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  1. Book ; Online: Large Language Model-Empowered Agents for Simulating Macroeconomic Activities

    Li, Nian / Gao, Chen / Li, Yong / Liao, Qingmin

    2023  

    Abstract: The advent of the Web has brought about a paradigm shift in traditional economics, particularly in the digital economy era, enabling the precise recording and analysis of individual economic behavior. This has led to a growing emphasis on data-driven ... ...

    Abstract The advent of the Web has brought about a paradigm shift in traditional economics, particularly in the digital economy era, enabling the precise recording and analysis of individual economic behavior. This has led to a growing emphasis on data-driven modeling in macroeconomics. In macroeconomic research, Agent-based modeling (ABM) emerged as an alternative, evolving through rule-based agents, machine learning-enhanced decision-making, and, more recently, advanced AI agents. However, the existing works are suffering from three main challenges when endowing agents with human-like decision-making, including agent heterogeneity, the influence of macroeconomic trends, and multifaceted economic factors. Large language models (LLMs) have recently gained prominence in offering autonomous human-like characteristics. Therefore, leveraging LLMs in macroeconomic simulation presents an opportunity to overcome traditional limitations. In this work, we take an early step in introducing a novel approach that leverages LLMs in macroeconomic simulation. We design prompt-engineering-driven LLM agents to exhibit human-like decision-making and adaptability in the economic environment, with the abilities of perception, reflection, and decision-making to address the abovementioned challenges. Simulation experiments on macroeconomic activities show that LLM-empowered agents can make realistic work and consumption decisions and emerge more reasonable macroeconomic phenomena than existing rule-based or AI agents. Our work demonstrates the promising potential to simulate macroeconomics based on LLM and its human-like characteristics.
    Keywords Computer Science - Artificial Intelligence
    Subject code 006
    Publishing date 2023-10-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Safe femoral condyle range for the reverse Rigidfix femoral fixation device in anterior cruciate ligament reconstruction.

    Luo, Zhongliu / Hu, Yong / Han, Qingmin / Gao, Zhi / Cheng, Songmiao

    BMC musculoskeletal disorders

    2022  Volume 23, Issue 1, Page(s) 288

    Abstract: Background: To determine the characteristics of cross-pin protrusion in patients treated with the reverse Rigidfix femoral fixation device for femoral tunnel preparation through the anteromedial portal in Arthroscopic anterior cruciate ligament ... ...

    Abstract Background: To determine the characteristics of cross-pin protrusion in patients treated with the reverse Rigidfix femoral fixation device for femoral tunnel preparation through the anteromedial portal in Arthroscopic anterior cruciate ligament reconstruction (ACLR), analyse the reasons for this outcome, and identify safety hazards of this surgical technique for improvement.
    Methods: A retrospective analysis of patients who underwent ACLR using this technology at our hospital in 2018 was conducted. Patients with and without cross-pin protrusion were included in the protrusion positive and negative groups, respectively. The sex, age and imaging characteristics of the patients with cross-pin protrusion were identified, and the reasons for cross-pin protrusion were analysed.
    Results: There were 64 and 212 patients in the protrusion positive and negative groups, respectively. The proportion of cross-pin protrusion cases was 23.19% (64/276). There was a significant difference in the ratio of males to females (P < 0.001, χ2 = 185.184), the mediolateral femoral condyle diameter (protrusion positive group, 70.59 ± 2.51 mm; protrusion negative group, 82.65 ± 4.16 mm; P < 0.001, t = 28.424), and the anteroposterior diameter of the lateral femoral condyle (protrusion positive group, 58.34 ± 2.89 mm; protrusion negative group, 66.38 ± 3.53 mm; P < 0.001, t = 16.615). The cross-pins did not penetrate the lateral femoral condyle cortex in patients with a mediolateral femoral condyle diameter ≥ 76 mm, but the cross-pins definitely penetrated the cortex when the diameter was ≤ 70 mm. The cross-pins did not penetrate when the anteroposterior lateral femoral condyle diameter was ≥ 66 mm, but the cross-pins definitely penetrated it when the diameter was ≤ 59 mm.
    Conclusion: The patients with cross-pin protrusion after reverse Rigidfix femoral fixation treatment to prepare the femoral tunnel through the anteromedial portal in ACLR were mainly females with small femoral condyles. For patients with a mediolateral femoral condyle diameter ≥ 76 mm and an anteroposterior lateral femoral condyle diameter ≥ 66 mm, there is no risk of cross-pin protrusion, so this technique can be used with confidence.
    Levels of evidence: III.
    MeSH term(s) Anterior Cruciate Ligament/surgery ; Anterior Cruciate Ligament Reconstruction/adverse effects ; Female ; Femur/diagnostic imaging ; Femur/surgery ; Humans ; Knee Joint/surgery ; Male ; Retrospective Studies
    Language English
    Publishing date 2022-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-022-05250-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Design, synthesis, antiviral and fungicidal activities of novel polycarpine simplified analogues.

