LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 96

Search options

  1. Article ; Online: Artificial Intelligence and Chatbots in Psychiatry.

    Pham, Kay T / Nabizadeh, Amir / Selek, Salih

    The Psychiatric quarterly

    2022  Volume 93, Issue 1, Page(s) 249–253

    Abstract: The utilization of artificial intelligence (AI) in psychiatry has risen over the past several years to meet the growing need for improved access to mental health solutions. Additionally, shortages of mental health providers during the COVID-19 pandemic ... ...

    Abstract The utilization of artificial intelligence (AI) in psychiatry has risen over the past several years to meet the growing need for improved access to mental health solutions. Additionally, shortages of mental health providers during the COVID-19 pandemic have continued to exacerbate the burden of mental illness worldwide. AI applications already in existence include those enabled to assist with psychiatric diagnoses, symptom tracking, disease course prediction, and psychoeducation. Modalities of AI mental health care delivery include availability through the internet, smartphone applications, and digital gaming. Here we review emerging AI-based interventions in the form of chat and therapy bots, specifically conversational applications that teach the user emotional coping mechanisms and provide support for people with communication difficulties, computer generated images of faces that form the basis of avatar therapy, and intelligent animal-like robots with new advances in digital psychiatry. We discuss the implications of incorporating AI chatbots into clinical practice and offer perspectives on how these AI-based interventions will further impact the field of psychiatry.
    MeSH term(s) Artificial Intelligence ; COVID-19 ; Humans ; Mental Health ; Pandemics ; Psychiatry
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207521-0
    ISSN 1573-6709 ; 0033-2720
    ISSN (online) 1573-6709
    ISSN 0033-2720
    DOI 10.1007/s11126-022-09973-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Clinical and economic burden of benign and malignant skin lesions in renal transplant recipients.

    Thet, Zaw / Lam, Alfred K / Pham, Tony / Ng, Shu-Kay / Steel, Jason C / Sawhney, Sirena / Arellano, Carolina T / Aung, Soe Yu / Han, Thin / Ranganathan, Dwarakanathan / John, George / Pepito, Christina / Rautenberg, Tamlyn / Khoo, Tien K

    Internal medicine journal

    2023  Volume 53, Issue 11, Page(s) 2042–2049

    Abstract: Background: Studies evaluating the economic burden of dermatological care in the transplant setting are currently not available in Australia.: Aims: To evaluate the clinical and economic burden of benign and malignant skin lesions in renal transplant ...

    Abstract Background: Studies evaluating the economic burden of dermatological care in the transplant setting are currently not available in Australia.
    Aims: To evaluate the clinical and economic burden of benign and malignant skin lesions in renal transplant recipients in Central Queensland.
    Methods: A bottom-up approach was used to determine the clinical burden and direct costs from patient-level Medicare data obtained from Service Australia for skin lesions.
    Results: Seventy-six percent of the renal transplant population in Central Queensland participated in this study. The median age was 57.0 years (standard deviation ± 13.6) and the majority (61.8%) of participants were men. The mean duration after transplant surgery was 99.9 months (interquartile range, 73.2-126.6 months). During a 2-year follow-up, 22 (40%) patients were diagnosed with benign skin lesions, 21 (38%) with nonmelanoma skin carcinoma (NMSC) and one (2%) with melanoma. There was a total of 231 visits to clinicians for diagnostic and therapeutic skin procedures and the direct costs to Medicare was $48 806 Australian Dollars (AUD) or $30 427 US Dollars (USD). Approximately 86% of the total direct costs was spent for nonNMSC and mean direct costs for NMSC was $763 AUD (or $476 USD).
    Conclusion: This Medicare data-based study provides further insight into the burgeoning clinical and economic burden of the care for benign and malignant skin lesions in the renal transplantation setting in Australia.
    MeSH term(s) Male ; Humans ; Aged ; Female ; Middle Aged ; Kidney Transplantation ; Carcinoma, Basal Cell/epidemiology ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/pathology ; Financial Stress ; Australia/epidemiology ; Risk Factors ; National Health Programs ; Skin Neoplasms/epidemiology ; Transplant Recipients
    Language English
    Publishing date 2023-02-13
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.16024
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Reduced digestion of circulating genomic DNA in systemic sclerosis patients with the DNASE1L3 R206C variant.

    Skaug, Brian / Guo, Xinjian / Li, Yuanteng Jeff / Charles, Julio / Pham, Kay T / Couturier, Jacob / Lewis, Dorothy E / Bracaglia, Claudia / Caiello, Ivan / Mayes, Maureen D / Assassi, Shervin

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 9, Page(s) 3197–3204

    Abstract: Objectives: Polymorphism in a coding region of deoxyribonuclease I-like III (DNASE1L3), causing amino acid substitution of Arg-206 to Cys (R206C), is a robustly replicated heritable risk factor for SSc and other autoimmune diseases. DNASE1L3 is secreted ...

