LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 117

Search options

  1. Article ; Online: MedOptNet: Meta-Learning Framework for Few-shot Medical Image Classification.

    Lu, Liangfu / Cui, Xudong / Tan, Zhiyuan / Wu, Yulei

    IEEE/ACM transactions on computational biology and bioinformatics

    2023  Volume PP

    Abstract: In the medical research domain, limited data and high annotation costs have made efficient classification under few-shot conditions a popular research area. This paper proposes a meta-learning framework, termed MedOptNet, for few-shot medical image ... ...

    Abstract In the medical research domain, limited data and high annotation costs have made efficient classification under few-shot conditions a popular research area. This paper proposes a meta-learning framework, termed MedOptNet, for few-shot medical image classification. The framework enables the use of various high-performance convex optimization models as classifiers, such as multi-class kernel support vector machines, ridge regression, and other models. End-to-end training is then implemented using dual problems and differentiation in the paper. Additionally, various regularization techniques are employed to enhance the model's generalization capabilities. Experiments on the BreakHis, ISIC2018, and Pap smear medical few-shot datasets demonstrate that the MedOptNet framework outperforms benchmark models. Moreover, the model training time is also compared to prove its effectiveness in the paper, and an ablation study is conducted to validate the effectiveness of each module.
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article
    ISSN 1557-9964
    ISSN (online) 1557-9964
    DOI 10.1109/TCBB.2023.3284846
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Coexistence of a nonresistance-conferring IncI1 plasmid favors persistence of the

    He, Kun / Lin, Jiayu / Liang, Yulei / Cui, Junling / Chen, Qiuru / Dong, Yanbin / Ma, Xiaoyuan / He, Dandan / Yuan, Li

    Microbiology spectrum

    2024  , Page(s) e0424023

    Abstract: The interaction between coexisting plasmids can affect plasmid-carried resistance gene persistence and spread. However, whether the persistence of the : Importance: So far, plasmid- ... ...

    Abstract The interaction between coexisting plasmids can affect plasmid-carried resistance gene persistence and spread. However, whether the persistence of the
    Importance: So far, plasmid-carried
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04240-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Application of 3D-printed osteotomy guide plates in proximal femoral osteotomy for DDH in children: a retrospective study.

    Sun, Jian / Mu, Yulei / Cui, Yong / Qu, Jing / Lian, Feng

    Journal of orthopaedic surgery and research

    2023  Volume 18, Issue 1, Page(s) 315

    Abstract: Background: Patients with developmental dysplasia of the hip (DDH) have complex proximal femoral deformities, and orthopedic surgery lacks objectivity. Expectations for surgical outcomes are often not achieved, and postoperative problems are common. ... ...

    Abstract Background: Patients with developmental dysplasia of the hip (DDH) have complex proximal femoral deformities, and orthopedic surgery lacks objectivity. Expectations for surgical outcomes are often not achieved, and postoperative problems are common. Using 3D-printed technology in orthopedics offers a novel approach to precise and individualized treatment in modern orthopedics. The aim of this study was to investigate the value of the application of 3D-printed osteotomy guide plates in femoral osteotomy. The clinical indices of femoral osteotomy in children with DDH using 3D-printed osteotomy guide plates were compared with those of traditional osteotomy.
    Methods: The clinical data of children with DDH who underwent open reduction and Salter pelvic osteotomy combined with femoral osteotomy from September 2010 to September 2020 were retrospectively collected and analyzed. Based on the inclusion and exclusion criteria, a total of 36 patients were included in the study: 16 in the guide plate group and 20 in the conventional group. Operation time (total), operation time (femoral side), X-ray fluoroscopy times (total), X-ray fluoroscopy times (femoral side) and intraoperative blood loss were analyzed and compared between the two groups. Comparison of treatment-related indicators such as postoperative neck-shaft angle, postoperative anteversion angle, hospitalization time, and hospitalization expenses is made between the two groups. The two groups of patients were evaluated at the last follow-up using the McKay clinical evaluation criteria.
    Results: Between the two groups, there were significant differences in operation time (total), operation time (femoral side), X-ray fluoroscopy times (total), X-ray fluoroscopy times (femoral side) and intraoperative blood loss (P < 0.05). The postoperative neck-shaft angle, postoperative anteversion angle, hospitalization time and hospitalization expenses did not differ significantly (P > 0.05). The MacKay clinical evaluation did not significantly differ at the most recent follow-up (P > 0.05).
    Conclusions: Children with DDH undergoing proximal femoral osteotomy using 3D-printed osteotomy guide plates benefit from a simpler surgical procedure, shorter operative time, less bleeding and less radiation exposure during surgery. This technique is of great clinical value.
    MeSH term(s) Humans ; Child ; Retrospective Studies ; Hip Dislocation, Congenital/surgery ; Blood Loss, Surgical ; Osteotomy/methods ; Printing, Three-Dimensional ; Treatment Outcome
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-023-03801-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Cost-Effective Fabrication of Modified Palygorskite-Reinforced Rigid Polyurethane Foam Nanocomposites.

