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Article ; Online: Corrigendum to "Comparison of antibiotic-resistant Escherichia coli and extra-intestinal pathogenic E. coli from main river basins under different levels of the sewer system development" [Ecotoxicol. Environ. Saf., 2023, 263, 115372].

Chen, Jung-Sheng / Hsu, Bing-Mu / Ko, Wen-Chien / Wang, Jiun-Ling

2024 Volume 274, Page(s) 116188

Language	English
Publishing date	2024-03-10
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116188
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Article ; Online: Poor in vitro activity of ceftazidime/avibactam against carbapenem-resistant Escherichia coli and Klebsiella pneumoniae in India: Results from the Antimicrobial Testing Leadership and Surveillance (ATLAS) program, 2018 - 2021.

Hsueh, Chun-Chung / Lai, Chih-Cheng / Tsai, Ya-Wen / Ko, Wen-Chien / Wang, Jiun-Ling

International journal of antimicrobial agents

2024 Volume 63, Issue 3, Page(s) 107087

MeSH term(s)	Ceftazidime/pharmacology ; Klebsiella pneumoniae ; Leadership ; Anti-Bacterial Agents/pharmacology ; Carbapenem-Resistant Enterobacteriaceae ; Escherichia coli ; Carbapenems/pharmacology ; Azabicyclo Compounds
Chemical Substances	Ceftazidime (9M416Z9QNR) ; avibactam (7352665165) ; Anti-Bacterial Agents ; Carbapenems ; Azabicyclo Compounds
Language	English
Publishing date	2024-01-12
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107087
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Article ; Online: Letter to the editor: More data on vaccine efficacy/effectiveness of COVID-19 vaccines against asymptomatic SARS-CoV-2 infection.

Chen, Ying-Wen / Ko, Wen-Chien

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2021 Volume 26, Issue 35

MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2021-09-03
Publishing country	Sweden
Document type	Letter ; Comment
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2021.26.35.2100826
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Article ; Online: In vitro activities of ceftazidime-avibactam, ceftolozane-tazobactam, meropenem-vaborbactam and other comparators against Pseudomonas aeruginosa isolates with discrepant resistance to carbapenems: Data from the Antimicrobial Testing Leadership and Surveillance (ATLAS) program, 2012-2021.

Lee, Yu-Lin / Ko, Wen-Chien / Hsueh, Po-Ren

International journal of antimicrobial agents

2023 Volume 62, Issue 2, Page(s) 106867

Abstract: Objectives: This study aimed to investigate the in vitro susceptibility and β-lactamase-encoding genes of Pseudomonas aeruginosa (P. aeruginosa) isolates with discrepant resistance to various carbapenems.: Methods: Data on P. aeruginosa isolates were ...

Abstract	Objectives: This study aimed to investigate the in vitro susceptibility and β-lactamase-encoding genes of Pseudomonas aeruginosa (P. aeruginosa) isolates with discrepant resistance to various carbapenems. Methods: Data on P. aeruginosa isolates were obtained from the Antimicrobial Testing Leadership and Surveillance program from 2012-2021. Minimum inhibitory concentrations of P. aeruginosa isolates were determined using the broth microdilution method. β-lactamase-encoding genes were identified using multiplex polymerase chain reaction assays. Results: Among the P. aeruginosa isolates that were tested, the percentages of isolates resistant to imipenem, meropenem and doripenem were 26.9% (14 447 of 53 617), 20.5% (14 098 of 68 897) and 17.5% (3660 of 20 946), respectively. Imipenem-resistant P. aeruginosa isolates were more susceptible to all tested antimicrobial agents (except colistin) than the meropenem-resistant or doripenem-resistant P. aeruginosa isolates. Carbapenemase genes were detected in 14.3% (2020 of 14 098) of meropenem-resistant P. aeruginosa isolates. Imipenem-resistant meropenem-susceptible P. aeruginosa isolates had higher susceptibility profiles, fewer carbapenemase genes (0.3% [five of 1858] vs. 4.1% [10 of 242]; P < 0.05) and a lower risk of being classified as multidrug-resistant than the imipenem-susceptible meropenem-resistant isolates (16.1% [299 of 1858] vs. 73.6% [178 of 242]; P < 0.05). Among all β-lactam combination agents, ceftazidime-avibactam and ceftolozane-tazobactam had higher susceptibility rates than meropenem-vaborbactam for meropenem-resistant P. aeruginosa (61.8% and 55.5% vs. 30.2%; P < 0.05). Conclusion: Discrepancy in the resistance of different P. aeruginosa isolates to various carbapenems suggests their different underlying resistance mechanisms. These findings can be useful for effective resistance trend monitoring and accurate antimicrobial treatment in the future.
MeSH term(s)	Humans ; Pseudomonas aeruginosa/genetics ; Meropenem/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology ; Doripenem/pharmacology ; Leadership ; Pseudomonas Infections/drug therapy ; Ceftazidime/pharmacology ; Cephalosporins/pharmacology ; Tazobactam/pharmacology ; Azabicyclo Compounds/pharmacology ; Anti-Infective Agents/pharmacology ; Imipenem/pharmacology ; beta-Lactamases/genetics ; beta-Lactamases/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	avibactam, ceftazidime drug combination ; ceftolozane (37A4IES95Q) ; Meropenem (FV9J3JU8B1) ; Anti-Bacterial Agents ; vaborbactam (1C75676F8V) ; Carbapenems ; Doripenem (BHV525JOBH) ; Ceftazidime (9M416Z9QNR) ; Cephalosporins ; ceftolozane, tazobactam drug combination ; Tazobactam (SE10G96M8W) ; Azabicyclo Compounds ; Anti-Infective Agents ; Imipenem (71OTZ9ZE0A) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2023-05-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106867
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Article ; Online: High ceftazidime-avibactam resistance among carbapenem-resistant Enterobacter species: Data from the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme, 2014-2021.

