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Article: D

Altwegg, K / Balsiger, H / Berthelier, J J / Bieler, A / Calmonte, U / De Keyser, J / Fiethe, B / Fuselier, S A / Gasc, S / Gombosi, T I / Owen, T / Le Roy, L / Rubin, M / Sémon, T / Tzou, C-Y

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

2017 Volume 375, Issue 2097

Abstract: ... water, D ...

Abstract	The European Rosetta mission has been following comet 67P/Churyumov-Gerasimenko for 2 years, studying the nucleus and coma in great detail. For most of these 2 years the Rosetta Orbiter Sensor for Ion and Neutral Analysis (ROSINA) has analysed the volatile part of the coma. With its high mass resolution and sensitivity it was able to not only detect deuterated water HDO, but also doubly deuterated water, D
Language	English
Publishing date	2017--13
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	208381-4
ISSN	1471-2962 ; 1364-503X ; 0080-4614 ; 0264-3820 ; 0264-3952
ISSN (online)	1471-2962
ISSN	1364-503X ; 0080-4614 ; 0264-3820 ; 0264-3952
DOI	10.1098/rsta.2016.0253
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Article ; Online: Sorting Out Whether Vitamin D Deficiency Raises COVID-19 Risk.

Rubin, Rita

JAMA

2021 Volume 325, Issue 4, Page(s) 329–330

MeSH term(s)	COVID-19/etiology ; COVID-19/mortality ; COVID-19/prevention & control ; Conflict of Interest ; Humans ; Risk Factors ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	News
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2020.24127
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Article ; Online: Defining D-irAEs: consensus-based disease definitions for the diagnosis of dermatologic adverse events from immune checkpoint inhibitor therapy.

Chen, Steven T / Semenov, Yevgeniy R / Alloo, Allireza / Bach, Daniel Q / Betof Warner, Allison / Bougrine, Amina / Burton, Leeann / Cappelli, Laura C / Castells, Mariana / Cohen, Justine / Dewan, Anna K / Fadden, Riley / Guggina, Lauren / Hegde, Aparna / Huang, Victor / Johnson, Douglas B / Kaffenberger, Benjamin / Kroshinsky, Daniela / Kwatra, Shawn /

Journal for immunotherapy of cancer

2024 Volume 12, Issue 4

Abstract: ... of immune-related adverse events (irAEs) is on the rise. Dermatologic immune-related adverse events (D-irAEs ... for the patient. Current guidelines lack clarity in terms of diagnostic criteria for D-irAEs. The goal ... of this project is to better define D-irAE for the purposes of identification, diagnosis, and future study ...

Abstract	With an increasing number of patients eligible for immune checkpoint inhibitors, the incidence of immune-related adverse events (irAEs) is on the rise. Dermatologic immune-related adverse events (D-irAEs) are the most common and earliest to manifest, often with important downstream consequences for the patient. Current guidelines lack clarity in terms of diagnostic criteria for D-irAEs. The goal of this project is to better define D-irAE for the purposes of identification, diagnosis, and future study of this important group of diseases.The objectives of this project were to develop consensus guidance for an approach to D-irAEs including disease definitions and severity grading. Knowing that consensus among oncologists, dermatologists, and irAE subspecialists would be critical for usability, we formed a Dermatologic irAE Disease Definition Panel. The panel was composed of 34 experts, including oncologists, dermatologists, a rheumatologist, and an allergist/immunologist from 22 institutions across the USA and internationally. A modified Delphi consensus process was used, with two rounds of anonymous ratings by panelists and two virtual meetings to discuss areas of controversy. Panelists rated content for usability, appropriateness, and accuracy on 9-point scales in electronic surveys and provided free text comments. A working group aggregated survey responses and incorporated them into revised definitions. Consensus was based on numeric ratings using the RAND/UCLA Appropriateness Method with prespecified definitions.Following revisions based on panelist feedback, all items received consensus in the second round of ratings. Consensus definitions were achieved for 10 core D-irAE diagnoses: ICI-vitiligo, ICI-lichen planus, ICI-psoriasis, ICI-exanthem, ICI-bullous pemphigoid, ICI-Grover's, ICI-eczematous, ICI-eruptive atypical squamous proliferation, ICI-pruritus without rash, and ICI-erosive mucocutaneous. A standard evaluation for D-irAE was also found to reach consensus, with disease-specific exceptions detailed when necessary. Each disorder's description includes further details on disease subtypes, symptoms, supportive exam findings, and three levels of diagnostic certainty (definite, probable, and possible).These consensus-driven disease definitions standardize D-irAE classification in a useable framework for multiple disciplines and will be the foundation for future work. Given consensus on their accuracy and usability from a representative panel group, we anticipate that they can be used broadly across clinical and research settings.
MeSH term(s)	Humans ; Consensus ; Immune Checkpoint Inhibitors/adverse effects ; Radioimmunotherapy ; Exanthema ; Oncologists
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2023-007675
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Article: Reduzieren Vitamin C, Vitamin D und Zink die Prävalenz und die Schwere viraler Atemwegsinfekte?

