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  1. Article: Trocar Site Recurrence after Laparoscopic Cholecystectomy for Unsuspected Isolated Gallbladder Metastasis of Melanoma: A Case Report and Review of the Literature.

    Sergeant, Céline / Kerger, Joseph / Drowart, Annie / Sales, François / Langouo, Mireille

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 1183–1195

    Abstract: Cutaneous melanoma can metastasize to almost any organ, including in-transit metastases, lymph nodes, liver, lungs, brain, and bones. Spread to the gastrointestinal tract is less common and generally concerns the small bowel, colon, and stomach. ... ...

    Abstract Cutaneous melanoma can metastasize to almost any organ, including in-transit metastases, lymph nodes, liver, lungs, brain, and bones. Spread to the gastrointestinal tract is less common and generally concerns the small bowel, colon, and stomach. Gallbladder involvement is rarer, and only few cases describe it as the sole site of metastasis upon diagnosis. Melanoma metastases to the gallbladder are usually detected on staging or surveillance imaging, as patients usually show few or no symptoms. In resectable stage IV melanoma patients, complete surgical resection appears to improve the prognosis. However, due to the rarity of isolated gallbladder metastasis of melanoma, there are no guidelines regarding the optimal surgical approach (endoscopic or open cholecystectomy). Here, we report the case of isolated gallbladder melanoma metastasis found after laparoscopic cholecystectomy performed in a 46-year-old female patient with no known history of cancer presenting with acute cholecystitis symptoms. Six weeks after surgery, the patient developed trocar site recurrence. This case highlights the importance of a planned and open surgery for resectable melanoma metastases rather than a laparoscopic approach.
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000534147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Eunethydis

    Sergeant, Joseph Anthony

    European approaches to hyperkinetic disorder

    1995  

    Author's details ed.: Joseph Sergeant
    Keywords Attention Deficit Disorder with Hyperactivity ; Research ; International Cooperation
    Language English
    Size 280 S. : Ill., graph. Darst.
    Publisher Sergeant
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT007472384
    ISBN 3-9520863-0-4 ; 978-3-9520863-0-8
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Developing and externally validating multinomial prediction models for methotrexate treatment outcomes in patients with rheumatoid arthritis: results from an international collaboration.

    Gehringer, Celina K / Martin, Glen P / Hyrich, Kimme L / Verstappen, Suzanne M M / Sexton, Joseph / Kristianslund, Eirik K / Provan, Sella A / Kvien, Tore K / Sergeant, Jamie C

    Journal of clinical epidemiology

    2023  Volume 166, Page(s) 111239

    Abstract: Objectives: In rheumatology, there is a clinical need to identify patients at high risk (>50%) of not responding to the first-line therapy methotrexate (MTX) due to lack of disease control or discontinuation due to adverse events (AEs). Despite this ... ...

    Abstract Objectives: In rheumatology, there is a clinical need to identify patients at high risk (>50%) of not responding to the first-line therapy methotrexate (MTX) due to lack of disease control or discontinuation due to adverse events (AEs). Despite this need, previous prediction models in this context are at high risk of bias and ignore AEs. Our objectives were to (i) develop a multinomial model for outcomes of low disease activity and discontinuing due to AEs 6 months after starting MTX, (ii) update prognosis 3-month following treatment initiation, and (iii) externally validate these models.
    Study design and setting: A multinomial model for low disease activity (submodel 1) and discontinuing due to AEs (submodel 2) was developed using data from the UK Rheumatoid Arthritis Medication Study, updated using landmarking analysis, internally validated using bootstrapping, and externally validated in the Norwegian Disease-Modifying Antirheumatic Drug register. Performance was assessed using calibration (calibration-slope and calibration-in-the-large), and discrimination (concordance-statistic and polytomous discriminatory index).
    Results: The internally validated model showed good calibration in the development setting with a calibration-slope of 1.01 (0.87, 1.14) (submodel 1) and 0.83 (0.30, 1.34) (submodel 2), and moderate discrimination with a c-statistic of 0.72 (0.69, 0.74) and 0.53 (0.48, 0.59), respectively. Predictive performance decreased after external validation (calibration-slope 0.78 (0.64, 0.93) (submodel 1) and 0.86 (0.34, 1.38) (submodel 2)), which may be due to differences in disease-specific characteristics and outcome prevalence.
    Conclusion: We addressed previously identified methodological limitations of prediction models for outcomes of MTX therapy. The multinomial approach predicted outcomes of disease activity more accurately than AEs, which should be addressed in future work to aid implementation into clinical practice.
    MeSH term(s) Humans ; Methotrexate/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Antirheumatic Agents/therapeutic use ; Treatment Outcome ; Prognosis
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; Antirheumatic Agents
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2023.111239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Are we ready for endophenotypes in attention deficit hyperactivity disorder?

