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  1. Article ; Online: A biomarker-based solution for the limited access to early diagnosis and assessment of autism.

    Klin, Ami

    Medicina

    2024  Volume 84 Suppl 1, Page(s) 50–56

    Abstract: With the upsurge of community uptake in population-based early screening for autism, the main obstacle to increasing access to early treatment and intervention services is the extremely limited access to high quality diagnosis, specifically the shortage ... ...

    Title translation Una solución basada en biomarcadores para el acceso limitado al diagnóstico precoz y evaluación del autismo.
    Abstract With the upsurge of community uptake in population-based early screening for autism, the main obstacle to increasing access to early treatment and intervention services is the extremely limited access to high quality diagnosis, specifically the shortage of expert clinicians. Diagnostic evaluation models deployed by academic centers of excellence, which typically require the investment of 6-10 hours by specialized multidisciplinary teams, is not a viable solution to the vast needs of communities, resulting in parents' "diagnostic odysseys" and delays, often of several years, for treatment, interventions and supports. Biomarker-based objective procedures for early diagnosis and assessment of autism are now available, clinically validated, and cleared for broad implementation by the US Food and Drug Administration (FDA). They are intended to increase access while maintaining high quality. Such solutions, however, will require change in entrenched models of diagnostic care, and aggressive prioritization of the needs of the community at large. If these innovations are successful, the number of children diagnosed in the first three years of life will double or triple. This will, in turn, require much greater investments in resources for treatment, including massive workforce training of providers capable of delivering community-viable caregiver-mediated interventions, and of early educators capable of serving autistic children in therapeutic inclusive preschool settings.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Autistic Disorder/diagnosis ; Autistic Disorder/therapy ; Early Diagnosis ; Educational Status
    Language English
    Publishing date 2024-02-14
    Publishing country Argentina
    Document type Journal Article
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
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  2. Article ; Online: Translating advances in developmental social neuroscience into greater access to early diagnosis in autism spectrum disorder.

    Klin, Ami

    Medicina

    2023  Volume 83 Suppl 2, Page(s) 32–36

    Abstract: Early identification and diagnosis of autism spectrum disorder (ASD) is necessary to promote access to early treatment, a critical factor in optimizing children's lifetime outcomes. And yet, diagnosis is often late, delaying interventions to a time in ... ...

    Title translation Repercusión de los avances en la neurociencia social del desarrollo en un mayor acceso al diagnóstico temprano en el trastorno del espectro autista.
    Abstract Early identification and diagnosis of autism spectrum disorder (ASD) is necessary to promote access to early treatment, a critical factor in optimizing children's lifetime outcomes. And yet, diagnosis is often late, delaying interventions to a time in which symptoms have aggravated and communication skills already show impairing differences. This review illustrates progress in developmental social neuroscience that shows promise in generating novel tools for objective and cost-effective early diagnosis of ASD. We focus on research of social visual engagement, which is the way infants and toddlers look at and learn from their social environment. Moment-by-moment quantification of social visual engagement is yielding measures that are beginning to approximate best-practice procedures used by experienced clinicians in the assessment of young children. This progress and potential solutions have public health import ance because experienced clinicians are limited in number, and specialized clinical assessment services tend to be lengthy, costly, and plagued by extended wait time, all of which contributing to limited access, particularly in the case of low-resource families. The research reviewed here illustrates a wider effort to advance biomarker-based measurements intended to develop better and more efficient tools and procedures for screening, diagnosing and monitoring treatment response in children with ASD. The advent of such tools could increase access to early diagnostic services and promote efficiencies in early treatment delivery, with the ultimate goal of ensuring that children with ASD are afforded the services they need to thrive.
    MeSH term(s) Infant ; Humans ; Child, Preschool ; Autism Spectrum Disorder/diagnosis ; Cognitive Neuroscience ; Early Diagnosis
    Language English
    Publishing date 2023-02-17
    Publishing country Argentina
    Document type Journal Article ; Review
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
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  3. Article ; Online: Frontiers in the research of autism pathogenesis.

    Klin, Ami

    Medicina

    2022  Volume 82 Suppl 1, Page(s) 33–36

    Abstract: This review focuses on four interrelated teams and research lines that form the basis for new research on the pathogenesis of autism spectrum disorder (ASD) at the Marcus Autism Center, in Atlanta (US). These themes probe typical social behavior and ... ...

    Title translation Fronteras en la investigación de la patogenia del autismo.
    Abstract This review focuses on four interrelated teams and research lines that form the basis for new research on the pathogenesis of autism spectrum disorder (ASD) at the Marcus Autism Center, in Atlanta (US). These themes probe typical social behavior and brain development from birth, and disruptions thereof in babies later diagnosed with ASD. These four themes are: to leverage lifetime maximal neuroplasticity; to test the hypothesis that developmental disruption of early-emerging mechanisms of socialization drives pathogenesis and results in autistic social disability; the focus on the infant-caregiver dyad, and the iterative context associated with mutually reinforcing and adapted social and communitive inter-action, or emerging cycles of social contingency, from the first days and weeks of life; and the study of time-varying neurodevelopmental transitions in social behavior from experience-expectant (reflexive, endogenous) and subcortically-guided to experience-dependent (caregiver- and reward-driven) and cortically-guided, a transition that our work suggests is uniquely disrupted in babies later diagnosed with ASD. This science is opening a world of opportunities to optimize children's outcomes despite the genetic liabilities that they are born with. It provides the scientific grounding for new community-viable solutions for increasing access to early interventions using treatments that scaffold and strengthen infant-caregiver interactions, which is the platform for early brain development.
    MeSH term(s) Autism Spectrum Disorder/genetics ; Autistic Disorder/genetics ; Child ; Humans ; Infant ; Social Behavior
    Language English
    Publishing date 2022-02-11
    Publishing country Argentina
    Document type Journal Article ; Review
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
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  4. Article ; Online: Diagnosis of Autism-Reply.