Lauscher, Josephine / Rubin, Diana

Zeitschrift für Komplementärmedizin

2024 Volume 16, Issue 01, Page(s) 46–49

Abstract: Die Rolle von Mikronährstoffen wie Vitamin C, Vitamin D oder Zink in der Prävention und Therapie ... an den Ernährungsstatus, an Grunderkrankungen und Laborparameter anzupassen. Ein Vitamin-D-Mangel sollte ausgeglichen ...

Abstract	Die Rolle von Mikronährstoffen wie Vitamin C, Vitamin D oder Zink in der Prävention und Therapie von Erkältungskrankheiten wird seit Langem diskutiert. Die Evidenzlage hierzu ist gemischt, was der Heterogenität der Studienpopulationen, dem oftmals fehlenden Erregernachweis sowie der unterschiedlichen Dauer, Frequenz und Dosis der Mikronährstoffgabe geschuldet ist. Festgehalten werden kann, dass es sinnvoll ist, die Supplementation individuell an den Ernährungsstatus, an Grunderkrankungen und Laborparameter anzupassen. Ein Vitamin-D-Mangel sollte ausgeglichen werden. Von einer Vitamin-C-Supplementation profitieren insbesondere Personen, die unter hohem körperlichen Stress stehen, sowie jene mit Exposition gegenüber Menschen mit akuten Atemwegsinfektionen.
Keywords	Infekte ; Infektion ; Mikronährstoffe ; Vitamin C ; Zink
Language	German
Publishing date	2024-02-01
Publisher	© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2495975-3
ISSN	1867-6103 ; 1867-6081
ISSN (online)	1867-6103
ISSN	1867-6081
DOI	10.1055/a-2237-0086
Database	Thieme publisher's database

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Article ; Online: Lower Out-of-Pocket Insulin Costs for Medicare Plan D Beneficiaries.

Rubin, Rita

JAMA

2020 Volume 323, Issue 16, Page(s) 1542

Language	English
Publishing date	2020-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2020.5604
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Article ; Online: The effects of mitotane and 1α,25-dihydroxyvitamin D

Rubin, B / Pilon, C / Pezzani, R / Rebellato, A / Fallo, F

Journal of endocrinological investigation

2019 Volume 43, Issue 3, Page(s) 357–367

Abstract: ... in combination with mitotane. The active vitamin D metabolite 1α,25-dihydroxyvitamin D: Methods and results ...

Abstract	Purpose: Mitotane is the only chemotherapeutic agent available for the treatment of adrenocortical carcinoma (ACC), however, the anti-neoplastic efficacy is limited due to several side-effects in vivo. There is, therefore, a need of exploring for new anti-tumoral agents which can be used either alone or in combination with mitotane. The active vitamin D metabolite 1α,25-dihydroxyvitamin D Methods and results: Multiple concentrations of mitotane and 1α,25(OH) Conclusion: Our results show an additive effect of mitotane and 1α,25(OH)
MeSH term(s)	Adrenal Cortex/drug effects ; Adrenal Cortex/metabolism ; Adrenal Cortex Neoplasms/metabolism ; Adrenocortical Carcinoma/metabolism ; Calcitriol/pharmacology ; Cell Line, Tumor ; Humans ; Mitotane/pharmacology ; Wnt Signaling Pathway/drug effects ; beta Catenin/metabolism
Chemical Substances	beta Catenin ; Mitotane (78E4J5IB5J) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2019-10-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-019-01127-1
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Article ; Online: Diagnostic et prise en charge des bactériémies liées au cathéter d’hémodialyse : 10 ans après les dernières recommandations.

