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Article ; Online: Current and Innovated Managements for Autoimmune Bullous Skin Disorders

Kuan-Yu Chu / Hsin-Su Yu / Sebastian Yu

Journal of Clinical Medicine, Vol 11, Iss 3528, p

An Overview

2022 Volume 3528

Abstract: Autoimmune bullous skin disorders are a group of disorders characterized by the formation of numerous blisters and erosions on the skin and/or the mucosal membrane, arising from autoantibodies against the intercellular adhesion molecules and the ... ...

Abstract	Autoimmune bullous skin disorders are a group of disorders characterized by the formation of numerous blisters and erosions on the skin and/or the mucosal membrane, arising from autoantibodies against the intercellular adhesion molecules and the structural proteins. They can be classified into intraepithelial or subepithelial autoimmune bullous dermatoses based on the location of the targeted antigens. These dermatoses are extremely debilitating and fatal in certain cases, depending on the degree of cutaneous and mucosal involvement. Effective treatments should be implemented promptly. Glucocorticoids serve as the first-line approach due to their rapid onset of therapeutic effects and remission of the acute phase. Nonetheless, long-term applications may lead to major adverse effects that outweigh the benefits. Hence, other adjuvant therapies are mandatory to minimize the potential harm and ameliorate the quality of life. Herein, we summarize the current therapeutic strategies and introduce promising therapies for intractable autoimmune bullous diseases.
Keywords	autoimmune bullous dermatoses ; pemphigus vulgaris ; pemphigus foliaceus ; IgA pemphigus ; paraneoplastic pemphigus ; bullous pemphigoid ; Medicine ; R
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Current and Innovated Managements for Autoimmune Bullous Skin Disorders: An Overview.

Chu, Kuan-Yu / Yu, Hsin-Su / Yu, Sebastian

Journal of clinical medicine

2022 Volume 11, Issue 12

Abstract	Autoimmune bullous skin disorders are a group of disorders characterized by the formation of numerous blisters and erosions on the skin and/or the mucosal membrane, arising from autoantibodies against the intercellular adhesion molecules and the structural proteins. They can be classified into intraepithelial or subepithelial autoimmune bullous dermatoses based on the location of the targeted antigens. These dermatoses are extremely debilitating and fatal in certain cases, depending on the degree of cutaneous and mucosal involvement. Effective treatments should be implemented promptly. Glucocorticoids serve as the first-line approach due to their rapid onset of therapeutic effects and remission of the acute phase. Nonetheless, long-term applications may lead to major adverse effects that outweigh the benefits. Hence, other adjuvant therapies are mandatory to minimize the potential harm and ameliorate the quality of life. Herein, we summarize the current therapeutic strategies and introduce promising therapies for intractable autoimmune bullous diseases.
Language	English
Publishing date	2022-06-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11123528
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cutaneous Adverse Events Associated with Immune Checkpoint Inhibitors: A Review Article.

Chen, Chieh-Hsun / Yu, Hsin-Su / Yu, Sebastian

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 4, Page(s) 2871–2886

Abstract: Immune checkpoint inhibitors (ICIs) have emerged as novel options that are effective in treating various cancers. They are monoclonal antibodies that target cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1), and programmed cell ... ...

Abstract	Immune checkpoint inhibitors (ICIs) have emerged as novel options that are effective in treating various cancers. They are monoclonal antibodies that target cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1), and programmed cell death-ligand 1 (PD-L1). However, activation of the immune systems through ICIs may concomitantly trigger a constellation of immunologic symptoms and signs, termed immune-related adverse events (irAEs), with the skin being the most commonly involved organ. The dermatologic toxicities are observed in nearly half of the patients treated with ICIs, mainly in the form of maculopapular rash and pruritus. In the majority of cases, these cutaneous irAEs are self-limiting and manageable, and continuation of the ICIs is possible. This review provides an overview of variable ICI-mediated dermatologic reactions and describes the clinical and histopathologic presentation. Early and accurate diagnosis, recognition of severe toxicities, and appropriate management are key goals to achieve the most favorable outcomes and quality of life in cancer patients.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents, Immunological/adverse effects ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Neoplasms/drug therapy ; Quality of Life
Chemical Substances	Antibodies, Monoclonal ; Antineoplastic Agents, Immunological ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2022-04-18
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29040234
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Article ; Online: Chronic blue light-emitting diode exposure harvests gut dysbiosis related to cholesterol dysregulation.

