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Article ; Online: Clinical and laboratory features of patients with undifferentiated spondyloarthritis and ankylosing spondylitis.

Gemcioglu, Emin / Erten, Sökran

2022 Volume 149, Issue 10, Page(s) 1423–1429

Abstract: Background: The terms Spondyloarthritis and spondyloarthropathy (Spa) are used to define a group of diseases with related clinical characteristics and genetics.: Aim: To report the clinical and demographic characteristics of ankylosing spondylitis ( ... ...

Abstract	Background: The terms Spondyloarthritis and spondyloarthropathy (Spa) are used to define a group of diseases with related clinical characteristics and genetics. Aim: To report the clinical and demographic characteristics of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (USpA) and to evaluate the frequency of cyclic citrullinated peptide antibody (anti-CCP) positivity. Material and methods: Two hundred patients with USpA or AS, 100 control patients with a diagnosis of rheumatoid arthritis (RA) and 100 healthy volunteers were included. For each patient, their detailed medical histories, physical examination, whole blood counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-CCP, routine biochemical tests, and HLA-B27 test results were evaluated. ASDAS and BASDAI scores and morning stiffness were used to evaluate the disease activity. Results: The presenting symptom of 73 (73%) patients in the AS group and 58 (58%) patients in the USpA group was pain in axial joints. A family history of Spa was positive in 32 patients from both groups (32%). A positive HLA-B27 was found in 55% of the AS group and 25% of the USpA group (p < 0.01 for the difference between groups). The frequency of positive HLA-B27 was significantly higher in individuals with a family history of SpA (p = 0.022). A positive Anti-CCP was found in 56% of the RA group, a significantly higher frequency compared with other groups (p < 0.001). The frequency of positive Anti-CCP in patients in AS (9%) and USpA (6%) was significantly higher than in healthy controls (p < 0.001). Conclusions: The frequency of anti-CCP positivity was higher in SpA patients than in healthy controls.
MeSH term(s)	Arthritis, Rheumatoid/diagnosis ; Blood Sedimentation ; HLA-B27 Antigen/genetics ; Humans ; Spondylarthritis/diagnosis ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/genetics
Chemical Substances	HLA-B27 Antigen
Language	English
Publishing date	2022-03-21
Publishing country	Chile
Document type	Journal Article
ZDB-ID	732136-3
ISSN	0717-6163 ; 0034-9887
ISSN (online)	0717-6163
ISSN	0034-9887
DOI	10.4067/s0034-98872021001001423
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Article: Do the etiology of hyponatremia and serum sodium levels affect the length of hospital stay in geriatric patients with hyponatremia?

Baser, Salih / Yılmaz, Cakmak Nuray / Gemcioglu, Emin

Journal of medical biochemistry

2022 Volume 41, Issue 1, Page(s) 40–46

Abstract: Background: Hyponatremia can lead to a prolonged hospital stay and increased morbidity and mortality rates in geriatric patients. This study aimed to evaluate the effects of hyponatremia etiology and serum sodium (Na) levels on hospitalisation time in ... ...