    Yan, Lili / Gao, Yongyue / Li, Taiqing / Wang, Xiangyu / Xie, Rong / Liu, Yaxi / Xie, Yuxuan / Wang, Ziwen / Lu, Aidang / Wang, Qingmin

    Bioorganic chemistry

    2023  Volume 135, Page(s) 106508

    Abstract: Fungal and viral diseases account for 70-80% of agricultural production losses caused by microbial diseases. Synthetic fungicides and antiviral agents have been used to treat plant diseases caused by plant pathogenic fungi and viruses, but their use has ... ...

    Abstract Fungal and viral diseases account for 70-80% of agricultural production losses caused by microbial diseases. Synthetic fungicides and antiviral agents have been used to treat plant diseases caused by plant pathogenic fungi and viruses, but their use has been criticized due to their adverse side effects. As alternative strategies, natural fungicides and antiviral agents have attracted many researchers' interest in recent years. Herein, we designed and synthesized a series of novel polycarpine simplified analogues. Antiviral activity research against tobacco mosaic virus (TMV) revealed that most of the designed compounds have good antiviral activities. The virucidal activities of 4, 6d, 6f, 6h, and 8c are higher than that of polycarpine and similar to that of ningnanmycin. The structure simplified compound 8c was selected for further antiviral mechanism research which showed that compound 8c could inhibit the formation of 20S protein discs by acting on TMV coat protein. These compounds also displayed broad-spectrum fungicidal activities against 7 kinds of plant fungi. This work lays the foundation for the application of polycarpine simplified analogues in crop protection.
    MeSH term(s) Antiviral Agents/chemistry ; Fungicides, Industrial/chemistry ; Structure-Activity Relationship ; Tobacco Mosaic Virus ; Fungi ; Drug Design
    Chemical Substances Antiviral Agents ; polycarpine ; Fungicides, Industrial
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Solution combustion synthesis of a nanometer-scale Co

    Michalska, Monika / Xu, Huajun / Shan, Qingmin / Zhang, Shiqiang / Dall'Agnese, Yohan / Gao, Yu / Jain, Amrita / Krajewski, Marcin

    Beilstein journal of nanotechnology

    2021  Volume 12, Page(s) 424–431

    Abstract: A novel solution combustion synthesis of nanoscale spinel-structured ... ...

    Abstract A novel solution combustion synthesis of nanoscale spinel-structured Co
    Language English
    Publishing date 2021-05-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2583584-1
    ISSN 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.12.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ruthenium Carbene-Mediated Construction of Strained Allenes via the Enyne Cross-Metathesis/Cyclopropanation of 1,6-Enynes.

    Gao, Ming / Gao, Qiangqiang / Hao, Xiangbin / Wu, Ying / Zhang, Qingmin / Liu, Guohua / Liu, Rui

    Organic letters

    2020  Volume 22, Issue 3, Page(s) 1139–1143

    Abstract: Herein, we report on the unprecedented dimerization of 1,6-enynes using a commercially available ruthenium complex ... ...

    Abstract Herein, we report on the unprecedented dimerization of 1,6-enynes using a commercially available ruthenium complex RuCl
    Language English
    Publishing date 2020-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.9b04662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: LLM-Powered Hierarchical Language Agent for Real-time Human-AI Coordination

    Liu, Jijia / Yu, Chao / Gao, Jiaxuan / Xie, Yuqing / Liao, Qingmin / Wu, Yi / Wang, Yu

    2023  

    Abstract: AI agents powered by Large Language Models (LLMs) have made significant advances, enabling them to assist humans in diverse complex tasks and leading to a revolution in human-AI coordination. LLM-powered agents typically require invoking LLM APIs and ... ...

