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  1. Article ; Online: M

    Maksymetz, James / Joffe, Max E / Moran, Sean P / Stansley, Branden J / Li, Brianna / Temple, Kayla / Engers, Darren W / Lawrence, J Josh / Lindsley, Craig W / Conn, P Jeffrey

    Biological psychiatry

    2019  Volume 85, Issue 12, Page(s) 989–1000

    Abstract: ... tools to assess the involvement of M: Results: M: Conclusions: M ...

    Abstract Background: The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In psychiatric disorders such as posttraumatic stress disorder, PFC hyperactivity is associated with inappropriate fear in safe situations. We previously reported a form of muscarinic acetylcholine receptor (mAChR)-dependent long-term depression in the PFC that we hypothesize is involved in appropriate fear responding and could serve to reduce cortical hyperactivity following stress. However, it is unknown whether this long-term depression occurs at fear-related inputs.
    Methods: Using optogenetics with extracellular and whole-cell electrophysiology, we assessed the effect of mAChR activation on the synaptic strength of specific PFC inputs. We used selective pharmacological tools to assess the involvement of M
    Results: M
    Conclusions: M
    MeSH term(s) Animals ; Basolateral Nuclear Complex/physiology ; Conditioning, Classical ; Extinction, Psychological/physiology ; Fear/physiology ; Hippocampus/physiology ; Long-Term Synaptic Depression ; Mediodorsal Thalamic Nucleus/physiology ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Neurons/physiology ; Prefrontal Cortex/physiology ; Receptor, Muscarinic M1/physiology ; Stress Disorders, Post-Traumatic/physiopathology ; Synaptic Transmission/physiology
    Chemical Substances Receptor, Muscarinic M1
    Language English
    Publishing date 2019-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2019.02.020
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  2. Article: Hormonal and subjective responses to intravenous m-chlorophenylpiperazine in women with seasonal affective disorder.

    Levitan, R D / Kaplan, A S / Brown, G M / Vaccarino, F J / Kennedy, S H / Levitt, A J / Joffe, R T

    Archives of general psychiatry

    1998  Volume 55, Issue 3, Page(s) 244–249

    Abstract: ... by means of neuroendocrine and subjective responses to the postsynaptic serotonin receptor agonist m ... neuroendocrine and subjective responses to m-chlorophenylpiperazine (0.1 mg/kg intravenously) and placebo in 14 ... by means of visual analog scales of 10 mood states.: Results: On the basis of net responses to m ...

    Abstract Background: There is emerging evidence of serotonergic dysfunction in patients with seasonal affective disorder (SAD). We examined central serotonergic function in female patients with SAD (fall-winter pattern) by means of neuroendocrine and subjective responses to the postsynaptic serotonin receptor agonist m-chlorophenylpiperazine.
    Methods: Using a double-blind, randomized, placebo-controlled design, we assessed neuroendocrine and subjective responses to m-chlorophenylpiperazine (0.1 mg/kg intravenously) and placebo in 14 unmedicated female patients with SAD in the depressed state and 15 female normal controls. All testing was done in the fall-winter months and during the follicular phase of the menstrual cycle. Plasma prolactin and cortisol levels were used as neuroendocrine measures, while subjective responses were assessed by means of visual analog scales of 10 mood states.
    Results: On the basis of net responses to m-chlorophenylpiperazine (placebo effects subtracted from drug effects), patients with SAD exhibited blunted prolactin responses and less sadness than normal controls in response to the drug. When order of presentation of drug and placebo was taken into consideration, altered "calm" and "high" responses were also found in the patient group.
    Conclusion: Evidence of dysfunction at or downstream to central serotonergic receptors in female patients with SAD confirms and extends findings from previous research.
    MeSH term(s) Adult ; Affect/drug effects ; Double-Blind Method ; Female ; Follicular Phase ; Humans ; Hydrocortisone/blood ; Injections, Intravenous ; Middle Aged ; Piperazines/administration & dosage ; Piperazines/pharmacology ; Placebos ; Prolactin/blood ; Seasonal Affective Disorder/blood ; Seasonal Affective Disorder/diagnosis ; Seasonal Affective Disorder/psychology ; Serotonin Receptor Agonists/administration & dosage ; Serotonin Receptor Agonists/pharmacology
    Chemical Substances Piperazines ; Placebos ; Serotonin Receptor Agonists ; Prolactin (9002-62-4) ; 1-(3-chlorophenyl)piperazine (REY0CNO998) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 1998-03
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 211589-x
    ISSN 1538-3636 ; 0003-990X
    ISSN (online) 1538-3636
    ISSN 0003-990X
    DOI 10.1001/archpsyc.55.3.244
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  3. Article ; Online: Perioperative and Anesthetic Considerations in Vascular Rings and Slings.

