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Artikel ; Online: A hidden gem Catenin-α-1 is essential for Chikungunya virus infection.

Chatterjee, Sanchari / Subudhi, Bharat Bhusan / Chattopadhyay, Soma

2023 Band 11, Heft 6, Seite(n) e0248523

Mesh-Begriff(e)	Humans ; Chikungunya Fever ; Virus Replication ; Viral Nonstructural Proteins ; Catenins
Chemische Substanzen	Viral Nonstructural Proteins ; Catenins
Sprache	Englisch
Erscheinungsdatum	2023-11-14
Erscheinungsland	United States
Dokumenttyp	Letter
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02485-23
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Chikungunya virus perturbs the Wnt/β-catenin signaling pathway for efficient viral infection.

Chatterjee, Sanchari / Ghosh, Soumyajit / Datey, Ankita / Mahish, Chandan / Chattopadhyay, Subhasis / Chattopadhyay, Soma

Journal of virology

2023 Band 97, Heft 11, Seite(n) e0143023

Abstract: Importance: Being obligate parasites, viruses use various host cell machineries in effectively replicating their genome, along with virus-encoded enzymes. In order to carry out infection and pathogenesis, viruses are known to manipulate fundamental ... ...

Abstract	Importance: Being obligate parasites, viruses use various host cell machineries in effectively replicating their genome, along with virus-encoded enzymes. In order to carry out infection and pathogenesis, viruses are known to manipulate fundamental cellular processes in cells and interfere with host gene expression. Several viruses interact with the cellular proteins involved in the Wnt/β-catenin pathway; however, reports regarding the involvement of protein components of the Wnt/β-catenin pathway in Chikungunya virus (CHIKV) infection are scarce. Additionally, there are currently no remedies or vaccines available for CHIKV. This is the first study to report that modulation of the Wnt/β-catenin pathway is crucial for effective CHIKV infection. These investigations deepen the understanding of the underlying mechanisms of CHIKV infection and offer new avenue for developing effective countermeasures to efficiently manage CHIKV infection.
Mesh-Begriff(e)	Humans ; beta Catenin/metabolism ; Chikungunya Fever/metabolism ; Chikungunya Fever/virology ; Chikungunya virus/physiology ; Virus Replication ; Wnt Signaling Pathway
Chemische Substanzen	beta Catenin
Sprache	Englisch
Erscheinungsdatum	2023-10-20
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01430-23
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Versatile β-Catenin Is Crucial for SARS-CoV-2 Infection.

Chatterjee, Sanchari / Keshry, Supriya Suman / Ghosh, Soumyajit / Ray, Amrita / Chattopadhyay, Soma

Microbiology spectrum

2022 Band 10, Heft 5, Seite(n) e0167022

Mesh-Begriff(e)	Humans ; beta Catenin/genetics ; beta Catenin/metabolism ; COVID-19 ; SARS-CoV-2 ; Signal Transduction
Chemische Substanzen	beta Catenin
Sprache	Englisch
Erscheinungsdatum	2022-08-31
Erscheinungsland	United States
Dokumenttyp	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01670-22
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Perturbations in spike-specific peripheral T follicular helper cells in SARS-CoV2 breakthrough convalescent individuals immunized by BBV152 vaccine.

Sengupta, Soumya / Shaw, Shubham K / Chatterjee, Sanchari / Bhattacharya, Gargee / Barik, Prakash K / Chattopadhyay, Soma / Devadas, Satish