Abstract	Background: Hyponatremia can lead to a prolonged hospital stay and increased morbidity and mortality rates in geriatric patients. This study aimed to evaluate the effects of hyponatremia etiology and serum sodium (Na) levels on hospitalisation time in geriatric patients hospitalised due to hyponatremia. Methods: The demographic characteristics, laboratory data, etiology of hyponatremia, and length of hospital stay were retrospectively recorded for 132 patients over 65 years of age who were hospitalised for hyponatremia. Results: Of the 132 patients, 90 were female (68.2%), and 42 were male (31.8%). The serum Na levels of 66 (50%) patients were <120 mmol/L, those of 64 (48.5%) patients were 120-129 mmol/L, and those of two (1.5%) patients were >130 mmol/L. One hundred nine (82.6%) patients had hypoosmolar hyponatremia, 14 (10.6%) patients had isoosmolar hyponatremia, and nine (6.8%) patients had hyperosmolar hyponatremia. Also, 19.7% of the patients were hypovolemic, 37.9% were euvolemic, and 42.4% were hypervolemic. Hyponatremia etiology was congestive heart failure in 38 (28.8%) patients, syndrome of inappropriate antidiuretic hormone in 29 (22.0%) patients, gastrointestinal fluid loss in 24 (18.2%) patients, renal pathologies in 20 (15.2%) patients, the presence of drugs in 20 (15.2%) patients, and hypocortisolemia in one (0.8%) patient. The mean length of hospital stay for the patients was five (1-60) days. There was no statistically significant difference between the lengths of hospital stay based on hyponatremia etiology and serum Na levels (p=0.861 and p=0.076). It was observed that the lengths of stay for patients who developed hyponatremia during their hospitalisation in various clinics were longer than those for patients who presented to the emergency department (p<0.001). Conclusions: In this study, it was determined that the length of hospital stay did not change with the etiology of hyponatremia and serum Na level at the time of admission, but patients who developed hyponatremia during their hospitalisation had longer hospitalisation times.
Language	English
Publishing date	2022-03-11
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	2387367-X
ISSN	1452-8258
ISSN	1452-8258
DOI	10.5937/jomb0-29914
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Article ; Online: Transport of awake hypoxemic probable COVID 19 patients in the prone position.

Şan, İshak / Yıldırım, Çağdaş / Bekgöz, Burak / Gemcioğlu, Emin

The American journal of emergency medicine

2020 Volume 46, Page(s) 420–423

Abstract: Objective: We aimed to investigate the effects of transport with prone position on hypoxemia in hypoxemic and awake probable COVID 19 pneumonia patients.: Methods: Hypoxic and awake patients with probable COVID 19 pneumonia who were referred to the ... ...

Abstract	Objective: We aimed to investigate the effects of transport with prone position on hypoxemia in hypoxemic and awake probable COVID 19 pneumonia patients. Methods: Hypoxic and awake patients with probable COVID 19 pneumonia who were referred to the Ankara City Hospital Emergency Department from 1 April to 31 May 2020 were included in this prospective study. Patients were transported in prone position and fixed on the stretcher. During the transport, patients continued receiving 2 l per minute oxygen with nasal cannula. Arterial blood gases were obtained from the patients before and after transport. The transport time was recorded as minutes. The primary outcome of the study is the increase of partial oxygen value in the arterial blood gas of patients after transport. Results: It was found that pO2 and SpO2 end values were statistically significantly higher in the patient group compared to the initial values. In the group with transport duration of more than 15 min, a difference was found between the initial and end values in pO2 and SpO2 parameters similar to the whole group. However, there was no statistically significant difference between the initial and end values in the group with transport duration of 15 min or below. Conclusions: Awake hypoxemic patients can be transported without complications in prone position during transport. Transports more than 15 min, prone position may be recommended because the partial oxygen pressure of the patients increases.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/therapy ; Female ; Follow-Up Studies ; Humans ; Intubation, Intratracheal/methods ; Male ; Middle Aged ; Pandemics ; Patient Positioning/methods ; Prone Position/physiology ; Prospective Studies ; Respiration, Artificial/methods ; SARS-CoV-2 ; Transportation of Patients/methods ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2020.10.036
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Article ; Online: Clinical Evaluation of Non-Traumatic Rhabdomyolysis Patients Followed in the Internal Diseases Clinic

Emin Gemcioğlu / Nuray Yılmaz Çakmak / Salih Başer

Ankara Medical Journal, Vol 21, Iss 3, Pp 364-

2021 Volume 373

Abstract: INTRODUCTION: Rhabdomyolysis is a clinical and biochemical condition that occurs when substances that have a toxic potential inside of cells enter systemic circulation as a result of the destruction of striated muscle fibers. In this study, the ... ...

