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  1. Article: Art markets in crisis: how personal bonds and market subcultures mediate the effects of COVID-19.

    Buchholz, Larissa / Fine, Gary Alan / Wohl, Hannah

    American journal of cultural sociology

    2020  Volume 8, Issue 3, Page(s) 462–476

    Abstract: We examine how the contemporary art market has changed as a result of the disruptions caused by the novel coronavirus. Based on interviews with artists, collectors, a dealer, and an auction house executive, we argue that the decline of face-to-face ... ...

    Abstract We examine how the contemporary art market has changed as a result of the disruptions caused by the novel coronavirus. Based on interviews with artists, collectors, a dealer, and an auction house executive, we argue that the decline of face-to-face interaction, previously essential to art market transactions, has placed strain on each corner of the community. In the absence of physical co-presence with the artworks and art world actors, participants struggle to evaluate and appreciate artworks, make new social ties, develop trust, and experience a shared sense of pleasure and collective effervescence. These challenges especially impact the primary gallery market, where participants emphasize a communal commitment to art above instrumental speculation, which is more accepted in the secondary auction market. We find a transition to distant online communication, but the likelihood of this continuing after the lockdowns end and the virus dissipates varies according to the subcultures of these market segments.
    Keywords covid19
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2775179-X
    ISSN 2049-7121 ; 2049-7113
    ISSN (online) 2049-7121
    ISSN 2049-7113
    DOI 10.1057/s41290-020-00119-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Art markets in crisis: how personal bonds and market subcultures mediate the effects of COVID-19

    Buchholz, Larissa / Fine, Gary Alan / Wohl, Hannah

    Am J Cult Sociol

    Abstract: We examine how the contemporary art market has changed as a result of the disruptions caused by the novel coronavirus. Based on interviews with artists, collectors, a dealer, and an auction house executive, we argue that the decline of face-to-face ... ...

    Abstract We examine how the contemporary art market has changed as a result of the disruptions caused by the novel coronavirus. Based on interviews with artists, collectors, a dealer, and an auction house executive, we argue that the decline of face-to-face interaction, previously essential to art market transactions, has placed strain on each corner of the community. In the absence of physical co-presence with the artworks and art world actors, participants struggle to evaluate and appreciate artworks, make new social ties, develop trust, and experience a shared sense of pleasure and collective effervescence. These challenges especially impact the primary gallery market, where participants emphasize a communal commitment to art above instrumental speculation, which is more accepted in the secondary auction market. We find a transition to distant online communication, but the likelihood of this continuing after the lockdowns end and the virus dissipates varies according to the subcultures of these market segments.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #843278
    Database COVID19

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  3. Article ; Online: Fluorescent Indolo[3,2-a]phenazines against Toxoplasma gondii: Concise Synthesis by Gold-Catalyzed Cycloisomerization with 1,2-Silyl Migration and ipso-Iodination Suzuki Sequence.

    Merkt, Franziska K / Mazzone, Flaminia / Sazzadeh, Shabnam Shaneh / Bonda, Lorand / Hinz, Larissa K E / Gruber, Irina / Buchholz, Karin / Janiak, Christoph / Pfeffer, Klaus / Müller, Thomas J J

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Volume 27, Issue 38, Page(s) 9774–9781

    Abstract: A gold-catalyzed cycloisomerization of 2-indolyl-3-[(trimethylsilyl)ethynyl)]quinoxalines with concomitant 1,2-silyl shift forms 6-(trimethylsilyl)indolo[3,2-a]phenazines in moderate to excellent yield. These silylated heterocycles are readily ... ...