    Sergeant, Joseph

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2005  Volume 27, Issue 4, Page(s) 262–263

    MeSH term(s) Attention Deficit Disorder with Hyperactivity/genetics ; Genetic Predisposition to Disease/genetics ; Humans ; Phenotype
    Language English
    Publishing date 2005-12-12
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 1482747-5
    ISSN 1516-4446
    ISSN 1516-4446
    DOI 10.1590/s1516-44462005000400001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: EUNETHYDIS -- searching for valid aetiological candidates of Attention-Deficit Hyperactivity Disorder or Hyperkinetic Disorder.

    Sergeant, Joseph

    European child & adolescent psychiatry

    2004  Volume 13 Suppl 1, Page(s) I43–9

    Abstract: Background: To step up research in ADHD, exchange of ideas, working together on key theoretical models and cooperative studies are necessary.: Objective: To report about a European approach with strong links to the rest of the world.: Method: ... ...

    Abstract Background: To step up research in ADHD, exchange of ideas, working together on key theoretical models and cooperative studies are necessary.
    Objective: To report about a European approach with strong links to the rest of the world.
    Method: European Network on Hyperkinetic Disorders (Eunethydis) studies of Attention -- Deficit Hyperactivity Disorder (ADHD) or Hyperkinetic Disorder (HKD) is briefly reviewed in the context of the international effort to discover the aetiology of the disorder.
    Results: There are promising neurobiological, neurophysiological and neuropsychological candidates to explain the nature of ADHD/HKD.
    Conclusion: Eunethydis has shown to be a fruitful platform for ADHD research and has good resources for its further development.
    MeSH term(s) Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/etiology ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Cerebellum/physiopathology ; Child ; Child Behavior Disorders/diagnosis ; Child Behavior Disorders/epidemiology ; Cognition Disorders/diagnosis ; Cognition Disorders/epidemiology ; Europe ; Frontal Lobe/physiopathology ; Humans ; Hyperkinesis/diagnosis ; Hyperkinesis/etiology ; Hyperkinesis/physiopathology ; International Cooperation ; Neuropsychological Tests
    Language English
    Publishing date 2004
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-004-1005-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mini-review: Robotic wheelchair taxonomy and readiness.

    Sivakanthan, Sivashankar / Candiotti, Jorge L / Sundaram, Andrea S / Duvall, Jonathan A / Sergeant, James Joseph Gunnery / Cooper, Rosemarie / Satpute, Shantanu / Turner, Rose L / Cooper, Rory A

    Neuroscience letters

    2022  Volume 772, Page(s) 136482

    Abstract: Robotic wheelchair research and development is a growing sector. This article introduces a robotic wheelchair taxonomy, and a readiness model supported by a mini-review. The taxonomy is constructed by power wheelchair and, mobile robot standards, the ICF ...

    Abstract Robotic wheelchair research and development is a growing sector. This article introduces a robotic wheelchair taxonomy, and a readiness model supported by a mini-review. The taxonomy is constructed by power wheelchair and, mobile robot standards, the ICF and, PHAATE models. The mini-review of 2797 articles spanning 7 databases produced 205 articles and 4 review articles that matched inclusion/exclusion criteria. The review and analysis illuminate how innovations in robotic wheelchair research progressed and have been slow to translate into the marketplace.
    MeSH term(s) Equipment Design ; Humans ; Robotics/methods ; Robotics/standards ; Wheelchairs/adverse effects ; Wheelchairs/classification ; Wheelchairs/standards
    Language English
    Publishing date 2022-01-29
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2022.136482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Are we ready for endophenotypes in attention deficit hyperactivity disorder?

    Sergeant Joseph

    Revista Brasileira de Psiquiatria, Vol 27, Iss 4, Pp 262-

    2005  Volume 263

    Keywords Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Psychiatry ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2005-01-01T00:00:00Z
    Publisher Associação Brasileira de Psiquiatria (ABP)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Are we ready for endophenotypes in attention deficit hyperactivity disorder? Estamos prontos para os endofenótipos no transtorno do déficit de atenção e hiperatividade?