    Wang, Yulei / Cui, Kaibin / Fang, Baizeng / Wang, Fei

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: Integration of nanoclay minerals into rigid polyurethane foams (RPUFs) is a cost-effective solution to enhance foam's performance via environmental protection technology. In this work, palygorskite/RPUFs nanocomposites (Pal/RPUFNs) with excellent ... ...

    Abstract Integration of nanoclay minerals into rigid polyurethane foams (RPUFs) is a cost-effective solution to enhance foam's performance via environmental protection technology. In this work, palygorskite/RPUFs nanocomposites (Pal/RPUFNs) with excellent mechanical properties and thermal stability were prepared via a one-step method, using 4,4'-diphenylmethane diisocyanate and polyether polyol as the starting materials, coupled with Pal modified by silane coupling agent KH570. The effects of the modified Pal on the mechanics, morphology, and thermal properties of the nanocomposites were studied systematically. When the content of the modified Pal was 8 wt% of polyether polyol, the elastic modulus and compressive strength of the Pal/RPUFNs were increased by ca. 131% and 97%, respectively. The scanning electron microscopy images indicated that the addition of the modified Pal significantly decreased the cell diameter of the Pal/RPUFNs. The results of thermogravimetric and derivative thermogravimetry analyses revealed that the addition of the modified Pal increased the thermal weight loss central temperature of the Pal/RPUFNs, showing better thermal stability in comparison with the pure RPUFs. A self-made evaluation device was used to estimate the thermal insulation ability of the Pal/RPUFNs. It was found that the small cell size and uniform cellular structure were keys to improving the thermal insulation performance of the RPUFs. The prepared Pal/RPUFNs are expected to have great potential in the field of building insulation.
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12040609
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Large-scale targetedly isolation of biflavonoids with high purity from industrial waste Ginkgo biloba exocarp using two-dimensional chromatography coupled with macroporous adsorption resin enrichment

    Shen, Na / Liu, Yanxia / Cui, Yulei / Xin, Huawei

    Industrial crops and products. 2022 Jan., v. 175

    2022  

    Abstract: Seeds and leaves of Ginkgo biloba have been widely applied for industrial application, viewing and medicinal resource. However, the exocarp of G. biloba is usually abandoned and considered as industrial waste. In this work, an efficient and industrially ... ...

