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  1. Article ; Online: GVHD: better safe than sorry.

    Bonifazi, Francesca

    Blood

    2023  Volume 142, Issue 8, Page(s) 680–682

    MeSH term(s) Humans ; Abatacept ; Graft vs Host Disease/etiology
    Chemical Substances Abatacept (7D0YB67S97)
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023021552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients.

    Bagnato, Gianmarco / Stefoni, Vittorio / Broccoli, Alessandro / Argnani, Lisa / Pellegrini, Cinzia / Casadei, Beatrice / Bonifazi, Francesca / Zinzani, Pier Luigi

    Mediterranean journal of hematology and infectious diseases

    2024  Volume 16, Issue 1, Page(s) e2024004

    Abstract: We report the case of 2 patients with relapsed/refractory peripheral T-cell lymphoma treated with valemetostat tosylate, a selective dual inhibitor of histone-lysine N-methyltransferases enhancer of zest homolog 1 and 2, and subsequently bridged to ... ...

    Abstract We report the case of 2 patients with relapsed/refractory peripheral T-cell lymphoma treated with valemetostat tosylate, a selective dual inhibitor of histone-lysine N-methyltransferases enhancer of zest homolog 1 and 2, and subsequently bridged to allogeneic stem cell transplantation. Valemetostat led to a quick response and was well tolerated, offering a promising bridge therapy to transplantation for patients with relapsed/refractory peripheral T-cell lymphoma, which is still an unmet medical need.
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Case Reports
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2024.004
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  3. Article ; Online: Malignant pleural effusion: current understanding and therapeutic approach.

    Gonnelli, Francesca / Hassan, Wafa / Bonifazi, Martina / Pinelli, Valentina / Bedawi, Eihab O / Porcel, José M / Rahman, Najib M / Mei, Federico

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 47

    Abstract: Malignant pleural effusion (MPE) is a common complication of thoracic and extrathoracic malignancies and is associated with high mortality and elevated costs to healthcare systems. Over the last decades the understanding of pathophysiology mechanisms, ... ...

    Abstract Malignant pleural effusion (MPE) is a common complication of thoracic and extrathoracic malignancies and is associated with high mortality and elevated costs to healthcare systems. Over the last decades the understanding of pathophysiology mechanisms, diagnostic techniques and optimal treatment intervention in MPE have been greatly advanced by recent high-quality research, leading to an ever less invasive diagnostic approach and more personalized management. Despite a number of management options, including talc pleurodesis, indwelling pleural catheters and combinations of the two, treatment for MPE remains symptom directed and centered around drainage strategy. In the next future, because of a better understanding of underlying tumor biology together with more sensitive molecular diagnostic techniques, it is likely that combined diagnostic and therapeutic procedures allowing near total outpatient management of MPE will become popular. This article provides a review of the current advances, new discoveries and future directions in the pathophysiology, diagnosis and management of MPE.
    MeSH term(s) Humans ; Pleural Effusion, Malignant/diagnosis ; Pleural Effusion, Malignant/therapy ; Pleurodesis ; Talc ; Catheters, Indwelling ; Drainage/methods
    Chemical Substances Talc (14807-96-6)
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-024-02684-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cost of implementing CAR-T activity and managing CAR-T patients: an exploratory study.

    Cavallo, Maria Caterina / Cavazza, Marianna / Bonifazi, Francesca / Casadei, Beatrice / Cutini, Ilaria / Tonietti, Barbara / Saccardi, Riccardo / Zinzani, PierLuigi / Jommi, Claudio

    BMC health services research

    2024  Volume 24, Issue 1, Page(s) 121

    Abstract: Background: Chimeric antigen receptor T cells (CAR-T) represent an innovation but raise issues for healthcare payers because of the uncertainty on impact at market launch, high cost and important organisational impact. The literature has focused on ... ...

