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Article ; Online: Richard Ho-Ping Sia: pioneer of infectiology in China.

Liu, Xudong / Li, Yuanmeng / Li, Naishi

2022 Volume 14, Issue 4, Page(s) 235–237

Language	English
Publishing date	2022-11-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543451-2
ISSN	1674-8018 ; 1674-8018
ISSN (online)	1674-8018
ISSN	1674-8018
DOI	10.1093/procel/pwac050
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A mini review of Yu-Ping-Feng polysaccharides

Yang Liu / Binbin Tong / Shuangxing Wang / Gen Li / Yuansheng Tan / Hui Yu / Kelin Yang / Yingying Yu

Aquaculture Reports, Vol 20, Iss , Pp 100697- (2021)

Their biological activities and potential applications in aquaculture

2021

Abstract: ... become a focus of attention in many fields, particularly in medical research industry. Yu-Ping-Feng (YPF ... not studied. Under the guidance of the Pharmacological Efficacy Index, we have extracted Yu-Ping-Feng ...

Abstract	Polysaccharides, one of the important active ingredients of traditional Chinese herbal medicine, become a focus of attention in many fields, particularly in medical research industry. Yu-Ping-Feng (YPF) is a primary component of many traditional Chinese medicine prescriptions, and it’s proven to be significantly beneficial to human health. In recent years, polysaccharides from YPF have been well documented after successful isolation and purification, but the polysaccharides from YPF post-processing wastes are not studied. Under the guidance of the Pharmacological Efficacy Index, we have extracted Yu-Ping-Feng polysaccharides (YPF-P) from the wastes of YPF in our previous work. Our previous findings showed that YPF-P promote the growth, enhance immunity and organ structure or function of cultured fish northern snakehead fish (Channa argus) and grass carp (Ctenopharyngodon idellus), and significantly improve the intestinal microflora of fish. This paper reviews the current status of YPF-P and their application in aquaculture, including the development of green feed for aquatic animals and the re-utilization of the YPF wastes. This series of work is a way to have the best of both worlds, not only to realize the rational treatment of medical wastes, but also to effectively use the wastes, to find a green raw material for aquatic feed.
Keywords	Traditional Chinese medicine ; Yu-Ping-Feng polysaccharides ; Feed additive ; Aquaculture. Fisheries. Angling ; SH1-691
Subject code	540
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ping weisan alleviates chronic colitis in mice by regulating intestinal microbiota composition.

Zhang, Zecai / Cao, Hongyang / Shen, Peng / Liu, Jiuxi / Cao, Yongguo / Zhang, Naisheng

Journal of ethnopharmacology

2020 Volume 255, Page(s) 112715

Abstract: Ethnopharmacological relevance: Ping weisan (PWS), a complex formulation used ...

Abstract	Ethnopharmacological relevance: Ping weisan (PWS), a complex formulation used in traditional Chinese medicine, is first described in 1107 AD and published in the Prescriptions of Taiping Benevolent Dispensary. We have previously confirmed that PWS has the effect of alleviating DSS-induced chronic ulcerative colitis (UC) in mice. Aim of the study: We aimed to examine whether PWS protects mice from chronic UC by regulating intestinal microbiota composition. Materials and methods: Chronic colitis was induced in C57BL/6 mice with 2.5% DSS in drinking water. PWS (8 g/kg) was orally administered throughout the experiment. Body weight changes, stool consistency and myeloperoxidase (MPO) activity were measured in these mice. Interleukin-17A (IL-17A) and interferon gamma (IFN-γ) mRNA levels were detected by qRT-PCR. The alterations of fecal microflora were investigated by 16S rRNA sequencing. Furthermore, intestinal tight junction protein including occludin, and serum lipopolysaccharide (LPS) level were also detected. Results: PWS relieved DSS-induced loss of body weight, and improved stool consistency and MPO activity in mice. The levels of IL-17A and IFN-γ mRNA were also reduced after treatment with PWS. PWS not only regulated occludin level but also decreased serum LPS. We further showed DSS-induced changes in intestinal microbial composition and richness are significantly regulated by PWS. PWS treatment significantly decreased the abundance of Bacteroidetes, but increased the abundance of Firmicutes in chronic UC mice induced by DSS. Conclusions: Combining with our previous results, we found that PWS could exert anti-UC role by rebalancing intestinal bacteria.
MeSH term(s)	Animals ; Chronic Disease ; Colitis/chemically induced ; Colitis/metabolism ; Colitis/microbiology ; Colitis/prevention & control ; Colon/drug effects ; Colon/metabolism ; Colon/microbiology ; Dextran Sulfate ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Dysbiosis ; Gastrointestinal Agents/pharmacology ; Gastrointestinal Microbiome/drug effects ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Lipopolysaccharides/blood ; Male ; Mice, Inbred C57BL ; Occludin/genetics ; Occludin/metabolism ; Peroxidase/metabolism ; Weight Loss/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Gastrointestinal Agents ; IFNG protein, mouse ; Il17a protein, mouse ; Interleukin-17 ; Lipopolysaccharides ; Occludin ; Ocln protein, mouse ; ping wei san ; Interferon-gamma (82115-62-6) ; Dextran Sulfate (9042-14-2) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2020-02-27
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112715
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Article ; Online: Trace N-doped manganese dioxide cooperated with Ping-pong chrysanthemum-like NiAl-layered double hydroxide on cathode for improving bioelectrochemical performance of microbial fuel cell.