    Abstract Seeds and leaves of Ginkgo biloba have been widely applied for industrial application, viewing and medicinal resource. However, the exocarp of G. biloba is usually abandoned and considered as industrial waste. In this work, an efficient and industrially viable protocol for large-scale targetedly isolation of bioactive biflavonoids with high purity from industrial waste G. biloba exocarp was established firstly. Macroporous adsorption resin was used for enriching bioflavonoids, and targeted on-line recognition of biflavonoids was based on their characteristic UV absorption at 210, 270 and 330 nm. Two-dimensional preparative normal phase/reversed phase HPLC-DAC50 system was applied for isolating biflavonoids. A total of 3 biflavonoids including bilobetin, ginkgetin and isoginkgetin were isolated and their purity > 99.0%, dozens or hundreds of milligrams were obtained in one isolation within 30 min. This work will not only provide an effective method for isolating large-scale high purity biflavonoids, but contribute to making full use resources of industrial waste G. biloba exocarp.
    Keywords Ginkgo biloba ; absorption ; adsorption ; bioflavonoids ; chromatography ; exocarp ; industrial applications ; industrial wastes ; porous media ; seeds
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2021.114264
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  6. Article ; Online: Unsaturated fatty acids in natural edible resources, a systematic review of classification, resources, biosynthesis, biological activities and application

    Liu, Yao / Shen, Na / Xin, Huawei / Yu, Lili / Xu, Qing / Cui, Yulei

    Food Bioscience. 2023 May 29, p.102790-

    2023  , Page(s) 102790–

    Abstract: Unsaturated fatty acids are widely distributed in natural edible resources, and have various uses and biological activities. However, no relevant review on unsaturated fat acids from natural edible resources has been found. Therefore, this paper reviewed ...

    Abstract Unsaturated fatty acids are widely distributed in natural edible resources, and have various uses and biological activities. However, no relevant review on unsaturated fat acids from natural edible resources has been found. Therefore, this paper reviewed unsaturated fatty acids in natural edible resources, including the classification and resources of unsaturated fatty acids, biosynthetic pathway, biological activities and application. It was found that unsaturated fatty acids have good therapeutic value in preventing oxidative stress, inflammation, cardiovascular and cerebrovascular diseases, cancer and osteoporosis. This paper will provide reference for the study of unsaturated fatty acids in natural edible resources.
    Keywords biochemical pathways ; biosynthesis ; inflammation ; osteoporosis ; oxidative stress ; systematic review ; therapeutics ; unsaturated fats ; Unsaturated fatty acids ; Natural edible resources ; Bioactivity ; Application
    Language English
    Dates of publication 2023-0529
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ISSN 2212-4292
    DOI 10.1016/j.fbio.2023.102790
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  7. Article ; Online: Iridium-Catalyzed Enantioselective Transfer Hydrogenation of 1,1-Dialkylethenes with Ethanol: Scope and Mechanism.

    Qian, Lu / Yu, Cui / Gan, Lan / Tang, Xixia / Wang, Yulei / Liu, Guixia / Leng, Xuebing / Sun, Zhao / Guo, Yinlong / Xue, Xiao-Song / Huang, Zheng

    Journal of the American Chemical Society

    2024  Volume 146, Issue 5, Page(s) 3427–3437

    Abstract: Despite half a century's advance in the field of transition-metal-catalyzed asymmetric alkene hydrogenation, the enantioselective hydrogenation of purely alkyl-substituted 1,1-dialkylethenes has remained an unmet challenge. Herein, we describe a chiral ... ...

    Abstract Despite half a century's advance in the field of transition-metal-catalyzed asymmetric alkene hydrogenation, the enantioselective hydrogenation of purely alkyl-substituted 1,1-dialkylethenes has remained an unmet challenge. Herein, we describe a chiral PCN
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c12985
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Network pharmacology and molecular docking combined with widely targeted metabolomics to elucidate the potential compounds and targets of Euphorbia helioscopia seeds for the treatment of pulmonary fibrosis.

    Liu, Yanxia / Sun, Wanqing / Shen, Na / Hao, Wenhua / Xin, Huawei / Che, Fengyuan / Cui, Yulei

    Computers in biology and medicine

    2023  Volume 160, Page(s) 107007

    Abstract: Background: The whole herb of Euphorbia helioscopia has been traditionally used for treating pulmonary tuberculosis, malaria, warts, lung cancer and bacillary dysentery for a long time in China. However, E. helioscopia seeds are often discarded and its ... ...