    Joseph Sergeant

    Revista Brasileira de Psiquiatria, Vol 27, Iss 4, Pp 262-

    2005  Volume 263

    Keywords Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Psychiatry ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2005-12-01T00:00:00Z
    Publisher Associação Brasileira de Psiquiatria (ABP)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Modeling attention-deficit/hyperactivity disorder: a critical appraisal of the cognitive-energetic model.

    Sergeant, Joseph A

    Biological psychiatry

    2005  Volume 57, Issue 11, Page(s) 1248–1255

    Abstract: A number of theoretical models of attention-deficit/hyperactivity disorder (ADHD) have emerged in recent years that may be used as systematic guides for clinical research. The cognitive-energetic model (CEM) proposes that the overall efficiency of ... ...

    Abstract A number of theoretical models of attention-deficit/hyperactivity disorder (ADHD) have emerged in recent years that may be used as systematic guides for clinical research. The cognitive-energetic model (CEM) proposes that the overall efficiency of information processing is determined by the interplay of three levels: computational mechanisms of attention, state factors, and management/executive function (EF). The CEM encompasses both top-down and bottom-up processes and draws attention to the fact that ADHD causes defects at all three levels. These include cognitive mechanisms, such as response output; energetic mechanisms, such as activation and effort; and management/EF deficits. Increasing evidence suggests that inhibition deficits associated with ADHD may, at least in part, be explained in terms of an energetic dysfunction. The activation and effort energetic pools appear most relevant to ADHD, being directly related to response organization; however, further testing of CEM is critically dependent on the development of direct measures of these energetic pools. The CEM is a comprehensive model of ADHD but is not without limitations. In particular, further research is required to define more specifically the relationship between process dysfunction and state dysregulation in ADHD.
    MeSH term(s) Animals ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Cognition/physiology ; Energy Metabolism/physiology ; Humans ; Inhibition (Psychology) ; Memory, Short-Term/physiology ; Models, Neurological ; Motor Activity/physiology ; Problem Solving/physiology ; Sleep/physiology
    Language English
    Publishing date 2005-06-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2004.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A behavioral neuroenergetics theory of ADHD.

    Killeen, Peter R / Russell, Vivienne A / Sergeant, Joseph A

    Neuroscience and biobehavioral reviews

    2013  Volume 37, Issue 4, Page(s) 625–657

    Abstract: Energetic insufficiency in neurons due to inadequate lactate supply is implicated in several neuropathologies, including attention-deficit/hyperactivity disorder (ADHD). By formalizing the mechanism and implications of such constraints on function, the ... ...

    Abstract Energetic insufficiency in neurons due to inadequate lactate supply is implicated in several neuropathologies, including attention-deficit/hyperactivity disorder (ADHD). By formalizing the mechanism and implications of such constraints on function, the behavioral Neuroenergetics Theory (NeT) predicts the results of many neuropsychological tasks involving individuals with ADHD and kindred dysfunctions, and entails many novel predictions. The associated diffusion model predicts that response times will follow a mixture of Wald distributions from the attentive state, and ex-Wald distributions after attentional lapses. It is inferred from the model that ADHD participants can bring only 75-85% of the neurocognitive energy to bear on tasks, and allocate only about 85% of the cognitive resources of comparison groups. Parameters derived from the model in specific tasks predict performance in other tasks, and in clinical conditions often associated with ADHD. The primary action of therapeutic stimulants is to increase norepinephrine in active regions of the brain. This activates glial adrenoceptors, increasing the release of lactate from astrocytes to fuel depleted neurons. The theory is aligned with other approaches and integrated with more general theories of ADHD. Therapeutic implications are explored.
    MeSH term(s) Attention/physiology ; Attention Deficit Disorder with Hyperactivity/genetics ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Attention Deficit Disorder with Hyperactivity/psychology ; Energy Metabolism/physiology ; Female ; Humans ; Lactic Acid/metabolism ; Male ; Memory, Short-Term/physiology ; Norepinephrine/physiology ; Psychomotor Performance/physiology ; Receptors, Adrenergic/physiology
    Chemical Substances Receptors, Adrenergic ; Lactic Acid (33X04XA5AT) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2013.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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