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  1. Article ; Online: Grayken lessons: the role of an interdisciplinary endocarditis working group in evaluating and optimizing care for a woman with opioid use disorder requiring a second tricuspid valve replacement.

    Rozansky, Hallie / Awtry, Eric / Weinstein, Zoe M / Peterkin, Alyssa F

    Addiction science & clinical practice

    2023  Volume 18, Issue 1, Page(s) 9

    Abstract: Background: Injection drug use-related endocarditis is increasingly common among hospitalized patients in the United States, and associated morbidity and mortality are rising.: Case presentation: Here we present the case of a 34-year-old woman with ... ...

    Abstract Background: Injection drug use-related endocarditis is increasingly common among hospitalized patients in the United States, and associated morbidity and mortality are rising.
    Case presentation: Here we present the case of a 34-year-old woman with severe opioid use disorder and multiple episodes of infective endocarditis requiring prosthetic tricuspid valve replacement, who developed worsening dyspnea on exertion. Her echocardiogram demonstrated severe tricuspid regurgitation with a flail prosthetic valve leaflet, without concurrent endocarditis, necessitating a repeat valve replacement. Her care was overseen by our institution's Endocarditis Working Group, a multidisciplinary team that includes providers from addiction medicine, cardiology, infectious disease, cardiothoracic surgery, and neurocritical care. The team worked together to evaluate her, develop a treatment plan for her substance use disorder in tandem with her other medical conditions, and advocate for her candidacy for valve replacement.
    Conclusions: Multidisciplinary endocarditis teams such as these are important emerging innovations, which have demonstrated improvements in outcomes for patients with infective endocarditis and substance use disorders, and have the potential to reduce bias by promoting standard-of-care treatment.
    MeSH term(s) Female ; Humans ; United States ; Adult ; Tricuspid Valve/surgery ; Heart Valve Prosthesis Implantation ; Endocarditis/surgery ; Endocarditis, Bacterial/surgery ; Opioid-Related Disorders
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2492632-2
    ISSN 1940-0640 ; 1940-0640
    ISSN (online) 1940-0640
    ISSN 1940-0640
    DOI 10.1186/s13722-023-00360-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aspirin.

    Awtry, E H / Loscalzo, J

    Circulation

    2000  Volume 101, Issue 10, Page(s) 1206–1218

    MeSH term(s) Angina, Unstable/drug therapy ; Angina, Unstable/metabolism ; Angina, Unstable/prevention & control ; Aspirin/adverse effects ; Aspirin/pharmacokinetics ; Aspirin/pharmacology ; Aspirin/therapeutic use ; Cerebrovascular Disorders/drug therapy ; Cerebrovascular Disorders/metabolism ; Cerebrovascular Disorders/prevention & control ; Digestive System/drug effects ; Digestive System/metabolism ; Humans ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocardial Infarction/prevention & control ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/pharmacokinetics ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use
    Chemical Substances Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2000-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/01.cir.101.10.1206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Validation of a Crisis Standards of Care Model for Prioritization of Limited Resources During the Coronavirus Disease 2019 Crisis in an Urban, Safety-Net, Academic Medical Center.

    Nadjarian, Albert / LeClair, Jessica / Mahoney, Taylor F / Awtry, Eric H / Bhatia, Jasvinder S / Caruso, Lisa B / Clay, Alexis / Greer, David / Hingorani, Karan S / Horta, L F B / Ibrahim, Michel / Ieong, Michael H / James, Thea / Kulke, Matthew H / Lim, Remington / Lowe, Robert C / Moses, James M / Murphy, Jaime / Nozari, Ala /
    Patel, Anuj D / Silver, Brent / Theodore, Arthur C / Wang, Ryan Shufei / Weinstein, Ellen / Wilson, Stephen A / Cervantes-Arslanian, Anna M

    Critical care medicine

    2021  Volume 49, Issue 10, Page(s) 1739–1748

    Abstract: Objectives: The coronavirus disease 2019 pandemic has overwhelmed healthcare resources even in wealthy nations, necessitating rationing of limited resources without previously established crisis standards of care protocols. In Massachusetts, triage ... ...

