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  1. Article ; Online: Intratumoral pro-oxidants promote cancer immunotherapy by recruiting and reprogramming neutrophils to eliminate tumors.

    Ralph, Stephen John / Reynolds, Maxwell J

    Cancer immunology, immunotherapy : CII

    2022  Volume 72, Issue 3, Page(s) 527–542

    Abstract: Neutrophils have recently gained recognition for their potential in the fight against cancer. Neutrophil plasticity between the N1 anti-tumor and N2 pro-tumor subtypes is now apparent, as is the ability to polarize these individual subtypes by ... ...

    Abstract Neutrophils have recently gained recognition for their potential in the fight against cancer. Neutrophil plasticity between the N1 anti-tumor and N2 pro-tumor subtypes is now apparent, as is the ability to polarize these individual subtypes by interventions such as intratumoral injection of various agents including bacterial products or pro-oxidants. Metabolic responses and the production of reactive oxygen species (ROS) such as hydrogen peroxide act as potent chemoattractants and activators of N1 neutrophils that facilitates their recruitment and ensuing activation of a toxic respiratory burst in tumors. Greater understanding of the precise mechanism of N1 neutrophil activation, recruitment and regulation is now needed to fully exploit their anti-tumor potential against cancers both locally and at distant sites. This systematic review critically analyzes these new developments in cancer immunotherapy.
    MeSH term(s) Humans ; Reactive Oxygen Species/metabolism ; Neutrophils/metabolism ; Respiratory Burst ; Immunotherapy ; Neoplasms/metabolism
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2022-08-17
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-022-03248-8
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: 13

    Baker, Cameron F / Seed, John A / Adams, Ralph W / Lee, Daniel / Liddle, Stephen T

    Chemical science

    2023  Volume 15, Issue 1, Page(s) 238–249

    Abstract: Diphosphonioalkylidene dianions have emerged as highly effective ligands for lanthanide and actinide ions, and the resulting formal metal-carbon double bonds have challenged and developed conventional thinking about f-element bond multiplicity and ... ...

    Abstract Diphosphonioalkylidene dianions have emerged as highly effective ligands for lanthanide and actinide ions, and the resulting formal metal-carbon double bonds have challenged and developed conventional thinking about f-element bond multiplicity and covalency. However, f-element-diphosphonioalkylidene complexes can be represented by several resonance forms that render their metal-carbon double bond status unclear. Here, we report an experimentally-validated
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc04449a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 31

    Du, Jingzhen / Hurd, Joseph / Seed, John A / Balázs, Gábor / Scheer, Manfred / Adams, Ralph W / Lee, Daniel / Liddle, Stephen T

    Journal of the American Chemical Society

    2023  Volume 145, Issue 40, Page(s) 21766–21784

    Abstract: We report the use of solution and solid- ... ...

    Abstract We report the use of solution and solid-state
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c02775
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    In stock of ZB MED Bonn / Germany

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  4. Article: Mesoionic Carbene Complexes of Uranium(IV) and Thorium(IV).

    Seed, John A / Vondung, Lisa / Adams, Ralph W / Wooles, Ashley J / Lu, Erli / Liddle, Stephen T

    Organometallics

    2022  Volume 41, Issue 11, Page(s) 1353–1363

    Abstract: We report the synthesis and characterization of uranium(IV) and thorium(IV) mesoionic carbene complexes [An{N( ... ...

    Abstract We report the synthesis and characterization of uranium(IV) and thorium(IV) mesoionic carbene complexes [An{N(SiMe
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006302-7
    ISSN 1520-6041 ; 0276-7333
    ISSN (online) 1520-6041
    ISSN 0276-7333
    DOI 10.1021/acs.organomet.2c00120
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  5. Article ; Online: N-Heterocyclic Carbene to Actinide d-Based π-bonding Correlates with Observed Metal-Carbene Bond Length Shortening Versus Lanthanide Congeners.

