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Article ; Online: A re-assessment of Dr Robert Knox and his contribution to early evolution science.

Donaldson, Ken / Henry, Christopher

2024 , Page(s) 9677720231223507

Abstract: Dr Robert Knox was publicly scorned and disgraced for his unwitting involvement in the Burke and Hare serial murders in 1828. Far less appreciated is his brilliance as an anatomist and he espoused the European movement in Transcendental Anatomy, which ... ...

Abstract	Dr Robert Knox was publicly scorned and disgraced for his unwitting involvement in the Burke and Hare serial murders in 1828. Far less appreciated is his brilliance as an anatomist and he espoused the European movement in Transcendental Anatomy, which aimed to uncover the laws governing what we now know as evolution and the origin of species. Knox fully embraced Transcendental Anatomy during a sojourn in Paris and taught it on his return to Edinburgh, where there was a critical mass of like-minded Transcendental Anatomists. Charles Darwin spent 1825-1827 as a medical student in Edinburgh when Transcendental Anatomy was at its peak amongst the city's anatomists, and evolution - then known as transmutation - was a source of great interest and controversy. Knox intended to research Transcendental Anatomy, but this was thwarted by conflicting demands on his time in the second half of the 1820s decade and the Burke and Hare tragedy. He did, however, go on to champion Transcendental Anatomy and write extensively on it.
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1159267-9
ISSN	1758-1087 ; 0967-7720
ISSN (online)	1758-1087
ISSN	0967-7720
DOI	10.1177/09677720231223507
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Book: Particle toxicology

Donaldson, Ken

2007

Author's details	ed. by Ken Donaldson
Keywords	Air Pollutants / toxicity ; Mineral Fibers / toxicity ; Oxidative Stress ; Inflammation
Language	English
Size	434 S., [4] Bl. : Ill., graph. Darst.
Publisher	CRC Press
Publishing place	Boca Raton, Fla. u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT015053785
ISBN	0-8493-5092-1 ; 978-0-8493-5092-4
Database	Catalogue ZB MED Medicine, Health

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2007 A 3271	order for loan	Magazin

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Article ; Online: Dr Robert Knox and his book on fishing in Scotland: A window into his mind.

Donaldson, Ken / Henry, Christopher

The journal of the Royal College of Physicians of Edinburgh

2022 Volume 52, Issue 2, Page(s) 159–165

Abstract: Robert Knox was publicly vilified for his suspected complicity in the 16 murders committed by Burke and Hare, although he had no involvement in them. Along with several books on anatomy Knox also wrote a book on angling in Lowland Scotland. In 'Fish and ... ...

Abstract	Robert Knox was publicly vilified for his suspected complicity in the 16 murders committed by Burke and Hare, although he had no involvement in them. Along with several books on anatomy Knox also wrote a book on angling in Lowland Scotland. In 'Fish and Fishing in the Lone Glens of Scotland' Knox's deep love for nature and for fishing emerges. Most interesting however is that although generally focussed on fish and fishing, the book abounds with asides on Knox's other preoccupations and passions. These provide rare insights into the character of the great anatomist, whose personality has otherwise retained its opacity over the years. In the book, Knox writes in passing and in a relatively unguarded fashion, about such topics as transcendental anatomy, Scottish Independence, empiricism, race and Edinburgh medical figures. In so-doing, we contend that he affords the reader some insight into the mind of the real Dr Robert Knox.
MeSH term(s)	History, 19th Century ; Homicide ; Humans ; Hunting ; Male ; Scotland
Language	English
Publishing date	2022-06-17
Publishing country	England
Document type	Historical Article ; Journal Article
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
DOI	10.1177/14782715221103720
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Article ; Online: Richard Muir: Edinburgh-based pioneer biomedical scientist and medical artist.

Donaldson, Ken / Henry, Christopher

Journal of medical biography

2022 Volume 31, Issue 2, Page(s) 113–118

Abstract: Richard Muir (1862-1931) began his career as a 'lab boy' in the Pathology Department of the University of Edinburgh in 1876 at the age of 13. This was a newly created category of worker that eventually became today's biomedical scientist Muir rapidly ... ...