Journal of medical virology

2023 Band 95, Heft 9, Seite(n) e29053

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infection has caused an increase in mortality and morbidity, but with vaccination, the disease severity has significantly reduced. With the emergence of various variants of concern (VOCs), the ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infection has caused an increase in mortality and morbidity, but with vaccination, the disease severity has significantly reduced. With the emergence of various variants of concern (VOCs), the vaccine breakthrough infection has also increased. Here we studied circulating spike-specific T follicular response (cTfh) in infection-naïve vaccinees and convalescent vaccinees (individuals who got the Delta breakthrough infection after two doses of BBV152 vaccine) to understand their response as they are the most crucial cells that are involved in vaccine-mediated protection by helping in B-cell maturation. Our results indicated that cTfh cells in both the groups recognized the wild-type and Delta spike protein but memory response to the wild-type spike was superior in infection-naïve than in the convalescent group. The cytokine response, particularly interleukin-21 (IL-21) from cTfh, was also higher in infection-naïve than in convalescent vaccinees, indicating a dampened cTfh response in convalescent vaccinees after breakthrough infection. Also, there was a positive correlation between IL-21 from cTfh cells and neutralizing antibodies of infection-naïve vaccinees. Multiple cytokine analysis also revealed higher inflammation in convalescent vaccinees. Our data indicated that the necessity of a third booster dose may be individual-specific depending on the steady-state functional phenotype of immune cells.
Mesh-Begriff(e)	Humans ; COVID-19/prevention & control ; RNA, Viral ; SARS-CoV-2 ; T Follicular Helper Cells ; Cytokines ; Breakthrough Infections
Chemische Substanzen	BBV152 COVID-19 vaccine (76JZE5DSN6) ; RNA, Viral ; Cytokines
Sprache	Englisch
Erscheinungsdatum	2023-09-07
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29053
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.

Mahish, Chandan / De, Saikat / Chatterjee, Sanchari / Ghosh, Soumyajit / Keshry, Supriya Suman / Mukherjee, Tathagata / Khamaru, Somlata / Tung, Kshyama Subhadarsini / Subudhi, Bharat Bhusan / Chattopadhyay, Soma / Chattopadhyay, Subhasis

Frontiers in immunology

2023 Band 14, Seite(n) 1139808

Abstract: Toll like receptor 4 (TLR4), a pathogen-associated molecular pattern (PAMP) receptor, is known to exert inflammation in various cases of microbial infection, cancer and autoimmune disorders. However, any such involvement of TLR4 in Chikungunya virus ( ... ...

Abstract	Toll like receptor 4 (TLR4), a pathogen-associated molecular pattern (PAMP) receptor, is known to exert inflammation in various cases of microbial infection, cancer and autoimmune disorders. However, any such involvement of TLR4 in Chikungunya virus (CHIKV) infection is yet to be explored. Accordingly, the role of TLR4 was investigated towards CHIKV infection and modulation of host immune responses in the current study using mice macrophage cell line RAW264.7, primary macrophage cells of different origins and
Mesh-Begriff(e)	Animals ; Mice ; Chikungunya Fever ; Chikungunya virus ; Inflammation ; Macrophages ; Molecular Docking Simulation ; Toll-Like Receptor 4 ; Viral Envelope Proteins ; Virus Replication
Chemische Substanzen	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate ; Toll-Like Receptor 4 ; Viral Envelope Proteins ; Tlr4 protein, mouse
Sprache	Englisch
Erscheinungsdatum	2023-04-20
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1139808
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication.

Chatterjee, Sanchari / Kumar, Sameer / Mamidi, Prabhudutta / Datey, Ankita / Sengupta, Soumya / Mahish, Chandan / Laha, Eshna / De, Saikat / Keshry, Supriya Suman / Nayak, Tapas Kumar / Ghosh, Soumyajit / Singh, Sharad / Subudhi, Bharat Bhusan / Chattopadhyay, Subhasis / Chattopadhyay, Soma

Journal of virology

2022 , Seite(n) e0133422

Abstract: Viruses utilize a plethora of strategies to manipulate the host pathways and hijack host machineries for efficient replication. Several DNA and few RNA viruses are reported to interact with proteins involved in DNA damage responses (DDRs). As the DDR ... ...

Abstract	Viruses utilize a plethora of strategies to manipulate the host pathways and hijack host machineries for efficient replication. Several DNA and few RNA viruses are reported to interact with proteins involved in DNA damage responses (DDRs). As the DDR pathways have never been explored in alphaviruses, this investigation intended to understand the importance of the DDR pathways in chikungunya virus (CHIKV) infection
Sprache	Englisch
Erscheinungsdatum	2022-11-15
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01334-22
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2.