    Goodwin, Conrad A P / Adams, Ralph W / Gaunt, Andrew J / Hanson, Susan K / Janicke, Michael T / Kaltsoyannis, Nikolas / Liddle, Stephen T / May, Iain / Miller, Jeffrey L / Scott, Brian L / Seed, John A / Whitehead, George F S

    Journal of the American Chemical Society

    2024  Volume 146, Issue 15, Page(s) 10367–10380

    Abstract: Comparison of bonding and electronic structural features between trivalent lanthanide (Ln) and actinide (An) complexes across homologous series' of molecules can provide insights into subtle and overt periodic trends. Of keen interest and debate is the ... ...

    Abstract Comparison of bonding and electronic structural features between trivalent lanthanide (Ln) and actinide (An) complexes across homologous series' of molecules can provide insights into subtle and overt periodic trends. Of keen interest and debate is the extent to which the valence f- and d-orbitals of trivalent Ln/An ions engage in covalent interactions with different ligand donor functionalities and, crucially, how bonding differences change as both the Ln and An series are traversed. Synthesis and characterization (SC-XRD, NMR, UV-vis-NIR, and computational modeling) of the homologous lanthanide and actinide N-heterocyclic carbene (NHC) complexes [M(C
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c12721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: A Series of Rare-Earth Mesoionic Carbene Complexes.

    Seed, John A / Vondung, Lisa / Barton, Franky / Wooles, Ashley J / Lu, Erli / Gregson, Matthew / Adams, Ralph W / Liddle, Stephen T

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2022  Volume 28, Issue 37, Page(s) e202200761

    Abstract: We report the synthesis and characterisation of a series of rare-earth mesoionic carbene complexes, [RE{N( ... ...

    Abstract We report the synthesis and characterisation of a series of rare-earth mesoionic carbene complexes, [RE{N(SiMe
    Language English
    Publishing date 2022-05-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202200761
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  7. Article ; Online: Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer.

    Echtenkamp, Frank J / Ishida, Ryo / Rivera-Marquez, Genesis M / Maisiak, Marisa / Johnson, Oleta T / Shrimp, Jonathan H / Sinha, Arnav / Ralph, Stephen John / Nisbet, Ian / Cherukuri, Murali Krishna / Gestwicki, Jason E / Neckers, Leonard M

    PNAS nexus

    2023  Volume 2, Issue 4, Page(s) pgad115

    Abstract: The androgen receptor is a key regulator of prostate cancer and the principal target of current prostate cancer therapies collectively termed androgen deprivation therapies. Insensitivity to these drugs is a hallmark of progression to a terminal disease ... ...

    Abstract The androgen receptor is a key regulator of prostate cancer and the principal target of current prostate cancer therapies collectively termed androgen deprivation therapies. Insensitivity to these drugs is a hallmark of progression to a terminal disease state termed castration-resistant prostate cancer. Therefore, novel therapeutic options that slow progression of castration-resistant prostate cancer and combine effectively with existing agents are in urgent need. We show that JG-98, an allosteric inhibitor of HSP70, re-sensitizes castration-resistant prostate cancer to androgen deprivation drugs by targeting mitochondrial HSP70 (HSPA9) to suppress aerobic respiration. Rather than impacting androgen receptor stability as previously described, JG-98's primary effect is inhibition of mitochondrial translation, leading to disruption of electron transport chain activity. Although functionally distinct from HSPA9 inhibition, direct inhibition of the electron transport chain with a complex I or II inhibitor creates a similar physiological state capable of re-sensitizing castration-resistant prostate cancer to androgen deprivation therapies. These data identify a significant role for HspA9 in mitochondrial ribosome function and highlight an actionable metabolic vulnerability of castration-resistant prostate cancer.
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgad115
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  8. Article ; Online: Exceptional uranium(VI)-nitride triple bond covalency from 15N nuclear magnetic resonance spectroscopy and quantum chemical analysis

    Jingzhen Du / John A. Seed / Victoria E. J. Berryman / Nikolas Kaltsoyannis / Ralph W. Adams / Daniel Lee / Stephen T. Liddle

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Determining the covalency of actinide chemical bonding is a fundamentally important challenge. Here, the authors report a 15N nuclear magnetic resonance spectroscopy study of a terminal uranium-nitride, revealing exceptional NMR properties and covalency ... ...