Acquier, Mathieu / De Précigout, Valérie / Delmas, Yahsou / Dubois, Véronique / M'Zali, Fatima / Zabala, Arnaud / De-La-Faille, Renaud / Rubin, Sébastien / Cazanave, Charles / Puges, Mathilde / Combe, Christian / Kaminski, Hannah

Nephrologie & therapeutique

2022 Volume 18, Issue 2, Page(s) 80–88

Abstract: Patients in hemodialysis on central venous catheter as vascular access are at risk of infections. Catheter-related bloodstream infection is one of the most serious catheter-complications in hemodialysis patients. Its clinical and microbiological ... ...

Title translation	Diagnosis and treatment of catheter-related bloodstream infection in hemodialysis: 10 years later.
Abstract	Patients in hemodialysis on central venous catheter as vascular access are at risk of infections. Catheter-related bloodstream infection is one of the most serious catheter-complications in hemodialysis patients. Its clinical and microbiological diagnosis is challenging. The implementation of empiric antibiotic therapy is based on old recommendations proposing the combination of a molecule targeting methicillin-resistant Staphylococcus aureus and a betalactamin active on P. aeruginosa, and also adapting this probabilistic treatment by carrying out a microbiological register on a local scale, which is rarely done. In our hemodialysis center at Bordeaux University Hospital, an analysis of the microorganisms causing all catheter-related bloodstream infection over the period 2018-2020 enabled us to propose, in agreement with the infectious disease specialists, an adapted probabilistic antibiotic therapy protocol. This approach allowed us to observe a low incidence of meticillinoresistance of Staphylococcus. For catheters inserted more than 6 months ago, we observed no Staphylococcus, no multi-resistant Pseudomonas, and only 2% of Enterobacteria resistant to cephalosporins. A frequent updating of the microbiological epidemiology of catheter-related bloodstream infection, in partnership with the infectious diseases team in each hemodialysis center, allowing an adaptation of the probabilistic antibiotic therapy, and seems to have a good feasibility. This strategy might favor the preservation of microbial ecology on an individual and collective scale in maintenance hemodialysis patients.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Catheter-Related Infections/diagnosis ; Catheter-Related Infections/drug therapy ; Catheter-Related Infections/epidemiology ; Catheterization, Central Venous/adverse effects ; Central Venous Catheters/adverse effects ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Renal Dialysis/adverse effects
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2022-01-13
Publishing country	France
Document type	Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/j.nephro.2021.08.010
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Article ; Online: Vitamin D Status and COVID-19 Clinical Outcomes in Hospitalized Patients.

Szeto, Betsy / Zucker, Jason E / LaSota, Elijah D / Rubin, Mishaela R / Walker, Marcella D / Yin, Michael T / Cohen, Adi

Endocrine research

2020 Volume 46, Issue 2, Page(s) 66–73

Abstract: ... ...

Abstract	Context
MeSH term(s)	Adult ; Aged ; COVID-19/blood ; COVID-19/complications ; COVID-19/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2020-12-30
Publishing country	England
Document type	Journal Article
ZDB-ID	605823-1
ISSN	1532-4206 ; 0743-5800
ISSN (online)	1532-4206
ISSN	0743-5800
DOI	10.1080/07435800.2020.1867162
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Article ; Online: Vitamin D Status as a Predictor of Postoperative Hypocalcemia after Thyroidectomy.

Rubin, Samuel J / Park, Jong H / Pearce, Elizabeth N / Holick, Michael F / McAneny, David / Noordzij, J Pieter

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2020 Volume 163, Issue 3, Page(s) 501–507

Abstract: Objective: To determine whether perioperative vitamin D levels are predictive of postoperative ... January 2007 and March 2017 at a single tertiary care hospital. 25-Hydroxyvitamin D (25[OH]D) levels were ... retrospective study design, we demonstrated that 25(OH)D level is a significant predictor of postoperative ...