    Abstract Objectives: The coronavirus disease 2019 pandemic has overwhelmed healthcare resources even in wealthy nations, necessitating rationing of limited resources without previously established crisis standards of care protocols. In Massachusetts, triage guidelines were designed based on acute illness and chronic life-limiting conditions. In this study, we sought to retrospectively validate this protocol to cohorts of critically ill patients from our hospital.
    Design: We applied our hospital-adopted guidelines, which defined severe and major chronic conditions as those associated with a greater than 50% likelihood of 1- and 5-year mortality, respectively, to a critically ill patient population. We investigated mortality for the same intervals.
    Setting: An urban safety-net hospital ICU.
    Patients: All adults hospitalized during April of 2015 and April 2019 identified through a clinical database search.
    Interventions: None.
    Measurements and main results: Of 365 admitted patients, 15.89% had one or more defined chronic life-limiting conditions. These patients had higher 1-year (46.55% vs 13.68%; p < 0.01) and 5-year (50.00% vs 17.22%; p < 0.01) mortality rates than those without underlying conditions. Irrespective of classification of disease severity, patients with metastatic cancer, congestive heart failure, end-stage renal disease, and neurodegenerative disease had greater than 50% 1-year mortality, whereas patients with chronic lung disease and cirrhosis had less than 50% 1-year mortality. Observed 1- and 5-year mortality for cirrhosis, heart failure, and metastatic cancer were more variable when subdivided into severe and major categories.
    Conclusions: Patients with major and severe chronic medical conditions overall had 46.55% and 50.00% mortality at 1 and 5 years, respectively. However, mortality varied between conditions. Our findings appear to support a crisis standards protocol which focuses on acute illness severity and only considers underlying conditions carrying a greater than 50% predicted likelihood of 1-year mortality. Modifications to the chronic lung disease, congestive heart failure, and cirrhosis criteria should be refined if they are to be included in future models.
    MeSH term(s) Academic Medical Centers/organization & administration ; Academic Medical Centers/statistics & numerical data ; Adult ; COVID-19/epidemiology ; COVID-19/therapy ; Crisis Intervention/methods ; Crisis Intervention/standards ; Crisis Intervention/statistics & numerical data ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Massachusetts ; Middle Aged ; Resource Allocation/methods ; Resource Allocation/statistics & numerical data ; Retrospective Studies ; Safety-net Providers/organization & administration ; Safety-net Providers/statistics & numerical data ; Standard of Care/standards ; Standard of Care/statistics & numerical data ; Urban Population/statistics & numerical data
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Owl: electronic datasheet generator.

    Appleton, Evan / Tao, Jenhan / Wheatley, F Carter / Desai, Devina H / Lozanoski, Thomas M / Shah, Pooja D / Awtry, Jake A / Jin, Shawn S / Haddock, Traci L / Densmore, Douglas M

    ACS synthetic biology

    2014  Volume 3, Issue 12, Page(s) 966–968

    Abstract: Owl ( www.owlcad.org ) is a biodesign automation tool that generates electronic datasheets for synthetic biological parts using common formatting. Data can be retrieved automatically from existing repositories and modified in the Owl user interface (UI). ...

    Abstract Owl ( www.owlcad.org ) is a biodesign automation tool that generates electronic datasheets for synthetic biological parts using common formatting. Data can be retrieved automatically from existing repositories and modified in the Owl user interface (UI). Owl uses the data to generate an HTML page with standard typesetting that can be saved as a PDF file. Here we present the Owl software tool in its alpha version, its current UI, its description of input data for generating a datasheet, its example datasheets, and the vision of the tool's role in biodesign automation.
    MeSH term(s) Automation ; Databases, Genetic ; Software ; Synthetic Biology/methods
    Language English
    Publishing date 2014-12-19
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/sb500053j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A conserved Toll-like receptor-to-NF-κB signaling pathway in the endangered coral Orbicella faveolata.

    Williams, Leah M / Fuess, Lauren E / Brennan, Joseph J / Mansfield, Katelyn M / Salas-Rodriguez, Erick / Welsh, Julianne / Awtry, Jake / Banic, Sarah / Chacko, Cecilia / Chezian, Aarthia / Dowers, Donovan / Estrada, Felicia / Hsieh, Yu-Hsuan / Kang, Jiawen / Li, Wanwen / Malchiodi, Zoe / Malinowski, John / Matuszak, Sean / McTigue, Thomas /
    Mueller, David / Nguyen, Brian / Nguyen, Michelle / Nguyen, Phuong / Nguyen, Sinead / Njoku, Ndidi / Patel, Khusbu / Pellegrini, William / Pliakas, Tessa / Qadir, Deena / Ryan, Emma / Schiffer, Alex / Thiel, Amber / Yunes, Sarah A / Spilios, Kathryn E / Pinzón C, Jorge H / Mydlarz, Laura D / Gilmore, Thomas D

    Developmental and comparative immunology

    2018  Volume 79, Page(s) 128–136

    Abstract: Herein, we characterize the Toll-like receptor (TLR)-to-NF-κB innate immune pathway of Orbicella faveolata (Of), which is an ecologically important, disease-susceptible, reef-building coral. As compared to human TLRs, the intracellular TIR domain of Of- ... ...