    Wadle, Michael / Joffe, Denise / Backer, Carl / Ross, Faith

    Seminars in cardiothoracic and vascular anesthesia

    2024  , Page(s) 10892532241234404

    Abstract: Vascular rings represent an increasingly prevalent and diverse set of congenital malformations in which the aortic arch and its primary branches encircle and constrict the esophagus and trachea. Perioperative management varies significantly based on the ... ...

    Abstract Vascular rings represent an increasingly prevalent and diverse set of congenital malformations in which the aortic arch and its primary branches encircle and constrict the esophagus and trachea. Perioperative management varies significantly based on the type of lesion, its associated comorbidities, and the compromise of adjacent structures. Multiple review articles have been published describing the scope of vascular rings and relevant concerns from a surgical perspective. This review seeks to discuss the perioperative implications and recommendations of such pathology from the perspective of an anesthesia provider.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2012371-1
    ISSN 1940-5596 ; 1089-2532
    ISSN (online) 1940-5596
    ISSN 1089-2532
    DOI 10.1177/10892532241234404
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  4. Article ; Online: Response to Commentaries: Frequent Preservation of Neurologic Function in Brain Death and Brainstem Death Entails False-Positive Misdiagnosis and Cerebral Perfusion.

    Joffe, Ari R / Nair-Collins, Michael

    AJOB neuroscience

    2024  Volume 15, Issue 1, Page(s) W1–W3

    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2576262-X
    ISSN 2150-7759 ; 2150-7740
    ISSN (online) 2150-7759
    ISSN 2150-7740
    DOI 10.1080/21507740.2023.2292488
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  5. Article ; Online: The Relationship Between Manifestation of Diabetes Insipidus and Estimated Glomerular Filtration Rate in Brain Death: Implications Require Clarification.

    Joffe, Ari R / Nair-Collins, Michael

    Critical care medicine

    2024  Volume 52, Issue 4, Page(s) e213–e214

    MeSH term(s) Humans ; Brain Death ; Glomerular Filtration Rate ; Diabetes Insipidus ; Diabetes Mellitus
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006169
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  6. Article: Comparing the prevalence of tetrahydrocannabinol (THC) toxicities in dogs before and after legalization of cannabis in Canada.

    Joffe, Molly / Joffe, Daniel

    The Canadian veterinary journal = La revue veterinaire canadienne

    2020  Volume 61, Issue 9, Page(s) 997–999

    MeSH term(s) Animals ; Canada/epidemiology ; Cannabis ; Dogs ; Dronabinol ; Prevalence
    Chemical Substances Dronabinol (7J8897W37S)
    Language English
    Publishing date 2020-09-02
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 41603-4
    ISSN 0008-5286
    ISSN 0008-5286
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  7. Article: Acute alcohol and chronic drinking bidirectionally regulate the excitability of prefrontal cortex vasoactive intestinal peptide interneurons.

    Thompson, Shannon M / Ferranti, Anthony S / Joffe, Max E

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The prefrontal cortex (PFC) regulates drinking behaviors and affective changes following chronic alcohol use. PFC activity is dynamically modulated by local inhibitory interneurons (INs), which can be divided into non-overlapping groups with distinct ... ...

