a) align health promotion risk factors with existing guidelines; (b) develop training and educational resources for clinicians and patients; and (c) foster leadership buy-in. Conversely, clinical implementers reported several barriers to SBIR implementation including, increased and disrupted workflow due to SBIR-related documentation, a lack of knowledge on patients' readiness and motivation to change, as well as perceived patient stigma in relation to SBIR risk factors.
    Conclusion: The CFIR provided a comprehensive framework to gauge facilitators and barriers relating to SBIR implementation. Our pilot investigation revealed that future SBIR implementation must address organizational, clinical implementer, and patient readiness to implement SBIR at all phases of the implementation process in a hospital.
    MeSH term(s) Humans ; Alberta ; Qualitative Research ; Hospitals, Rural ; Crisis Intervention ; Health Promotion ; Referral and Consultation
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-024-10676-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Long-term care transitions during a global pandemic: Planning and decision-making of residents, care partners, and health professionals in Ontario, Canada.

    Carbone, Sarah / Berta, Whitney / Law, Susan / Kuluski, Kerry

    PloS one

    2023  Volume 18, Issue 12, Page(s) e0295865

    Abstract: The COVID-19 pandemic appears to have shifted the care trajectories of many residents and care partners in Ontario who considered leaving LTC to live in the community for a portion or the duration of the pandemic. This type of care transition-from LTC to ...

    Abstract The COVID-19 pandemic appears to have shifted the care trajectories of many residents and care partners in Ontario who considered leaving LTC to live in the community for a portion or the duration of the pandemic. This type of care transition-from LTC to home care-was highly uncommon prior to the pandemic, therefore we know relatively little about the planning and decision-making involved. The aim of this study was to describe who was involved in LTC to home care transitions in Ontario during the COVID-19 pandemic, to what extent, and the factors that guided their decision-making. A qualitative description study involving semi-structured interviews with 32 residents, care partners and health professionals was conducted. Transition decisions were largely made by care partners, with varied input from residents or health professionals. Stakeholders considered seven factors, previously identified in a scoping review, when making their transition decisions: (a) institutional priorities and requirements; (b) resources; (c) knowledge; (d) risk; (e) group structure and dynamic; (f) health and support needs; and (g) personality preferences and beliefs. Participants' emotional responses to the pandemic also influenced the perceived need to pursue a care transition. The findings of this research provide insights towards the planning required to support LTC to home care transitions, and the many challenges that arise during decision-making.
    MeSH term(s) Humans ; Caregivers ; COVID-19/epidemiology ; Long-Term Care ; Nursing Homes ; Ontario/epidemiology ; Pandemics ; Patient Transfer
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0295865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: "We have to save him": a qualitative study on care transition decisions in Ontario's long-term care settings during the COVID-19 pandemic.

    Carbone, Sarah / Berta, Whitney / Law, Susan / Kuluski, Kerry

    BMC geriatrics

    2023  Volume 23, Issue 1, Page(s) 598

    Abstract: Background: The COVID-19 pandemic has contributed to a global crisis in long-term care (LTC) with devastating consequences for residents, families and health professionals. In Ontario, Canada the severity of this crisis has prompted some care partners ... ...

    Abstract Background: The COVID-19 pandemic has contributed to a global crisis in long-term care (LTC) with devastating consequences for residents, families and health professionals. In Ontario, Canada the severity of this crisis has prompted some care partners to move residents home with them for the duration or a portion of the pandemic. This type of care transition, from LTC to home care, was highly unusual pre-pandemic and arguably suboptimal for adults with complex needs. This paper presents the findings of a qualitative study to better understand how residents, care partners, and health professionals made care transition decisions in Ontario's LTC settings during the pandemic.
    Methods: Semi-structured interviews were conducted with 32 residents, care partners and health professionals who considered, supported or pursued a care transition in a LTC setting in Ontario during the pandemic. Crisis Decision Theory was used to structure the analysis.
    Results: The results highlighted significant individual and group differences in how participants assessed the severity of the crisis and evaluated response options. Key factors that had an impact on decision trajectories included the individuals' emotional responses to the pandemic, personal identities and available resources.
    Conclusions: The findings from this study offer novel important insights regarding how individuals and groups perceive and respond to crisis events.
    MeSH term(s) Humans ; Male ; COVID-19/epidemiology ; Long-Term Care ; Ontario/epidemiology ; Pandemics ; Patient Transfer ; Qualitative Research
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-023-04295-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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