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  1. Book: Cancer Pharmacology

    Emadi, Ashkan / Karp, Judith E

    An Illustrated Manual of Anticancer Drugs

    2023  

    Language English
    Size 454 p.
    Edition 2
    Publisher Springer Publishing Company
    Document type Book
    Note PDA Manuell_25
    Format 185 x 244 x 38
    ISBN 9780826149329 ; 0826149324
    Database PDA

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  2. Article ; Online: Helicobacter pullorum and Helicobacter canadensis: Etiology, pathogenicity, epidemiology, identification, and antibiotic resistance implicating food and public health.

    Akhlaghi, Hosein / Javan, Ashkan Jebelli / Chashmi, Seyed Hesamodin Emadi

    International journal of food microbiology

    2024  Volume 413, Page(s) 110573

    Abstract: Nowadays, it is well-established that the consumption of poultry meat, especially chicken meat products has been drastically increasing. Even though more attentions are being paid to the major foodborne pathogens, it seems that scientists in the area of ... ...

    Abstract Nowadays, it is well-established that the consumption of poultry meat, especially chicken meat products has been drastically increasing. Even though more attentions are being paid to the major foodborne pathogens, it seems that scientists in the area of food safety and public health would prefer tackling the minor food borne zoonotic emerging or reemerging pathogens, namely Helicobacter species. Recently, understanding the novel aspects of zoonotic Enterohepatic Helicobacter species, including pathogenesis, isolation, identification, and genomic features is regarded as a serious challenge. In this regard, considerable attention is given to emerging elusive zoonotic Enterohepatic Helicobacter species, comprising Helicobacter pullorum and Helicobacter canadensis. In conclusion, the current review paper would attempt to elaborately summarize and somewhat compare the etiology, pathogenesis, cultivation process, identification, genotyping, and antimicrobial resistance profile of both H. pullorum and H. Canadensis. Further, H. pullorum has been introduced as the most significant food borne pathogen in chicken meat products.
    MeSH term(s) Animals ; Public Health ; Virulence ; Helicobacter/genetics ; Drug Resistance, Microbial ; Chickens
    Language English
    Publishing date 2024-01-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 87122-9
    ISSN 1879-3460 ; 0168-1605
    ISSN (online) 1879-3460
    ISSN 0168-1605
    DOI 10.1016/j.ijfoodmicro.2024.110573
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  3. Article: Long-Term Follow up of Blinatumomab in Older Patients with B-Cell Acute Lymphoblastic Leukemia.

    Kathari, Yamini K / An, Max / Dougherty, Christine / Emadi, Ashkan

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: Older adults who are diagnosed with acute lymphoblastic leukemia (ALL) and are treated with chemotherapy generally have poor outcomes. Blinatumomab is a CD19/CD3 bispecific T-cell engager that has been approved for the treatment of B-cell ALL in the ... ...

    Abstract Older adults who are diagnosed with acute lymphoblastic leukemia (ALL) and are treated with chemotherapy generally have poor outcomes. Blinatumomab is a CD19/CD3 bispecific T-cell engager that has been approved for the treatment of B-cell ALL in the relapsed/refractory setting or in patients with minimal residual disease (MRD) positivity. We previously reported on a small cohort of older adults with newly diagnosed Philadelphia chromosome negative B-cell ALL who were treated with blinatumomab monotherapy in the first line setting. This is a long-term follow up of those patients and their clinical courses. All five patients achieved complete remission (CR) after one cycle of blinatumomab, and three were MRD-negative. Two patients completed three cycles of blinatumomab, two patients completed four cycles of blinatumomab, and one patient completed 17 cycles of blinatumomab total. In the last four years, four of these patients had relapsed disease requiring additional therapy. Two patients are alive after 61 months and 57 months since their first cycle of blinatumomab. Two of the patients died at 10 months and one died at 20 months. Here we describe the long-term clinical courses of these patients.
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030335
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  4. Article: 1-C Metabolism-Serine, Glycine, Folates-In Acute Myeloid Leukemia.

    Mahmood, Kanwal / Emadi, Ashkan

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 3

    Abstract: Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Studies in hematological malignancies have shown alterations in fatty acid, folate, and amino acid metabolism pathways in ...

    Abstract Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Studies in hematological malignancies have shown alterations in fatty acid, folate, and amino acid metabolism pathways in cancer cells. One-carbon (1-C) metabolism is essential for numerous cancer cell functions, including protein and nucleic acid synthesis and maintaining cellular redox balance, and inhibition of the 1-C pathway has yielded several highly active drugs, such as methotrexate and 5-FU. Glutamine depletion has also emerged as a therapeutic approach for cancers that have demonstrated dependence on glutamine for survival. Recent studies have shown that in response to glutamine deprivation leukemia cells upregulate key enzymes in the serine biosynthesis pathway, suggesting that serine upregulation may be a targetable compensatory mechanism. These new findings may provide opportunities for novel cancer treatments.
    Language English
    Publishing date 2021-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14030190
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  5. Article ; Online: 1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia

    Kanwal Mahmood / Ashkan Emadi

    Pharmaceuticals, Vol 14, Iss 3, p

    2021  Volume 190

    Abstract: Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Studies in hematological malignancies have shown alterations in fatty acid, folate, and amino acid metabolism pathways in ...

    Abstract Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Studies in hematological malignancies have shown alterations in fatty acid, folate, and amino acid metabolism pathways in cancer cells. One-carbon (1-C) metabolism is essential for numerous cancer cell functions, including protein and nucleic acid synthesis and maintaining cellular redox balance, and inhibition of the 1-C pathway has yielded several highly active drugs, such as methotrexate and 5-FU. Glutamine depletion has also emerged as a therapeutic approach for cancers that have demonstrated dependence on glutamine for survival. Recent studies have shown that in response to glutamine deprivation leukemia cells upregulate key enzymes in the serine biosynthesis pathway, suggesting that serine upregulation may be a targetable compensatory mechanism. These new findings may provide opportunities for novel cancer treatments.
    Keywords amino acid metabolism ; cancer therapy ; leukemia ; amino-acid-degrading enzymes ; amino acid restriction in cancer ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Exploiting AML vulnerability: glutamine dependency.