Wang, Jiun-Ling / Lai, Chih-Cheng / Tsai, Ya-Wen / Ko, Wen-Chien / Hsueh, Po-Ren

International journal of antimicrobial agents

2024 Volume 63, Issue 4, Page(s) 107105

Abstract: Objectives: Trends in the susceptibility to ceftazidime-avibactam (CZA) and tigecycline (TGC) among Enterobacter species from different geographic areas are unknown.This study aimed to analyse the trends in CZA and TGC susceptibility changes across ... ...

Abstract	Objectives: Trends in the susceptibility to ceftazidime-avibactam (CZA) and tigecycline (TGC) among Enterobacter species from different geographic areas are unknown.This study aimed to analyse the trends in CZA and TGC susceptibility changes across different continents from 2014 to 2021 utilizing Antimicrobial Testing Leadership and Surveillance (ATLAS) data. Methods: A total of 23 669 isolates of Enterobacter species were collected over an 8-y period. Results: The overall non-susceptibility rate of Enterobacter isolates to both CZA and TGC was 3.2%. India (16.5%), Guatemala (15.4%), and the Philippines (13.1%) exhibited the highest resistance to CZA. The increase in CZA resistance rates was particularly evident in Asia, with an increase from 4.0% to 8.3%, and in Latin America, from 1.5% to 5%. The non-susceptibility rate for TGC mildly increased in Africa/Middle East but decreased in other continents during the study period. The overall rate of carbapenem resistance increased from 2.9% in 2014-2017 to 4.3% in 2018-2021. Among carbapenem-resistant Enterobacter isolates, the CZA resistance rate was highest in Asia (87.4%), followed by Europe (69.2%) and Africa/Middle East (60.8%). Among the 380 Enterobacter isolates resistant to CZA and carbapenem, the most common genotype of carbapenemase genes was bla Conclusions: The heterogeneous distribution of CZA resistance rates among different geographical regions highlights the divergent therapeutic options for drug-resistant Enterobacter species.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology ; Enterobacter/genetics ; Leadership ; Ceftazidime/pharmacology ; Ceftazidime/therapeutic use ; Azabicyclo Compounds/pharmacology ; Azabicyclo Compounds/therapeutic use ; Anti-Infective Agents ; Drug Combinations ; Tigecycline ; beta-Lactamases/genetics ; Microbial Sensitivity Tests
Chemical Substances	avibactam, ceftazidime drug combination ; Anti-Bacterial Agents ; Carbapenems ; Ceftazidime (9M416Z9QNR) ; Azabicyclo Compounds ; Anti-Infective Agents ; Drug Combinations ; Tigecycline (70JE2N95KR) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2024-02-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107105
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Article ; Online: Global trends in non-susceptibility rates of Streptococcus pneumoniae isolates to ceftriaxone: Data from the antimicrobial testing leadership and surveillance (ATLAS) programme, 2016-21.