    Abstract Background: The whole herb of Euphorbia helioscopia has been traditionally used for treating pulmonary tuberculosis, malaria, warts, lung cancer and bacillary dysentery for a long time in China. However, E. helioscopia seeds are often discarded and its medicinal value is often ignored, resulting in a waste of resources.
    Method: In this work, widely targeted metabolomics based on UPLC-ESI-QTRAP-MS/MS methods and metware database (MWDB) were firstly used to identify the chemical compositions of EHS. Besides, network pharmacology, molecular docking and molecular dynamics simulation were performed for elucidating the potential compounds and targets of E. helioscopia seeds for the treatment of pulmonary fibrosis via common database (like TCMSP, Genecards, DAVID, STRING) and common software (like Sybyl, Cytoscape, Pymol and Schrödinger).
    Result: The results of widely targeted metabolomics showed 231 compounds including 12 categories were identified. The highest content compositions are lipids (33.89%) followed by amino acids and derivatives (21.78%), nucleotides and derivatives (15.73%), as well as the content of functional ingredients like phenolic acids (7.33%), alkaloids (7.03%) and flavonoids (4.51%) are relatively high. Besides, the results of network pharmacology and molecular docking showed that EHS presented anti-pulmonary fibrosis medicinal value through multi-ingredients, multi-targets and multi-pathways approach. Key ingredients including 9-Hydroxy-12-oxo-15(Z)-octadecenoic acid, Nordihydrocapsiate, 1-O-Salicyl-d-glucose, 9-(Arabinosyl)hypoxanthine, Xanthosine and Galangin-7-O-glucoside. Key targets including SRC, HSP90AA1, AKT1, EGFR, JUN, EP300 and VEGFA, and key signaling pathways mainly related to AGE-RAGE, EGFR tyrosine kinase inhibitor resistance, VEGF and HIF-1 signaling pathway. Molecular dynamics simulation showed that HSP90AA1 and 9-Hydroxy-12-oxo-15(Z)-octadecenoic complex (with the highest docking score) have a stable combination effect.
    Conclusion: In conclusion, this study revealed the chemical compositions of EHS and its anti-pulmonary fibrosis medicinal effect for the first time, it will provide scientific insight for the development of EHS as medicinal resource.
    MeSH term(s) Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; ErbB Receptors ; Euphorbia ; Fibrosis ; Molecular Docking Simulation ; Network Pharmacology ; Tandem Mass Spectrometry ; Humans
    Chemical Substances Drugs, Chinese Herbal ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2023.107007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Gypsophila oldhamiana leaves as a potential industrial resource of lipids, alkaloids, flavonoids and anti-osteoporosis components

    Shen, Na / Li, Yuanrong / Liu, Yanxia / Liu, Yao / Xin, Huawei / Cui, Yulei

    Industrial Crops & Products. 2023 June, v. 196 p.116510-

    2023  

    Abstract: The usage of Gypsophila oldhamiana roots for bone growth can be traced back to many years ago in China. However, G.oldhamiana leaves (GOL) is often discarded in modern times or picked as wild vegetable in famine age, researches on the chemical components ...