    Abstract Objectives: Polymorphism in a coding region of deoxyribonuclease I-like III (DNASE1L3), causing amino acid substitution of Arg-206 to Cys (R206C), is a robustly replicated heritable risk factor for SSc and other autoimmune diseases. DNASE1L3 is secreted into the circulation, where it can digest genomic DNA (gDNA) in apoptosis-derived membrane vesicles (AdMVs). We sought to determine the impact of DNASE1L3 R206C on digestion of circulating gDNA in SSc patients and healthy controls (HCs).
    Methods: The ability of DNASE1L3 to digest AdMV-associated gDNA was tested in vitro. The effect of R206C substitution on extracellular secretion of DNASE1L3 was determined using a transfected cell line and primary monocyte-derived dendritic cells from SSc patients. Plasma samples from SSc patients and HCs with DNASE1L3 R206C or R206 wild type were compared for their ability to digest AdMV-associated gDNA. The digestion status of endogenous gDNA in plasma samples from 123 SSc patients and 74 HCs was determined by measuring the proportion of relatively long to short gDNA fragments.
    Results: The unique ability of DNASE1L3 to digest AdMV-associated gDNA was confirmed. Extracellular secretion of DNASE1L3 R206C was impaired. Plasma from individuals with DNASE1L3 R206C had reduced ability to digest AdMV-associated gDNA. The ratio of long: short gDNA fragments was increased in plasma from SSc patients with DNASE1L3 R206C, and this ratio correlated inversely with DNase activity.
    Conclusion: Our results confirm that circulating gDNA is a physiological DNASE1L3 substrate and show that its digestion is reduced in SSc patients with the DNASE1L3 R206C variant.
    MeSH term(s) Humans ; Endodeoxyribonucleases/genetics ; Endodeoxyribonucleases/metabolism ; Cell-Free Nucleic Acids ; DNA/genetics ; Genomics ; Scleroderma, Systemic/genetics ; Digestion
    Chemical Substances Endodeoxyribonucleases (EC 3.1.-) ; Cell-Free Nucleic Acids ; DNA (9007-49-2) ; DNASE1L3 protein, human (EC 3.1.-)
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead050
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Development, implementation, and dissemination of operational innovations across the trial innovation network.

    Palm, Marisha E / Edwards, Terri L / Wieber, Cortney / Kay, Marie T / Marion, Eve / Boone, Leslie / Nanni, Angeline / Jones, Michelle / Pham, Eilene / Hildreth, Meghan / Lane, Karen / McBee, Nichol / Benjamin, Daniel K / Bernard, Gordon R / Dean, J Michael / Dwyer, Jamie P / Ford, Daniel E / Hanley, Daniel F / Harris, Paul A /
    Wilkins, Consuelo H / Selker, Harry P

    Journal of clinical and translational science

    2023  Volume 7, Issue 1, Page(s) e251

    Abstract: Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are ... ...

    Abstract Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are unsuccessful. The National Center for Advancing Translational Science launched the Trial Innovation Network to address critical roadblocks in multi-center trials by leveraging existing infrastructure and developing operational innovations. We provide an overview of the roadblocks that led to opportunities for operational innovation, our work to develop, define, and map innovations across the network, and how we implemented and disseminated mature innovations.
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2023.658
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Development, implementation, and dissemination of operational innovations across the trial innovation network

    Marisha E. Palm / Terri L. Edwards / Cortney Wieber / Marie T. Kay / Eve Marion / Leslie Boone / Angeline Nanni / Michelle Jones / Eilene Pham / Meghan Hildreth / Karen Lane / Nichol McBee / Daniel K. Benjamin / Gordon R. Bernard / J. Michael Dean / Jamie P. Dwyer / Daniel E. Ford / Daniel F. Hanley / Paul A. Harris /
    Consuelo H. Wilkins / Harry P. Selker

    Journal of Clinical and Translational Science, Vol

    2023  Volume 7

    Abstract: Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are ... ...

    Abstract Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are unsuccessful. The National Center for Advancing Translational Science launched the Trial Innovation Network to address critical roadblocks in multi-center trials by leveraging existing infrastructure and developing operational innovations. We provide an overview of the roadblocks that led to opportunities for operational innovation, our work to develop, define, and map innovations across the network, and how we implemented and disseminated mature innovations.
    Keywords Trial innovation network ; CTSA ; clinical trials ; clinical trial roadblocks ; innovation ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Article ; Online: Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells.

