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  1. Article: Preoperative Optimization Before Elective Total Joint Replacement.

    Kromka, Joseph J / O'Malley, Michael J

    Instructional course lectures

    2022  Volume 71, Page(s) 65–75

    Abstract: The identification and preoperative optimization of modifiable risk factors is proposed to be an effective method to decrease complications and improve the value of elective total joint arthroplasty. It is important to highlight the best practices as ... ...

    Abstract The identification and preoperative optimization of modifiable risk factors is proposed to be an effective method to decrease complications and improve the value of elective total joint arthroplasty. It is important to highlight the best practices as well as controversies in the preoperative evaluation and treatment of patients undergoing total joint arthroplasty.
    MeSH term(s) Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Knee/adverse effects ; Elective Surgical Procedures ; Humans ; Preoperative Care/methods ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 802490-x
    ISSN 0065-6895
    ISSN 0065-6895
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  2. Article ; Online: Detransition and Desistance Among Previously Trans-Identified Young Adults.

    Littman, Lisa / O'Malley, Stella / Kerschner, Helena / Bailey, J Michael

    Archives of sexual behavior

    2023  Volume 53, Issue 1, Page(s) 57–76

    Abstract: Persons who have renounced a prior transgender identification, often after some degree of social and medical transition, are increasingly visible. We recruited 78 US individuals ages 18-33 years who previously identified as transgender and had stopped ... ...

    Abstract Persons who have renounced a prior transgender identification, often after some degree of social and medical transition, are increasingly visible. We recruited 78 US individuals ages 18-33 years who previously identified as transgender and had stopped identifying as transgender at least six months prior. On average, participants first identified as transgender at 17.1 years of age and had done so for 5.4 years at the time of their participation. Most (83%) participants had taken several steps toward social transition and 68% had taken at least one medical step. By retrospective reports, fewer than 17% of participants met DSM-5 diagnostic criteria for Gender Dysphoria in Childhood. In contrast, 53% of participants believed that "rapid-onset gender dysphoria" applied to them. Participants reported a high rate of psychiatric diagnoses, with many of these prior to trans-identification. Most participants (N = 71, 91%) were natal females. Females (43%) were more likely than males (0%) to be exclusively homosexual. Participants reported that their psychological health had improved dramatically since detransition/desistance, with marked decreases in self-harm and gender dysphoria and marked increases in flourishing. The most common reason given for initial trans-identification was confusing mental health issues or reactions to trauma for gender dysphoria. Reasons for detransition were more likely to reflect internal changes (e.g., the participants' own thought processes) than external pressures (e.g., pressure from family). Results suggest that, for some transgender individuals, detransition is both possible and beneficial.
    MeSH term(s) Male ; Female ; Humans ; Young Adult ; Retrospective Studies ; Transsexualism/psychology ; Transgender Persons/psychology ; Mental Health ; Sexual and Gender Minorities ; Gender Dysphoria/diagnosis ; Gender Dysphoria/psychology ; Gender Identity
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-023-02716-1
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  3. Article ; Online: 'Acceleration' of the food delivery marketplace: Perspectives of local authority professionals in the North-East of England on temporary COVID regulations.

    Bradford, Callum P J / O'Malley, Claire L / Moore, Helen J / Gray, Nick / Townshend, Tim G / Chang, Michael / Mathews, Claire / Lake, Amelia A

    Nutrition bulletin

    2024  

    Abstract: In January 2021, we assessed the implications of temporary regulations in the United Kingdom allowing pubs and restaurants to operate on a takeaway basis without instigating a change of use. Local authorities (LAs) across the North-East of England were ... ...

    Abstract In January 2021, we assessed the implications of temporary regulations in the United Kingdom allowing pubs and restaurants to operate on a takeaway basis without instigating a change of use. Local authorities (LAs) across the North-East of England were unaware of any data regarding the take-up of these regulations, partially due to ongoing capacity issues; participants also raised health concerns around takeaway use increasing significantly. One year on, we repeated the study aiming to understand the impact of these regulations on the policy and practice of key professional groups. Specifically, we wanted to understand if LAs were still struggling with staff capacity to address the regulations, whether professionals still had public health trepidations, and if any unexpected changes had occurred across the local food environment because of the pandemic. We conversed with 16 public health professionals, planners and environmental health officers across seven LAs throughout the North-East of England via focus groups and interviews. Data collated were analysed via an inductive and semantic, reflexive-thematic approach. Through analysis of the data, three themes were generated and are discussed throughout: popular online delivery services as a mediator to increased takeaway usage; potential long-term health implications and challenges; continued uncertainty regarding the temporary regulations. This paper highlights important changes to local food environments, which public health professionals should be aware of, so they are better equipped to tackle health inequalities across urban and sub-urban areas.
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020505-3
    ISSN 1467-3010 ; 1471-9827
    ISSN (online) 1467-3010
    ISSN 1471-9827
    DOI 10.1111/nbu.12672
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  4. Article ; Online: Association of Functional Status, Cognition, Social Support, and Geriatric Syndrome With Admission From the Emergency Department.