Abstract	INTRODUCTION: Rhabdomyolysis is a clinical and biochemical condition that occurs when substances that have a toxic potential inside of cells enter systemic circulation as a result of the destruction of striated muscle fibers. In this study, the epidemiological data of patients who were symptomatic and followed-up with a diagnosis of non-traumatic rhabdomyolysis were evaluated in terms of morbidity, mortality, and length of hospitalization. METHODS: The serum creatinine kinase(CK), myoglobin, and creatinine(CR) levels of 95 patients who were over 18 years of age and had been hospitalized and followed up in the Internal Diseases ward after being diagnosed with non-traumatic rhabdomyolysis at the hospital were evaluated retrospectively. RESULTS: In this study, no statistically significant difference was found between disease etiology and the duration of hospitalization. There was a positive correlation between the CR values and the duration of hospitalization. A statistically significant difference was found between the length of hospitalization and the CR values on admission and at 24h following admission(p=0.043). No statistically significant difference was found between the CK values on admission and the CR values at follow-up and hospital discharge (p=0.594). It was found that patients admitted with a diagnosis of non-traumatic rhabdomyolysis did not negatively affect kidney function with appropriate follow-up and treatment, regardless of the initial CK value. DISCUSSION AND CONCLUSION: Although non-traumatic rhabdomyolysis is common, possible complications can be minimized with early diagnosis, appropriate treatment, and follow-up. Although serum CK and creatinine values have an important prognostic value in the follow-up of patients, many parameters need to be evaluated together, and more studies are needed to standardize the evaluation of disease prognosis.
Keywords	rhabdomyolysis ; creatine kinase ; length of stay ; renal insufficiency ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Ankara Yildirim Beyazit University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transport of awake hypoxemic probable COVID 19 patients in the prone position

Şan, İshak / Yıldırım, Çağdaş / Bekgöz, Burak / Gemcioğlu, Emin

The American Journal of Emergency Medicine ; ISSN 0735-6757

2020

Keywords	Emergency Medicine ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.ajem.2020.10.036
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Article ; Online: Objective evaluation of the nasal mucosal secretion in COVID-19 patients with anosmia.

Islamoglu, Yuce / Gemcioglu, Emin / Ates, Ihsan

Irish journal of medical science

2020 Volume 190, Issue 3, Page(s) 889–891

Abstract: Background: COVID-19 is a new disease caused by the SARS-CoV-2 virus. The olfactory dysfunction linked to COVID-19 is not associated with rhinorrhea but there is no objective evaluation.: Aims: To evaluate nasal mucosal secretion objectively in COVID- ...

Abstract	Background: COVID-19 is a new disease caused by the SARS-CoV-2 virus. The olfactory dysfunction linked to COVID-19 is not associated with rhinorrhea but there is no objective evaluation. Aims: To evaluate nasal mucosal secretion objectively in COVID-19 patients with anosmia. Methods: Fifty-two COVID-19 patients with anosmia and 51 healthy individuals included. Anosmia was diagnosed by subjective questionnaires. Nasal Schirmer test was done to the left and the right nasal cavity separately. Results: All patients had anosmia and 82.6% had gustatory dysfunction. In group 1, the mean of the nasal Schirmer test results in the right cavity was 12.4 mm, 12.01 mm in the left nasal cavity. The median wetting distance (right plus left divided by two) was calculated 12.21 mm. In group 2, the mean of the nasal Schirmer test results in the right cavity was 12.1 mm, 11.8 mm in the left nasal cavity. The median wetting distance (right plus left divided by two) was calculated11.97 mm. There was no difference between the two groups in terms of nasal schirmer. Conclusion: Olfactory dysfunction and gustatory dysfunction are the two of the unknown for this disease. We evaluated the nasal mucosa secretions in COVID-19 patients with anosmia objectively to evaluate if there is inflammation in the nasal mucosa. We found no difference between healthy individuals. According to our study, SARS-CoV-2 causes anosmia without causing nasal mucosal inflammation. Invasion of the olfactory bulb and central nervous system by SARS-CoV-2 may lead to anosmia in COVID-19, which may cause olfactory dysfunction.
MeSH term(s)	Anosmia ; COVID-19/complications ; Humans ; Inflammation ; Nasal Mucosa ; SARS-CoV-2 ; Smell
Keywords	covid19
Language	English
Publishing date	2020-10-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-020-02405-1
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Article ; Online: Evaluation of inflammatory rheumatic diseases from an emergency medicine perspective.

San, Ishak / Erden, Abdulsamet / Gemcioglu, Emin / Kücüksahin, Orhan

International journal of rheumatic diseases

2020 Volume 23, Issue 12, Page(s) 1670–1675

Abstract: Background: Patients with rheumatological complaints may visit an emergency department (ED) because of an acute attack or complication. Because of the recent increased use of immunosuppressant drugs to treat rheumatic diseases, more patients with these ... ...