    Abstract A gold-catalyzed cycloisomerization of 2-indolyl-3-[(trimethylsilyl)ethynyl)]quinoxalines with concomitant 1,2-silyl shift forms 6-(trimethylsilyl)indolo[3,2-a]phenazines in moderate to excellent yield. These silylated heterocycles are readily transformed into 6-aryl-indolo[3,2-a]phenazines in moderate to good yield by one-pot ipso-iodination Suzuki coupling. The title compounds represent a novel type of tunable luminophore. Structure-property relationships for 6-aryl-indolo[3,2-a]phenazines obtained from Hammett correlations with σ
    MeSH term(s) Catalysis ; Gold ; Halogenation ; Phenazines ; Toxoplasma
    Chemical Substances Phenazines ; Gold (7440-57-5)
    Language English
    Publishing date 2021-05-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202101391
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  4. Article ; Online: The drug-induced phenotypic landscape of colorectal cancer organoids

    Johannes Betge / Niklas Rindtorff / Jan Sauer / Benedikt Rauscher / Clara Dingert / Haristi Gaitantzi / Frank Herweck / Kauthar Srour-Mhanna / Thilo Miersch / Erica Valentini / Kim E. Boonekamp / Veronika Hauber / Tobias Gutting / Larissa Frank / Sebastian Belle / Timo Gaiser / Inga Buchholz / Ralf Jesenofsky / Nicolai Härtel /
    Tianzuo Zhan / Bernd Fischer / Katja Breitkopf-Heinlein / Elke Burgermeister / Matthias P. Ebert / Michael Boutros

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: The heterogeneity underlying cancer organoid phenotypes is not yet well understood. Here, the authors develop an imaging analysis assay for high throughput phenotypic screening of colorectal organoids that allows to define specific morphological changes ... ...

    Abstract The heterogeneity underlying cancer organoid phenotypes is not yet well understood. Here, the authors develop an imaging analysis assay for high throughput phenotypic screening of colorectal organoids that allows to define specific morphological changes that occur following different drug treatments.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The drug-induced phenotypic landscape of colorectal cancer organoids.

    Betge, Johannes / Rindtorff, Niklas / Sauer, Jan / Rauscher, Benedikt / Dingert, Clara / Gaitantzi, Haristi / Herweck, Frank / Srour-Mhanna, Kauthar / Miersch, Thilo / Valentini, Erica / Boonekamp, Kim E / Hauber, Veronika / Gutting, Tobias / Frank, Larissa / Belle, Sebastian / Gaiser, Timo / Buchholz, Inga / Jesenofsky, Ralf / Härtel, Nicolai /
    Zhan, Tianzuo / Fischer, Bernd / Breitkopf-Heinlein, Katja / Burgermeister, Elke / Ebert, Matthias P / Boutros, Michael

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3135

    Abstract: Patient-derived organoids resemble the biology of tissues and tumors, enabling ex vivo modeling of human diseases. They have heterogeneous morphologies with unclear biological causes and relationship to treatment response. Here, we use high-throughput, ... ...

    Abstract Patient-derived organoids resemble the biology of tissues and tumors, enabling ex vivo modeling of human diseases. They have heterogeneous morphologies with unclear biological causes and relationship to treatment response. Here, we use high-throughput, image-based profiling to quantify phenotypes of over 5 million individual colorectal cancer organoids after treatment with >500 small molecules. Integration of data using multi-omics modeling identifies axes of morphological variation across organoids: Organoid size is linked to IGF1 receptor signaling, and cystic vs. solid organoid architecture is associated with LGR5 + stemness. Treatment-induced organoid morphology reflects organoid viability, drug mechanism of action, and is biologically interpretable. Inhibition of MEK leads to cystic reorganization of organoids and increases expression of LGR5, while inhibition of mTOR induces IGF1 receptor signaling. In conclusion, we identify shared axes of variation for colorectal cancer organoid morphology, their underlying biological mechanisms, and pharmacological interventions with the ability to move organoids along them.
    MeSH term(s) Colorectal Neoplasms/genetics ; Humans ; Organoids/pathology ; Phenotype ; Signal Transduction
    Language English
    Publishing date 2022-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30722-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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