Article ; Online: Effect of basal metabolic rate on lifespan: a sex-specific Mendelian randomization study.
2023 Volume 13, Issue 1, Page(s) 7761
Abstract: Observationally, the association of basal metabolic rate (BMR) with mortality is mixed, although some ageing theories suggest that higher BMR should reduce lifespan. It remains unclear whether a causal association exists. In this one-sample Mendelian ... ...
Abstract | Observationally, the association of basal metabolic rate (BMR) with mortality is mixed, although some ageing theories suggest that higher BMR should reduce lifespan. It remains unclear whether a causal association exists. In this one-sample Mendelian randomization study, we aimed to estimate the casual effect of BMR on parental attained age, a proxy for lifespan, using two-sample Mendelian randomization methods. We obtained genetic variants strongly (p-value < 5 × 10 |
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MeSH term(s) | Male ; Humans ; Female ; Longevity/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Basal Metabolism/genetics ; Causality ; Polymorphism, Single Nucleotide |
Language | English |
Publishing date | 2023-05-12 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2615211-3 |
ISSN | 2045-2322 ; 2045-2322 |
ISSN (online) | 2045-2322 |
ISSN | 2045-2322 |
DOI | 10.1038/s41598-023-34410-6 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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