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  1. Article ; Online: Manu Platt talks about the new NIH Center for Biomedical Engineering Technology Acceleration.

    Horejs, Christine

    Nature reviews bioengineering

    2023  Volume 1, Issue 4, Page(s) 232–233

    Abstract: The National Institute of Biomedical Imaging and Bioengineering has established a new Center for Biomedical Engineering Technology Acceleration, dedicated to applying engineering principles to biomedical discovery and therapeutics. We talk to the Center' ... ...

    Abstract The National Institute of Biomedical Imaging and Bioengineering has established a new Center for Biomedical Engineering Technology Acceleration, dedicated to applying engineering principles to biomedical discovery and therapeutics. We talk to the Center's Director Manu Platt about their plans and the focus on diversity, equity, inclusion and accessibility.
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article
    ISSN 2731-6092
    ISSN (online) 2731-6092
    DOI 10.1038/s44222-023-00053-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The cause of cardiac dysfunction.

    Horejs, Christine

    Nature reviews. Materials

    2021  Volume 6, Issue 5, Page(s) 380

    Language English
    Publishing date 2021-04-12
    Publishing country England
    Document type Journal Article
    ISSN 2058-8437
    ISSN 2058-8437
    DOI 10.1038/s41578-021-00318-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nebulized lipid nanoparticles.

    Horejs, Christine

    Nature reviews. Materials

    2021  Volume 6, Issue 12, Page(s) 1077

    Abstract: An article ... ...

    Abstract An article in
    Language English
    Publishing date 2021-10-18
    Publishing country England
    Document type Journal Article
    ISSN 2058-8437
    ISSN 2058-8437
    DOI 10.1038/s41578-021-00392-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Artificially intelligent nanopore for rapid SARS-CoV-2 testing.

    Horejs, Christine

    Nature reviews. Materials

    2021  Volume 6, Issue 8, Page(s) 650

    Abstract: An article ... ...

    Abstract An article in
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article
    ISSN 2058-8437
    ISSN 2058-8437
    DOI 10.1038/s41578-021-00346-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Organ chips, organoids and the animal testing conundrum.

    Horejs, Christine

    Nature reviews. Materials

    2021  Volume 6, Issue 5, Page(s) 372–373

    Abstract: Nature Reviews ... ...

    Abstract Nature Reviews Materials
    Language English
    Publishing date 2021-04-26
    Publishing country England
    Document type Journal Article
    ISSN 2058-8437
    ISSN 2058-8437
    DOI 10.1038/s41578-021-00313-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: From lipids to lipid nanoparticles to mRNA vaccines.

    Horejs, Christine

    Nature reviews. Materials

    2021  Volume 6, Issue 12, Page(s) 1075–1076

    Abstract: Lipid nanoparticles are essential to mRNA vaccines. The groundwork for lipid-based drug delivery systems was laid more than 40 years ago in the lab of Pieter Cullis, Professor at the University of British Columbia. ...

    Abstract Lipid nanoparticles are essential to mRNA vaccines. The groundwork for lipid-based drug delivery systems was laid more than 40 years ago in the lab of Pieter Cullis, Professor at the University of British Columbia.
    Language English
    Publishing date 2021-09-21
    Publishing country England
    Document type Journal Article
    ISSN 2058-8437
    ISSN 2058-8437
    DOI 10.1038/s41578-021-00379-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Basement membrane fragments in the context of the epithelial-to-mesenchymal transition.

    Horejs, Christine-Maria

    European journal of cell biology

    2016  Volume 95, Issue 11, Page(s) 427–440

    Abstract: The epithelial-to-mesenchymal transition (EMT) enables cells of epithelial phenotype to become motile and change to a migratory mesenchymal phenotype. EMT is known to be a fundamental requisite for tissue morphogenesis, and EMT-related pathways have been ...

    Abstract The epithelial-to-mesenchymal transition (EMT) enables cells of epithelial phenotype to become motile and change to a migratory mesenchymal phenotype. EMT is known to be a fundamental requisite for tissue morphogenesis, and EMT-related pathways have been described in cancer metastasis and tissue fibrosis. Epithelial structures are marked by the presence of a sheet-like extracellular matrix, the basement membrane, which is assembled from two major proteins, laminin and collagen type IV. This specialized matrix is essential for tissue function and integrity, and provides an important barrier to the potential pathogenic migration of cells. The profound phenotypic transition in EMT involves the epithelial cells disrupting the basement membrane. Matrix metalloproteinases (MMPs) are known to cleave components of basement membranes, but MMP-basement membrane crosstalk during EMT in vivo is poorly understood. However, MMPs have been reported to play a role in EMT-related processes and a variety of basement membrane fragments have been shown to be released by specific MMPs in vitro and in vivo exhibiting distinct biological activities. This review discusses general considerations regarding the basement membrane in the context of EMT, a possible role for specific MMPs in EMT and highlights biologically active basement membrane fragments liberated by MMPs.
    MeSH term(s) Animals ; Basement Membrane/metabolism ; Collagenases/metabolism ; Epithelial-Mesenchymal Transition/physiology ; Extracellular Matrix/metabolism ; Humans
    Chemical Substances Collagenases (EC 3.4.24.-)
    Language English
    Publishing date 2016-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391967-5
    ISSN 1618-1298 ; 0070-2463 ; 0171-9335
    ISSN (online) 1618-1298
    ISSN 0070-2463 ; 0171-9335
    DOI 10.1016/j.ejcb.2016.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 667: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair.