Huang, Cheng-Hsieh / Yu, Sebastian / Yu, Hsu-Sheng / Tu, Hung-Pin / Yeh, Yao-Tsung / Yu, Hsin-Su

Frontiers in cellular and infection microbiology

2024 Volume 13, Page(s) 1320713

Abstract: Night shift workers have been associated with circadian dysregulation and metabolic disorders, which are tightly coevolved with gut microbiota. The chronic impacts of light-emitting diode (LED) lighting at night on gut microbiota and serum lipids were ... ...

Abstract	Night shift workers have been associated with circadian dysregulation and metabolic disorders, which are tightly coevolved with gut microbiota. The chronic impacts of light-emitting diode (LED) lighting at night on gut microbiota and serum lipids were investigated. Male C57BL/6 mice were exposed to blue or white LED lighting at Zeitgeber time 13.5-14 (ZT; ZT0 is the onset of "lights on" and ZT12 is the "lights off" onset under 12-hour light, 12-hour dark schedule). After 33 weeks, only the high irradiance (7.2 J/cm
MeSH term(s)	Male ; Animals ; Mice ; Mice, Inbred C57BL ; Blue Light ; Dysbiosis ; Cholesterol ; Triglycerides
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Triglycerides
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1320713
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Article ; Online: Inherited Reticulate Pigmentary Disorders

Lin, Min-Huei / Chou, Pei-Chen / Lee, I-Chen / Yang, Syuan-Fei / Yu, Hsin-Su / Yu, Sebastian

Genes (Basel). 2023 June 20, v. 14, no. 6

2023

Abstract: Reticulate pigmentary disorders (RPDs) are a group of inherited and acquired skin conditions characterized by hyperpigmented and/or hypopigmented macules. Inherited RPDs include dyschromatosis symmetrica hereditaria (DSH), dyschromatosis universalis ... ...

Abstract	Reticulate pigmentary disorders (RPDs) are a group of inherited and acquired skin conditions characterized by hyperpigmented and/or hypopigmented macules. Inherited RPDs include dyschromatosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH), reticulate acropigmentation of Kitamura (RAK), Dowling-Degos disease (DDD), dyskeratosis congenita (DKC), Naegeli–Franceschetti–Jadassohn syndrome (NFJS), dermatopathia pigmentosa reticularis (DPR), and X-linked reticulate pigmentary disorder. Although reticulate pattern of pigmentation is a common characteristic of this spectrum of disorders, the distribution of pigmentation varies among these disorders, and there may be clinical manifestations beyond pigmentation. DSH, DUH, and RAK are mostly reported in East Asian ethnicities. DDD is more common in Caucasians, although it is also reported in Asian countries. Other RPDs show no racial predilection. This article reviews the clinical, histological, and genetic variations of inherited RPDs.
Keywords	Asians ; Whites ; exhibitions ; genes ; genetic variation ; histology ; pigmentation ; skinning ; Asia
Language	English
Dates of publication	2023-0620
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14061300
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inherited Reticulate Pigmentary Disorders.

Lin, Min-Huei / Chou, Pei-Chen / Lee, I-Chen / Yang, Syuan-Fei / Yu, Hsin-Su / Yu, Sebastian

Genes

2023 Volume 14, Issue 6

Abstract	Reticulate pigmentary disorders (RPDs) are a group of inherited and acquired skin conditions characterized by hyperpigmented and/or hypopigmented macules. Inherited RPDs include dyschromatosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH), reticulate acropigmentation of Kitamura (RAK), Dowling-Degos disease (DDD), dyskeratosis congenita (DKC), Naegeli-Franceschetti-Jadassohn syndrome (NFJS), dermatopathia pigmentosa reticularis (DPR), and X-linked reticulate pigmentary disorder. Although reticulate pattern of pigmentation is a common characteristic of this spectrum of disorders, the distribution of pigmentation varies among these disorders, and there may be clinical manifestations beyond pigmentation. DSH, DUH, and RAK are mostly reported in East Asian ethnicities. DDD is more common in Caucasians, although it is also reported in Asian countries. Other RPDs show no racial predilection. This article reviews the clinical, histological, and genetic variations of inherited RPDs.
MeSH term(s)	Humans ; Hyperpigmentation/genetics ; Hyperpigmentation/pathology ; Skin Diseases, Genetic/genetics
Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14061300
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genetics of Generalized Pustular Psoriasis: Current Understanding and Implications for Future Therapeutics.