Xu, Yuling / Zhang, Xinyi / Liu, Yanyan / Wei, Yushan / Lan, Feng / Wang, Renjun / Yang, Yuewei / Chen, Junfeng

Bioresource technology

2023 Volume 381, Page(s) 129139

Abstract: Trace N-doped manganese dioxide ( ... ...

Abstract	Trace N-doped manganese dioxide (MnO
MeSH term(s)	Oxides/chemistry ; Bioelectric Energy Sources ; Manganese Compounds/chemistry ; Electrodes ; Hydroxides
Chemical Substances	manganese dioxide (TF219GU161) ; Oxides ; Manganese Compounds ; hydroxide ion (9159UV381P) ; Hydroxides
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129139
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Article ; Online: Efficacy and safety of Xiao-ai-ping injection add-on therapy to chemotherapy in patients with non-small cell lung cancer: A systematic review and meta-analysis.

Li, Andong / Liu, Shilin / Zhang, Hui / Lin, Minghao / Guo, Lijiao / Yuan, Chengbo / Li, Zhenyu / Xu, Jianan / Wang, Tan

Medicine

2023 Volume 102, Issue 40, Page(s) e35483

Abstract: Background: Xiao-ai-ping injection (XAPI) combined with chemotherapy has potential efficacy and ...

Abstract	Background: Xiao-ai-ping injection (XAPI) combined with chemotherapy has potential efficacy and less side effects in the treatment of non-small cell lung cancer (NSCLC). At present, there are many clinical studies on XAPI combined with chemotherapy in the treatment of NSCLC, but the results are different. The purpose of this study was to evaluate the efficacy and safety of XAPI combined with chemotherapy in the treatment of NSCLC by meta-analysis system. Methods: The databases to be searched include PubMed, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang database, Chinese Scientific Journal Database, and so on. In addition, relevant journals and magazines will manually search in various fields as supplements. The search date is set from the establishment of the database until July 8, 2023. The 2 researchers will use Endnote X9 software for literature screening and data extraction and independently evaluate the quality. We then assessed the quality and risk of inclusion in the study and observed outcome indicators. Results: A total of 28 trials were included in this study, 1947 patients with NSCLC (974 receiving XAPI combined chemotherapy and 973 receiving chemotherapy alone). The results of meta-analysis showed that: Objective tumor response rate of NSCLC (P < .00001). Improvement in Karnofsky performance score of NSCLC (P < .00001). Quality of life score of NSCLC (P < .00001). The result of CD3 + (P < .00001). The result of CD4 + (P < .00001). The result of CD8 + (P < .00001). The result of CD4+/CD8 + (P = .0001). Leukopenia (P < .00001). Thrombocytopenia (P < .00001). Hemoglobin decrease (P < .00001). Liver function (P = .04). Nausea and vomiting (P < .00001). Conclusion: Our meta-analyses demonstrated that XAPI adjunct with chemotherapy can improve the patient quality of life, reduce adverse reactions, and enhanced immune function, the treatment is effective and high safety. Which suggests that it might be used for NSCLC. However, a large sample of randomized controlled trials are needed to further study the long-term efficacy of XAPI.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Quality of Life ; Drugs, Chinese Herbal/adverse effects ; Thrombocytopenia/chemically induced
Chemical Substances	Marsdeniae tenacissimae extract ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035483
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Article ; Online: Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology.

Yang, Shasha / Fu, Qinwei / Deng, Hua / Liu, Zhiqing / Zhong, Juan / Zhu, Xiaoyu / Wang, Qian / Sun, Chuanhui / Wu, Jing

Medicine

2021 Volume 100, Issue 35, Page(s) e26929

Abstract: Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat ...

