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  1. Article: Advancements in Nucleic Acid Based Therapeutics against Respiratory Viral Infections

    Kumar, Binod

    Journal of Clinical Medicine, 8(1):6

    2018  

    Abstract: Several viruses cause pulmonary infections due to their shared tropism with cells of the respiratory tract. These respiratory problems due to viral infection become a public health concern due to rapid transmission through air/aerosols or via direct- ... ...

    Abstract Several viruses cause pulmonary infections due to their shared tropism with cells of the respiratory tract. These respiratory problems due to viral infection become a public health concern due to rapid transmission through air/aerosols or via direct-indirect contact with infected persons. In addition, the cross-species transmission causes alterations to viral genetic makeup thereby increasing the risk of emergence of pathogens with new and more potent infectivity. With the introduction of effective nucleic acid-based technologies, post translational gene silencing (PTGS) is being increasingly used to silence viral gene targets and has shown promising approach towards management of many viral infections. Since several host factors are also utilized by these viruses during various stages of infection, silencing these host factors can also serve as promising therapeutic tool. Several nucleic acid-based technologies such as short interfering RNAs (siRNA), antisense oligonucleotides, aptamers, deoxyribozymes (DNAzymes), and ribozymes have been studied and used against management of respiratory viruses. These therapeutic nucleic acids can be efficiently delivered through the airways. Studies have also shown efficacy of gene therapy in clinical trials against respiratory syncytial virus (RSV) as well as models of respiratory diseases including severe acute respiratory syndrome (SARS), measles and influenza. In this review, we have summarized some of the recent advancements made in the area of nucleic acid based therapeutics and highlighted the emerging roles of nucleic acids in the management of some of the severe respiratory viral infections. We have also focused on the methods of their delivery and associated challenges.
    Keywords COVID-19 ; DNAzyme ; SARS-CoV ; RSV ; antiviral drugs ; adenovirus ; aptamers ; influenza virus ; nucleic acid therapy ; siRNA ; ribozyme
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article: Editorial: Influenza and related viruses: Epidemiology, pathogenesis, and therapeutics.

    Asha, Kumari / Meseko, Clement / Kumar, Binod

    Frontiers in molecular biosciences

    2023  Volume 9, Page(s) 1117067

    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.1117067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Exploring circular RNAs and their applications within health and disease.

    Becatti, Matteo / Dmello, Crismita / Kumar, Binod

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1145738

    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1145738
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  4. Article ; Online: Biomass valorization of agriculture wastewater grown freshwater diatom Nitzschia sp. for metabolites, antibacterial activity, and biofertilizer.

    Singh, Pankaj Kumar / Saxena, Abhishek / Tyagi, Rashi / Sindhu, Raveendran / Binod, Parameswaran / Tiwari, Archana

    Bioresource technology

    2023  Volume 377, Page(s) 128976

    Abstract: The sustainable utilization of agricultural wastewater is a major global challenge. This study evaluated the impact of agricultural fertilizer on the biomass potential of Nitzschia sp. for metabolite production, antibacterial activity, and slow release ... ...

    Abstract The sustainable utilization of agricultural wastewater is a major global challenge. This study evaluated the impact of agricultural fertilizer on the biomass potential of Nitzschia sp. for metabolite production, antibacterial activity, and slow release biofertilizer. Cultivation of Nitzschia sp. in agriculture wastewater (0.5 mg ml
    MeSH term(s) Wastewater ; Diatoms ; Biomass ; Microalgae ; Agriculture ; Fresh Water
    Chemical Substances Wastewater
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2023.128976
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  5. Article ; Online: Biochar preparation and evaluation of its effect in composting mechanism: A review.

    Li, Yue / Kumar Awasthi, Mukesh / Sindhu, Raveendran / Binod, Parameswaran / Zhang, Zengqiang / Taherzadeh, Mohammad J

    Bioresource technology

    2023  Volume 384, Page(s) 129329

    Abstract: This article provides an overview of biochar application for organic waste co-composting and its biochemical transformation mechanism. As a composting amendment, biochar work in the adsorption of nutrients, the retention of oxygen and water, and the ... ...

    Abstract This article provides an overview of biochar application for organic waste co-composting and its biochemical transformation mechanism. As a composting amendment, biochar work in the adsorption of nutrients, the retention of oxygen and water, and the promotion of electron transfer. These functions serve the micro-organisms (physical support of niche) and determine changes in community structure beyond the succession of composing primary microorganisms. Biochar mediates resistance genes, mobile gene elements, and biochemical metabolic activities of organic matter degrading. The participation of biochar enriched the α-diversity of microbial communities at all stages of composting, and ultimately reflects the high γ-diversity. Finally, easy and convincing biochar preparation methods and characteristic need to be explored, in turn, the mechanism of biochar on composting microbes at the microscopic level can be studied in depth.
    MeSH term(s) Composting ; Soil ; Charcoal ; Microbiota ; Manure
    Chemical Substances biochar ; Soil ; Charcoal (16291-96-6) ; Manure
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2023.129329
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  6. Article: Epidemiology of and Genetic Factors Associated with

    Ilyas, Muhammad / Stapleton, Fiona / Willcox, Mark D P / Henriquez, Fiona / Peguda, Hari Kumar / Rayamajhee, Binod / Zahid, Tasbiha / Petsoglou, Constantinos / Carnt, Nicole A

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: ... ...

    Abstract Acanthamoeba
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13020142
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  7. Article ; Online: Partial genomic characterization of Chromobacterium piscinae from India reveals multi drug resistance.

    Choudhary, Binod Kumar / Choudhary, Mamta / Barbuddhe, Sukhadeo B / Shanker, Asheesh

    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

    2024  

    Abstract: Species of genus Chromobacterium have been isolated from diverse geographical settings, which exhibits significant metabolic flexibility as well as biotechnological and pathogenic properties. This study describes the isolation, characterization, draft ... ...