    Jacobse, Justin / Brown, Rachel E / Li, Jing / Pilat, Jennifer M / Pham, Ly / Short, Sarah P / Peek, Christopher T / Rolong, Andrea / Washington, M Kay / Martinez-Barricarte, Ruben / Byndloss, Mariana X / Shelton, Catherine / Markle, Janet G / Latour, Yvonne L / Allaman, Margaret M / Cassat, James E / Wilson, Keith T / Choksi, Yash A / Williams, Christopher S /
    Lau, Ken S / Flynn, Charles R / Casanova, Jean-Laurent / Rings, Edmond H H M / Samsom, Janneke N / Goettel, Jeremy A

    Cell reports

    2023  Volume 42, Issue 2, Page(s) 112128

    Abstract: The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched in intestinal Tregs, yet whether IL-23 modulates intestinal Tregs remains unknown. ...

    Abstract The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched in intestinal Tregs, yet whether IL-23 modulates intestinal Tregs remains unknown. Here, investigating IL-23R signaling in Tregs specifically, we show that colonic Tregs highly express Il23r compared with Tregs from other compartments and their frequency is reduced upon IL-23 administration and impairs Treg suppressive function. Similarly, colonic Treg frequency is increased in mice lacking Il23r specifically in Tregs and exhibits a competitive advantage over IL-23R-sufficient Tregs during inflammation. Finally, IL-23 antagonizes liver X receptor pathway, cellular cholesterol transporter Abca1, and increases Treg apoptosis. Our results show that IL-23R signaling regulates intestinal Tregs by increasing cell turnover, antagonizing suppression, and decreasing cholesterol efflux. These results suggest that IL-23 negatively regulates Tregs in the intestine with potential implications for promoting chronic inflammation in patients with IBD.
    MeSH term(s) Animals ; Humans ; Mice ; Colitis/pathology ; Forkhead Transcription Factors/metabolism ; Inflammation/pathology ; Inflammatory Bowel Diseases/pathology ; Interleukin-23/metabolism ; T-Lymphocytes, Regulatory
    Chemical Substances Forkhead Transcription Factors ; Interleukin-23 ; interleukin-23 receptor, mouse ; IL23R protein, human
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112128
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations.

    Luong, An B / Do, Huy Q / Tarchi, Paola / Bonazza, Deborah / Bottin, Cristina / Cabral, Loraine Kay D / Tran, Long D C / Doan, Thao P T / Crocè, Lory S / Pham, Hoa L T / Tiribelli, Claudio / Sukowati, Caecilia H C

    Cells

    2020  Volume 9, Issue 12

    Abstract: Epidemiology of hepatocellular carcinoma (HCC) showed a correlation between incidence and geographical-relevant risk factors. This study aims to compare the distributions of cancer stem cells (CSC) in two distant populations in Asia and Europe. We ... ...

    Abstract Epidemiology of hepatocellular carcinoma (HCC) showed a correlation between incidence and geographical-relevant risk factors. This study aims to compare the distributions of cancer stem cells (CSC) in two distant populations in Asia and Europe. We analyzed 52 and 43 selected HCC patients undergoing hepatectomy in Ho Chi Minh City (Vietnam) and Trieste (Italy). Each patient sample consisted of HCC, peri-HCC, and non-tumoral (distal) tissue. Demographic data were recorded together with clinical findings. The protocol for the collection of tissue samples and RNA was standardized in both laboratories and gene expression analysis was performed in a single laboratory with identical PCR conditions. Baseline data showed comparable laboratory findings between the two cohorts. mRNA distribution showed a comparable pattern of all CSC markers analyzed with the expression of CD90 progressively increasing from distal and peri-HCC to be highest in HCC (
    MeSH term(s) Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/virology ; Cohort Studies ; Female ; Gene Expression Regulation, Neoplastic ; Hepatitis B/complications ; Hepatitis B/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/virology ; Male ; Middle Aged ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Thy-1 Antigens/genetics ; Thy-1 Antigens/metabolism
    Chemical Substances Biomarkers, Tumor ; RNA, Messenger ; Thy-1 Antigens
    Language English
    Publishing date 2020-12-12
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9122672
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells

    Justin Jacobse / Rachel E. Brown / Jing Li / Jennifer M. Pilat / Ly Pham / Sarah P. Short / Christopher T. Peek / Andrea Rolong / M. Kay Washington / Ruben Martinez-Barricarte / Mariana X. Byndloss / Catherine Shelton / Janet G. Markle / Yvonne L. Latour / Margaret M. Allaman / James E. Cassat / Keith T. Wilson / Yash A. Choksi / Christopher S. Williams /
    Ken S. Lau / Charles R. Flynn / Jean-Laurent Casanova / Edmond H.H.M. Rings / Janneke N. Samsom / Jeremy A. Goettel

    Cell Reports, Vol 42, Iss 2, Pp 112128- (2023)

    2023  

    Abstract: Summary: The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched in intestinal Tregs, yet whether IL-23 modulates intestinal Tregs remains ...