    Keane, Timothy J / Horejs, Christine-Maria / Stevens, Molly M

    Advanced drug delivery reviews

    2018  Volume 129, Page(s) 407–419

    Abstract: All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most often culminates in scar formation. Accounting for nearly 45% of deaths in the ... ...

    Abstract All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most often culminates in scar formation. Accounting for nearly 45% of deaths in the developed world, fibrosis is a process that stands diametrically opposed to functional tissue regeneration. Strategies to improve wound healing outcomes therefore require methods to limit fibrosis. Wound healing is guided by precise spatiotemporal deposition and remodelling of the extracellular matrix (ECM). The ECM, comprising the non-cellular component of tissues, is a signalling depot that is differentially regulated in scarring and regenerative healing. This Review focuses on the importance of the native matrix components during mammalian wound healing alongside a comparison to scar-free healing and then presents an overview of matrix-based strategies that attempt to exploit the role of the ECM to improve wound healing outcomes.
    MeSH term(s) Animals ; Cicatrix/metabolism ; Cicatrix/pathology ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Wound Healing
    Language English
    Publishing date 2018-02-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2018.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2241: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Model based variable selection as a tool to highlight biological differences in Raman spectra of cells.

    Hedegaard, Martin A B / Cloyd, Kristy L / Horejs, Christine-Maria / Stevens, Molly M

    The Analyst

    2014  Volume 139, Issue 18, Page(s) 4629–4633

    Abstract: In vitro Raman spectroscopy used for non-invasive, non-destructive characterization of single cells and tissues has proven to be a powerful tool for understanding the complex biochemical processes within these biological systems. Additionally it enables ... ...

    Abstract In vitro Raman spectroscopy used for non-invasive, non-destructive characterization of single cells and tissues has proven to be a powerful tool for understanding the complex biochemical processes within these biological systems. Additionally it enables the comparison of a wide range of in vitro model systems by discriminating them based on their biomolecular differences. However, one persistent challenge in Raman spectroscopy has been the highly complex structure of cell and tissue spectra, which comprise signals from lipids, proteins, carbohydrates and nucleic acids, which may overlap significantly. This leads to difficulty in discerning which molecular components are responsible for the changes seen between experimental groups. To address this problem, we introduce a technique to highlight the significant biochemical changes between sample groups by applying a novel approach using Partial Least Squares - Discriminant Analysis (PLS-DA) Variable Importance Projection (VIP) scores normally used for variable selection as heat maps combined with group difference spectra to highlight significant differences in Raman band shapes and position. To illustrate this method we analyzed single HeLa cells in their live, fixed, fixed and ethanol dehydrated, to the fixed, dehydrated and then rehydrated states respectively. Fixation, ethanol dehydration and rehydration are known to induce molecular changes in the lipids and proteins within each cell.
    MeSH term(s) Discriminant Analysis ; HeLa Cells ; Humans ; Least-Squares Analysis ; Spectrum Analysis, Raman/methods ; Tissue Fixation
    Language English
    Publishing date 2014-09-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/c4an00731j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Extracellular Stiffness Modulates the Expression of Functional Proteins and Growth Factors in Endothelial Cells.

    Santos, Lívia / Fuhrmann, Gregor / Juenet, Maya / Amdursky, Nadav / Horejs, Christine-Maria / Campagnolo, Paola / Stevens, Molly M

    Advanced healthcare materials

    2015  

    Abstract: Angiogenesis, the formation of blood vessels from pre-existing ones, is of vital importance during the early stages of bone healing. Extracellular stiffness plays an important role in regulating endothelial cell behavior and angiogenesis, but how this ... ...

    Abstract Angiogenesis, the formation of blood vessels from pre-existing ones, is of vital importance during the early stages of bone healing. Extracellular stiffness plays an important role in regulating endothelial cell behavior and angiogenesis, but how this mechanical cue affects proliferation kinetics, gene regulation, and the expression of proteins implicated in angiogenesis and bone regeneration remains unclear. Using collagen-coated polyacrylamide (PAAm) hydrogels, human umbilical vein endothelial cells (HUVECs) are exposed to an environment that mimics the elastic properties of collagenous bone, and cellular proliferation and gene and protein expressions are assessed. The proliferation and gene expression of HUVECs are not differentially affected by culture on 3 or 30 kPa PAAm hydrogels, henceforth referred to as low and high stiffness gels, respectively. Although the proliferation and gene transcript levels remain unchanged, significant differences are found in the expressions of functional proteins and growth factors implicated both in the angiogenic and osteogenic processes. The down-regulation of the vascular endothelial growth factor receptor-2 protein with concomitant over-expression of caveolin-1, wingless-type 2, bone morphogenic protein 2, and basic fibroblast growth factor on the high stiffness PAAm hydrogel suggests that rigidity has a pro-angiogenic effect with inherent benefits for bone regeneration.
    Language English
    Publishing date 2015-08-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.201500338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6966: Show issues Location:
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