    Jones, Warren / Klaiman, Cheryl / Klin, Ami

    JAMA

    2024  Volume 331, Issue 3, Page(s) 259–260

    MeSH term(s) Humans ; Autistic Disorder/diagnosis
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.24158
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  5. Book: Asperger syndrome

    Klin, Ami

    (Child and adolescent psychiatric clinics of North America ; 12,1)

    2003  

    Author's details Ami Klin ..., guest eds
    Series title Child and adolescent psychiatric clinics of North America ; 12,1
    Collection
    Language English
    Size XVI S., S. 1 - 169 : Ill.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013614312
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 1345 -12,1- verfügbar in Königswinter Königswinter

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  6. Book: Asperger syndrome

    Klin, Ami

    2000  

    Author's details Ami Klin ..., ed
    Keywords Autistic Disorder ; Asperger-Syndrom
    Subject Asperger-Störung ; Asperger's Syndrome
    Language English
    Size XVII, 489 S. : Ill., graph. Darst.
    Publisher Guilford Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012783202
    ISBN 1-57230-534-7 ; 978-1-57230-534-2
    Database Catalogue ZB MED Medicine, Health

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    2000 A 3851 order for loan Magazin

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  7. Article: Biomarkers in Autism Spectrum Disorder: Challenges, Advances, and the Need for Biomarkers of Relevance to Public Health.

    Klin, Ami

    Focus (American Psychiatric Publishing)

    2018  Volume 16, Issue 2, Page(s) 135–142

    Abstract: Although autism spectrum disorder (ASD) is the most strongly genetic of all complex neuropsychiatric disorders, it is still defined and diagnosed behaviorally. The vast genotypic and phenotypic heterogeneity of the condition necessitate a vigorous search ...

    Abstract Although autism spectrum disorder (ASD) is the most strongly genetic of all complex neuropsychiatric disorders, it is still defined and diagnosed behaviorally. The vast genotypic and phenotypic heterogeneity of the condition necessitate a vigorous search for biological markers capable of aiding in diagnosis, identifying more homogeneous subgroups for biological study, individualizing treatment, and measuring treatment response. Many candidate biomarkers are available, spanning genetic, metabolic, electroencephalographic, magnetic resonance imaging, and neuropsychological methods. Although biomarker research has focused primarily on mechanistic etiologic hypotheses, the biomarkers more likely to result in optimized clinical outcomes in the near term are cost-effective and community-viable measures obtained through eye-tracking technology involving infants and toddlers. Although these tools are still far from being ready for widespread application, the goal is to develop objective procedures and measures for population-based screening and diagnosis to increase access to early treatment and intervention.
    Language English
    Publishing date 2018-04-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1541-4094
    ISSN 1541-4094
    DOI 10.1176/appi.focus.20170047
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  8. Article ; Online: The Intersection of Autism Spectrum Disorder, Food Allergy, and Avoidant/Restrictive Food Intake Disorder: A Clinical Case Study.

    Proctor, Kaitlin B / Volkert, Valerie M / Klin, Ami / Vickery, Brian P / Sharp, William G

    The Journal of pediatrics

    2024  Volume 269, Page(s) 113965

    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2024.113965
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  9. Article ; Online: Access to Part C, Early Intervention for children younger than 4 years evaluated for autism spectrum disorder.

    Mendez, Adriana I / McQueen, Emma / Gillespie, Scott / Klin, Ami / Klaiman, Cheryl / Pickard, Katherine

    Autism : the international journal of research and practice

    2024  , Page(s) 13623613241229150

    Abstract: Lay abstract: Health disparities are defined as preventable differences in the opportunities to achieve optimal health outcomes experienced by marginalized and underrepresented communities. For families with autistic children, health disparities limit ... ...

    Abstract Lay abstract: Health disparities are defined as preventable differences in the opportunities to achieve optimal health outcomes experienced by marginalized and underrepresented communities. For families with autistic children, health disparities limit accessing early intervention services-which have been found to improve quality of life and other outcomes. One specific early intervention service in the United States is Individuals with Disabilities Education Act, Part C Early Intervention programs, which are federally funded interventions for children birth-to-three with developmental delays. This study adds to this topic by examining which factors impact accessing Part C, Early Intervention services for children who were evaluated for autism. Results showed that only half of the sample received these services despite there being concerns about development for all children. In addition, results showed that those who identified as Black had decreased odds of having accessed Part C, Early Intervention compared to those who identified as White. These results suggest that there are disparities when it comes to accessing important early intervention services that may be negatively impacting the Black autistic community.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1338513-6
    ISSN 1461-7005 ; 1362-3613
    ISSN (online) 1461-7005
    ISSN 1362-3613
    DOI 10.1177/13623613241229150
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  10. Book: Asperger syndrome

    McPartland, James C. / Klin, Ami / Volkmar, Fred R.

    assessing and treating high-function autism spectrum disorders

    2014  

    Author's details ed. by James McPartland ; Ami Klin ; Fred R. Volkmar
    Keywords Autistic Disorder ; Asperger-Syndrom
    Subject Asperger-Störung ; Asperger's Syndrome
    Language English
    Size XIV, 482 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Guilford
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017823176
    ISBN 978-1-4625-1414-4 ; 1-4625-1414-6
    Database Catalogue ZB MED Medicine, Health

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    2014 A 2346 on loan 0 Vormerkungen

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