Yang, Syuan-Fei / Lin, Min-Huei / Chou, Pei-Chen / Hu, Sheng-Kai / Shih, Sin-Yi / Yu, Hsin-Su / Yu, Sebastian

Genes

2023 Volume 14, Issue 6

Abstract: Psoriasis is a chronic inflammatory skin disease characterized by the appearance of clearly demarcated erythematous and scaly plaques. It can be divided into various types, including plaque, nail, guttate, inverse, and pustular psoriasis. Plaque ... ...

Abstract	Psoriasis is a chronic inflammatory skin disease characterized by the appearance of clearly demarcated erythematous and scaly plaques. It can be divided into various types, including plaque, nail, guttate, inverse, and pustular psoriasis. Plaque psoriasis is the most commonly occurring type, though there is another rare but severe pustular autoinflammatory skin disease called generalized pustular psoriasis (GPP), which manifests with acute episodes of pustulation and systemic symptoms. Though the etiopathogenesis of psoriasis is not yet fully understood, a growing body of literature has demonstrated that both genetic and environmental factors play a role. The discovery of genetic mutations associated with GPP has shed light on our comprehension of the mechanisms of the disease, promoting the development of targeted therapies. This review will summarize genetic determinants as known and provide an update on the current and potential treatments for GPP. The pathogenesis and clinical presentation of the disease are also included for a comprehensive discussion.
MeSH term(s)	Humans ; Interleukins/genetics ; Psoriasis/genetics ; Psoriasis/pathology ; Skin/pathology ; Mutation ; Skin Diseases, Vesiculobullous/pathology
Chemical Substances	Interleukins
Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14061297
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Article ; Online: Arsenic-Induced Carcinogenesis and Immune Dysregulation.

Huang, Hsin-Wei / Lee, Chih-Hung / Yu, Hsin-Su

International journal of environmental research and public health

2019 Volume 16, Issue 15

Abstract: Arsenic, a metal ubiquitously distributed in the environment, remains an important global health threat. Drinking arsenic-contaminated water is the major route of human exposure. Exposure to arsenic contributes to several malignancies, in the ... ...

Abstract	Arsenic, a metal ubiquitously distributed in the environment, remains an important global health threat. Drinking arsenic-contaminated water is the major route of human exposure. Exposure to arsenic contributes to several malignancies, in the integumentary, respiratory, hepatobiliary, and urinary systems. Cutaneous lesions are important manifestations after long-term arsenic exposure. Arsenical skin cancers usually herald the development of other internal cancers, making the arsenic-induced skin carcinogenesis a good model to investigate the progression of chemical carcinogenesis. In fact, only a portion of arsenic-exposed humans eventually develop malignancies, likely attributed to the arsenic-impaired immunity in susceptible individuals. Currently, the exact pathophysiology of arsenic-induced carcinogenesis remains elusive, although increased reactive oxidative species, aberrant immune regulations, and chromosome abnormalities with uncontrolled cell growth might be involved. This review discusses how arsenic induces carcinogenesis, and how the dysregulated innate and adaptive immunities in systemic circulation and in the target organs contribute to arsenic carcinogenesis. These findings offer evidence for illustrating the mechanism of arsenic-related immune dysregulation in the progression of carcinogenesis, and this may help explain the nature of multiple and recurrent clinical lesions in arsenic-induced skin cancers.
MeSH term(s)	Arsenic/toxicity ; Bowen's Disease/chemically induced ; Carcinogenesis ; Chromosome Aberrations ; Humans ; Skin Diseases/chemically induced ; Skin Neoplasms/chemically induced
Chemical Substances	Arsenic (N712M78A8G)
Language	English
Publishing date	2019-08-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph16152746
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1.