Wang, Jiun-Ling / Lai, Chih-Cheng / Ko, Wen-Chien / Hsueh, Po-Ren

International journal of antimicrobial agents

2023 Volume 63, Issue 2, Page(s) 107072

Abstract: To understand the global changes in non-susceptibility rates of Streptococcus pneumoniae to ceftriaxone, we conducted a study using the Antimicrobial Testing Leadership and Surveillance database. A total of 15,717 S. pneumoniae isolates were collected ... ...

Abstract	To understand the global changes in non-susceptibility rates of Streptococcus pneumoniae to ceftriaxone, we conducted a study using the Antimicrobial Testing Leadership and Surveillance database. A total of 15,717 S. pneumoniae isolates were collected from 2016 to 2021. The minimum inhibitory concentrations (MICs) were determined using broth microdilution. The overall susceptibility rates of S. pneumoniae isolates to penicillin, ceftriaxone and ceftaroline were 63.4%, 94.0% and 99.6%, respectively. The geometric mean of MICs and MIC
MeSH term(s)	Humans ; Ceftriaxone/pharmacology ; Anti-Bacterial Agents/pharmacology ; Streptococcus pneumoniae ; Leadership ; Anti-Infective Agents/pharmacology ; Pneumonia ; Microbial Sensitivity Tests
Chemical Substances	Ceftriaxone (75J73V1629) ; Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2023-12-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.107072
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Article ; Online: Geographical patterns of in vitro susceptibilities to tigecycline and colistin among worldwide isolates of Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae: Data from the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme, 2016-2021.

Wang, Jiun-Ling / Lai, Chih-Cheng / Ko, Wen-Chien / Hsueh, Po-Ren

International journal of antimicrobial agents

2023 Volume 62, Issue 3, Page(s) 106930

Abstract: This study aimed to investigate the geographical trends of minimum inhibitory concentrations (MICs) for tigecycline and colistin in Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae isolates which were collected for the Antimicrobial ... ...

Abstract	This study aimed to investigate the geographical trends of minimum inhibitory concentrations (MICs) for tigecycline and colistin in Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae isolates which were collected for the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme from 2016-2021. MICs of the isolates were determined using the broth microdilution method. In the study period, there was an increase in MIC
MeSH term(s)	Tigecycline/pharmacology ; Anti-Bacterial Agents/pharmacology ; Colistin/pharmacology ; Escherichia coli ; Klebsiella pneumoniae ; Acinetobacter baumannii ; Minocycline/pharmacology ; Leadership ; Anti-Infective Agents ; Thailand ; Microbial Sensitivity Tests
Chemical Substances	Tigecycline (70JE2N95KR) ; Anti-Bacterial Agents ; Colistin (Z67X93HJG1) ; Minocycline (FYY3R43WGO) ; Anti-Infective Agents
Language	English
Publishing date	2023-07-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106930
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Article ; Online: Comparison of antibiotic-resistant Escherichia coli and extra-intestinal pathogenic E. coli from main river basins under different levels of the sewer system development.

Chen, Jung-Sheng / Hsu, Bing-Mu / Ko, Wen-Chien / Wang, Jiun-Ling

Ecotoxicology and environmental safety

2023 Volume 263, Page(s) 115372

Abstract: Antimicrobial-resistant Escherichia coli in the aquatic environments is considered a strong indicator of sewage or animal waste contamination and antibiotic pollution. Sewer construction and wastewater treatment plant (WWTP) infrastructure may serve as ... ...

Abstract	Antimicrobial-resistant Escherichia coli in the aquatic environments is considered a strong indicator of sewage or animal waste contamination and antibiotic pollution. Sewer construction and wastewater treatment plant (WWTP) infrastructure may serve as concentrated point sources of contamination of antibiotic-resistant bacteria and antibiotic resistance genes. In this study, we focused on the distribution of antimicrobial-resistant E. coli in two rivers with large drainage areas and different urbanisation levels. E. coli from Kaoping River with drainage mainly from livestock farming had higher resistance to antibiotics (e.g. penicillins, tetracyclines, phenicols, aminoglycosides, and sulpha drugs) and presented more positive detection of antibiotic-resistance genes (e.g. ampC, bla
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Escherichia coli/genetics ; Sulfanilamide ; Penicillins ; Enterobacteriaceae ; Livestock
Chemical Substances	Anti-Bacterial Agents ; Sulfanilamide (21240MF57M) ; Penicillins
Language	English
Publishing date	2023-08-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.115372
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Article ; Online: In vitro susceptibilities of Stenotrophomonas maltophilia isolates to antimicrobial agents commonly used for related infections: Results from the Antimicrobial Testing Leadership and Surveillance (ATLAS) program, 2004-2020.