    Abstract Background: Chimeric antigen receptor T cells (CAR-T) represent an innovation but raise issues for healthcare payers because of the uncertainty on impact at market launch, high cost and important organisational impact. The literature has focused on their assessment, appraisal and market access solutions. No evidence on the costs sustained to implement CAR-T is available and a few studies reported the cost of the CAR-T clinical pathway, including the activities that are remunerated through inpatient or outpatient fee-for-service/episode. This paper aims at filling the information gap, assessing the cost of implementing CAR-T activity and the full cost of managing the CAR-T clinical pathway.
    Methods: Cost analysis relied on the Activity Based Costing approach, which was applied to two Italian healthcare organisations, both CAR-T Centres authorized by the regional governments with a minimum of 20 patients treated with the first two CAR-T therapies launched on the market.
    Results: The cost of implementing CAR-T was estimated at €1.31 million (calculated for one of the organizations with complete data). Most of these costs (77%) were generated by quality assurance activity. The mean cost per patient entering the CAR-T pathway (59 and 27) and surviving at follow-up (21 and 5) ranges from €48K to €57K and from €96K to €106K, respectively. Fees for hospitalization and infusion of gene therapy accounts for more than 70% of these costs. The actual hospitalisation cost varies greatly across patients and is in general lower than the fee-for-episode paid by the region to the hospital.
    Conclusions: Despite its limitations (exploratory nature; the time spent by staff on activities which are not remunerated through fees was estimated through interviews with the CAR-T coordinators; cost items are not fully comparable), this research highlighted the relevant organisational and economic impact of CAR-T and provided important insights for policy makers and healthcare managers: the necessity to invest resources in CAR-T implementation; the need for assessing activities which are not remunerated through fees for service / episode; the opportunity to shift from fee-for-episode / service to bundled payments for CAR-T clinical pathway.
    MeSH term(s) Humans ; Receptors, Chimeric Antigen ; Inpatients ; Outpatients ; Administrative Personnel ; Costs and Cost Analysis
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-10443-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The complexity of stem cell transplants: can we improve our understanding?

    Bacigalupo, Andrea / Bonifazi, Francesca

    Haematologica

    2018  Volume 103, Issue 9, Page(s) 1417–1418

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Stem Cell Transplantation
    Language English
    Publishing date 2018-08-31
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2018.198010
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  6. Article ; Online: Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer.

    Zuccatosta, Lina / Mei, Federico / Sediari, Michele / Di Marco Berardino, Alessandro / Bonifazi, Martina / Barbisan, Francesca / Goteri, Gaia / Gasparini, Stefano / Gonnelli, Francesca

    Advances in respiratory medicine

    2023  Volume 91, Issue 1, Page(s) 1–8

    Abstract: Introduction: The role of EBUS-TBNA in the diagnosis and staging of lung cancer is well established. EBUS-TBNA can be performed using different aspiration techniques. The most common aspiration technique is known as "suction". One alternative to the ... ...

    Abstract Introduction: The role of EBUS-TBNA in the diagnosis and staging of lung cancer is well established. EBUS-TBNA can be performed using different aspiration techniques. The most common aspiration technique is known as "suction". One alternative to the suction technique is the slow-pull capillary aspiration. To the best of our knowledge, no studies have assessed the diagnostic yield of slow-pull capillary EBUS-TBNA in PD-L1 amplification assessment in NSCLC. Herein, we conducted a single-centre retrospective study to establish the diagnostic yield of slow-pull capillary EBUS-TBNA in terms of PD-L1 in patients with NSCLC and hilar/mediastinal lymphadenopathies subsequent to NSCLC.
    Materials and methods: Patients with hilar and/or mediastinal lymph node (LN) NSCLC metastasis, diagnosed by EBUS-TBNA between January 2021 and April 2022 at Pulmonology Unit of "Ospedali Riuniti di Ancona" (Ancona, Italy) were enrolled. We evaluated patient characteristics, including demographic information, CT scan/ FDG-PET features and final histological diagnoses, including PD-L1 assessment.
    Results: A total of 174 patients underwent EBUS-TBNA for diagnosis of hilar/mediastinal lymphadenopathies between January 2021 and April 2022 in the Interventional Pulmonology Unit of the "Ospedali Riuniti di Ancona". Slow-pull capillary aspiration was adopted in 60 patients (34.5%), and in 30/60 patients (50.0%) NSCLC was diagnosed. EBUS-TBNA with slow-pull capillary aspiration provided adequate sampling for molecular biology and PD-L1 testing in 96.7% of patients (29/30); in 15/29 (51.7%) samples with more than 1000 viable cells/HPF were identified, whereas in 14/29 (48.3%) samples contained 101-1000 viable cells/HPF.
    Conclusion: These retrospective study shows that slow-pull capillary aspiration carries an excellent diagnostic accuracy, almost equal to that one reported in literature, supporting its use in EBUS-TBNA for PD-L1 testing in NSCLC.
    MeSH term(s) Humans ; B7-H1 Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lymphadenopathy ; Lymphatic Metastasis/diagnostic imaging ; Retrospective Studies
    Chemical Substances B7-H1 Antigen ; CD274 protein, human
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.3390/arm91010001
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  7. Article ; Online: OBITUARY- Riccardo Saccardi (20th April 1956-19th February 2024).