Abstract	Richard Muir (1862-1931) began his career as a 'lab boy' in the Pathology Department of the University of Edinburgh in 1876 at the age of 13. This was a newly created category of worker that eventually became today's biomedical scientist Muir rapidly gained expertise in pathological and bacteriological techniques including staining and microscopy. Exceptionally, for someone non-medical and non-university-educated individual, he was elected a member of the Pathological Society of Great Britain and appointed Demonstrator in Pathology in the University of Edinburgh Pathology Department. He authored papers on staining techniques for bacteria and on the pathology of syphilis of the ear and became a recognised diagnostic histopathologist, despite having no medical qualifications. He especially excelled as an artist, depicting the microscopic world of pathology and microbiology and produced diagrams for hundreds of publications including his own book and also large wall hangings of the microscopic world for teaching purposes. This paper describes the unique contribution of Richard Muir to pathology in Edinburgh and beyond in the early 20
MeSH term(s)	Humans ; History, 20th Century ; United Kingdom ; Books
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Historical Article ; Journal Article
ZDB-ID	1159267-9
ISSN	1758-1087 ; 0967-7720
ISSN (online)	1758-1087
ISSN	0967-7720
DOI	10.1177/09677720221095515
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Article: John Goodsir: discovering

Donaldson, Ken / Henry, Christopher

Scottish medical journal

2020 Volume 65, Issue 2, Page(s) 40–45

Abstract: In 1842, when John Goodsir was Conservator to the Museum of the RCSEd, he saw a 19-year-old male patient who vomited a large volume of acidic, fermented-smelling, watery fluid every morning. Under his microscope, Goodsir found the vomitus to be populated ...

Abstract	In 1842, when John Goodsir was Conservator to the Museum of the RCSEd, he saw a 19-year-old male patient who vomited a large volume of acidic, fermented-smelling, watery fluid every morning. Under his microscope, Goodsir found the vomitus to be populated with a micro-organism he named
MeSH term(s)	Portraits as Topic ; Humans ; Male ; Young Adult ; Causality ; Dyspepsia/microbiology ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/history ; History, 19th Century ; Sarcina/isolation & purification ; Stomach Diseases/metabolism ; Stomach Diseases/microbiology ; Vomiting/microbiology
Language	English
Publishing date	2020-03-24
Publishing country	Scotland
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	414085-0
ISSN	2045-6441 ; 0036-9330
ISSN (online)	2045-6441
ISSN	0036-9330
DOI	10.1177/0036933020912329
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Article ; Online: John Goodsir and local opposition to Rudolf Virchow's election to Fellowship of the Royal Society of Edinburgh in 1868.

Donaldson, Ken / Henry, Christopher

The journal of the Royal College of Physicians of Edinburgh

2020 Volume 50, Issue 2, Page(s) 188–195

Abstract: In 1869 Rudolf Virchow, the distinguished Prussian pathologist who pioneered the modern concept of cellular pathology, was offered an honorary Fellowship of The Royal Society of Edinburgh (RSE). However, the Rev. Joseph T Goodsir, Fellow of the Royal ... ...

Abstract	In 1869 Rudolf Virchow, the distinguished Prussian pathologist who pioneered the modern concept of cellular pathology, was offered an honorary Fellowship of The Royal Society of Edinburgh (RSE). However, the Rev. Joseph T Goodsir, Fellow of the Royal Society of Edinburgh (FRSE), the brother of Professor John Goodsir FRSE, the famed Edinburgh anatomist who had died two years previously, mounted a campaign to stop the award. As part of this he published a pamphlet entitled Grounds of Objection to the Admission of Professor Virchow as an Honorary Fellow of the Royal Society of Edinburgh. The disagreement centred on John Goodsir's pioneering research and writings on cell theory. These had in fact been recognised by Virchow, who dedicated the English language edition of his most famous publication Cellular Pathology to John Goodsir. Joseph Goodsir was not, however, satisfied by this and the basis of his objection was that Virchow had plagiarised from his brother. We describe the background and outcome of this dispute.
MeSH term(s)	Death ; Dissent and Disputes ; Fellowships and Scholarships ; History, 19th Century ; Humans ; Male ; Societies
Language	English
Publishing date	2020-08-18
Publishing country	Scotland
Document type	Historical Article ; Journal Article
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
DOI	10.4997/JRCPE.2020.225
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Article ; Online: The recognition of lung disease in coal workers: The role of Gough-Wentworth whole lung sections.