    Smulowitz, Peter B / Weinreb, Gabe / McWilliams, J Michael / O'Malley, A James / Landon, Bruce E

    JAMA internal medicine

    2023  Volume 183, Issue 8, Page(s) 784–792

    Abstract: Importance: The role of patient-level factors that are unrelated to the specific clinical condition leading to an emergency department (ED) visit, such as functional status, cognitive status, social supports, and geriatric syndromes, in admission ... ...

    Abstract Importance: The role of patient-level factors that are unrelated to the specific clinical condition leading to an emergency department (ED) visit, such as functional status, cognitive status, social supports, and geriatric syndromes, in admission decisions is not well understood, partly because these data are not available in administrative databases.
    Objective: To determine the extent to which patient-level factors are associated with rates of hospital admission from the ED.
    Design, setting, and participants: This cohort study analyzed survey data collected from participants (or their proxies, such as family members) enrolled in the Health and Retirement Study (HRS) from January 1, 2000, to December 31, 2018. These HRS data were linked to Medicare fee-for-service claims data from January 1, 1999, to December 31, 2018. Information on functional status, cognitive status, social supports, and geriatric syndromes was obtained from the HRS data, whereas ED visits, subsequent hospital admission or ED discharge, and other claims-derived comorbidities and sociodemographic characteristics were obtained from Medicare data. Data were analyzed from September 2021 to April 2023.
    Main outcomes and measures: The primary outcome measure was hospital admission after an ED visit. A baseline logistic regression model was estimated, with a binary indicator of admission as the dependent variable of interest. For each primary variable of interest derived from the HRS data, the model was reestimated, including the HRS variable of interest as an independent variable. For each of these models, the odds ratio (OR) and average marginal effect (AME) of changing the value of the variable of interest were calculated.
    Results: A total of 42 392 ED visits by 11 783 unique patients were included. At the time of the ED visit, patients had a mean (SD) age of 77.4 (9.6) years, and visits were predominantly for female (25 719 visits [60.7%]) and White (32 148 visits [75.8%]) individuals. The overall percentage of patients admitted was 42.5%. After controlling for ED diagnosis and demographic characteristics, functional status, cognition status, and social supports all were associated with the likelihood of admission. For instance, difficulty performing 5 activities of daily living was associated with an 8.5-percentage point (OR, 1.47; 95% CI, 1.29-1.66) AME increase in the likelihood of admission. Having dementia was associated with an AME increase in the likelihood of admission of 4.6 percentage points (OR, 1.23; 95% CI, 1.14-1.33). Living with a spouse was associated with an AME decrease in the likelihood of admission of 3.9 percentage points (OR, 0.84; 95% CI, 0.79-0.89), and having children living within 10 miles was associated with an AME decrease in the likelihood of admission of 5.0 percentage points (OR, 0.80; 95% CI, 0.71-0.89). Other common geriatric syndromes, including trouble falling asleep, waking early, trouble with vision, glaucoma or cataract, use of hearing aids or trouble with hearing, falls in past 2 years, incontinence, depression, and polypharmacy, were not meaningfully associated with the likelihood of admission.
    Conclusion and relevance: Results of this cohort study suggest that the key patient-level characteristics, including social supports, cognitive status, and functional status, were associated with the decision to admit older patients to the hospital from the ED. These factors are critical to consider when devising strategies to reduce low-value admissions among older adult patients from the ED.
    MeSH term(s) Child ; Humans ; Female ; Aged ; United States/epidemiology ; Cohort Studies ; Syndrome ; Activities of Daily Living ; Functional Status ; Social Cognition ; Retrospective Studies ; Medicare ; Emergency Service, Hospital/statistics & numerical data ; Hospitals ; Cognition
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.2149
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  5. Article ; Online: Diagnostic criteria for gestational diabetes mellitus.

    O'Malley, Eimer / Turner, Michael J

    The Australian & New Zealand journal of obstetrics & gynaecology

    2020  Volume 60, Issue 5, Page(s) E16–E17

    MeSH term(s) Diabetes, Gestational ; Female ; Glucose Tolerance Test ; Humans ; Pregnancy
    Language English
    Publishing date 2020-10-12
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 390815-x
    ISSN 1479-828X ; 0004-8666
    ISSN (online) 1479-828X
    ISSN 0004-8666
    DOI 10.1111/ajo.13214
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  6. Article ; Online: Key Recommendations on Managing Dyslipidemia for Cardiovascular Risk Reduction: Stopping Where the Evidence Does.