    Emadi, Ashkan

    Blood

    2015  Volume 126, Issue 11, Page(s) 1269–1270

    MeSH term(s) Animals ; Glutamine/metabolism ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors
    Chemical Substances Proto-Oncogene Proteins c-bcl-2 ; Glutamine (0RH81L854J)
    Language English
    Publishing date 2015-09-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-07-659508
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  7. Article: High dose cytarabine, mitoxantrone, pegasapargase (HAM-pegA) in combination with dasatinib for the first-line treatment of Philadelphia chromosome positive mixed phenotype acute leukemia.

    Patzke, Ciera L / Emadi, Ashkan

    American journal of leukemia research

    2020  Volume 4, Issue 1

    Abstract: The treatment of mixed phenotype acute leukemia (MPAL) is challenging due to the presence of disease characteristics of both myeloid and lymphoid leukemia. Regimens historically used to treat acute lymphoblastic leukemia are often used to treat MPAL, ... ...

    Abstract The treatment of mixed phenotype acute leukemia (MPAL) is challenging due to the presence of disease characteristics of both myeloid and lymphoid leukemia. Regimens historically used to treat acute lymphoblastic leukemia are often used to treat MPAL, particularly for patients whose diseases also possess the Philadelphia chromosome (Ph+). Here we present a novel regimen, HAM-pegA plus dasatinib, for the treatment of two patients with newly diagnosed Ph+ MPAL. This regimen is a blend of both myeloid-targeted and lymphoid-targeted chemotherapy agents, and is given as a single cycle of intensive chemotherapy followed by oral dasatinib maintenance therapy. Without proceeding to allogeneic transplant, this regimen produced durable remissions of 18 months and longer. This novel regimen offers an exciting alternative to other intensive regimens that require multiple cycles of intensive chemotherapy and allogeneic transplant in first remission.
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cytogenetics and molecular genetics of myelodysplastic neoplasms.

    Ning, Yi / Zhang, Yanming / Kallen, Michael A / Emadi, Ashkan / Baer, Maria R

    Best practice & research. Clinical haematology

    2023  Volume 36, Issue 4, Page(s) 101512

    Abstract: According to the 2022 World Health Organization (WHO) Classification (5th edition), the term myelodysplastic neoplasms (abbreviated MDS) has been introduced to replace myelodysplastic syndromes. MDS are a group of clonal hematopoietic stem cell diseases ... ...

    Abstract According to the 2022 World Health Organization (WHO) Classification (5th edition), the term myelodysplastic neoplasms (abbreviated MDS) has been introduced to replace myelodysplastic syndromes. MDS are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more of lineages, ineffective hematopoiesis, and an increased risk of progression to bone marrow failure or to acute myeloid leukemia (AML). Current NCCN guidelines and recent review articles have provided in depth discussion on the clinical diagnosis and management of MDS. This review will focus on discussion of the WHO and International Consensus Classification (ICC) updates on the role of cytogenetics and molecular genetics in the diagnosis and risk stratification of MDS.
    MeSH term(s) Humans ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Myelodysplastic Syndromes/diagnosis ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Prognosis ; Molecular Biology ; Cytogenetic Analysis
    Language English
    Publishing date 2023-08-16
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2023.101512
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  9. Article ; Online: Public health significance of Helicobacter pullorum, a putative food-associated emerging zoonotic pathogen in Iran.

    Akhlaghi, Hosein / Javan, Ashkan Jebelli / Chashmi, Seyed Hesamodin Emadi

    Comparative immunology, microbiology and infectious diseases

    2022  Volume 87, Page(s) 101849

    Abstract: According to the World Health Organization, diseases which are naturally transmissible from vertebrate animals to human beings or from humans to vertebrates are defined as the zoonotic diseases. Among the most common zoonotic pathogens, Helicobacter ... ...

    Abstract According to the World Health Organization, diseases which are naturally transmissible from vertebrate animals to human beings or from humans to vertebrates are defined as the zoonotic diseases. Among the most common zoonotic pathogens, Helicobacter pullorum has earned public recognition regarding its public health significance. This Enterohepatic Helicobacter species has been shown to be a very dangerous and life-threatening microorganism, accounting for several clinically important infections in the human population. However, despite the several studies indicating the significance of H.pullorum in both humans and animals, there is a lack of documented information and reliable statistics about this pathogen throughout the world. Thus, in this review, we would provide a novel knowledge about the general characteristics, isolation methods, host ranges and transmission routes, and occurrences of H.pullorum in poultry, chicken meat, and human in Iran. We would also clarify the status of antimicrobial resistance (AMR) profile of the H.pullorum isolates from various samples in this country.
    MeSH term(s) Animals ; Bacterial Zoonoses/epidemiology ; Chickens/microbiology ; Helicobacter ; Humans ; Iran/epidemiology ; Public Health
    Language English
    Publishing date 2022-06-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2022.101849
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  10. Article ; Online: Breaking Mitochondrial Fasting for Cancer Treatment: Old Wine in New Bottles.

    Emadi, Ashkan / Lapidus, Rena G

    Journal of the National Cancer Institute

    2018  Volume 109, Issue 11

    MeSH term(s) Humans ; Mitochondria/metabolism ; Neoplasms/therapy ; Oxidative Phosphorylation
    Language English
    Publishing date 2018-01-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djx069
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