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  1. Article: Élimination du paludisme en Asie du Sud-Est? Moyens médicamenteux.

    Nosten, François

    Bulletin de l'Academie nationale de medecine

    2017  Volume 200, Issue 3, Page(s) 467–75; discussion 475–6

    Abstract: Artemisinin resistance in P. falciparum is spreading in South East Asia and threatens the recent progresses made in the fight against malaria. A race against time has started to eliminate P.falciparum in this region before it becomes resistant to all ... ...

    Title translation Elimination in South-East Asia? The role of antimalarial drugs.
    Abstract Artemisinin resistance in P. falciparum is spreading in South East Asia and threatens the recent progresses made in the fight against malaria. A race against time has started to eliminate P.falciparum in this region before it becomes resistant to all available treatments. Antimalarials have a central role in the current elimination programme in eastern Burma on the border with Thailand. The combination of artemether and lumefantrine is used in association with primaquine for the early treatment of clinical cases. The slowly eliminated dihydro-artemisinin and piperaquine is the drug of choice in mass drug administration in the foci of high prevalence of sub-microscopic and asymptomatic infections. Initial results after 18 months of activities are promising: the participation of the population was excellent and there was a sharp reduction of P.falciparum incidence without evidence of worsening resistance.
    MeSH term(s) Antimalarials/therapeutic use ; Artemether ; Artemisinins/administration & dosage ; Artemisinins/therapeutic use ; Asia, Southeastern/epidemiology ; Disease Eradication/methods ; Drug Therapy, Combination ; Ethanolamines/administration & dosage ; Fluorenes/administration & dosage ; Humans ; Lumefantrine ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/prevention & control ; Quinolines/administration & dosage
    Chemical Substances Antimalarials ; Artemisinins ; Ethanolamines ; Fluorenes ; Quinolines ; artemisinin (9RMU91N5K2) ; piperaquine (A0HV2Q956Y) ; Artemether (C7D6T3H22J) ; Lumefantrine (F38R0JR742)
    Language French
    Publishing date 2017-06-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 213227-8
    ISSN 0001-4079
    ISSN 0001-4079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SERCAP: is the perfect the enemy of the good?

    White, Nicholas J / Nosten, François H

    Malaria journal

    2021  Volume 20, Issue 1, Page(s) 281

    Abstract: Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. The ... ...

    Abstract Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. The operational advantage of a single encounter has to be balanced against the need for a high dose, reliable absorption, little variability in pharmacokinetic properties, slow elimination (to ensure curative drug exposures in all patients) and a very low rate of vomiting. The demanding aspirational target may have hindered anti-malarial drug development. Aiming for three-day regimens, as in current anti-malarial treatments, would be better.
    MeSH term(s) Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Drug Discovery ; Humans ; Malaria/prevention & control ; Malaria/veterinary
    Chemical Substances Antimalarials
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Letter
    ISSN 1475-2875
    ISSN (online) 1475-2875
    DOI 10.1186/s12936-021-03821-z
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  3. Article ; Online: A brief history of malaria.

    Nosten, François / Richard-Lenoble, Dominique / Danis, Martin

    Presse medicale (Paris, France : 1983)

    2022  Volume 51, Issue 3, Page(s) 104130

    Abstract: For millions of years, invertebrates and malaria parasites have coexisted and to date, malaria remains the most important human parasitic disease. This co-evolution had profound impacts on the movements of early hominids and on the genome of modern ... ...

    Abstract For millions of years, invertebrates and malaria parasites have coexisted and to date, malaria remains the most important human parasitic disease. This co-evolution had profound impacts on the movements of early hominids and on the genome of modern humans. Over the past two centuries, progress has been made with the discovery of the parasite, its transmission, and medicines, paving the way to the control of the disease and its elimination in some countries. However, the Plasmodium parasite is a formidable foe capable of developing resistance to drugs, and the mosquito vector has adapted to insecticides, foiling all attempts to eradicate the disease. Over recent years the economic and social costs of malaria have been recognized and more funds have been mobilized than ever before, however further efforts are needed. National programs, international institutions and researchers will need to do better if the preventable deaths of hundreds of thousands of mostly African children are to be averted.
    Language English
    Publishing date 2022-06-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2022.104130
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  4. Article ; Online: Beriberi in Cambodia.

    Nosten, François

    Paediatrics and international child health

    2015  Volume 35, Issue 4, Page(s) 283–284

    Abstract: Beriberi had plagued humans for centuries. It was responsible for over 50% of infant deaths in the Philippines in the early 1900s. But since the discovery of its cause and treatment it has become a rarity, or has it? ...

    Abstract Beriberi had plagued humans for centuries. It was responsible for over 50% of infant deaths in the Philippines in the early 1900s. But since the discovery of its cause and treatment it has become a rarity, or has it?
    MeSH term(s) Beriberi ; Cambodia ; Humans
    Language English
    Publishing date 2015
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2649065-1
    ISSN 2046-9055 ; 2046-9047
    ISSN (online) 2046-9055
    ISSN 2046-9047
    DOI 10.1080/20469047.2015.1109246
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  5. Article ; Online: New malaria maps.