    Abstract The prefrontal cortex (PFC) regulates drinking behaviors and affective changes following chronic alcohol use. PFC activity is dynamically modulated by local inhibitory interneurons (INs), which can be divided into non-overlapping groups with distinct functional roles. Within deeper layers of neocortex, INs that express either parvalbumin or somatostatin directly inhibit pyramidal cells. By contrast, the plurality of all remaining INs express vasoactive intestinal peptide (VIP), reside within superficial layers, and preferentially target other types of INs. While recent studies have described adaptations to PFC parvalbumin-INs and somatostatin-INs in alcohol use models, whether ethanol or drinking affect the physiology of PFC VIP-INs has not been reported. To address this gap, we used genetically engineered female and male mice to target VIP-INs in layers 1-3 of prelimbic PFC for whole-cell patch-clamp electrophysiology. We found that ethanol (20 mM, ∼0.09 BEC) application to PFC brain slices enhances VIP-IN excitability. We next examined effects following chronic drinking by providing mice with 4 weeks of intermittent access (IA) ethanol two-bottle choice in the home cage. In these studies, VIP-INs from female and male IA ethanol mice displayed reduced excitability relative to cells from water-only controls. Finally, we assessed whether these effects continue into abstinence. After 7-11 days without ethanol, the hypo-excitability of VIP-INs from male IA ethanol mice persisted, whereas cells from female IA ethanol mice were not different from their controls. Together, these findings illustrate that acute ethanol enhances VIP-IN excitability and suggest these cells undergo pronounced homeostatic changes following long-term drinking.
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.07.531614
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  8. Article ; Online: Guidance for a New Clinical Challenge.

    Joffe, Aaron M / Tung, Avery

    Anesthesia and analgesia

    2021  Volume 133, Issue 4, Page(s) 873–875

    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005703
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  9. Article ; Online: Novel Transcatheter Approach to Treat Primum Atrial Septal Defects.

    Condos, Gregory J / McCabe, James M / Joffe, Denise C / Sheu, Richard D

    CASE (Philadelphia, Pa.)

    2024  Volume 8, Issue 3Part A, Page(s) 180–185

    Abstract: Degenerative common AVC defect can mimic rheumatic MV stenosis.•Closure of primum ASD can be achieved percutaneously.•Live 3D multiplanar TEE is crucial for procedural guidance. ...

    Abstract •Degenerative common AVC defect can mimic rheumatic MV stenosis.•Closure of primum ASD can be achieved percutaneously.•Live 3D multiplanar TEE is crucial for procedural guidance.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Case Reports
    ISSN 2468-6441
    ISSN (online) 2468-6441
    DOI 10.1016/j.case.2023.12.002
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  10. Article ; Online: Differences in gross motor and fine motor outcomes for toddlers after early complex cardiac surgery.

    Robertson, Charlene M T / Khademioureh, Sara / Dinu, Irina A / Sorenson, Julie A / Joffe, Ari R

    Cardiology in the young

    2024  , Page(s) 1–9

    Abstract: Objectives: To determine whether gross motor scores of toddlers after complex cardiac surgery were different from fine motor scores and were adequately represented by motor composite scores and, whether acute care predictors and chronic childhood health ...

    Abstract Objectives: To determine whether gross motor scores of toddlers after complex cardiac surgery were different from fine motor scores and were adequately represented by motor composite scores and, whether acute care predictors and chronic childhood health markers of gross motor scores differed from those of fine motor.
    Methods: This prospective inception-cohort outcomes study included 171 toddlers after complex cardiac surgery with cardiopulmonary bypass at age <6 months, born in Northern Alberta from 2009 to 2019, and without known chromosomal abnormalities. At a mean (standard deviation) age of 21.7 (3.7) months, the Bayley Scales of Infant and Toddler Development-III determined motor composite and scaled scores (normative values, 100 (15), 10 (3), respectively). The same variables from surgery and assessment were analysed using multivariate regression to predict gross and fine motor scores; results expressed as effect size (95% confidence interval) with % variance.
    Results: Composite, fine, and gross motor scores were 89.7 (14.2), 9.4 (2.5), and 7.2 (2.7), respectively. Predictive variables accounted for 21.2% of the variance for fine motor, and 36.9% for gross motor. Multivariate analysis for gross motor scores included toddlers need for cardiac medication, effect size (95% confidence interval) -0.801 (-1.62, -0.02), gastrostomy, -1.35 (-2.39, -0.319), and single ventricle, -0.93 (-1.71, -0.15). These same variables did not predict fine motor scores.
    Conclusion: Gross motor skills commonly were lower than fine motor skills for toddlers after complex cardiac surgery. Predictors for gross motor scores differed from fine motor scores. Separate reporting of gross motor scores could lead to improved identification of predictors of delay and to optimised early intervention.
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951124000428
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