Sengupta, Soumya / Bhattacharya, Gargee / Chatterjee, Sanchari / Datey, Ankita / Shaw, Shubham K / Suranjika, Sandhya / Nath, Paritosh / Barik, Prakash K / Prasad, Punit / Chattopadhyay, Soma / Swain, Rajeeb K / Parida, Ajay / Devadas, Satish

Frontiers in immunology

2022 Band 13, Seite(n) 848335

Abstract: Background: SARS-CoV2 infection in patients with comorbidities, particularly T2DM, has been a major challenge globally and has been shown to be associated with high morbidity and mortality. Here, we did whole blood immunophenotyping along with plasma ... ...

Abstract	Background: SARS-CoV2 infection in patients with comorbidities, particularly T2DM, has been a major challenge globally and has been shown to be associated with high morbidity and mortality. Here, we did whole blood immunophenotyping along with plasma cytokine, chemokine, antibody isotyping, and viral load from oropharyngeal swab to understand the immune pathology in the T2DM patients infected with SARS-CoV2. Methods: Blood samples from 25 Covid-19 positive patients having T2DM, 10 Covid-19 positive patients not having T2DM, and 10 Covid-19 negative, non-diabetic healthy controls were assessed for various immune cells by analyzing for their signature surface proteins in mass cytometry. Circulating cytokines, chemokines, and antibody isotypes were determined from plasma while viral copy number was determined from oropharyngeal swabs. All our representative data corroborated with laboratory findings. Results: Our observations encompass T2DM patients having elevated levels of both type I and type II cytokines and higher levels of circulating IgA, IgM, IgG1, and IgG2 as compared to NDM and healthy volunteers. They also displayed higher percentages of granulocytes, mDCs, plasmablasts, Th2-like cells, CD4 Conclusion: Our study demonstrated that patients with T2DM displayed higher inflammatory markers and a dysregulated anti-viral and anti-inflammatory response when compared to NDM and healthy controls and the dysregulated immune response may be attributed to meta inflammation.
Mesh-Begriff(e)	COVID-19 ; Chemokines ; Cytokines ; Diabetes Mellitus, Type 2 ; Humans ; RNA, Viral ; SARS-CoV-2
Chemische Substanzen	Chemokines ; Cytokines ; RNA, Viral
Sprache	Englisch
Erscheinungsdatum	2022-04-27
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.848335
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India.

Singh, Bharati / Avula, Kiran / Chatterjee, Sanchari / Datey, Ankita / Ghosh, Arup / De, Saikat / Keshry, Supriya Suman / Ghosh, Soumyajit / Suryawanshi, Amol Ratnakar / Dash, Rupesh / Senapati, Shantibhusan / Beuria, Tushar K / Prasad, Punit / Raghav, Sunil / Swain, Rajeeb / Parida, Ajay / Hussain Syed, Gulam / Chattopadhyay, Soma

Frontiers in microbiology

2022 Band 13, Seite(n) 856913

Abstract: The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a serious pandemic has altered the global socioeconomic dynamics. The wide prevalence, high death counts, and rapid emergence of new variants urge for the establishment ... ...

Abstract	The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a serious pandemic has altered the global socioeconomic dynamics. The wide prevalence, high death counts, and rapid emergence of new variants urge for the establishment of research infrastructure to facilitate the rapid development of efficient therapeutic modalities and preventive measures. In agreement with this, SARS-CoV-2 strains were isolated from patient swab samples collected during the first COVID-19 wave in Odisha, India. The viral isolates were adapted to
Sprache	Englisch
Erscheinungsdatum	2022-06-30
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.856913
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway.

Prabhudutta Mamidi / Tapas Kumar Nayak / Abhishek Kumar / Sameer Kumar / Sanchari Chatterjee / Saikat De / Ankita Datey / Soumyajit Ghosh / Supriya Suman Keshry / Sharad Singh / Eshna Laha / Amrita Ray / Subhasis Chattopadhyay / Soma Chattopadhyay

PLoS Pathogens, Vol 17, Iss 11, p e

2021 Band 1009667

Abstract: Chikungunya virus (CHIKV) epidemics around the world have created public health concern with the unavailability of effective drugs and vaccines. This emphasizes the need for molecular understanding of host-virus interactions for developing effective ... ...

