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  1. Article ; Online: ApoE induced by high-fat diet: a pathological model of atherosclerosis in mice.

    Xia, Xiaoru / Wang, Lijing

    Panminerva medica

    2023  

    Language English
    Publishing date 2023-06-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123572-2
    ISSN 1827-1898 ; 0031-0808
    ISSN (online) 1827-1898
    ISSN 0031-0808
    DOI 10.23736/S0031-0808.23.04913-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 179: Show issues Location:
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  2. Article ; Online: Case report: Rare neurological symptoms of sulfasalazine-induced hypersensitivity syndrome.

    Shen, Yiqi / Li, Sijie / Qian, Mengting / Xia, Xiaoru

    International journal of rheumatic diseases

    2023  Volume 27, Issue 3, Page(s) e15108

    MeSH term(s) Humans ; Sulfasalazine/adverse effects ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/therapy ; Syndrome ; Sulfonamides
    Chemical Substances Sulfasalazine (3XC8GUZ6CB) ; Sulfonamides
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.15108
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    Zs.A 6098: Show issues Location:
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  3. Article ; Online: Comparative Genomic Analysis of

    Fan, Lianxue / Zhu, Ziyi / Lin, Xiaoru / Shen, Xia / Yang, Tianjiao / Wang, Haixin / Zhou, Xiuyan

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: The family of phosphatidylethanolamine-binding proteins (PEBPs) participates in various plant biological processes, mainly flowering regulation and seed germination. In cucurbit crops, ... ...

    Abstract The family of phosphatidylethanolamine-binding proteins (PEBPs) participates in various plant biological processes, mainly flowering regulation and seed germination. In cucurbit crops, several
    MeSH term(s) Female ; Male ; Animals ; Cucumis sativus/genetics ; Reproduction ; Comparative Genomic Hybridization ; Time Factors ; Crops, Agricultural ; Gastropoda ; Genomics
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073815
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  4. Article ; Online: Chiral NHC-Catalyzed [4+2] Cycloadditions: Highly Diastereo/Enantioselective Access to Spiro[cyclohex-4-ene-1,3'-indoles] and DFT Calculations.

    Chen, Xiaoyu / Xia, Siqi / Hu, Xiaoru / Zhong, Guofu / Yang, Limin

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 23, Page(s) e202203818

    Abstract: A highly efficient NHC-catalyzed cycloaddition of (E)-alkenylisatins and γ-chloroenals with a broad substrate scope has been developed to provide spiro[cyclohex-4-ene-1,3'-indole] in good yields (up to 99 % yield) with excellent diastereo- and ... ...

    Abstract A highly efficient NHC-catalyzed cycloaddition of (E)-alkenylisatins and γ-chloroenals with a broad substrate scope has been developed to provide spiro[cyclohex-4-ene-1,3'-indole] in good yields (up to 99 % yield) with excellent diastereo- and enantioselectivities (up to >20 : 1 d.r., >99 % ee) under mild conditions without the use of metal and additives. Based on computational investigations, the role of the NHC on the diastereo- and enantioselectivity is discussed.
    Language English
    Publishing date 2023-03-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202203818
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  5. Article: Whole-Exome Sequencing Identifies a Novel

    Guo, Yong / Jin, Jing / Zhou, Zhenni / Chen, Yihui / Sun, Li / Zhang, Chunwu / Xia, Xiaoru

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 802635

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.802635
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  6. Article: Corrigendum: Whole-exome sequencing identifies a novel CPT2 mutation in a pedigree with gout.

    Guo, Yong / Jin, Jing / Zhou, Zhenni / Chen, Yihui / Sun, Li / Zhang, Chunwu / Xia, Xiaoru

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 988348

    Abstract: This corrects the article DOI: 10.3389/fcell.2022.802635.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcell.2022.802635.].
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.988348
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  7. Article ; Online: Corrigendum

    Yong Guo / Jing Jin / Zhenni Zhou / Yihui Chen / Li Sun / Chunwu Zhang / Xiaoru Xia

    Frontiers in Cell and Developmental Biology, Vol

    Whole-exome sequencing identifies a novel CPT2 mutation in a pedigree with gout

    2022  Volume 10

    Keywords whole-exome sequencing ; novel mutation ; gout ; CPT2 gene ; pedigree ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1.

    Li, Jianqin / Xia, Yalin / Fan, Xiaoru / Wu, Xiaofang / Yang, Feiyun / Hu, Shaoyan / Wang, Zhaoyue

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 708562

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.708562
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  9. Article ; Online: Correction: Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation.

    Li, Jianqin / Xia, Yalin / Fan, Xiaoru / Wu, Xiaofang / Yang, Feiyun / Hu, Shaoyan / Wang, Zhaoyue

    Laboratory investigation; a journal of technical methods and pathology

    2021  Volume 101, Issue 8, Page(s) 1113

    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 80178-1
    ISSN 1530-0307 ; 0023-6837
    ISSN (online) 1530-0307
    ISSN 0023-6837
    DOI 10.1038/s41374-021-00605-6
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.164: Show issues Location:
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  10. Article ; Online: Whole-Exome Sequencing Identifies a Novel CPT2 Mutation in a Pedigree With Gout

    Yong Guo / Jing Jin / Zhenni Zhou / Yihui Chen / Li Sun / Chunwu Zhang / Xiaoru Xia

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: Background: Gout is a common inflammatory arthritis, and its exact pathogenesis remains unclear. Multiple studies have demonstrated that genetic factors play important roles in the development of gout. This study aims to investigate the genetic basis of ... ...

    Abstract Background: Gout is a common inflammatory arthritis, and its exact pathogenesis remains unclear. Multiple studies have demonstrated that genetic factors play important roles in the development of gout. This study aims to investigate the genetic basis of gout in a three-generation pedigree of affected individuals.Methods: Whole-exome sequencing (WES), comprehensive variant analyses, and co-segregation testing were performed. The effects of candidate variants on protein localization and cellular expression were analyzed, as were interactions with gout-related genes.Results: After comprehensive bioinformatic analysis, Sanger sequencing validation, and pedigree co-segregation analysis, we identified a rare heterozygous missense variant (c.1891C > T, p.R631C) in CPT2. Although no associated changes in localization were observed, the fluorescence intensity of p.R631C mutants was obviously reduced in comparison to the wild-type protein, suggesting that protein degradation is induced by the mutant. Furthermore, our results also indicate that the c.1891C > T variant influences the ability of CPT2 to bind UCP2.Conclusion: This study identified a rare CPT2 mutation in a large Chinese pedigree with gout. Functional studies were used to define the effect of this mutant. This study provides novel insight into the genetic etiology of gout.
    Keywords whole-exome sequencing ; novel mutation ; gout ; CPT2 gene ; pedigree ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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