Article ; Online: IKK-mediated CYLD phosphorylation and cellular redox activity.
Molecular medicine (Cambridge, Mass.)
2022 Volume 28, Issue 1, Page(s) 14
Abstract: Oxidative stress is important in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been described. However, contradictory explanations about the functioning of the ... ...
Abstract | Oxidative stress is important in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been described. However, contradictory explanations about the functioning of the mechanisms that will be effective in the pathogenesis require clarification. |
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MeSH term(s) | I-kappa B Kinase/genetics ; I-kappa B Kinase/metabolism ; I-kappa B Kinase/pharmacology ; Oxidation-Reduction ; Oxidative Stress ; Phosphorylation ; Signal Transduction/drug effects |
Chemical Substances | I-kappa B Kinase (EC 2.7.11.10) |
Language | English |
Publishing date | 2022-02-02 |
Publishing country | England |
Document type | Letter ; Comment |
ZDB-ID | 1283676-x |
ISSN | 1528-3658 ; 1076-1551 |
ISSN (online) | 1528-3658 |
ISSN | 1076-1551 |
DOI | 10.1186/s10020-022-00439-y |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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