    Bacigalupo, Andrea / Bonifazi, Francesca / Ciceri, Fabio / Gluckman, Eliane / Greco, Raffaella / Nozzoli, Chiara / Lombardini, Letizia / Martino, Massimo / Rambaldi, Alessandro / Rocha, Vanderson / Ruggeri, Annalisa / Snowden, John / Sureda, Anna

    Bone marrow transplantation

    2024  

    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Editorial
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02296-1
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  8. Article ; Online: Correction to: Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy.

    Pensato, Umberto / Pondrelli, Federica / de Philippis, Chiara / Asioli, Gian Maria / Crespi, Alessandra / Buizza, Alessandro / Mannina, Daniele / Casadei, Beatrice / Maffini, Enrico / Straffi, Laura / Marcheselli, Simona / Zinzani, Pier Luigi / Bonifazi, Francesca / Guarino, Maria / Bramanti, Stefania

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  

    Language English
    Publishing date 2024-04-04
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07510-y
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  9. Article ; Online: CMV-RNAemia as new marker of active viral replication in transplant recipients.

    Piccirilli, Giulia / Lanna, Federica / Gabrielli, Liliana / Motta, Vincenzo / Franceschiello, Martina / Cantiani, Alessia / Pavoni, Matteo / Leone, Marta / Borgatti, Eva Caterina / Gibertoni, Dino / Pascale, Renato / Giannella, Maddalena / Bonifazi, Francesca / Lazzarotto, Tiziana

    Journal of clinical microbiology

    2024  , Page(s) e0163023

    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Letter
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.01630-23
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  10. Article ; Online: Hepatosplenic T-Cell Non-Hodgkin Lymphoma Cured with Tandem Autologous and Allogeneic Stem Cell Transplantation.

    Lolli, Ginevra / Casadei, Beatrice / Stefoni, Vittorio / Argnani, Lisa / Bonifazi, Francesca / Zinzani, Pier Luigi

    Chemotherapy

    2022  Volume 67, Issue 4, Page(s) 253–255

    Abstract: Hepatosplenic T-cell lymphoma is a very difficult lymphoma to deal with, almost impossible to cure. "Tandem" consolidation therapy with auto-stem cell transplant and allo-stem cell transplant can induce a long-lasting response and potentially cure this ... ...

    Abstract Hepatosplenic T-cell lymphoma is a very difficult lymphoma to deal with, almost impossible to cure. "Tandem" consolidation therapy with auto-stem cell transplant and allo-stem cell transplant can induce a long-lasting response and potentially cure this disease.
    MeSH term(s) Humans ; Transplantation, Homologous ; Transplantation, Autologous ; Hematopoietic Stem Cell Transplantation/adverse effects ; Lymphoma, Non-Hodgkin/therapy ; T-Lymphocytes
    Language English
    Publishing date 2022-05-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 6708-8
    ISSN 1421-9794 ; 0009-3157
    ISSN (online) 1421-9794
    ISSN 0009-3157
    DOI 10.1159/000524891
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