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Article ; Online: 30 years of battling the cell wall.

Latgé, J P

2017 Volume 55, Issue 1, Page(s) 4–9

Abstract: In Aspergillus fumigatus, like in other pathogenic fungi, the cell wall is essential for fungal growth as well as for resisting environmental stresses such as phagocytic killing. Most of the chemical analyses undertaken on the cell wall of A. fumigatus ... ...

Abstract	In Aspergillus fumigatus, like in other pathogenic fungi, the cell wall is essential for fungal growth as well as for resisting environmental stresses such as phagocytic killing. Most of the chemical analyses undertaken on the cell wall of A. fumigatus are focused on the mycelial cell wall because it is the vegetative stage of the fungus. However, the cell walls of the mycelium and conidium (which is the infective propagule) are different especially at the level of the surface layer, which plays a significant role in the interaction between A. fumigatus conidia and phagocytic cells of the immune system. In spite of the essential function of the cell wall in fungal life, progresses have been extremely slow in the understanding of biosynthesis as well in the identification of the key host responses against the cell wall components. A major difficulty is the fact that the composition and structural organization of the cell wall is not immutably set and is constantly reshuffled depending on the environmental conditions.
MeSH term(s)	Aspergillus fumigatus/chemistry ; Aspergillus fumigatus/immunology ; Aspergillus fumigatus/metabolism ; Cell Wall/chemistry ; Cell Wall/immunology ; Cell Wall/metabolism ; Cell Wall/physiology ; Host-Pathogen Interactions ; Hyphae/chemistry ; Hyphae/immunology ; Hyphae/metabolism ; Spores, Fungal/chemistry ; Spores, Fungal/immunology ; Spores, Fungal/metabolism
Language	English
Publishing date	2017-01-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1093/mmy/myw076
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Article ; Online: Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model.

Mathur, Pallavi / De Barros Santos, Camilla / Lachuer, Hugo / Patat, Julie / Latgé, Bruno / Radvanyi, François / Goud, Bruno / Schauer, Kristine

Communications biology

2023 Volume 6, Issue 1, Page(s) 114

Abstract: Lysosomes orchestrate degradation and recycling of exogenous and endogenous material thus controlling cellular homeostasis. Little is known how this organelle changes during cancer. Here we investigate the intracellular landscape of lysosomes in a ... ...

Abstract	Lysosomes orchestrate degradation and recycling of exogenous and endogenous material thus controlling cellular homeostasis. Little is known how this organelle changes during cancer. Here we investigate the intracellular landscape of lysosomes in a cellular model of bladder cancer. Employing standardized cell culture on micropatterns we identify a phenotype of peripheral lysosome positioning prevailing in bladder cancer cell lines but not normal urothelium. We show that lysosome positioning is controlled by phosphatidylinositol-3-phosphate (PtdIns3P) levels on endomembranes which recruit FYVE-domain containing proteins for lysosomal dispersion. We identify transcription factor EB (TFEB) as an upstream regulator of PtdIns3P production by VPS34 that is activated in aggressive bladder cancer cells with peripheral lysosomes. This conceptually clarifies the dual role of TFEB as regulator of endosomal maturation and autophagy, two distinct processes controlled by PtdIns3P. Altogether, our findings uncover peripheral lysosome positioning, resulting from PtdIns3P production downstream of TFEB activation, as a potential biomarker for bladder cancer.
MeSH term(s)	Humans ; Lysosomes/metabolism ; Phosphates/metabolism ; Phosphatidylinositol Phosphates/metabolism ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism
Chemical Substances	Phosphates ; phosphatidylinositol 3-phosphate ; Phosphatidylinositol Phosphates ; TFEB protein, human ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Language	English
Publishing date	2023-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04501-1
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Article ; Online: The volatome of Aspergillus fumigatus.

Heddergott, C / Calvo, A M / Latgé, J P

Eukaryotic cell

2014 Volume 13, Issue 8, Page(s) 1014–1025

Abstract: Early detection of invasive aspergillosis is absolutely required for efficient therapy of this fungal infection. The identification of fungal volatiles in patient breath can be an alternative for the detection of Aspergillus fumigatus that still remains ... ...