Lin, Ying-Chu / Wuputra, Kenly / Kato, Kohsuke / Ku, Chia-Chen / Saito, Shigeo / Noguchi, Michiya / Nakamura, Yukio / Hsiao, Michael / Lin, Chang-Shen / Wu, Deng-Chyang / Kawaguchi, Atsushi / Yu, Hsin-Su / Yokoyama, Kazunari K

Environmental pollution (Barking, Essex : 1987)

2024 Volume 347, Page(s) 123722

Abstract: An understanding of the risk of gene deletion and mutation posed by endocrine-disrupting chemicals (EDCs) is necessary for the identification of etiological reagents for many human diseases. Therefore, the characterization of the genetic traits caused by ...

Abstract	An understanding of the risk of gene deletion and mutation posed by endocrine-disrupting chemicals (EDCs) is necessary for the identification of etiological reagents for many human diseases. Therefore, the characterization of the genetic traits caused by developmental exposure to EDCs is an important research subject. A new regenerative approach using embryonic stem cells (ESCs) holds promise for the development of stem-cell-based therapies and the identification of novel therapeutic agents against human diseases. Here, we focused on the characterization of the genetic traits and alterations in pluripotency/stemness triggered by phthalate ester derivatives. Regarding their in vitro effects, we reported the abilities of ESCs regarding proliferation, cell-cycle control, and neural ectoderm differentiation. The expression of their stemness-related genes and their genetic changes toward neural differentiation were examined, which led to the observation that the tumor suppressor gene product p53/retinoblastoma protein 1 and its related cascades play critical functions in cell-cycle progression, cell death, and neural differentiation. In addition, the expression of neurogenic differentiation 1 was affected by exposure to di-n-butyl phthalate in the context of cell differentiation into neural lineages. The nervous system is one of the most sensitive tissues to exposure to phthalate ester derivatives. The present screening system provides a good tool for studying the mechanisms underlying the effects of EDCs on the developmental regulation of humans and rodents, especially on the neuronal development of ESCs.
MeSH term(s)	Animals ; Humans ; Mice ; Mouse Embryonic Stem Cells ; Dibutyl Phthalate/toxicity ; Cell Differentiation ; Esters ; Phthalic Acids
Chemical Substances	phthalic acid (6O7F7IX66E) ; Dibutyl Phthalate (2286E5R2KE) ; Esters ; Phthalic Acids
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123722
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2599: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Arsenic-Induced Carcinogenesis and Immune Dysregulation

Hsin-Wei Huang / Chih-Hung Lee / Hsin-Su Yu

International Journal of Environmental Research and Public Health, Vol 16, Iss 15, p

2019 Volume 2746

Abstract	Arsenic, a metal ubiquitously distributed in the environment, remains an important global health threat. Drinking arsenic-contaminated water is the major route of human exposure. Exposure to arsenic contributes to several malignancies, in the integumentary, respiratory, hepatobiliary, and urinary systems. Cutaneous lesions are important manifestations after long-term arsenic exposure. Arsenical skin cancers usually herald the development of other internal cancers, making the arsenic-induced skin carcinogenesis a good model to investigate the progression of chemical carcinogenesis. In fact, only a portion of arsenic-exposed humans eventually develop malignancies, likely attributed to the arsenic-impaired immunity in susceptible individuals. Currently, the exact pathophysiology of arsenic-induced carcinogenesis remains elusive, although increased reactive oxidative species, aberrant immune regulations, and chromosome abnormalities with uncontrolled cell growth might be involved. This review discusses how arsenic induces carcinogenesis, and how the dysregulated innate and adaptive immunities in systemic circulation and in the target organs contribute to arsenic carcinogenesis. These findings offer evidence for illustrating the mechanism of arsenic-related immune dysregulation in the progression of carcinogenesis, and this may help explain the nature of multiple and recurrent clinical lesions in arsenic-induced skin cancers.
Keywords	arsenic ; carcinogenesis ; Bowen’s disease ; drinking water ; Medicine ; R
Subject code	616
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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