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  1. Article ; Online: Precisión conceptual sobre el llamado “dilema de la última cama”.

    Aguilera, Bernardo

    Revista medica de Chile

    2022  Volume 149, Issue 10, Page(s) 1516–1517

    Title translation Conceptual precision on the so-called "last bed dilemma".
    Language Spanish
    Publishing date 2022-04-12
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/s0034-98872021001001516
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  2. Article ; Online: 97:oral Priority setting and health rights litigation in Latin America

    Bernardo Aguilera

    BMJ Global Health, Vol 7, Iss Suppl

    2022  Volume 2

    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Trends in clinical trials performed in Chile.

    Aguilera, Bernardo

    Revista medica de Chile

    2021  Volume 149, Issue 1, Page(s) 110–118

    Abstract: Background: An increasingly large proportion of clinical trials is being conducted at non-traditional geographic regions such as Latin America. However, concerns have been raised that hosting countries may lack adequate research regulations and that ... ...

    Abstract Background: An increasingly large proportion of clinical trials is being conducted at non-traditional geographic regions such as Latin America. However, concerns have been raised that hosting countries may lack adequate research regulations and that clinical trials may not address local health needs. In this context, Chile has been hosting a relatively large proportion of clinical trials and has introduced new regulatory protections.
    Aim: To study trends and characteristics of clinical trials in Chile, including the effects of regulatory protections and whether clinical trials are aligned with the local burden of diseases.
    Material and methods: Data from clinical trials on pharmaceutical products registered over the last decade in Chile's Institute of Public Health was reviewed. Clinical trials were analyzed according to sponsorship, phase, disease studied, and whether distribution of trials according to diseases was aligned with the local burden of diseases measured in disability-adjusted life years.
    Results: Most of the 876 clinical trials analyzed were funded by external pharmaceutical companies and corresponded to late-phase trials. The most commonly studied disease groups were neoplasms, musculoskeletal disorders, other noncommunicable diseases, chronic respiratory diseases, diabetes and kidney diseases, neurological disorders, and circulatory diseases. The distribution of clinical trials was partially aligned with the distribution of major causes of disease burden. The introduction of new regulatory protections was followed by changes in the number of trials studying certain disease groups associated with a high burden.
    Conclusions: Clinical trials conducted in Chile over the last decade are largely funded by external pharmaceutical companies. Their distribution is partially aligned with local disease burden. The introduction of regulatory protections was followed by changes in the distribution of diseases studied.
    MeSH term(s) Cardiovascular Diseases ; Chile ; Clinical Trials as Topic ; Humans ; Latin America ; Noncommunicable Diseases ; Public Health
    Language English
    Publishing date 2021-06-09
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872021000100110
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  4. Book ; Online: Diferencias departamentales del comercio intraindustrial colombiano con Estados Unidos y Latinoamérica

    González Lozano, Bernardo / Valencia G, Catherine / Aguilera-Prado, Marco / Paola García-Castiblanco, Claudia

    2020  

    Keywords Business studies: general ; International business ; Business innovation ; Industrial applications of scientific research & technological innovation ; International economy ; international trade ; intra-industry trade ; competitive advantages ; economies of scale
    Size 1 electronic resource (52 pages)
    Publisher Editorial Uniagustiniana
    Document type Book ; Online
    Note Spanish ; Open Access
    HBZ-ID HT021233190
    ISBN 9789585498464 ; 9585498464
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Ethical allocation of scarce health care resources in the context of the COVID-19 crisis.

    Aguilera, Bernardo

    Medwave

    2020  Volume 20, Issue 5, Page(s) e7935

    Abstract: The current COVID-19 pandemic has the potential to overwhelm the capacity of hospitals and Intensive Care Units in Chile and Latin America. Thus local authorities have an ethical obligation to be prepared by implementing pertinent measures to prevent a ... ...

    Title translation Asignación ética de recursos sanitarios escasos en el contexto de crisis por COVID-19.
    Abstract The current COVID-19 pandemic has the potential to overwhelm the capacity of hospitals and Intensive Care Units in Chile and Latin America. Thus local authorities have an ethical obligation to be prepared by implementing pertinent measures to prevent a situation of rationing of scarce healthcare resources, and by defining ethically acceptable and socially legitimate criteria for the allocation of these resources. This paper responds to recent ethical guidelines issued by a Chilean academic institution and discusses the main moral principles for the ethical foundations of criteria for rationing during the present crisis. It argues that under exceptional circumstances such as the current pandemic, the traditional patient-centered morality of medicine needs to be balanced with ethical principles formulated from a public health perspective, including the principles of social utility, social justice and equity, among others. The paper concludes with some recommendations regarding how to reach an agreement about rationing criteria and about their implementation in clinical practice.
    MeSH term(s) COVID-19 ; Chile ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Guidelines as Topic ; Health Care Rationing/ethics ; Hospitals/ethics ; Hospitals/statistics & numerical data ; Humans ; Intensive Care Units/ethics ; Intensive Care Units/statistics & numerical data ; Latin America ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Public Health/ethics ; Social Justice ; Surge Capacity/statistics & numerical data
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2818022-7
    ISSN 0717-6384 ; 0717-6384
    ISSN (online) 0717-6384
    ISSN 0717-6384
    DOI 10.5867/medwave.2020.05.7935
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  6. Article ; Online: Ethical allocation of scarce health care resources in the context of the COVID-19 crisis

    Bernardo Aguilera

    Medwave, Vol 20, Iss 05, Pp e7935-e

    2020  Volume 7935

    Abstract: The current COVID-19 pandemic has the potential to overwhelm the capacity of hospitals and Intensive Care Units in Chile and Latin America. Thus local authorities have an ethical obligation to be prepared by implementing pertinent measures to prevent a ... ...