    Abstract Species of genus Chromobacterium have been isolated from diverse geographical settings, which exhibits significant metabolic flexibility as well as biotechnological and pathogenic properties. This study describes the isolation, characterization, draft assembly, and detailed sequence analysis of Chromobacterium piscinae strain W1B-CG-NIBSM isolated from water samples from multi use community pond. The organism was characterized by biochemical tests, Matrix Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI TOF-MS) and partial genome sequencing. The partial genomic data of Chromobacterium pisciane isolate W1B NIBSM strain was submitted to GenBank with Bio project number PRJNA803347 and accession no CP092474. An integrated genome analysis of Chromobacterium piscinae has been accomplished with PATRIC which indicates good quality genome. DNA sequencing using the illumina HiSeq 4000 system generated total length of 4,155,481 bp with 63 contig with G + C content is 62.69%. This partial genome contains 4,126 protein-coding sequences (CDS), 27 repeats region and 78 transfer RNA (tRNA) genes as well as 3 ribosomal RNA (rRNA) genes. The genomic annotation of Chromobacterium W1B depicts 2,925 proteins with functional assignments and 1201 hypothetical proteins. A repertoire of specialty genes implicated in antibiotic resistance (45 genes), drug target (6 genes), Transporter (3 genes) and virulence factor (10 genes). The genomic analysis reveals the adaptability, displays metabolic varied pathways and shows specific structural complex and various virulence factors which makes this strain multi drug resistant. The isolate was found to be highly resistant to β-lactam antibiotics whereas it showed sensitivity towards aminoglycosides and fluoroquinolone antibiotics. Hence, the recovery of Chromobacterium piscinae from community pond evidenced for uncertain hidden source of public health hazard. To the best of authors knowledge this is first report of isolation and genomic description of C. piscinae from India.
    Language English
    Publishing date 2024-02-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2017175-4
    ISSN 1678-4405 ; 1517-8382
    ISSN (online) 1678-4405
    ISSN 1517-8382
    DOI 10.1007/s42770-024-01288-z
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  8. Article: Psychiatry as a major subject in undergraduate training: A step in the right direction.

    Patra, Suravi / Patro, Binod Kumar / Parmar, Arpit

    Indian journal of psychiatry

    2021  Volume 63, Issue 3, Page(s) 313–314

    Language English
    Publishing date 2021-06-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_1423_20
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  9. Article ; Online: EXPLORING THE LINK BETWEEN CHRONIC OBSTRUCTIVE PULMONARY DISEASE, BRONCHIAL ASTHMA, AND LIPID PROFILES

    Shouvik Chatterjee / Deepak Kumar Thakur / Rahul Kumar / Binod Kumar Choudhary

    Student's Journal of Health Research Africa, Vol 4, Iss

    A CROSS-SECTIONAL STUDY.

    2023  Volume 12

    Abstract: Introduction: This pilot cross-sectional study intended to explore the relationship between Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma, and serum lipid levels (HDL, LDL, Total Cholesterol, Triglycerides) as well as serum urea and ... ...

    Abstract Introduction: This pilot cross-sectional study intended to explore the relationship between Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma, and serum lipid levels (HDL, LDL, Total Cholesterol, Triglycerides) as well as serum urea and creatinine. Conducted at Patna Medical College and Hospital, Patna it involved 21 clinically diagnosed stable COPD and bronchial asthma patients. The study cohort was categorized into Mild, Moderate, and Severe COPD based on GOLD criteria. Methods: Data collection involved detailed medical histories and fasting blood specimens. Serum lipids were assessed via enzymatic colorimetric assays, and LDL, HDL, and total cholesterol levels were calculated. Fasting and postprandial blood sugar levels were measured. Results: The study revealed associations between COPD severity and lipid profiles. Notably, Total Cholesterol was 177.19 mg/dL, HDL was 41.87 mg/dL, LDL was 109.92 mg/dL, and Triglycerides were 115.58 mg/dL. An increase in airway resistance, detectable with an impulse oscillometer, was observed even with minor airway alterations. The study indicated significant correlations between serum triglycerides, LDL, LDL/HDL ratio, cholesterol/HDL ratio, and elevated airway resistance in individuals with bronchial asthma and COPD. Conclusion: This pilot study provides initial insights into the interplay between COPD, Bronchial Asthma, and lipid profiles. While lipid findings generally fell within the normal range, elevated LDL levels emphasize the need for monitoring and potential interventions to mitigate cardiovascular risk in COPD patients. Recommendations: Healthcare providers should regularly monitor serum lipid levels, urea, and creatinine in COPD and bronchial asthma patients, particularly those with severe COPD, to detect and manage abnormalities early, potentially enhancing patient outcomes. Further research with larger sample sizes is required to validate these findings and develop comprehensive guidelines for the care of COPD and bronchial asthma patients.
    Keywords Chronic Obstructive Pulmonary Disease ; Lipid Profile ; Bronchial Asthma ; Serum Level ; General works ; R5-130.5 ; Infectious and parasitic diseases ; RC109-216 ; Surgery ; RD1-811 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Student's Journal of Health Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Corrigendum to "Biosynthesis of 2,5-furan dicarboxylic acid by Aspergillus flavus APLS-1: Process optimization and intermediate product analysis" [Bioresour. Technol. 284 (2019) 155-160].

    Rajesh, Rajendran Omana / Godan, Tharangattumana Krishnan / Rai, Amit Kumar / Sahoo, Dinabandhu / Pandey, Ashok / Binod, Parameswaran

    Bioresource technology

    2022  Volume 351, Page(s) 126995

    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2022.126995
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