    Abstract Determining the covalency of actinide chemical bonding is a fundamentally important challenge. Here, the authors report a 15N nuclear magnetic resonance spectroscopy study of a terminal uranium-nitride, revealing exceptional NMR properties and covalency that redefine 15N NMR parameter space and actinide chemical bonding.
    Keywords Science ; Q
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Vaccination for Patients Receiving Dialysis.

    Sam, Ramin / Rankin, Laura / Ulasi, Ifeoma / Frantzen, Luc / Nitsch, Dorothea / Henner, David / Molony, Donald / Wagner, John / Chen, Jing / Agarwal, Sanjay Kumar / Howard, Andrew / Atkinson, Ralph / Landry, Daniel / Pastan, Stephen O / Kalantar-Zadeh, Kamyar

    Kidney medicine

    2023  Volume 6, Issue 3, Page(s) 100775

    Abstract: Vaccinating patients receiving dialysis may prevent morbidity and mortality in this vulnerable population. The National Forum of End-Stage Renal Disease Networks (the Forum) published a revised vaccination toolkit in 2021 to update evidence and ... ...

    Abstract Vaccinating patients receiving dialysis may prevent morbidity and mortality in this vulnerable population. The National Forum of End-Stage Renal Disease Networks (the Forum) published a revised vaccination toolkit in 2021 to update evidence and recommendations on vaccination for patients receiving dialysis. Significant changes in the last 10 years include more data supporting the use of a high-dose influenza vaccine, the introduction of the Heplisav-B vaccine for hepatitis B, and changes in pneumococcal vaccines, including the approval of the PCV15 and PCV20 to replace the PCV13 and PPSV23 vaccines. Additional key items include the introduction of vaccines against severe acute respiratory syndrome coronavirus 2, the virus that causes coronavirus disease 2019 (COVID-19), and a new vaccine to prevent respiratory syncytial virus disease. Historically, influenza and pneumococcal vaccinations were routinely administered by dialysis facilities, and because of possible risks of hematogenous spread of hepatitis B, dialysis providers often have detailed hepatitis B vaccine protocols. In March 2021, COVID-19 vaccines were made available for dialysis facilities to administer, although with the end of the public health emergency, vaccine policies by dialysis facilities against COVID-19 remains uncertain. The respiratory syncytial virus vaccine was authorized in 2023, and how dialysis facilities will approach this vaccine also remains uncertain. This review summarizes the Forum's vaccination toolkit and discusses the role of the dialysis facility in vaccinating patients to reduce the risk of severe infections.
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2023.100775
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  10. Article ; Online: Exceptional uranium(VI)-nitride triple bond covalency from

    Du, Jingzhen / Seed, John A / Berryman, Victoria E J / Kaltsoyannis, Nikolas / Adams, Ralph W / Lee, Daniel / Liddle, Stephen T

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 5649

    Abstract: Determining the nature and extent of covalency of early actinide chemical bonding is a fundamentally important challenge. Recently, X-ray absorption, electron paramagnetic, and nuclear magnetic resonance spectroscopic studies have probed actinide-ligand ... ...

    Abstract Determining the nature and extent of covalency of early actinide chemical bonding is a fundamentally important challenge. Recently, X-ray absorption, electron paramagnetic, and nuclear magnetic resonance spectroscopic studies have probed actinide-ligand covalency, largely confirming the paradigm of early actinide bonding varying from ionic to polarised-covalent, with this range sitting on the continuum between ionic lanthanide and more covalent d transition metal analogues. Here, we report measurement of the covalency of a terminal uranium(VI)-nitride by
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-25863-2
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