    Abstract The usage of Gypsophila oldhamiana roots for bone growth can be traced back to many years ago in China. However, G.oldhamiana leaves (GOL) is often discarded in modern times or picked as wild vegetable in famine age, researches on the chemical components of GOL are lacking, and the possible industrial application of GOL is still unclear. In this study, widely targeted metabolomics were used to reveal the secondary metabolites of GOL qualitatively and quantitatively. Network pharmacology and molecular docking were used to explore the potential anti-osteoporosis effect of GOL and possible mechanism. Results showed that lipids, alkaloids and flavonoids are the main ingredients in GOL. Network pharmacology results indicated that the anti-osteoporosis effect of GOL is involved in 148 signaling pathways, 78 ingredients and related 147 targets. Among them, AGE-RAGE, HIF-1, and PI3K-Akt signaling pathway are the main signal pathways for treating osteoporosis. 9-Hydroxy-12-oxo-15(Z)-octadecenoic acid, 10-Heptadecenoic Acid, 9,10,13-Trihydroxy-11-Octadecenoic Acid, 9,12,13-Trihydroxy-10,15-octadecadienoic acid, 3-O-Acetylpinobanksin and L-Leucyl-L- phenylalanine are the main bioactive ingredients which regulated above pathways through binding with MAPK1, MAPK3, RXRA, AKT1, ESR1 and STAT3 targets, respectively. In conclusion, our results showed that GOL is a potential industrially functional resource for obtaining lipids, alkaloids and flavonoids.
    Keywords Gypsophila ; famine ; flavonoids ; industrial applications ; metabolomics ; osteoporosis ; pharmacology ; phenylalanine ; secondary metabolites ; vegetables ; China ; Gypsophila oldhamiana leaves ; UPLC-ESI-QTRAP-MS/MS ; Network pharmacology ; Molecular docking
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2023.116510
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  10. Article ; Online: Effect of fertilizer and harvesting stage on growth and bioactive compounds content of Rheum tanguticum

    Shen, Na / Xu, Wenhua / Guo, Fengxia / Cui, Yulei / Chen, Yuan / Su, Xinyang

    Journal of Plant Nutrition. 2023 Nov. 8, v. 46, no. 18 p.4462-4476

    2023  

    Abstract: Rhubarb is a popular food in Europe due to the purgative action. Cultivation is the key way to ensure sustainable development and utilization of this herbal plant. In this paper, standardized cultivation of Rheum tanguticum (a kind of rhubarb) was ... ...

    Abstract Rhubarb is a popular food in Europe due to the purgative action. Cultivation is the key way to ensure sustainable development and utilization of this herbal plant. In this paper, standardized cultivation of Rheum tanguticum (a kind of rhubarb) was explored through a three-year field experiment which investigated the effect of phosphorus (P) and potassium (K) fertilizer on growth indexes, sennoside content of R. tanguticum at different harvesting stages. Results showed that P and K fertilizer significantly increased root length, root diameter and root fresh weight, the maximum root fresh weight was 894.22 g/plant. Sennoside content of three-year-old R. tanguticum applied K fertilizer was over 5.87% at each harvesting stage in the third growth cycle and it increased along with growing year. Sennoside content has no obviously increment at the same harvesting stage, it also has no positive correlation with different harvesting stages and the wilting stage > green stage > growth stage in the same year. This study demonstrated that P and K fertilizer had accelerated effect on growth of R. tanguticum at the same harvesting stage, but had no obvious influence on the sennoside content. This will provide experimental data and guidance for the standardized cultivation of R. tanguticum. HighlightsThe effect of different fertilizer (P, K) doses, harvesting stages and growth years on growth indexes and sennosides contents of R. tanguticum was firstly explored. A modified HPLC detective method was developed to quantify the sennosides content of R. tanguticum. The effect of different fertilizer doses on growth indexes of R. tanguticum was firstly explored. Variation of sennoside content after applying fertilizers was firstly explored. The effect of harvesting stages on growth indexes and sennosides contents was firstly explored.
    Keywords Rheum tanguticum ; developmental stages ; field experimentation ; phosphorus ; plant nutrition ; potassium ; potassium fertilizers ; rhubarb ; sennosides ; sustainable development ; Europe ; Fertilizer ; growth indexes ; harvesting stages ; sennoside content
    Language English
    Dates of publication 2023-1108
    Size p. 4462-4476.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 446190-3
    ISSN 1532-4087 ; 0190-4167
    ISSN (online) 1532-4087
    ISSN 0190-4167
    DOI 10.1080/01904167.2023.2232407
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

To top