Abstract	Objective: To determine whether perioperative vitamin D levels are predictive of postoperative hypocalcemia in patients receiving thyroidectomy. Study design: Single center retrospective study. Subjects and methods: This study included all patients receiving total or completion thyroidectomy between January 2007 and March 2017 at a single tertiary care hospital. 25-Hydroxyvitamin D (25[OH]D) levels were measured within 42 days prior to surgery or 1 day postoperatively. Hypocalcemia was defined as an adjusted serum calcium <8.0 mg/dL (based on albumin levels) or symptomatic hypocalcemia. Univariate analysis was performed with a 2-sample Results: A total of 517 subjects were included in the study, 15.7% (n = 81) of whom experienced postoperative hypocalcemia with a mean ± SD serum calcium level of 7.6 ± 0.5 mg/dL as compared with 8.9 ± 0.5 mg/dL in the normocalcemic population ( Conclusion: Using a single-center retrospective study design, we demonstrated that 25(OH)D level is a significant predictor of postoperative hypocalcemia after thyroidectomy.
MeSH term(s)	Adult ; Female ; Humans ; Hypocalcemia/blood ; Hypocalcemia/etiology ; Male ; Middle Aged ; Postoperative Complications/blood ; Postoperative Complications/etiology ; Predictive Value of Tests ; Retrospective Studies ; Risk Factors ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/surgery ; Thyroidectomy/adverse effects ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2020-04-21
Publishing country	England
Document type	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599820917907
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Article ; Online: The use of vitamin D in preventing post-thyroidectomy hypocalcemia: An endocrinologist survey study.

Pinardo, Heinrich / Rubin, Samuel J / Hashemi, Sean / DePietro, Joseph / Pearce, Elizabeth N / Ananthakrishnan, Sonia / Alexanian, Sara M / Steenkamp, Devin W / Noordzij, Jacob Pieter

Clinical endocrinology

2020 Volume 93, Issue 5, Page(s) 598–604

Abstract: Objective: To evaluate the use of preoperative vitamin D levels and postoperative vitamin D ... the respondents' use of preoperative vitamin D levels, dose and duration of preoperative vitamin D repletion ... decision to delay surgery for low vitamin D levels in the case of a benign or malignant disease, and ...

Abstract	Objective: To evaluate the use of preoperative vitamin D levels and postoperative vitamin D supplementation among endocrinologists for the prevention of post-thyroidectomy hypocalcaemia. Methods: Endocrinologist members of the American Thyroid Association (ATA) were contacted via email to complete a 21-question survey, which included both questions about demographic information, and preventing and managing postoperative hypocalcaemia after thyroidectomy. Univariate and multivariate analysis was performed to determine the respondents' use of preoperative vitamin D levels, dose and duration of preoperative vitamin D repletion, decision to delay surgery for low vitamin D levels in the case of a benign or malignant disease, and routine prescription of postoperative calcium or vitamin D supplementation. Results: 225 endocrinologists who were ATA members responded to the questionnaire. When compared to endocrinologists practicing in other countries, those that practice in the United States were 2.5 times more likely to check preoperative vitamin D levels (95% CI[1.404, 4.535], P = .002), significantly more likely to replete vitamin D deficient patients with high-dose vitamin D (ie ≥50K IU/week), 4.458 times more likely to prescribe prophylactic supplemental calcium (95% CI[2.446, 8.126]; P < .0001) and 3.48 more likely to prescribe supplemental vitamin D (95% CI [1.906, 6.355]; P < .0001). Endocrinologists who have been in practice for >10 years were also 1.915 times more likely to prescribe supplemental vitamin D (95% CI (1.080, 3.395); P = .0263). Physicians that treat >50 thyroidectomy cases/year were 2.083 more likely to recommend a vitamin D repletion duration of >1 month than those that treat ≤50 cases/year ([1.036, 4.190], P = .0395). Lastly, if the patient has low preoperative vitamin D levels, 47.05% of respondents chose to delay surgery in a benign disease, while only 11.61% of respondents would do so in a case of malignant disease. Conclusions: Approximately one-half of surveyed endocrinologists reported using preoperative vitamin D levels to assess a patient's risk for post-thyroidectomy hypocalcaemia. Endocrinologists practicing in the United States, compared to those practicing in other countries, were more likely to both test for preoperative vitamin D levels and to recommend prophylactic post-thyroidectomy calcium and vitamin D supplementation.
MeSH term(s)	Calcium ; Endocrinologists ; Humans ; Hypocalcemia/etiology ; Hypocalcemia/prevention & control ; Postoperative Complications/prevention & control ; Surveys and Questionnaires ; Thyroidectomy/adverse effects ; Vitamin D/therapeutic use
Chemical Substances	Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-06-16
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.14259
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