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  1. Article: Michael Smith (1932-2000).

    Hayden, M R / Ling, V

    Nature

    2000  Volume 408, Issue 6814, Page(s) 786

    MeSH term(s) Chemistry, Organic/history ; England ; Genetics/history ; History, 20th Century ; Mutagenesis, Site-Directed
    Language English
    Publishing date 2000-04-27
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/35048663
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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  2. Article: Towards a Point-of-Care Test of CD4

    Leuthner, Moritz / Reisbeck, Mathias / Helou, Michael / Hayden, Oliver

    Micromachines

    2024  Volume 15, Issue 4

    Abstract: For the treatment of human immunodeficiency virus (HIV)-infected patients, the regular assessment of the immune status is indispensable. The quantification of ... ...

    Abstract For the treatment of human immunodeficiency virus (HIV)-infected patients, the regular assessment of the immune status is indispensable. The quantification of CD4
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi15040520
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  3. Article: A true mentor and pioneer in medical genetics.

    Hayden, Michael

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2016  Volume 106, Issue 6 Suppl 1, Page(s) S7–9

    MeSH term(s) Career Choice ; Genetics, Medical/history ; History, 20th Century ; Humans ; Mentors
    Language English
    Publishing date 2016-05-26
    Publishing country South Africa
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0256-9574 ; 0038-2469
    ISSN (online) 2078-5135
    ISSN 0256-9574 ; 0038-2469
    DOI 10.7196/SAMJ.2016.v106i6.11022
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.406: Show issues Location:
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    Zs.MO 645: Show issues

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  4. Article ; Online: Nocturnal High-Flow Nasal Cannula Therapy and Sinonasal Symptoms During Cystic Fibrosis Exacerbations.

    Davis, Michael D / Brockbank, Justin / Hayden, Ryan / Schechter, Michael S / Rubin, Bruce K

    Respiratory care

    2023  Volume 68, Issue 11, Page(s) 1527–1531

    Abstract: Background: Both nasal obstruction and sleep disturbance are common in patients with cystic fibrosis (CF). In patients with obstructive sleep apnea (OSA), studies suggest that these conditions are related and that nasal congestion improves with CPAP ... ...

    Abstract Background: Both nasal obstruction and sleep disturbance are common in patients with cystic fibrosis (CF). In patients with obstructive sleep apnea (OSA), studies suggest that these conditions are related and that nasal congestion improves with CPAP therapy. We hypothesized that subjects admitted to hospital for therapy of an exacerbation of CF would have both nasal symptoms and sleep disturbance and that these would improve with the initiation of nocturnal high-flow nasal cannula therapy (HFNC).
    Methods: Twenty-five subjects with an exacerbation of CF were enrolled to randomly receive either 5 d of nocturnal HFNC at 20 L/min in the treatment group or 5 L/min of nocturnal nasal cannula air at ambient temperature and humidity in the low-flow group. On the first and last day of the study, the Sino-Nasal Outcome Test (SNOT-20) was administered to evaluate nasal symptoms, and sleep quality was measured using the Actiwatch 2.
    Results: Fifteen subjects completed the study (6 HFNC, 9 low flow). We confirmed that subjects had significant sleep disturbance that did not improve over the 5 d of the study. Subjects also had disturbing nasal symptoms that significantly improved only in those receiving HFNC (pre 14 [20] vs post 6 [13],
    Conclusions: Similar to what has been reported in older subjects with OSA, nocturnal HFNC improves sinonasal symptoms in subjects with an exacerbation of CF. There was no measurable effect on sleep quality, which may be due to the short duration of the study, or to subjects being evaluated while being treated in a hospital setting.
    MeSH term(s) Humans ; Aged ; Cannula ; Cystic Fibrosis/complications ; Cystic Fibrosis/therapy ; Oxygen Inhalation Therapy ; Sleep Apnea, Obstructive/therapy ; Continuous Positive Airway Pressure
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.09890
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  5. Article ; Online: Joint Particle Detection and Analysis by a CNN and Adaptive Norm Minimization Approach.

    Baur, Michael / Reisbeck, Mathias / Hayden, Oliver / Utschick, Wolfgang

    IEEE transactions on bio-medical engineering

    2022  Volume 69, Issue 8, Page(s) 2468–2479

    Abstract: Optical flow cytometry is used as the gold standard in single cell function diagnostics with the drawback of involving high complexity and operator costs. Magnetic flow cytometers try to overcome this problem by replacing optical labeling with magnetic ... ...