Abstract	Early detection of invasive aspergillosis is absolutely required for efficient therapy of this fungal infection. The identification of fungal volatiles in patient breath can be an alternative for the detection of Aspergillus fumigatus that still remains problematic. In this work, we investigated the production of volatile organic compounds (VOCs) by A. fumigatus in vitro, and we show that volatile production depends on the nutritional environment. A. fumigatus produces a multiplicity of VOCs, predominantly terpenes and related compounds. The production of sesquiterpenoid compounds was found to be strongly induced by increased iron concentrations and certain drugs, i.e., pravastatin. Terpenes that were always detectable in large amounts were α-pinene, camphene, and limonene, as well as sesquiterpenes, identified as α-bergamotene and β-trans-bergamotene. Other substance classes that were found to be present in the volatome, such as 1-octen-3-ol, 3-octanone, and pyrazines, were found only under specific growth conditions. Drugs that interfere with the terpene biosynthesis pathway influenced the composition of the fungal volatome, and most notably, a block of sesquiterpene biosynthesis by the bisphosphonate alendronate fundamentally changed the VOC composition. Using deletion mutants, we also show that a terpene cyclase and a putative kaurene synthase are essential for the synthesis of volatile terpenes by A. fumigatus. The present analysis of in vitro volatile production by A. fumigatus suggests that VOCs may be used in the diagnosis of infections caused by this fungus.
MeSH term(s)	Alkyl and Aryl Transferases/genetics ; Aspergillus fumigatus/genetics ; Aspergillus fumigatus/metabolism ; Fungal Proteins/genetics ; Gene Knockout Techniques ; Metabolome ; Sesquiterpenes/metabolism ; Volatile Organic Compounds/metabolism
Chemical Substances	Fungal Proteins ; Sesquiterpenes ; Volatile Organic Compounds ; Alkyl and Aryl Transferases (EC 2.5.-) ; terpene carbocyclase (EC 2.5.1.-)
Language	English
Publishing date	2014-06-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077635-4
ISSN	1535-9786 ; 1535-9778
ISSN (online)	1535-9786
ISSN	1535-9778
DOI	10.1128/EC.00074-14
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Article: The pathobiology of Aspergillus fumigatus.

Latgé, J P

Trends in microbiology

2001 Volume 9, Issue 8, Page(s) 382–389

Abstract: Aspergillus fumigatus is the most prevalent airborne fungal pathogen in developed countries, and in immunocompromised patients causes a usually fatal invasive aspergillosis (IA). Understanding the pathobiology of this fungal species requires not only ... ...

Abstract	Aspergillus fumigatus is the most prevalent airborne fungal pathogen in developed countries, and in immunocompromised patients causes a usually fatal invasive aspergillosis (IA). Understanding the pathobiology of this fungal species requires not only analysis of the putative fungal virulence factors that stimulate fungal growth and/or survival in the lung environment, but also knowledge of the immune factors containing A. fumigatus in the immunocompetent host that can be debilitated by immunosuppressive therapies, triggering IA. Although the incidence of IA has dramatically increased in recent years, progress in these areas has been limited and, as yet, a single, true virulence factor has not been identified and the mechanisms responsible for protective immunity against A. fumigatus have yet to be elucidated.
MeSH term(s)	Animals ; Aspergillosis/immunology ; Aspergillosis/microbiology ; Aspergillosis/physiopathology ; Aspergillus fumigatus/pathogenicity ; Aspergillus fumigatus/physiology ; Humans ; Lung/microbiology ; Lung Diseases, Fungal/immunology ; Lung Diseases, Fungal/microbiology ; Lung Diseases, Fungal/physiopathology ; Mice ; Virulence
Language	English
Publishing date	2001-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/s0966-842x(01)02104-7
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Zs.A 3738: Show issues

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Article: Structural Polymorphism of Chitin and Chitosan in Fungal Cell Walls From Solid-State NMR and Principal Component Analysis.