Donaldson, Ken / Wallace, William A / MacNee, William / Henry, Christopher / Seaton, Anthony

The journal of the Royal College of Physicians of Edinburgh

2022 Volume 52, Issue 1, Page(s) 65–72

Abstract: From the identification of a specific lung disease caused by coal dust exposure in miners in 1831 until the demonstration of the association of that exposure to risk of emphysema in 1984, there was continuous argument about the harmfulness of coal dust. ... ...

Abstract	From the identification of a specific lung disease caused by coal dust exposure in miners in 1831 until the demonstration of the association of that exposure to risk of emphysema in 1984, there was continuous argument about the harmfulness of coal dust. Ill health in miners was attributed variously to tuberculosis, quartz exposure or cigarette smoking. An acceptance that coal dust was harmful only started with investigative radiology and pathology in the 1920s, and physiology in the 1950s. Most of the early investigations were in South Wales, the centre of the most important coal field in Great Britain. Among the investigators was Professor Jethro Gough who, with his technician James Wentworth, introduced a technique for making thick sections of whole, inflated lungs on paper backing. Here, we describe this method and its central role in understanding the relationships between coal dust exposure, pneumoconiosis, emphysema and lung dysfunction in miners.
MeSH term(s)	Coal/adverse effects ; Coal Mining ; Dust ; Emphysema/pathology ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases ; Pulmonary Emphysema/pathology ; Quartz
Chemical Substances	Coal ; Dust ; Quartz (14808-60-7)
Language	English
Publishing date	2022-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
DOI	10.1177/14782715221088982
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Article ; Online: Comparing dry needling or local acupuncture to various wet needling injection types for musculoskeletal pain and disability. A systematic review of randomized clinical trials.

Griswold, David / Learman, Ken / Ickert, Edmund / Clewley, Derek / Donaldson, Megan B / Wilhelm, Mark / Cleland, Joshua

Disability and rehabilitation

2023 Volume 46, Issue 3, Page(s) 414–428

Abstract: Purpose: Systematically evaluate the comparative effectiveness of dry needling (DN) or local acupuncture to various types of wet needling (WN) for musculoskeletal pain disorders (MPD).: Methods: Seven databases (PubMed, PEDro, SPORTDiscus, CINAHL, ... ...

Abstract	Purpose: Systematically evaluate the comparative effectiveness of dry needling (DN) or local acupuncture to various types of wet needling (WN) for musculoskeletal pain disorders (MPD). Methods: Seven databases (PubMed, PEDro, SPORTDiscus, CINAHL, Scopus, Embase, and Cochrane Central Register of Controlled Trials) were searched following PROSPERO registration. Randomized clinical trials were included if they compared DN or local acupuncture with WN for MPD. Primary outcomes were pain and/or disability. The Revised Cochrane Collaboration tool (RoB 2.0) assessed the risk of bias. Results: Twenty-six studies were selected. Wet Needling types included cortisone (CSI) ( Conclusion: Evidence suggests the effectiveness of DN to WN injections is variable depending on the injection type, outcome time frame, and diagnosis. In addition, adverse event data were similar but inconsistently reported.
MeSH term(s)	Humans ; Musculoskeletal Pain ; Anesthetics, Local ; Cortisone ; Botulinum Toxins, Type A ; Percutaneous Collagen Induction ; Randomized Controlled Trials as Topic ; Acupuncture Therapy/methods ; Rheumatic Diseases
Chemical Substances	Anesthetics, Local ; Cortisone (V27W9254FZ) ; Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2023.2165731
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Article ; Online: Quantifying the Impact of Alternative Definitions of Sepsis-Associated Acute Kidney Injury on its Incidence and Outcomes: A Systematic Review and Meta-Analysis.

Donaldson, Lachlan H / Vlok, Ruan / Sakurai, Ken / Burrows, Morgan / McDonald, Gabrielle / Venkatesh, Karthik / Bagshaw, Sean M / Bellomo, Rinaldo / Delaney, Anthony / Myburgh, John / Hammond, Naomi E / Venkatesh, Balasubramanian

Critical care medicine

2024

Abstract: Objectives: To derive a pooled estimate of the incidence and outcomes of sepsis-associated acute kidney injury (SA-AKI) in ICU patients and to explore the impact of differing definitions of SA-AKI on these estimates.: Data sources: Medline, Medline ... ...