    Abstract Herein, we characterize the Toll-like receptor (TLR)-to-NF-κB innate immune pathway of Orbicella faveolata (Of), which is an ecologically important, disease-susceptible, reef-building coral. As compared to human TLRs, the intracellular TIR domain of Of-TLR is most similar to TLR4, and it can interact in vitro with the human TLR4 adapter MYD88. Treatment of O. faveolata tissue with lipopolysaccharide, a ligand for mammalian TLR4, resulted in gene expression changes consistent with NF-κB pathway mobilization. Biochemical and cell-based assays revealed that Of-NF-κB resembles the mammalian non-canonical NF-κB protein p100 in that C-terminal truncation results in translocation of Of-NF-κB to the nucleus and increases its DNA-binding and transcriptional activation activities. Moreover, human IκB kinase (IKK) and Of-IKK can both phosphorylate conserved residues in Of-NF-κB in vitro and induce C-terminal processing of Of-NF-κB in vivo. These results are the first characterization of TLR-to-NF-κB signaling proteins in an endangered coral, and suggest that these corals have conserved innate immune pathways.
    MeSH term(s) Animals ; Anthozoa/immunology ; Biological Evolution ; Conserved Sequence/genetics ; Humans ; I-kappa B Kinase/metabolism ; Immunity, Innate ; Lipopolysaccharides/immunology ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Phosphorylation ; Protein Binding ; Signal Transduction ; Toll-Like Receptor 4/genetics ; Toll-Like Receptors/genetics ; Toll-Like Receptors/metabolism
    Chemical Substances Lipopolysaccharides ; MYD88 protein, human ; Myeloid Differentiation Factor 88 ; NF-kappa B ; TLR4 protein, human ; Toll-Like Receptor 4 ; Toll-Like Receptors ; I-kappa B Kinase (EC 2.7.11.10)
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2017.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 2015 ACC/AHA/HRS Advanced Training Statement on Clinical Cardiac Electrophysiology (A Revision of the ACC/AHA 2006 Update of the Clinical Competence Statement on Invasive Electrophysiology Studies, Catheter Ablation, and Cardioversion).

    Zipes, Douglas P / Calkins, Hugh / Daubert, James P / Ellenbogen, Kenneth A / Field, Michael E / Fisher, John D / Fogel, Richard Ira / Frankel, David S / Gupta, Anurag / Indik, Julia H / Kusumoto, Fred M / Lindsay, Bruce D / Marine, Joseph E / Mehta, Laxmi S / Mendes, Lisa A / Miller, John M / Munger, Thomas M / Sauer, William H / Shen, Win-Kuang /
    Stevenson, William G / Su, Wilber W / Tracy, Cynthia M / Tsiperfal, Angela / Williams, Eric S / Halperin, Jonathan L / Arrighi, James A / Awtry, Eric H / Bates, Eric R / Brush, John E / Costa, Salvatore / Daniels, Lori / Desai, Akshay / Drachman, Douglas E / Fernandes, Susan / Freeman, Rosario / Ijioma, Nkechinyere / Khan, Sadiya S / Kuvin, Jeffrey T / McPherson, John A / Sivaram, Chittur A / Spicer, Robert L / Wang, Andrew / Weitz, Howard H

    Circulation. Arrhythmia and electrophysiology

    2015  Volume 8, Issue 6, Page(s) 1522–1551

    MeSH term(s) Cardiology/education ; Cardiology/standards ; Catheter Ablation/standards ; Clinical Competence ; Credentialing ; Curriculum ; Education, Medical, Graduate/standards ; Electric Countershock/standards ; Electrophysiologic Techniques, Cardiac/standards ; Humans
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Practice Guideline
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/HAE.0000000000000014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A conserved Toll-like receptor-to-NF-κB signaling pathway in the endangered coral Orbicella faveolata

    Williams, Leah M / Aarthia Chezian / Alex Schiffer / Amber Thiel / Brian Nguyen / Cecilia Chacko / David Mueller / Deena Qadir / Donovan Dowers / Emma Ryan / Erick Salas-Rodriguez / Felicia Estrada / Jake Awtry / Jiawen Kang / John Malinowski / Jorge H. Pinzón C / Joseph J. Brennan / Julianne Welsh / Katelyn M. Mansfield /
    Kathryn E. Spilios / Khusbu Patel / Laura D. Mydlarz / Lauren E. Fuess / Michelle Nguyen / Ndidi Njoku / Phuong Nguyen / Sarah A. Yunes / Sarah Banic / Sean Matuszak / Sinead Nguyen / Tessa Pliakas / Thomas D. Gilmore / Thomas McTigue / Wanwen Li / William Pellegrini / Yu-Hsuan Hsieh / Zoe Malchiodi

    Developmental and comparative immunology. 2018 Feb., v. 79

    2018  

    Abstract: Herein, we characterize the Toll-like receptor (TLR)-to-NF-κB innate immune pathway of Orbicella faveolata (Of), which is an ecologically important, disease-susceptible, reef-building coral. As compared to human TLRs, the intracellular TIR domain of Of- ... ...