Lee, Yu-Lin / Liu, Chun-Eng / Ko, Wen-Chien / Hsueh, Po-Ren

International journal of antimicrobial agents

2023 Volume 62, Issue 2, Page(s) 106878

Abstract: Stenotrophomonas maltophilia is an emerging opportunistic pathogen for which there are limited therapeutic options because of intrinsic multidrug resistance. S. maltophilia isolates were collected as part of the Antimicrobial Testing Leadership and ... ...

Abstract	Stenotrophomonas maltophilia is an emerging opportunistic pathogen for which there are limited therapeutic options because of intrinsic multidrug resistance. S. maltophilia isolates were collected as part of the Antimicrobial Testing Leadership and Surveillance (ATLAS) program and minimum inhibitory concentrations (MICs) were determined using broth microdilution methods. Susceptibility was interpreted according to Clinical and Laboratory Standards Institute (CLSI) breakpoints. Isolates with tigecycline MIC ≤2 mg/L were defined as susceptible, using the United States Food and Drug Administration criteria of Enterobacterales. A total of 2330 S. maltophilia isolates were collected from 47 countries worldwide in the ATLAS program from 2004 to 2020. Most patients were hospitalized (92.3%, 2151/2330) and respiratory tract infections (47.8%, 1114/2330) were the most common source of isolates. Minocycline had the highest susceptibility rate (98.8%), followed by levofloxacin (85.0%), trimethoprim-sulfamethoxazole (TMP-SMX) (84.4%), and ceftazidime (53.7%). A total of 98.3% (2290/2330) of S. maltophilia isolates had tigecycline MIC ≤2 mg/L. Among the S. maltophilia isolates exhibiting resistance to levofloxacin and ceftazidime, 89.3% (150/168) and 97.3% (692/711), respectively, were susceptible to tigecycline. Eight countries provided more than 30 isolates and were selected for comparison. Geographical difference in antimicrobial resistance was significant for levofloxacin, minocycline, and tigecycline (all P<0.05) but not for ceftazidime (P=0.467). These in vitro data demonstrated that minocycline had a higher susceptibility rate than levofloxacin and ceftazidime, and that tigecycline could be an alternative or salvage option for the treatment of S. maltophilia infections.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Tigecycline/pharmacology ; Levofloxacin/pharmacology ; Ceftazidime/pharmacology ; Stenotrophomonas maltophilia ; Leadership ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Microbial Sensitivity Tests ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/epidemiology
Chemical Substances	Anti-Bacterial Agents ; Minocycline (FYY3R43WGO) ; Tigecycline (70JE2N95KR) ; Levofloxacin (6GNT3Y5LMF) ; Ceftazidime (9M416Z9QNR) ; Anti-Infective Agents
Language	English
Publishing date	2023-06-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106878
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Article: Effects of Inappropriate Administration of Empirical Antibiotics on Mortality in Adults With Bacteraemia: Systematic Review and Meta-Analysis.

Hung, Yuan-Pin / Lee, Ching-Chi / Ko, Wen-Chien

Frontiers in medicine

2022 Volume 9, Page(s) 869822

Abstract: Introduction: Bloodstream infections are associated with high mortality rates and contribute substantially to healthcare costs, but a consensus on the prognostic benefits of appropriate empirical antimicrobial therapy (EAT) for bacteraemia is lacking.!## ...

Abstract	Introduction: Bloodstream infections are associated with high mortality rates and contribute substantially to healthcare costs, but a consensus on the prognostic benefits of appropriate empirical antimicrobial therapy (EAT) for bacteraemia is lacking. Methods: We performed a systematic search of the PubMed, Cochrane Library, and Embase databases through July 2021. Studies comparing the mortality rates of patients receiving appropriate and inappropriate EAT were considered eligible. The quality of the included studies was assessed using Joanna Briggs Institute checklists. Results: We ultimately assessed 198 studies of 89,962 total patients. The pooled odds ratio (OR) for the prognostic impacts of inappropriate EAT was 2.06 ( Conclusion: Although the current evidence is insufficient to demonstrate the benefits of prompt EAT in specific bacteraemic populations, we indicated that inappropriate EAT is associated with unfavorable mortality outcomes overall and in numerous subgroups. Prospective studies designed to test these specific populations are needed to ensure reliable conclusions. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42021270274.
Language	English
Publishing date	2022-05-30
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.869822
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