Abstract	Objectives: To derive a pooled estimate of the incidence and outcomes of sepsis-associated acute kidney injury (SA-AKI) in ICU patients and to explore the impact of differing definitions of SA-AKI on these estimates. Data sources: Medline, Medline Epub, EMBASE, and Cochrane CENTRAL between 1990 and 2023. Study selection: Randomized clinical trials and prospective cohort studies of adults admitted to the ICU with either sepsis and/or SA-AKI. Data extraction: Data were extracted in duplicate. Risk of bias was assessed using adapted standard tools. Data were pooled using a random-effects model. Heterogeneity was assessed by using a single covariate logistic regression model. The primary outcome was the proportion of participants in ICU with sepsis who developed AKI. Data synthesis: A total of 189 studies met inclusion criteria. One hundred fifty-four reported an incidence of SA-AKI, including 150,978 participants. The pooled proportion of patients who developed SA-AKI across all definitions was 0.40 (95% CI, 0.37-0.42) and 0.52 (95% CI, 0.48-0.56) when only the Risk Injury Failure Loss End-Stage, Acute Kidney Injury Network, and Improving Global Outcomes definitions were used to define SA-AKI. There was significant variation in the incidence of SA-AKI depending on the definition of AKI used and whether AKI defined by urine output criteria was included; the incidence was lowest when receipt of renal replacement therapy was used to define AKI (0.26; 95% CI, 0.24-0.28), and highest when the Acute Kidney Injury Network score was used (0.57; 95% CI, 0.45-0.69; p < 0.01). Sixty-seven studies including 29,455 participants reported at least one SA-AKI outcome. At final follow-up, the proportion of patients with SA-AKI who had died was 0.48 (95% CI, 0.43-0.53), and the proportion of surviving patients who remained on dialysis was 0.10 (95% CI, 0.04-0.17). Conclusions: SA-AKI is common in ICU patients with sepsis and carries a high risk of death and persisting kidney impairment. The incidence and outcomes of SA-AKI vary significantly depending on the definition of AKI used.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000006284
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Article ; Online: Could paramedics use the HEART Pathway to identify patients at low-risk of myocardial infarction in the prehospital setting?

Cooper, Jamie G / Ferguson, James / Donaldson, Lorna A / Black, Kim M M / Livock, Kate J / Horrill, Judith L / Davidson, Elaine M / Scott, Neil W / Lee, Amanda J / Fujisawa, Takeshi / Lee, Kuan Ken / Anand, Atul / Shah, Anoop S V / Mills, Nicholas L

American heart journal

2024 Volume 271, Page(s) 182–187

Abstract: In the Emergency Department, patients with suspected myocardial infarction can be risk stratified using the HEART pathway, which has recently been amended for prehospital use and modified for the incorporation of a high-sensitivity cardiac troponin test. ...

Abstract	In the Emergency Department, patients with suspected myocardial infarction can be risk stratified using the HEART pathway, which has recently been amended for prehospital use and modified for the incorporation of a high-sensitivity cardiac troponin test. In a prospective analysis, the performance of both HEART pathways in the prehospital setting, with a high-sensitivity cardiac troponin test using 3 different thresholds, was evaluated for major adverse cardiac events at 30 days. We found that both low-risk HEART pathways, when using the most conservative cardiac troponin thresholds, approached but did not reach accepted rule-out performance in the Emergency Department.
MeSH term(s)	Humans ; Myocardial Infarction/diagnosis ; Myocardial Infarction/blood ; Emergency Medical Services/methods ; Prospective Studies ; Risk Assessment/methods ; Male ; Female ; Middle Aged ; Aged ; Biomarkers/blood ; Emergency Service, Hospital ; Allied Health Personnel ; Troponin/blood ; Emergency Medical Technicians ; Paramedics
Chemical Substances	Biomarkers ; Troponin
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	80026-0
ISSN	1097-6744 ; 0002-8703
ISSN (online)	1097-6744
ISSN	0002-8703
DOI	10.1016/j.ahj.2024.02.018
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