    Abstract Herein, we characterize the Toll-like receptor (TLR)-to-NF-κB innate immune pathway of Orbicella faveolata (Of), which is an ecologically important, disease-susceptible, reef-building coral. As compared to human TLRs, the intracellular TIR domain of Of-TLR is most similar to TLR4, and it can interact in vitro with the human TLR4 adapter MYD88. Treatment of O. faveolata tissue with lipopolysaccharide, a ligand for mammalian TLR4, resulted in gene expression changes consistent with NF-κB pathway mobilization. Biochemical and cell-based assays revealed that Of-NF-κB resembles the mammalian non-canonical NF-κB protein p100 in that C-terminal truncation results in translocation of Of-NF-κB to the nucleus and increases its DNA-binding and transcriptional activation activities. Moreover, human IκB kinase (IKK) and Of-IKK can both phosphorylate conserved residues in Of-NF-κB in vitro and induce C-terminal processing of Of-NF-κB in vivo. These results are the first characterization of TLR-to-NF-κB signaling proteins in an endangered coral, and suggest that these corals have conserved innate immune pathways.
    Keywords coral reefs ; corals ; humans ; IKappaB kinase ; ligands ; lipopolysaccharides ; signal transduction ; Toll-like receptor 4 ; transcription factor NF-kappa B ; transcriptional activation
    Language English
    Dates of publication 2018-02
    Size p. 128-136.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2017.10.016
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure.

    Kotlyar, Eugene / Vita, Joseph A / Winter, Michael R / Awtry, Eric H / Siwik, Deborah A / Keaney, John F / Sawyer, Douglas B / Cupples, L Adrienne / Colucci, Wilson S / Sam, Flora

    Journal of cardiac failure

    2006  Volume 12, Issue 2, Page(s) 122–127

    Abstract: Background: Aldosterone antagonists reduce morbidity and mortality in patients with severe heart failure, but the mechanisms responsible are not fully understood. Observations in animal models suggest that elevated levels of aldosterone promote ... ...

    Abstract Background: Aldosterone antagonists reduce morbidity and mortality in patients with severe heart failure, but the mechanisms responsible are not fully understood. Observations in animal models suggest that elevated levels of aldosterone promote oxidative stress and inflammation in the myocardium. It is unknown if these findings are relevant to heart failure patients who may have much lower aldosterone levels.
    Methods and results: We therefore examined the relationship of plasma aldosterone levels to markers of oxidative stress, inflammation and matrix turnover in 58 patients with chronic, stable heart failure from systolic dysfunction (LV ejection fraction <0.40) who were not receiving aldosterone antagonists. Chronic, stable heart failure patients had modestly elevated levels of aldosterone. Additionally, these patients had elevated levels of 8-isoprostaglandin F(2alpha), C-reactive protein, soluble intercellular adhesion molecule-1, osteopontin, brain natriuretic peptide, procollagen type III aminoterminal peptide, and tissue inhibitor of metalloproteinase-1. Among these patients with heart failure, aldosterone levels correlated with 8-iso-PGF(2alpha) (P = .003), ICAM-1 (P = .008), and TIMP-1 (P = .006) after adjustment for age, gender, race, diabetes, smoking, heart rate, left ventricular mass, and body mass index.
    Conclusion: In chronic, stable heart failure patients on standard therapy, higher aldosterone levels are associated with systemic evidence of oxidative stress, inflammation, and matrix turnover.
    MeSH term(s) Aldosterone/blood ; Biomarkers/blood ; C-Reactive Protein/analysis ; Dinoprost/analogs & derivatives ; Dinoprost/blood ; Female ; Heart Failure/blood ; Heart Failure/physiopathology ; Humans ; Intercellular Adhesion Molecule-1/blood ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Osteopontin ; Oxidative Stress/physiology ; Peptide Fragments/blood ; Procollagen/blood ; Sialoglycoproteins/blood ; Tissue Inhibitor of Metalloproteinase-1/blood
    Chemical Substances Biomarkers ; Peptide Fragments ; Procollagen ; SPP1 protein, human ; Sialoglycoproteins ; Tissue Inhibitor of Metalloproteinase-1 ; procollagen Type III-N-terminal peptide ; Osteopontin (106441-73-0) ; Natriuretic Peptide, Brain (114471-18-0) ; Intercellular Adhesion Molecule-1 (126547-89-5) ; 8-epi-prostaglandin F2alpha (27415-26-5) ; Aldosterone (4964P6T9RB) ; C-Reactive Protein (9007-41-4) ; Dinoprost (B7IN85G1HY)
    Language English
    Publishing date 2006-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2005.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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