Abstract	Background: Patients with rheumatological complaints may visit an emergency department (ED) because of an acute attack or complication. Because of the recent increased use of immunosuppressant drugs to treat rheumatic diseases, more patients with these conditions visit the ED with a complaint about an infection. However, there are little data on the ED visits of patients with rheumatological complaints. This study evaluated the ED visits of patients with inflammatory rheumatic diseases. Materials and methods: A total of 2715 patients (1753 females, 962 males) who had been diagnosed with an inflammatory rheumatic disease and followed up at the rheumatology clinic of Yıldırım Beyazit University, Ankara Atatürk Training and Research Hospital between April 2014 and April 2018 were included in the study. The demographic, clinical, and laboratory characteristics of the patients were obtained from the hospital patient records. The ED visits of these patients were classified into five triage groups (T1: critical, T2: very urgent, T3: urgent, T4: less urgent, T5: not urgent). Results: Of the 2715 patients, 577 (21.3%) had visited the ED. The three most numerous groups who visited the ED were patients with rheumatoid arthritis (19.8%), ankylosing spondylitis (19.2%), and familial Mediterranean fever (15.9%). Of these 577 patients, 347 (60.1%) were discharged from the ED, 209 (36.2%) were hospitalized in the wards, and 21 (3.6%) were hospitalized in the intensive care unit (ICU). The 3 main reasons for visiting the ED were fever and malaise (n = 152, 26.3%), musculoskeletal complaints (n = 125, 21.7%), and abdominal pain (n = 89, 15.4%). The most numerous group of patients referred by the ED to the wards had vasculitis (n = 38, 17.9%), while the most numerous group of patients referred to the ICU had scleroderma (n = 7, 33.3%). Of the 21 patients who were referred by the ED to the ICU, 16 (76.1%) had respiratory system complaints. Of the 577 patients, 10 (1.7%) died. Eight of the 10 patients (80%) had a rheumatic disease and died after admission to the ICU. The other 2 patients had been diagnosed with pneumonia and myocardial infarction, respectively. Conclusions: Our study found that visits to the ED by patients with inflammatory rheumatic diseases were classified as urgent or less urgent. Patients with rheumatoid arthritis were the most numerous ED visitors. Vasculitis was the most common cause of hospitalization in the wards and scleroderma was the most common cause of hospitalization in the ICU and death. This suggests that ED physicians should be aware of these patients.
MeSH term(s)	Adult ; Emergency Medicine/methods ; Female ; Follow-Up Studies ; Humans ; Inflammation/diagnosis ; Inpatients ; Male ; Middle Aged ; Retrospective Studies ; Rheumatic Diseases/diagnosis ; Time Factors ; Triage/methods
Language	English
Publishing date	2020-09-30
Publishing country	England
Document type	Evaluation Study ; Journal Article ; Multicenter Study
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.13982
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Article ; Online: Factors affecting the use of herbal products in patients with Irritable Bowel Syndrome and their results: case-control study.

Gemcioglu, Emin / Yılmaz Cakmak, Nuray / Baser, Salih / Kocaoz, Servet / Ersoy, Osman

BMC gastroenterology

2022 Volume 22, Issue 1, Page(s) 43

Abstract: Background: Irritable bowel syndrome (IBS) is a functional bowel disease that is characterized by abdominal pain, discomfort, and changes in the frequency and form of stool without any organic pathology. In this study, the factors that affect the herbal ...