    Abstract AI agents powered by Large Language Models (LLMs) have made significant advances, enabling them to assist humans in diverse complex tasks and leading to a revolution in human-AI coordination. LLM-powered agents typically require invoking LLM APIs and employing artificially designed complex prompts, which results in high inference latency. While this paradigm works well in scenarios with minimal interactive demands, such as code generation, it is unsuitable for highly interactive and real-time applications, such as gaming. Traditional gaming AI often employs small models or reactive policies, enabling fast inference but offering limited task completion and interaction abilities. In this work, we consider Overcooked as our testbed where players could communicate with natural language and cooperate to serve orders. We propose a Hierarchical Language Agent (HLA) for human-AI coordination that provides both strong reasoning abilities while keeping real-time execution. In particular, HLA adopts a hierarchical framework and comprises three modules: a proficient LLM, referred to as Slow Mind, for intention reasoning and language interaction, a lightweight LLM, referred to as Fast Mind, for generating macro actions, and a reactive policy, referred to as Executor, for transforming macro actions into atomic actions. Human studies show that HLA outperforms other baseline agents, including slow-mind-only agents and fast-mind-only agents, with stronger cooperation abilities, faster responses, and more consistent language communications.

    Comment: This paper is accpeted by AAMAS 2024. More demonstrations can be seen on our website https://sites.google.com/view/overcooked-hla/
    Keywords Computer Science - Artificial Intelligence ; Computer Science - Human-Computer Interaction
    Subject code 004
    Publishing date 2023-12-23
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: In the Subtropical Monsoon Climate High-Density City, What Features of the Neighborhood Environment Matter Most for Public Health?

    Wei Gao / Ruoxiang Tu / Hao Li / Yongli Fang / Qingmin Que

    International Journal of Environmental Research and Public Health, Vol 17, Iss 9566, p

    2020  Volume 9566

    Abstract: Urbanization and climate change have been rapidly occurring globally. Evidence-based healthy city development is required to improve living quality and mitigate the adverse impact of the outdoor neighborhood environment on public health. Taking Guangzhou ...

    Abstract Urbanization and climate change have been rapidly occurring globally. Evidence-based healthy city development is required to improve living quality and mitigate the adverse impact of the outdoor neighborhood environment on public health. Taking Guangzhou as an example to explore the association of neighborhood environment and public health and preferably to offer some implications for better future city development, we measured ten environmental factors (temperature (T), wind-chill index (WCI), thermal stress index (HSI), relative humidity (RH), average wind speed (AWS), negative oxygen ions (NOI), PM2.5, luminous flux (LF), and illuminance (I)) in four seasons in four typical neighborhoods, and the SF-36 health scale was employed to assess the physical and mental health of neighborhood residents in nine subscales (health transition(HT), physiological functions (PF), general health status (GH), physical pain (BP), physiological functions (RP), energy vitality (VT), mental health (MH), social function (SF), and emotional functions (RE)). The linear mixed model was used in an analysis of variance. We ranked the different environmental factors in relation to aspects of health and weighted them accordingly. Generally, the thermal environment had the greatest impact on both physical and mental health and the atmospheric environment and wind environment had the least impact on physical health and mental health, respectively. In addition, the physical health of the resident was more greatly affected by the environment than mental health. According to the results, we make a number of strategic suggestions for the renewal of the outdoor neighborhood environment in subtropical monsoon climate high-density cities and provide a theoretical basis for improving public health through landscape architecture at the neighborhood scale.
    Keywords landscape architecture ; environmental factor ; correlation study ; physical health ; mental health ; urban regeneration ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Frequency and Temperature-Dependent Space Charge Characteristics of a Solid Polymer under Unipolar Electrical Stresses of Different Waveforms

    Hanwen Ren / Qingmin Li / Yasuhiro Tanaka / Hiroaki Miyake / Haoyu Gao / Zhongdong Wang

    Polymers, Vol 13, Iss 3401, p

    2021  Volume 3401

    Abstract: In this paper, we studied the space charge phenomena of a solid polymer under thermal and electrical stresses with different frequencies and waveforms. By analyzing the parameter selection method of a protection capacitor and resistor, the newly built ... ...