Fernando, Liyanage D / Dickwella Widanage, Malitha C / Penfield, Jackson / Lipton, Andrew S / Washton, Nancy / Latgé, Jean-Paul / Wang, Ping / Zhang, Liqun / Wang, Tuo

Frontiers in molecular biosciences

2021 Volume 8, Page(s) 727053

Abstract: Chitin is a major carbohydrate component of the fungal cell wall and a promising target for novel antifungal agents. However, it is technically challenging to characterize the structure of this polymer in native cell walls. Here, we recorded and ... ...

Abstract	Chitin is a major carbohydrate component of the fungal cell wall and a promising target for novel antifungal agents. However, it is technically challenging to characterize the structure of this polymer in native cell walls. Here, we recorded and compared
Language	English
Publishing date	2021-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2021.727053
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Article ; Online: Interaction of Aspergillus fumigatus with the alveolar macrophage.

Dubourdeau, M / Athman, R / Balloy, V / Philippe, B / Sengmanivong, L / Chignard, M / Philpott, D J / Latgé, J P / Ibrahim-Granet, O

Medical mycology

2018 Volume 44, Issue Supplement_1, Page(s) S213–S217

Abstract: Aspergillus fumigatus is a human pathogen, able to cause invasive aspergillosis in immunosuppressed patients. In the immunocompetent situation inhaled conidia are easily cleared by the immune system. Knowledge of the cellular pathways involved in the ... ...

Abstract	Aspergillus fumigatus is a human pathogen, able to cause invasive aspergillosis in immunosuppressed patients. In the immunocompetent situation inhaled conidia are easily cleared by the immune system. Knowledge of the cellular pathways involved in the innate immunity against A. fumigatus is poorly represented. Therefore, we aimed to investigate the immune response against A. fumigatus in murine alveolar macrophages in terms of MAP kinases, NF-kappaB and cytokine signalling. Our investigations revealed that in murine alveolar macrophages, MAP kinases, ERK and p38 are activated under in vitro conditions, following addition of A. fumigatus conidia. In vivo experiments, however, showed that only ERK is directly involved, because activation of p38 was negligible. Immunosuppression with corticosteroids inhibited phosphorylation of ERK and was directly accompanied with a strongly decreased level of TNF-alpha and additional cytokines. In addition, killing of A. fumigatus conidia is reduced using the ERK inhibitor. Therefore, ERK appears to be an essential MAP kinase in the defence against A. fumigatus. Activation of the transcription factor NFkappaB appeared only at late times after infection suggesting an association with the intracellular swelling of conidia.
Language	English
Publishing date	2018-07-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1080/13693780600904900
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Article: Antigen and DNA patterns characteristic of Aspergillus fumigatus.

Latgé, J P

Contributions to microbiology

1999 Volume 2, Page(s) 69–87

MeSH term(s)	Animals ; Antigens, Fungal/chemistry ; Aspergillus fumigatus/genetics ; Aspergillus fumigatus/immunology ; DNA, Fungal/chemistry ; Genotype ; Humans ; Phenotype
Chemical Substances	Antigens, Fungal ; DNA, Fungal
Language	English
Publishing date	1999
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1420-9519
ISSN	1420-9519
DOI	10.1159/000060304
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Article: Aspergillus fumigatus and aspergillosis.

Latgé, J P

Clinical microbiology reviews

1999 Volume 12, Issue 2, Page(s) 310–350

Abstract: Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi. Humans and animals constantly inhale numerous conidia of this fungus. The conidia are normally eliminated in the immunocompetent host by innate immune mechanisms, and ... ...