Abstract	Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat allergic rhinitis (AR) for centuries. However, the mechanisms underlying its effects or its molecular targets in AR treatment are yet to be elucidated. Therefore, the active compounds of YPFP and their targets were collected and identified from the Traditional Chinese Medicine Systems Pharmacology database. Moreover, AR-associated targets were acquired from the GeneCards and Online Mendelian Inheritance in Man database. Proteins interactions network of YPFP presumed targets and AR-associated targets were examined and merged to reveal the candidate YPFP targets against AR.Cytoscape software and BisoGenet Database were employed to perform the Visualization and Integrated Discovery (Cluster Profiler R package, version: 3.8.1). Kyoto Encyclopedia of Genes and Genomes and genome pathway analyses. To identify the key target genes, a gene-pathway network has been constructed.We identified 44 effective active compounds and 622 YPFP targets. Also 1324 target genes related to AR were identified. Twenty pathways, including those of AGE-RAGE signaling, fluid shear stress, atherosclerosis, PI3K-Akt signaling, and tumor necrosis factor signaling was enriched significantly. MAPK1 was identified as the core gene, while others including RELA, AKT1, NFKBIA, IL6, and JUN, were also important in the gene-pathway network. Clearly, network pharmacology can be applied in revealing the molecular targets and mechanisms of action of complex herbal preparations.These findings suggested that YPFP could treat AR by regulating immunological functions, diminishing inflammation, and improving immunity through different pathways.
MeSH term(s)	Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Pharmacology/methods ; Protein Interaction Maps/drug effects ; Rhinitis, Allergic/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026929
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yu ping feng san for pediatric allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials.

Liao, Yong / Zhong, Juan / Liu, Shuqin / Dai, Menglin / Liu, Yang / Li, Xinrong / Yang, Yepeng / Zhang, Dazheng / Lai, Dan / Lu, Tao / Zhang, Qinxiu / Zhao, Yu

Medicine

2021 Volume 100, Issue 13, Page(s) e24534

Abstract: Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric ...

Abstract	Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric allergic rhinitis (PAR) patients have yet to be studied systematically. Objectives: To assess the effects and safety of YPFS for treat pediatric patients, allergic rhinitis. Methods: We systematically searched PubMed, EMBASE (Excerpta Medical Database), Cochrane library, Chinese Cochrane Centre's Controlled Trials Register platform, Wanfang Chinese Digital Periodical and Conference Database, China National Knowledge Infrastructure Database, and VIP Chinese Science, from inception dates to November 1, 2019. Randomized controlled trials (RCTs) were included. The risk of bias in the trials was assessed in accordance with the Cochrane Handbook, version 5.1.0. RevMan 5.3 software was used to perform a meta-analysis. Grading of Recommendations Assessment, Development and Evaluation methodology was applied to evaluate the evidence quality for each outcome. The quality of evidence for each outcome measurement was low for 4 outcomes and very low for 5 outcomes. Results: A total of 10 RCTs involving 1069 participants (3-15 years old) fulfilled the inclusion criteria. After exclusion, 8 RCTs were pooled for efficacy assessment. The overall efficacy evaluation result did not show benefit for the experimental group (relative risk 0.32, CI 95% 0.24-0.45; P = .98;) Investigation of variation of serum IgA, immunoglobulin E, IgG in three studies in 2 groups returned no statistical significance. YPFS gave relatively better safety (relative risk 0.29, CI 95% 0.14-0.58; P = .0005; Fig. S8, http://links.lww.com/MD/F751) and lower recurrence rates than did Western medical therapy. Conclusions: Current evidence cannot support the routine use of YPFS for treatment of PAR. This may be due to poor-quality study-design limitations of the included YPFS studies. Our data showed that the use of YPFS for PAR is relatively safe compared to Western medical therapy, but a conclusion could not be drawn because only 5 studies were analyzed. Every study suffered from some methodological limitation. Therefore, further large, rigorously-designed studies are necessary to determine conclusively the utility of YPFS in PAR.
MeSH term(s)	Adolescent ; Child ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Randomized Controlled Trials as Topic ; Rhinitis, Allergic/drug therapy ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024534
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Article: Characteristics and weathering mechanisms of the traditional Chinese blue brick from the ancient city of Ping Yao.

Liu, Jian-Bin / Zhang, Zhong-Jian

Royal Society open science

2020 Volume 7, Issue 8, Page(s) 200058

Abstract: ... nineteenth century. The ancient city of Ping Yao ... a United Nations Educational, Scientific and Cultural Organization (UNESCO) heritage site, is an outstanding example of blue brick architecture. The Ping Yao bricks ... efflorescence were collected from the historical buildings of Ping Yao and were studied with regard ...