    Abstract In this paper, we studied the space charge phenomena of a solid polymer under thermal and electrical stresses with different frequencies and waveforms. By analyzing the parameter selection method of a protection capacitor and resistor, the newly built pulsed electro-acoustic (PEA) system can be used for special electrical stresses under 500 Hz, based on which the charge phenomena are studied in detail under positive and negative DC and half-wave sine and rectangular wave voltages. Experimental results show that the charge accumulated in the polyimide polymer under DC conditions mainly comes from the grounded electrode side, and the amount of charge accumulated with electric field distortion becomes larger in a high-temperature environment. At room temperature, positive charges tend to accumulate in low-frequency conditions under positive rectangular wave voltages, while they easily appear under high-frequency situations of negative ones. In contrast, the maximum electric field distortion and charge accumulation under both half-wave sine voltages occur at 10 Hz. When the measurement temperature increases, the accumulated positive charge decreases, with a more negative charge appearing under rectangular wave voltages, while a more positive charge accumulates at different frequencies of half-wave sine voltages. Therefore, our study of the charge characteristics under different voltage and temperature conditions can provide a reference for applications in the corresponding environments.
    Keywords space charge ; polyimide polymer ; unipolar electrical stress ; temperature ; frequency ; Organic chemistry ; QD241-441
    Subject code 620
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Toad Alkaloid for Pesticide Discovery: Dehydrobufotenine Derivatives as Novel Agents against Plant Virus and Fungi.

    Tian, Zhaoyong / Liao, Ancai / Kang, Jin / Gao, Yongyue / Lu, Aidang / Wang, Ziwen / Wang, Qingmin

    Journal of agricultural and food chemistry

    2021  Volume 69, Issue 34, Page(s) 9754–9763

    Abstract: Plant viruses and fungi are a serious threat to food security and natural ecosystems. The efficient and environment-friendly control methods are urgently needed to help safeguard such resources. Here, we achieved the efficient synthesis of toad alkaloid ... ...

    Abstract Plant viruses and fungi are a serious threat to food security and natural ecosystems. The efficient and environment-friendly control methods are urgently needed to help safeguard such resources. Here, we achieved the efficient synthesis of toad alkaloid dehydrobufotenine in eight steps with an overall yield of 8% from 5-methoxyindole. A series of dehydrobufotenine derivatives were designed, synthesized, and evaluated for their antiviral and fungicidal activities systematically. It was found for the first time that these compounds have good anti-plant virus activities and anti-plant pathogen activities. The antiviral activities of 21 compounds were similar to or better than those of ribavirin. Compounds
    MeSH term(s) Alkaloids/pharmacology ; Antiviral Agents/pharmacology ; Ascomycota ; Drug Design ; Ecosystem ; Fungi ; Fungicides, Industrial/pharmacology ; Molecular Docking Simulation ; Molecular Structure ; Pesticides ; Plant Viruses ; Structure-Activity Relationship ; Tobacco Mosaic Virus
    Chemical Substances Alkaloids ; Antiviral Agents ; Fungicides, Industrial ; Pesticides
    Language English
    Publishing date 2021-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c03714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Structural Optimization of the Natural Product: Discovery of Almazoles C-D and Their Derivatives as Novel Antiviral and Anti-phytopathogenic Fungus Agents.

    Yuan, Meiling / Tian, Zhaoyong / Yin, Xiangyang / Yuan, Xinyu / Gao, Jixuan / Yuan, Wenying / Lu, Aidang / Wang, Ziwen / Li, Liang / Wang, Qingmin

    Journal of agricultural and food chemistry

    2022  

    Abstract: Plant diseases seriously affect the growth of crops and the quality and yield of agricultural products. The search for plant-derived pesticide candidates based on natural products is a hot topic of current research. Marine natural products almazoles C-D ... ...

    Abstract Plant diseases seriously affect the growth of crops and the quality and yield of agricultural products. The search for plant-derived pesticide candidates based on natural products is a hot topic of current research. Marine natural products almazoles C-D were efficiently prepared and selected as the lead compounds in this work. Two series of almazole derivatives were designed and synthesized, and their antiviral and fungicidal activities were systematically evaluated. The results of anti-tobacco mosaic virus (anti-TMV) activity showed that almazoles C-D and their derivatives had good anti-TMV activities. Compounds
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c05898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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