Abstract	Chikungunya virus (CHIKV) epidemics around the world have created public health concern with the unavailability of effective drugs and vaccines. This emphasizes the need for molecular understanding of host-virus interactions for developing effective targeted antivirals. Microarray analysis was carried out using CHIKV strain (Prototype and Indian) infected Vero cells and two host isozymes, MAPK activated protein kinase 2 (MK2) and MAPK activated protein kinase 3 (MK3) were selected for further analysis. The substrate spectrum of both enzymes is indistinguishable and covers proteins involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling and transcriptional regulation. Gene silencing and drug treatment were performed in vitro and in vivo to unravel the role of MK2/MK3 in CHIKV infection. Gene silencing of MK2 and MK3 abrogated around 58% CHIKV progeny release from the host cell and a MK2 activation inhibitor (CMPD1) treatment demonstrated 68% inhibition of viral infection suggesting a major role of MAPKAPKs during late CHIKV infection in vitro. Further, it was observed that the inhibition in viral infection is primarily due to the abrogation of lamellipodium formation through modulation of factors involved in the actin cytoskeleton remodeling pathway. Moreover, CHIKV-infected C57BL/6 mice demonstrated reduction in the viral copy number, lessened disease score and better survivability after CMPD1 treatment. In addition, reduction in expression of key pro-inflammatory mediators such as CXCL13, RAGE, FGF, MMP9 and increase in HGF (a CHIKV infection recovery marker) was observed indicating the effectiveness of the drug against CHIKV. Taken together it can be proposed that MK2 and MK3 are crucial host factors for CHIKV infection and can be considered as important target for developing effective anti-CHIKV strategies.
Schlagwörter	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code)	570 ; 572
Sprache	Englisch
Erscheinungsdatum	2021-11-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway

PLoS Pathogens, Vol 17, Iss

2021 Band 11

Abstract	Chikungunya virus (CHIKV) epidemics around the world have created public health concern with the unavailability of effective drugs and vaccines. This emphasizes the need for molecular understanding of host-virus interactions for developing effective targeted antivirals. Microarray analysis was carried out using CHIKV strain (Prototype and Indian) infected Vero cells and two host isozymes, MAPK activated protein kinase 2 (MK2) and MAPK activated protein kinase 3 (MK3) were selected for further analysis. The substrate spectrum of both enzymes is indistinguishable and covers proteins involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling and transcriptional regulation. Gene silencing and drug treatment were performed in vitro and in vivo to unravel the role of MK2/MK3 in CHIKV infection. Gene silencing of MK2 and MK3 abrogated around 58% CHIKV progeny release from the host cell and a MK2 activation inhibitor (CMPD1) treatment demonstrated 68% inhibition of viral infection suggesting a major role of MAPKAPKs during late CHIKV infection in vitro. Further, it was observed that the inhibition in viral infection is primarily due to the abrogation of lamellipodium formation through modulation of factors involved in the actin cytoskeleton remodeling pathway. Moreover, CHIKV-infected C57BL/6 mice demonstrated reduction in the viral copy number, lessened disease score and better survivability after CMPD1 treatment. In addition, reduction in expression of key pro-inflammatory mediators such as CXCL13, RAGE, FGF, MMP9 and increase in HGF (a CHIKV infection recovery marker) was observed indicating the effectiveness of the drug against CHIKV. Taken together it can be proposed that MK2 and MK3 are crucial host factors for CHIKV infection and can be considered as important target for developing effective anti-CHIKV strategies. Author summary Chikungunya virus has been a dreaded disease from the first time it occurred in 1952 Tanzania. Since then ...
Schlagwörter	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code)	570
Sprache	Englisch
Erscheinungsdatum	2021-11-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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