    Abstract Optical flow cytometry is used as the gold standard in single cell function diagnostics with the drawback of involving high complexity and operator costs. Magnetic flow cytometers try to overcome this problem by replacing optical labeling with magnetic nanoparticles to assign each cell a magnetic fingerprint. This allows operators to obtain rich cell information from a biological sample with minimal sample preparation at near in-vivo conditions in a decentralized environment. A central task in flow cytometry is the determination of cell concentrations and cell parameters, e.g. hydrodynamic diameter. For the acquisition of this information, signal processing is an essential component. Previous approaches mainly focus on the processing of one-cell signals, leaving out superimposed signals originating from cells passing the magnetic sensors in close proximity. In this work, we present a framework for joint cell/particle detection and analysis, which is capable of processing one-cell as well as multi-cell signals. We employ deep learning and compressive sensing in this approach, which involves the minimization of an adaptive norm. We evaluate our method on simulated and experimental signals, the latter being obtained with polymer microparticles. Our results show that the framework is capable of counting cells with a relative error smaller than 2%. Inference of cell parameters works reliably at both low and high noise levels.
    MeSH term(s) Data Compression ; Flow Cytometry/methods ; Signal Processing, Computer-Assisted
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2022.3147701
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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Successful Percutaneous Ultrasonic Lithotripsy of Gallstones.

    Ostergar, Adam / Alkazemi, Muhammad Hassan / Hill, Hayden / Awad, Michael M / Ushinsky, Alexander / Darcy, Michael / Desai, Alana C / Figenshau, Robert Sherburne

    Ochsner journal

    2024  Volume 24, Issue 1, Page(s) 84–86

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Case Reports
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.23.0071
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  7. Article: Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage.

    Lemarié, Fanny L / Sanders, Shaun S / Nguyen, Yen / Martin, Dale D O / Hayden, Michael R

    Frontiers in physiology

    2023  Volume 14, Page(s) 1086112

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1086112
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  8. Article ; Online: Continuous decisions.

    Yoo, Seng Bum Michael / Hayden, Benjamin Yost / Pearson, John M

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2021  Volume 376, Issue 1819, Page(s) 20190664

    Abstract: Humans and other animals evolved to make decisions that extend over time with continuous and ever-changing options. Nonetheless, the academic study of decision-making is mostly limited to the simple case of choice between two options. Here, we advocate ... ...

    Abstract Humans and other animals evolved to make decisions that extend over time with continuous and ever-changing options. Nonetheless, the academic study of decision-making is mostly limited to the simple case of choice between two options. Here, we advocate that the study of choice should expand to include
    MeSH term(s) Animals ; Choice Behavior ; Decision Making ; Humans ; Primates/psychology
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2019.0664
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    Einzelsignatur: Show issues

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  9. Article ; Online: Subspace orthogonalization as a mechanism for binding values to space.

    Johnston, W Jeffrey / Fine, Justin M / Yoo, Seng Bum Michael / Ebitz, R Becket / Hayden, Benjamin Y

    ArXiv

    2023  

    Abstract: When choosing between options, we must solve an important binding problem. The values of the options must be associated with information about the action needed to select them. We hypothesize that the brain solves this binding problem through use of ... ...

    Abstract When choosing between options, we must solve an important binding problem. The values of the options must be associated with information about the action needed to select them. We hypothesize that the brain solves this binding problem through use of distinct population subspaces. To test this hypothesis, we examined the responses of single neurons in five reward-sensitive regions in rhesus macaques performing a risky choice task. In all areas, neurons encoded the value of the offers presented on both the left and the right side of the display in semi-orthogonal subspaces, which served to bind the values of the two offers to their positions in space. Supporting the idea that this orthogonalization is functionally meaningful, we observed a session-to-session covariation between choice behavior and the orthogonalization of the two value subspaces: trials with less orthogonalized subspaces were associated with greater likelihood of choosing the less valued option. Further inspection revealed that these semi-orthogonal subspaces arose from a combination of linear and nonlinear mixed selectivity in the neural population. We show this combination of selectivity balances reliable binding with an ability to generalize value across different spatial locations. These results support the hypothesis that semi-orthogonal subspaces support reliable binding, which is essential to flexible behavior in the face of multiple options.
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
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  10. Article: Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Treated with Radiation Therapy: A Case Report and Review of the Literature.

    Armstrong, Paul / Hayden, Patrick / Jeffers, Michael / Fitzpatrick, Lisa / Mcknight, Aoife / Armstrong, John

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 1528–1535

    Abstract: Introduction: Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma or MALToma) is a prevalent type of primary pulmonary lymphoma. Typically, the primary therapeutic approaches involve surgery or chemotherapy, although there have been instances of ... ...

    Abstract Introduction: Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma or MALToma) is a prevalent type of primary pulmonary lymphoma. Typically, the primary therapeutic approaches involve surgery or chemotherapy, although there have been instances of radiation therapy being employed.
    Case report: We present a case of pulmonary MALToma that exhibited progression despite rituximab therapy. Subsequently, the patient demonstrated a positive response to radiation therapy.
    Conclusion: This case highlights the potential efficacy of radiation therapy as a treatment option for pulmonary MALToma, especially in cases where other conventional treatments like rituximab have proven ineffective. Further research and studies are warranted to better understand the role of radiation therapy in managing pulmonary MALToma and to determine optimal treatment strategies for patients with this condition.
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000534802
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