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  1. Article ; Online: Gut Distribution, Impact Factor, and Action Mechanism of Bacteriocin-Producing Beneficial Microbes as Promising Antimicrobial Agents in Gastrointestinal Infection.

    Peng, Zhen / Wang, Donglin / He, Yuyan / Wei, Ziqi / Xie, Mingyong / Xiong, Tao

    Probiotics and antimicrobial proteins

    2024  

    Abstract: Gastrointestinal (GI) infection by intestinal pathogens poses great threats to human health, and the therapeutic use of antibiotics has reached a bottleneck due to drug resistance. The developments of antimicrobial peptides produced by beneficial ... ...

    Abstract Gastrointestinal (GI) infection by intestinal pathogens poses great threats to human health, and the therapeutic use of antibiotics has reached a bottleneck due to drug resistance. The developments of antimicrobial peptides produced by beneficial bacteria have drawn attention by virtue of effective, safe, and not prone to developing resistance. Though bacteriocin as antimicrobial agent in gut infection has been intensively investigated and reviewed, reviews on that of bacteriocin-producing beneficial microbes are very rare. It is important to explicitly state the prospect of bacteriocin-producing microbes in prevention of gastrointestinal infection towards their application in host. This review discusses the potential of gut as an appropriate resource for mining targeted bacteriocin-producing microbes. Then, host-related factors affecting the bacteriocin production and activity of bacteriocin-producing microbes in the gut are summarized. Accordingly, the multiple mechanisms (direct inhibition and indirect inhibition) behind the preventive effects of bacteriocin-producing microbes on gut infection are discussed. Finally, we propose several targeted strategies for the manipulation of bacteriocin-producing beneficial microbes to improve their performance in antimicrobial outcomes. We anticipate an upcoming emergence of developments and applications of bacteriocin-producing beneficial microbes as antimicrobial agent in gut infection induced by pathogenic bacteria.
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2487792-X
    ISSN 1867-1314 ; 1867-1306
    ISSN (online) 1867-1314
    ISSN 1867-1306
    DOI 10.1007/s12602-024-10222-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correlation between ESR1 and APOE gene polymorphisms and risk of osteonecrosis of the femoral head: a case-control study.

    Wang, Yuan / Ma, Xiaoya / Guo, Jinping / Li, Yujie / Xiong, Yuyan

    Journal of orthopaedic surgery and research

    2023  Volume 18, Issue 1, Page(s) 968

    Abstract: Background: Osteonecrosis of the femoral head (ONFH) is a disease with a high disability rate, and genetic factors are closely related to its pathogenesis. This study aimed to investigate the possible correlation between ESR1 and APOE gene polymorphisms ...

    Abstract Background: Osteonecrosis of the femoral head (ONFH) is a disease with a high disability rate, and genetic factors are closely related to its pathogenesis. This study aimed to investigate the possible correlation between ESR1 and APOE gene polymorphisms and the risk of ONFH.
    Methods: In this case-control study, the potential association between three genetic variants (rs2982573 C < T, rs10872678 C < T, and rs9322332 A < C) of the ESR1 gene and two genetic variants (rs7259620 A < G and rs769446 C < T) of the APOE gene with the risk of ONFH was investigated. Correlations between gene polymorphisms and ONFH risk were assessed using logistic regression analysis, with calculation of odds ratios (ORs) and 95% confidence intervals (CIs).
    Results: The overall analysis demonstrated that rs9322332 in the ESR1 gene exhibited a correlation with a decreased risk of ONFH under the homozygous (AA vs.CC: OR = 0.69, 95% CI [0.53-0.90], p = 0.006), dominant (CA + AA vs. CC: OR = 0.70, 95% CI [0.54-0.90], p = 0.006), and additive (OR = 0.79, 95% CI [0.66-0.95], p = 0.013) models. The stratification analysis revealed that rs9322332 was linked to a lower risk of ONFH in subgroups characterized by individuals aged over 51 years and non-smokers. Nevertheless, there were no notable correlations found between ESR1 rs2982573 and rs10872678, as well as APOE rs7259620 and rs769446, with the risk of ONFH.
    Conclusion: ESR1-rs9322332 is closely linked to a decreased risk of ONFH, thereby enhancing our understanding of the relationship between gene polymorphisms and ONFH.
    MeSH term(s) Aged ; Humans ; Apolipoproteins E/genetics ; Case-Control Studies ; Femur Head ; Femur Head Necrosis/genetics ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Estrogen Receptor alpha/genetics
    Chemical Substances Apolipoproteins E ; ESR1 protein, human ; ApoE protein, human ; Estrogen Receptor alpha
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-023-04447-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Analysis of Gut Microbiome Structure Based on GMPR+Spectrum

    Xin Xiong / Yuyan Ren / Jianfeng He

    Applied Sciences, Vol 12, Iss 5895, p

    2022  Volume 5895

    Abstract: The gut microbiome is related to many major human diseases, and it is of great significance to study the structure of the gut microbiome under different conditions. Multivariate statistics or pattern recognition methods were often used to identify ... ...