    Arnold, Michael J / O'Malley, Patrick G / Downs, John R

    American family physician

    2021  Volume 103, Issue 8, Page(s) 455–458

    MeSH term(s) Dyslipidemias/prevention & control ; Evidence-Based Medicine ; Humans ; Practice Guidelines as Topic
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  7. Article ; Online: Expert Consensus for the Use of Outpatient Rehabilitation Visits After Total Knee Arthroplasty: A Delphi Study.

    Graber, Jeremy / Churchill, Laura / Struessel, Tamara / O'Malley, Shane / Bade, Michael / Stevens-Lapsley, Jennifer

    The Journal of orthopaedic and sports physical therapy

    2023  Volume 53, Issue 9, Page(s) 566–574

    Abstract: OBJECTIVE: ...

    Abstract OBJECTIVE:
    MeSH term(s) Humans ; Arthroplasty, Replacement, Knee/rehabilitation ; Outpatients ; Delphi Technique
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604640-x
    ISSN 1938-1344 ; 0190-6011
    ISSN (online) 1938-1344
    ISSN 0190-6011
    DOI 10.2519/jospt.2023.11840
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  8. Article ; Online: Letter to the editor - Brief Communication.

    O'Malley, Eimer G / Reynolds, Ciara M E / Turner, Michael J

    European journal of obstetrics, gynecology, and reproductive biology

    2020  Volume 249, Page(s) 106

    Language English
    Publishing date 2020-01-30
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2020.01.044
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  9. Article ; Online: Cardiopulmonary exercise testing on adaptive equipment in children and adults with Friedreich ataxia.

    Cilenti, Nicolette A / Tamaroff, Jaclyn G / Capiola, Christopher J / Faig, Walter / McBride, Michael G / Paridon, Stephen M / O'Malley, Shannon / Edelson, Jonathan B / Lynch, David R / McCormack, Shana E / Lin, Kimberly Y

    Muscle & nerve

    2024  Volume 69, Issue 5, Page(s) 613–619

    Abstract: Introduction/aims: Traditional exercise is often difficult for individuals with Friedreich ataxia (FRDA), and evidence is limited regarding how to measure exercise performance in this population. We evaluated the feasibility, reliability, and natural ... ...

    Abstract Introduction/aims: Traditional exercise is often difficult for individuals with Friedreich ataxia (FRDA), and evidence is limited regarding how to measure exercise performance in this population. We evaluated the feasibility, reliability, and natural history of adaptive cardiopulmonary exercise test (CPET) performance in children and adults with FRDA.
    Methods: Participants underwent CPET on either an arm cycle ergometer (ACE) or recumbent leg cycle ergometer (RLCE) at up to four visits (baseline, 2 weeks, 4 weeks, and 1 year). Maximum work, oxygen consumption (peak VO
    Results: In our cohort (N = 23), median age was 18 years (interquartile range [IQR], 14-23), median age of FRDA onset was 8 years (IQR 6-13), median Friedreich Ataxia Rating Scale score was 58 (IQR 54-62), and GAA repeat length on the shorter FXN allele (GAA1) was 766 (IQR, 650-900). Twenty-one (91%) completed a maximal CPET (n = 8, ACE and n = 13, RLCE). Age, sex, and GAA1 repeat length were each associated with peak VO
    Discussion: Adaptive CPET is feasible in FRDA, a relevant clinical trial outcome for interventions that impact exercise performance and will increase access to participation as well as generalizability of findings.
    MeSH term(s) Adult ; Child ; Humans ; Adolescent ; Exercise Test ; Friedreich Ataxia/diagnosis ; Reproducibility of Results ; Oxygen Consumption ; Respiratory Function Tests
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.28085
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  10. Article ; Online: TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.

    O'Malley, John J / Seibt, Frederik / Chin, Jeannie / Beierlein, Michael

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2020  Volume 40, Issue 25, Page(s) 4813–4823

    Abstract: During sleep, neurons in the thalamic reticular nucleus (TRN) participate in distinct types of oscillatory activity. While the reciprocal synaptic circuits between TRN and sensory relay nuclei are known to underlie the generation of sleep spindles, the ... ...

    Abstract During sleep, neurons in the thalamic reticular nucleus (TRN) participate in distinct types of oscillatory activity. While the reciprocal synaptic circuits between TRN and sensory relay nuclei are known to underlie the generation of sleep spindles, the mechanisms regulating slow (<1 Hz) forms of thalamic oscillations are not well understood. Under
    MeSH term(s) Action Potentials/physiology ; Animals ; Female ; GABAergic Neurons/physiology ; Intralaminar Thalamic Nuclei/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Organ Culture Techniques ; Sleep/physiology ; TRPM Cation Channels/metabolism
    Chemical Substances TRPM Cation Channels ; TRPM4 protein, mouse
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0324-20.2020
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