    Nosten, Francois H / Phyo, Aung Pyae

    Lancet (London, England)

    2019  Volume 394, Issue 10195, Page(s) 278–279

    MeSH term(s) Humans ; Malaria ; Plasmodium vivax
    Language English
    Publishing date 2019-06-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)31273-5
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  6. Article ; Online: Spatio-temporal spread of artemisinin resistance in Southeast Asia.

    Flegg, Jennifer A / Kandanaarachchi, Sevvandi / Guerin, Philippe J / Dondorp, Arjen M / Nosten, Francois H / Otienoburu, Sabina Dahlström / Golding, Nick

    PLoS computational biology

    2024  Volume 20, Issue 4, Page(s) e1012017

    Abstract: Current malaria elimination targets must withstand a colossal challenge-resistance to the current gold standard antimalarial drug, namely artemisinin derivatives. If artemisinin resistance significantly expands to Africa or India, cases and malaria- ... ...

    Abstract Current malaria elimination targets must withstand a colossal challenge-resistance to the current gold standard antimalarial drug, namely artemisinin derivatives. If artemisinin resistance significantly expands to Africa or India, cases and malaria-related deaths are set to increase substantially. Spatial information on the changing levels of artemisinin resistance in Southeast Asia is therefore critical for health organisations to prioritise malaria control measures, but available data on artemisinin resistance are sparse. We use a comprehensive database from the WorldWide Antimalarial Resistance Network on the prevalence of non-synonymous mutations in the Kelch 13 (K13) gene, which are known to be associated with artemisinin resistance, and a Bayesian geostatistical model to produce spatio-temporal predictions of artemisinin resistance. Our maps of estimated prevalence show an expansion of the K13 mutation across the Greater Mekong Subregion from 2000 to 2022. Moreover, the period between 2010 and 2015 demonstrated the most spatial change across the region. Our model and maps provide important insights into the spatial and temporal trends of artemisinin resistance in a way that is not possible using data alone, thereby enabling improved spatial decision support systems on an unprecedented fine-scale spatial resolution. By predicting for the first time spatio-temporal patterns and extents of artemisinin resistance at the subcontinent level, this study provides critical information for supporting malaria elimination goals in Southeast Asia.
    MeSH term(s) Artemisinins/pharmacology ; Asia, Southeastern/epidemiology ; Drug Resistance/genetics ; Antimalarials/pharmacology ; Humans ; Bayes Theorem ; Spatio-Temporal Analysis ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/genetics ; Mutation ; Malaria/drug therapy ; Malaria/epidemiology ; Computational Biology ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/epidemiology
    Chemical Substances Artemisinins ; Antimalarials ; artemisinin (9RMU91N5K2)
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1012017
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  7. Article ; Online: Have we really failed to roll back malaria?

    White, Nicholas J / Day, Nicholas P J / Ashley, Elizabeth A / Smithuis, Frank M / Nosten, Francois H

    Lancet (London, England)

    2022  Volume 399, Issue 10327, Page(s) 799–800

    MeSH term(s) Humans ; Malaria/epidemiology ; Malaria/prevention & control ; World Health Organization
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00175-1
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  8. Article ; Online: SERCAP

    Nicholas J. White / François H. Nosten

    Malaria Journal, Vol 20, Iss 1, Pp 1-

    is the perfect the enemy of the good?

    2021  Volume 4

    Abstract: Abstract Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. ... ...

    Abstract Abstract Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. The operational advantage of a single encounter has to be balanced against the need for a high dose, reliable absorption, little variability in pharmacokinetic properties, slow elimination (to ensure curative drug exposures in all patients) and a very low rate of vomiting. The demanding aspirational target may have hindered anti-malarial drug development. Aiming for three-day regimens, as in current anti-malarial treatments, would be better.
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Waking the sleeping beauty.

    Nosten, François

    The Journal of infectious diseases

    2011  Volume 202, Issue 9, Page(s) 1300–1301

    MeSH term(s) Antimalarials/pharmacokinetics ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Artemether ; Artemisinins/pharmacokinetics ; Artemisinins/pharmacology ; Artemisinins/therapeutic use ; Artesunate ; Humans ; Malaria, Falciparum/drug therapy ; Microbial Viability/drug effects ; Plasmodium falciparum/drug effects ; Recurrence
    Chemical Substances Antimalarials ; Artemisinins ; Artesunate (60W3249T9M) ; Artemether (C7D6T3H22J)
    Language English
    Publishing date 2011-03-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1086/656478
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  10. Article ; Online: Malaria - Epidemiology, Treatment, and Prevention.

    Baden, Lindsey / Catteruccia, Flaminia / Diabaté, Abdoulaye / Donini, Cristina / Nosten, François / O'Neill, Scott / Osier, Faith / Phyo, Aung Pyae / White, Nicholas

    The New England journal of medicine

    2023  Volume 388, Issue 5, Page(s) e9

    MeSH term(s) Humans ; Biomedical Research ; Malaria/drug therapy ; Malaria/epidemiology ; Malaria/prevention & control ; Malaria/therapy
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2216703
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