    Abstract The gut microbiome is related to many major human diseases, and it is of great significance to study the structure of the gut microbiome under different conditions. Multivariate statistics or pattern recognition methods were often used to identify different structural patterns in gut microbiome data. However, these methods have some limitations. Minimal hepatic encephalopathy (MHE) datasets were taken as an example. Due to the physical lack or insufficient sampling of the gut microbiome in the sequencing process, the microbiome data contains many zeros. Therefore, the geometric mean of pairwise ratios (GMPR) was used to normalize gut microbiome data, then Spectrum was used to analyze the structure of the gut microbiome, and lastly, the structure of core microflora was compared with Network analysis. GMPR calculates the Intraclass correlation coefficient (ICC), whose reproducibility was significantly better than other normalization methods. In addition, running-time, Normalized Mutual Information (NMI), Davies-Boulding Index (DBI), and Calinski-Harabasz index (CH) of GMPR+Spectrum were far superior to other clustering algorithms such as M3C, iClusterPlus. GMPR+Spectrum can not only perform better but also effectively identify the structural differences of intestinal microbiota in different patients and excavate the unique critical bacteria such as Akkermansia , and Lactobacillus in MHE patients, which may provide a new reference for the study of the gut microbiome in disease.
    Keywords spectrum ; normalization ; gut microbiome ; minimal hepatic encephalopathy ; hepatic encephalopathy ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 006
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Cardiac Fibrosis: Cellular Effectors, Molecular Pathways, and Exosomal Roles.

    Jiang, Wenyang / Xiong, Yuyan / Li, Xiaosong / Yang, Yuejin

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 715258

    Abstract: Cardiac fibrosis, a common pathophysiologic process in most heart diseases, refers to an excess of extracellular matrix (ECM) deposition by cardiac fibroblasts (CFs), which can lead to cardiac dysfunction and heart failure subsequently. Not only CFs but ... ...

    Abstract Cardiac fibrosis, a common pathophysiologic process in most heart diseases, refers to an excess of extracellular matrix (ECM) deposition by cardiac fibroblasts (CFs), which can lead to cardiac dysfunction and heart failure subsequently. Not only CFs but also several other cell types including macrophages and endothelial cells participate in the process of cardiac fibrosis
    Language English
    Publishing date 2021-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.715258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An insight into novel therapeutic potentials of taxifolin.

    Liu, Yang / Shi, Xiaolu / Tian, Ye / Zhai, Shaobo / Liu, Yuyan / Xiong, Zhengrong / Chu, Shunli

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1173855

    Abstract: Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees, which is often found in foods such as onions and olive oil, and is also used in commercial preparations, and has attracted the interest of nutritionists and ... ...

    Abstract Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees, which is often found in foods such as onions and olive oil, and is also used in commercial preparations, and has attracted the interest of nutritionists and medicinal chemists due to its broad range of health-promoting effects. It is a powerful antioxidant with excellent antioxidant, anti-inflammatory, anti-microbial and other pharmacological activities. This review focuses on the breakthroughs in taxifolin for the treatment of diseases from 2019 to 2022 according to various systems of the human body, such as the nervous system, immune system, and digestive system, and on the basis of this review, we summarize the problems of current research and try to suggest solutions and future research directions.
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1173855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The broadband emission of Cr

    Li, Yuyan / Jin, Ye / Fang, Fei / Lin, Huayan / Chen, Hongtao / Xiong, Yanbin / Liu, Yongfu / Ma, Li / Wang, Xiao-Jun

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 47, Page(s) 17776–17784

    Abstract: A phosphor-converted light-emitting diode (pc-LED) is a prime light source in smart broadband near-infrared (NIR) spectroscopy. The performance of NIR pc-LEDs crucially depends on the employed NIR luminescent materials. In this study, we synthesized a ... ...