Abstract	Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi. Humans and animals constantly inhale numerous conidia of this fungus. The conidia are normally eliminated in the immunocompetent host by innate immune mechanisms, and aspergilloma and allergic bronchopulmonary aspergillosis, uncommon clinical syndromes, are the only infections observed in such hosts. Thus, A. fumigatus was considered for years to be a weak pathogen. With increases in the number of immunosuppressed patients, however, there has been a dramatic increase in severe and usually fatal invasive aspergillosis, now the most common mold infection worldwide. In this review, the focus is on the biology of A. fumigatus and the diseases it causes. Included are discussions of (i) genomic and molecular characterization of the organism, (ii) clinical and laboratory methods available for the diagnosis of aspergillosis in immunocompetent and immunocompromised hosts, (iii) identification of host and fungal factors that play a role in the establishment of the fungus in vivo, and (iv) problems associated with antifungal therapy.
MeSH term(s)	Animals ; Antigens, Fungal/analysis ; Aspergillosis/diagnosis ; Aspergillosis/immunology ; Aspergillosis/therapy ; Aspergillus fumigatus/classification ; Aspergillus fumigatus/immunology ; Aspergillus fumigatus/pathogenicity ; Disease Models, Animal ; Humans ; Serologic Tests ; Virulence
Chemical Substances	Antigens, Fungal
Language	English
Publishing date	1999-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645015-5
ISSN	1098-6618 ; 0893-8512
ISSN (online)	1098-6618
ISSN	0893-8512
DOI	10.1128/CMR.12.2.310
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Zs.A 2409: Show issues

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Article ; Online: Penetration of the Human Pulmonary Epithelium by Aspergillus fumigatus Hyphae.

Fernandes, Julien / Hamidi, Fatima / Leborgne, Remi / Beau, Remi / Castier, Yves / Mordant, Pierre / Boukkerou, Amira / Latgé, Jean Paul / Pretolani, Marina

The Journal of infectious diseases

2018 Volume 218, Issue 8, Page(s) 1306–1313

Abstract: Background: The airway epithelium is the first barrier interacting with Aspergillus fumigatus conidia after their inhalation, suggesting that this structure functions as point of entry of this fungus to initiate pulmonary aspergillosis.: Methods: To ... ...

Abstract	Background: The airway epithelium is the first barrier interacting with Aspergillus fumigatus conidia after their inhalation, suggesting that this structure functions as point of entry of this fungus to initiate pulmonary aspergillosis. Methods: To study epithelial entry by A fumigatus, primary human reconstituted pseudostratified epithelium cultured in air-liquid interface as well as bronchial epithelial cell monolayers were infected with conidia. Results: Under these experimental conditions, we found that A fumigatus hyphae traversed the bronchial epithelium through a mechanism involving the recruitment of actin, which formed a tunnel that allows hyphae to enter the cells without disturbing their integrity. Conclusions: These findings describe a new mechanism by which A fumigatus hyphae penetrate the airway epithelial barrier and can infect its human host.
MeSH term(s)	Aspergillus fumigatus/physiology ; Aspergillus fumigatus/ultrastructure ; Cell Culture Techniques ; Cells, Cultured ; Epithelial Cells/microbiology ; Epithelial Cells/ultrastructure ; Epithelium/microbiology ; Humans ; Hyphae/physiology ; Hyphae/ultrastructure ; Lung/microbiology ; Microscopy, Confocal ; Microscopy, Electron, Transmission
Language	English
Publishing date	2018-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiy298
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Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

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Article ; Online: Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca

Weichert, Martin / Guirao-Abad, José / Aimanianda, Vishukumar / Krishnan, Karthik / Grisham, Christina / Snyder, Patrick / Sheehan, Alex / Abbu, Ruthvik R / Liu, Hong / Filler, Scott G / Gruenstein, Eric I / Latgé, Jean-Paul / Askew, David S

mBio

2020 Volume 11, Issue 3

Abstract: Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding capacity of the endoplasmic reticulum (ER) in proportion to the demand for virulence-related proteins that traffic through the secretory pathway. Although ... ...

Abstract	Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding capacity of the endoplasmic reticulum (ER) in proportion to the demand for virulence-related proteins that traffic through the secretory pathway. Although Ca
MeSH term(s)	A549 Cells ; Adenosine Triphosphatases/metabolism ; Alveolar Epithelial Cells/microbiology ; Animals ; Aspergillus fumigatus/enzymology ; Aspergillus fumigatus/genetics ; Aspergillus fumigatus/pathogenicity ; Calcium/metabolism ; Cell Wall/physiology ; Endoplasmic Reticulum/enzymology ; Endoplasmic Reticulum Stress ; Female ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Golgi Apparatus/enzymology ; Humans ; Male ; Mice ; Signal Transduction ; Unfolded Protein Response ; Virulence
Chemical Substances	Fungal Proteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.01060-20
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