    Abstract Summary: The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched in intestinal Tregs, yet whether IL-23 modulates intestinal Tregs remains unknown. Here, investigating IL-23R signaling in Tregs specifically, we show that colonic Tregs highly express Il23r compared with Tregs from other compartments and their frequency is reduced upon IL-23 administration and impairs Treg suppressive function. Similarly, colonic Treg frequency is increased in mice lacking Il23r specifically in Tregs and exhibits a competitive advantage over IL-23R-sufficient Tregs during inflammation. Finally, IL-23 antagonizes liver X receptor pathway, cellular cholesterol transporter Abca1, and increases Treg apoptosis. Our results show that IL-23R signaling regulates intestinal Tregs by increasing cell turnover, antagonizing suppression, and decreasing cholesterol efflux. These results suggest that IL-23 negatively regulates Tregs in the intestine with potential implications for promoting chronic inflammation in patients with IBD.
    Keywords CP: Immunology ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  9. Article ; Online: Multimodality lymphatic imaging of postoperative chylothorax in an infant with Noonan syndrome: a case report.

    Pham, Kay T / Balaguru, Duraisamy / Tammisetti, Varaha S / Guevara, Carlos J / Rasmussen, John C / Zvavanjanja, Rodrick C / Hanfland, Robert / Sevick-Muraca, Eva M / Aldrich, Melissa B

    European journal of medical research

    2020  Volume 25, Issue 1, Page(s) 55

    Abstract: Background: Chylothorax is a rare complication of pediatric cardiac operations that occurs more frequently in children with Noonan syndrome, a genetic disorder associated with cardiac defects and lymphatic anomalies.: Case presentation: We report a ... ...

    Abstract Background: Chylothorax is a rare complication of pediatric cardiac operations that occurs more frequently in children with Noonan syndrome, a genetic disorder associated with cardiac defects and lymphatic anomalies.
    Case presentation: We report a case of postoperative chylothorax in a 6-month-old infant with Noonan syndrome where multimodality lymphatic imaging guided management was followed. Drainage patterns of the lymphatic capillaries in the lower and upper extremities were visualized during near-infrared fluorescence lymphatic imaging (NIRFLI). Dynamic magnetic resonance lymphangiography (MRL) further identified the site of leakage in the thoracic duct and subsequently guided surgical intervention.
    Conclusions: Application of multimodality imaging allows for greater individualization of treatment and should be considered in patients with complex cases such as those with syndromes associated with a higher incidence of chylothorax. IRB Number: HSC-MS-13-0754, December 10, 2013.
    MeSH term(s) Chylothorax/diagnostic imaging ; Female ; Humans ; Infant ; Lymphatic Vessels/diagnostic imaging ; Lymphedema/complications ; Lymphedema/diagnostic imaging ; Lymphography/methods ; Multimodal Imaging/methods ; Noonan Syndrome/complications ; Noonan Syndrome/diagnostic imaging ; Noonan Syndrome/surgery ; Postoperative Complications/diagnostic imaging
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-020-00455-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Multimodality lymphatic imaging of postoperative chylothorax in an infant with Noonan syndrome

    Kay T. Pham / Duraisamy Balaguru / Varaha S. Tammisetti / Carlos J. Guevara / John C. Rasmussen / Rodrick C. Zvavanjanja / Robert Hanfland / Eva M. Sevick-Muraca / Melissa B. Aldrich

    European Journal of Medical Research, Vol 25, Iss 1, Pp 1-

    a case report

    2020  Volume 4

    Abstract: Abstract Background Chylothorax is a rare complication of pediatric cardiac operations that occurs more frequently in children with Noonan syndrome, a genetic disorder associated with cardiac defects and lymphatic anomalies. Case presentation We report a ...

    Abstract Abstract Background Chylothorax is a rare complication of pediatric cardiac operations that occurs more frequently in children with Noonan syndrome, a genetic disorder associated with cardiac defects and lymphatic anomalies. Case presentation We report a case of postoperative chylothorax in a 6-month-old infant with Noonan syndrome where multimodality lymphatic imaging guided management was followed. Drainage patterns of the lymphatic capillaries in the lower and upper extremities were visualized during near-infrared fluorescence lymphatic imaging (NIRFLI). Dynamic magnetic resonance lymphangiography (MRL) further identified the site of leakage in the thoracic duct and subsequently guided surgical intervention. Conclusions Application of multimodality imaging allows for greater individualization of treatment and should be considered in patients with complex cases such as those with syndromes associated with a higher incidence of chylothorax. IRB Number: HSC-MS-13–0754, December 10, 2013
    Keywords Chylothorax ; Noonan syndrome ; NIRFLI ; MRL ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top