Abstract	Background: Irritable bowel syndrome (IBS) is a functional bowel disease that is characterized by abdominal pain, discomfort, and changes in the frequency and form of stool without any organic pathology. In this study, the factors that affect the herbal treatment choices of IBS patients and their results were investigated. Methods: Included in the study were 248 IBS patients who were over the age of 18. A questionnaire that comprised 25 questions was applied to the participants. Survey questions were asked to the participants regarding their age, place of birth, gender, educational status, demographic details, social standing, socioeconomic status and job, place of residence, and marital status. In addition, The participants were asked about which IBS symptoms they had, from whom they had received the recommendation for use of herbal products, whether the media had an effect on their selection of herbal products, and whether they had benefited from herbal products. Results: It was observed that 41.1% of the patients with IBS who participated in the study used herbal medicine, 9.8% of whom used them regularly. It was found that the IBS patients participating in the study made their decision to use herbal products mostly based on the recommendations that they were given by acquaintances (57%) and the media (34%). When the patients were evaluated according to their gender, IBS was found to be more common in unemployed women who had a low level of education, while it was more common in working men (p = 0.015, P < 0.001, respectively). The IBS patients who were single used more herbal products that those who were married (P = 0.036). While the use of herbal herbs and oils was predominant in patients whose recommendation content comprised the media/internet and acquaintances, the herbal treatment content recommended by healthcare professionals consisted of traditional treatments and mixtures (P = 0.012). It was determined that a higher percentage of those who used herbal treatments lived in city centers when compared to those who did not (P < 0.001). In addition, it was determined that patients with constipation used herbal products more than those without (P < 0.001). Among the IBS patients, those who had diarrhea and those who were receiving medical treatment preferred to use significantly less herbal products (P = 0.007 and P = 0.041, respectively). It was found that the patients who visited the Gastroenterology Outpatient Clinic mostly used herbal therapy, while those who visited a family doctor used herbal therapy the least (P = 0.029 and P < 0.001, respectively). Conclusion: The IBS patients revealed whose recommendations they followed when purchasing herbal products, which of the products they preferred, and how useful/beneficial they felt that these products were. In this regard, the addition of training curricula related to herbal treatment for professional healthcare workers will further raise awareness on this topic.
MeSH term(s)	Adult ; Case-Control Studies ; Constipation ; Diarrhea ; Female ; Humans ; Irritable Bowel Syndrome/drug therapy ; Male ; Middle Aged ; Surveys and Questionnaires
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-022-02125-z
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Article ; Online: Acute Ischemic Stroke in a Lupus Anticoagulant-Positive Woman With COVID-19.

Gemcioglu, Emin / Erden, Abdulsamet / Davutoglu, Mehmet / Karabuga, Berkan / Kucuksahin, Orhan

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

2020 Volume 26, Issue 6, Page(s) 236–237

MeSH term(s)	Adult ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Betacoronavirus ; Brain Ischemia/blood ; Brain Ischemia/etiology ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Female ; Humans ; Lupus Coagulation Inhibitor/blood ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Stroke/blood ; Stroke/etiology
Chemical Substances	Lupus Coagulation Inhibitor
Keywords	covid19
Language	English
Publishing date	2020-07-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1283266-2
ISSN	1536-7355 ; 1076-1608
ISSN (online)	1536-7355
ISSN	1076-1608
DOI	10.1097/RHU.0000000000001565
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Article: Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome.

Yilmaz, Cakmak Nuray / Gemcioglu, Emin / Baser, Salih / Erten, Sükran / Erel, Ozcan

Journal of medical biochemistry

2021 Volume 40, Issue 3, Page(s) 270–276

Abstract: Background: Primary Sjögren's syndrome (pSS) is a disease associated with the overexpression of proinflammatory cytokines, and oxidative stress is one of the factors responsible for its etiopathogenesis. This study aimed to investigate the thiol/ ... ...

Abstract	Background: Primary Sjögren's syndrome (pSS) is a disease associated with the overexpression of proinflammatory cytokines, and oxidative stress is one of the factors responsible for its etiopathogenesis. This study aimed to investigate the thiol/disulphide homeostasis in pSS patients. Methods: The study included 68 pSS patients and 69 healthy controls. Thiol/disulphide homeostasis (total thiol, native thiol, and disulphide levels) was measured using the automatic spectrophotometric method developed by Erel and Neselioglu, and the results of the 2 groups were compared. Results: The gender and age distributions of the pSS and control groups were similar ( Conclusions: It was concluded that the thiol/disulphide balance shifted towards disulphide in patients with pSS.
Language	English
Publishing date	2021-06-23
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	2387367-X
ISSN	1452-8258
ISSN	1452-8258
DOI	10.5937/jomb0-27281
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