    Abstract The current COVID-19 pandemic has the potential to overwhelm the capacity of hospitals and Intensive Care Units in Chile and Latin America. Thus local authorities have an ethical obligation to be prepared by implementing pertinent measures to prevent a situation of rationing of scarce healthcare resources, and by defining ethically acceptable and socially legitimate criteria for the allocation of these resources. This paper responds to recent ethical guidelines issued by a Chilean academic institution and discusses the main moral principles for the ethical foundations of criteria for rationing during the present crisis. It argues that under exceptional circumstances such as the current pandemic, the traditional patient-centered morality of medicine needs to be balanced with ethical principles formulated from a public health perspective, including the principles of social utility, social justice and equity, among others. The paper concludes with some recommendations regarding how to reach an agreement about rationing criteria and about their implementation in clinical practice.
    Keywords covid-19 ; pandemics ; resource allocation ; social justice ; public health ; chile ; Medicine ; R ; Medicine (General) ; R5-920 ; covid19
    Subject code 170
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Medwave Estudios Limitada
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Editorial Commentary: Hip Subspine Impact: Is There a Synergistic Effect Between Subspine Impact and Femoroacetabular Impingement?

    Aguilera-Bohórquez, Bernardo

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2021  Volume 37, Issue 10, Page(s) 3102–3103

    Abstract: Hip subspine impingement (SSI) is a condition located in the extra-articular area of the hip and is characterized by irregular contact between the anterior inferior iliac spine (AIIS) and the distal femoral neck. Recently, it also has been described that ...

    Abstract Hip subspine impingement (SSI) is a condition located in the extra-articular area of the hip and is characterized by irregular contact between the anterior inferior iliac spine (AIIS) and the distal femoral neck. Recently, it also has been described that SSI can occur in a normal AIIS, without or in combination with femoroacetabular impingement (FAI), which has redirected the focus of the research. In clinical practice, SSI has no characteristic symptoms/signs and shares similar clinical findings with FAI, making it an important cause of revision hip arthroscopy due to the increased risk of being underdiagnosed and untreated. Consequently, interest in studying SSI and FAI simultaneously has grown to determine whether injuries to the labrum, chondrolabral junction, and acetabular cartilage can be aggravated by dynamic dysfunction or abnormal morphology of the AIIS.
    MeSH term(s) Acetabulum/surgery ; Arthroscopy ; Femoracetabular Impingement/surgery ; Humans ; Range of Motion, Articular ; Retrospective Studies
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2021.05.003
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  8. Article ; Online: Knowledge, Perceptions, and Utilization of Generics and Biosimilars in Latin America and the Caribbean:

    Aguilera, Bernardo / Peña, Sebastián / Morales, Juan Pablo

    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

    2023  Volume 51, Issue S1, Page(s) 100–115

    Abstract: We conducted a scoping review to map and critically examine the knowledge, perceptions and utilization of generics and biosimilars, among physicians, pharmacists, patients, the general population, and other stakeholders from LAC. ...

    Abstract We conducted a scoping review to map and critically examine the knowledge, perceptions and utilization of generics and biosimilars, among physicians, pharmacists, patients, the general population, and other stakeholders from LAC.
    MeSH term(s) Humans ; Biosimilar Pharmaceuticals/therapeutic use ; Latin America ; Caribbean Region ; Physicians ; Drugs, Generic
    Chemical Substances Biosimilar Pharmaceuticals ; Drugs, Generic
    Language English
    Publishing date 2023-12-29
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1168812-9
    ISSN 1748-720X ; 1073-1105 ; 0277-8459
    ISSN (online) 1748-720X
    ISSN 1073-1105 ; 0277-8459
    DOI 10.1017/jme.2023.117
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  9. Article: Asignación ética de recursos sanitarios escasos en el contexto de crisis por COVID-19./ Asignación ética de recursos sanitarios escasos en el contexto de crisis por COVID-19./ Ethical allocation of scarce health care resources in the context of the COVID-19 crisis

    Aguilera, Bernardo

    Medwave

    Abstract: The current COVID-19 pandemic has the potential to overwhelm the capacity of hospitals and Intensive Care Units in Chile and Latin America. Thus local authorities have an ethical obligation to be prepared by implementing pertinent measures to prevent a ... ...

    Abstract The current COVID-19 pandemic has the potential to overwhelm the capacity of hospitals and Intensive Care Units in Chile and Latin America. Thus local authorities have an ethical obligation to be prepared by implementing pertinent measures to prevent a situation of rationing of scarce healthcare resources, and by defining ethically acceptable and socially legitimate criteria for the allocation of these resources. This paper responds to recent ethical guidelines issued by a Chilean academic institution and discusses the main moral principles for the ethical foundations of criteria for rationing during the present crisis. It argues that under exceptional circumstances such as the current pandemic, the traditional patient-centered morality of medicine needs to be balanced with ethical principles formulated from a public health perspective, including the principles of social utility, social justice and equity, among others. The paper concludes with some recommendations regarding how to reach an agreement about rationing criteria and about their implementation in clinical practice.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #599132
    Database COVID19

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  10. Article ; Online: Quince años de la ley de investigación con seres humanos: desafíos pendientes.

    Aguilera, Bernardo / Bascuñán, María de la Luz / Salas, Sofía P

    Revista medica de Chile

    2022  Volume 149, Issue 10, Page(s) 1517–1518

    Title translation Fifteen years ofthe human research law: pending challenges.
    Language Spanish
    Publishing date 2022-04-12
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/s0034-98872021001001517
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