    Abstract A phosphor-converted light-emitting diode (pc-LED) is a prime light source in smart broadband near-infrared (NIR) spectroscopy. The performance of NIR pc-LEDs crucially depends on the employed NIR luminescent materials. In this study, we synthesized a novel high-efficiency broadband NIR phosphor, CaY
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03370h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Effects of different crop starches on the cooking quality of Chinese dried noodles

    Li, Yao / Wang, Yuyan / Liu, Haibo / Liu, Xiong

    International journal of food science & technology. 2022 Apr., v. 57, no. 4

    2022  

    Abstract: To investigate the effects of seven starches made from different crop sources on noodle quality, Chinese dried noodles made from various reconstituted flours were prepared and analysed. Potato starch had better solubility and swelling power than the ... ...

    Abstract To investigate the effects of seven starches made from different crop sources on noodle quality, Chinese dried noodles made from various reconstituted flours were prepared and analysed. Potato starch had better solubility and swelling power than the other starches, leading to higher water absorption, cooking loss and breakage ratio of the potato starch noodles. The correlation results unravelled that the cooking breakage ratio of noodles presented positive correlations with solubility, swelling power, peak viscosity (PV), trough viscosity (TV) and final viscosity (FV) values of starches. Besides, the adhesiveness of noodles showed a positive correlation with conclusion temperature (Tc) and setback viscosity (SV) values of starches. Moreover, the peak temperature (Tₚ) value of starches was negatively correlated with cooking loss; the granule size of starches had a positive correlation with noodles water absorption; and the peak time (PkT) value of starches represented positive relationships with noodles chewiness, shearing force and breaking strength.
    Keywords adhesion ; chewiness ; noodles ; potato starch ; solubility ; temperature ; viscosity ; water uptake
    Language English
    Dates of publication 2022-04
    Size p. 2080-2092.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 883561-5
    ISSN 0950-5423
    ISSN 0950-5423
    DOI 10.1111/ijfs.15488
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2121: Show issues

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  8. Article ; Online: Modulation of Trivalent/Tetravalent Metallic Elements in Ni-Based Layered Double Hydroxides for Photocatalytic CO

    Wang, Ruonan / Wang, Xinyi / Xiong, Yongheng / Hou, Yuyan / Wang, Yaxuan / Ding, Jie / Zhong, Qin

    ACS applied materials & interfaces

    2022  Volume 14, Issue 31, Page(s) 35654–35662

    Abstract: Herein, by modulating trivalent/tetravalent metallic elements, NiMLDHs (M = Al, Co, Fe, Mn, and Ti) were successfully prepared and evaluated in photocatalytic ... ...

    Abstract Herein, by modulating trivalent/tetravalent metallic elements, NiMLDHs (M = Al, Co, Fe, Mn, and Ti) were successfully prepared and evaluated in photocatalytic CO
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c07940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Non-contact thermometer behavior of (Y

    Jin, Ye / Li, Kun / Chen, Hongtao / Fang, Fei / Li, Yuyan / Lin, Huayan / Xiong, Yanbin / Feng, Guoqing / Wang, Xiao-Jun / Ma, Li

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 29, Page(s) 10005–10012

    Abstract: Oxides are physically and chemically stable. Non-contact thermometer- ... ...

    Abstract Oxides are physically and chemically stable. Non-contact thermometer-Yb
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt01303k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Dysregulated Glucuronidation of Bilirubin Exacerbates Liver Inflammation and Fibrosis in Schistosomiasis Japonica through the NF-κB Signaling Pathway.

    Xue, Qingkai / Wang, Yuyan / Liu, Yiyun / Hua, Haiyong / Zhou, Xiangyu / Xu, Yongliang / Zhang, Ying / Xiong, Chunrong / Liu, Xinjian / Yang, Kun / Huang, Yuzheng

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Hepatic fibrosis is an important pathological manifestation of chronic schistosome infection. Patients with advanced schistosomiasis show varying degrees of abnormalities in liver fibrosis indicators and bilirubin metabolism. However, the relationship ... ...

    Abstract Hepatic fibrosis is an important pathological manifestation of chronic schistosome infection. Patients with advanced schistosomiasis show varying degrees of abnormalities in liver fibrosis indicators and bilirubin metabolism. However, the relationship between hepatic fibrosis in schistosomiasis and dysregulated bilirubin metabolism remains unclear. In this study, we observed a positive correlation between total bilirubin levels and the levels of ALT, AST, LN, and CIV in patients with advanced schistosomiasis. Additionally, we established mouse models at different time points following
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13040287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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