Abstract	The traditional blue brick was the dominant clay brick used in Chinese architecture before the mid-nineteenth century. The ancient city of Ping Yao, a United Nations Educational, Scientific and Cultural Organization (UNESCO) heritage site, is an outstanding example of blue brick architecture. The Ping Yao bricks within the damp areas (up to 4 m at highest) of the ancient city's walls and private houses are subjected to various weathering, including contour scaling, flaking, powdering and salt crystallization. This study aims to characterize the properties, analyse weathering mechanisms, determine the main weathering factors and discuss the anti-weathering strategies of blue bricks. To do so, samples of brick and salt efflorescence were collected from the historical buildings of Ping Yao and were studied with regard to their mineralogical and physico-mechanical (e.g. density, porosity, pore size distribution, water absorption and uniaxial compressive strength) properties. The resistance to salt crystallization and frost, and the maximum firing temperatures of the brick samples were determined in the laboratory. Weathering mechanisms and anti-weathering strategies were discussed. Salt crystallization and freeze-thaw cycles were found to be two important factors that lead to brick weathering. An anti-weathering strategy of 'damp blocking, desalination and brick replacing' was discussed based on the laboratory experiments, suggestions in literature and site conditions.
Language	English
Publishing date	2020-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.200058
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Article: Antiangiogenesis Roles of Exosomes with Fei-Liu-Ping Ointment Treatment are Involved in the Lung Carcinoma with the Lewis Xenograft Mouse Model.

Zheng, Qi / Liu, Haolong / Fan, Huiting / Zhang, Ying / Hou, Wei

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 9418593

Abstract: ... material delivery in a tumour-therapeutic approach. Following treatment with Fei-Liu-Ping (FLP) ointment ...

Abstract	Exosomes display efficient biocompatibility and represent valuable vehicles for drug or effective material delivery in a tumour-therapeutic approach. Following treatment with Fei-Liu-Ping (FLP) ointment, a traditional Chinese herbal formula, which is used for treating lung cancer patients, could inhibit lung carcinoma growth in clinical and animal studies. In the present study, the values of VEGF and PDGF, which were closely related to angiogenesis, were estimated in serum and carcinoma tissue exosomes to unveil the FLP effects on angiogenesis. The common inflammatory factors of IL-6, IL-1
Language	English
Publishing date	2020-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/9418593
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Article: The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells.

Du, Yingqing / Zheng, Yuzhong / Yu, Ciel Xiaomei / Zhong, Lishan / Li, Yafang / Wu, Baomeng / Hu, Weihui / Zhu, Elsa Wanyi / Xie, Venus Wei / Xu, Qitian / Zhan, Xingri / Huang, Yamiao / Zeng, Liyi / Zhang, Zhenxia / Liu, Xi / Yin, Jiachuan / Zha, Guangcai / Chan, Kelvin / Tsim, Karl Wah Keung

Frontiers in pharmacology

2021 Volume 12, Page(s) 678126

Abstract: ... however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS ...

Abstract	Cisplatin is one of the first line anti-cancer drugs prescribed for treatment of solid tumors; however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS), a well-known ancient Chinese herbal combination formula consisting of Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, is prescribed as a herbal decoction to treat immune disorders in clinic. To understand the fast-onset action of YPFS as an anti-cancer drug to fight against the drug resistance of cisplatin, we provided detailed analyses of intracellular cisplatin accumulation, cell viability, and expressions and activities of ATP-binding cassette transporters and glutathione S-transferases (GSTs) in YPFS-treated lung cancer cell lines. In cultured A549 or its cisplatin-resistance A549/DDP cells, application of YPFS increased accumulation of intracellular cisplatin, resulting in lower cell viability. In parallel, the activities and expressions of ATP-binding cassette transporters and GSTs were down-regulated in the presence of YPFS. The expression of p65 subunit of NF-κB complex was reduced by treating the cultures with YPFS, leading to a high ratio of Bax/Bcl-2, i.e. increasing the rate of cell death. Prim-O-glucosylcimifugin, one of the abundant ingredients in YPFS, modulated the activity of GSTs, and then elevated cisplatin accumulation, resulting in increased cell apoptosis. The present result supports the notion of YPFS in reversing drug resistance of cisplatin in lung cancer cells by elevating of intracellular cisplatin, and the underlying mechanism may be down regulating the activities and expressions of ATP-binding cassette transporters and GSTs.
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.678126
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