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  1. Article ; Online: "AI for the new GI": What role does artificial intelligence have in early colonoscopy training?

    Hookey, Lawrence

    Gastrointestinal endoscopy

    2023  Volume 99, Issue 1, Page(s) 100–101

    MeSH term(s) Humans ; Artificial Intelligence ; Colonoscopy ; Colonic Polyps ; Colorectal Neoplasms/diagnosis
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.09.004
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  2. Article ; Online: Assessing Bowel Cleansing for Colonoscopy: Changing Our Focus to What Really Matters.

    Hookey, Lawrence

    Canadian journal of gastroenterology & hepatology

    2016  Volume 2016, Page(s) 6754584

    MeSH term(s) Cathartics ; Colonoscopy ; Humans ; Polyethylene Glycols ; Prospective Studies
    Chemical Substances Cathartics ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2016-05-09
    Publishing country Egypt
    Document type Editorial ; Comment
    ZDB-ID 2762182-0
    ISSN 2291-2797 ; 1916-7237 ; 0835-7900
    ISSN (online) 2291-2797 ; 1916-7237
    ISSN 0835-7900
    DOI 10.1155/2016/6754584
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    Zs.A 2360: Show issues Location:
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  3. Article ; Online: Comparison of Predictive Models for Prevention of Missed Endoscopy Appointments- failure of a Predictive Model to Outperform Overbooking Model.

    Hookey, Lawrence / Lu, Thomas / Khan, Sana / Reed, Joshua / Day, Andrew / Norman, Patrick

    Journal of clinical gastroenterology

    2024  Volume 58, Issue 4, Page(s) 415–418

    Abstract: Background: Patient late cancelation and nonattendance for endoscopy appointments is an ongoing problem affecting the productivity and wait times of endoscopy units. Previous research evaluated a model for predictive overbooking and had promising ... ...

    Abstract Background: Patient late cancelation and nonattendance for endoscopy appointments is an ongoing problem affecting the productivity and wait times of endoscopy units. Previous research evaluated a model for predictive overbooking and had promising results.
    Study: All endoscopy visits at an outpatient endoscopy unit during 4 nonconsecutive months were included in the data analysis. Patients who did not attend their appointment, or canceled with 48 hours of their appointment were considered nonattendees. Demographic, health, and prior visit behavior data was collected and the groups compared.
    Results: 1780 patients attended 2331 visits in the study period. Comparing the attendee versus non-attendees, there were significant differences in mean age, prior absenteeism, prior cancelations, and total number of hospital visits. No significant differences were seen between groups in winter versus non-winter months, the day of the week, sex distribution, type of procedure booked, or whether the referral was from specialist clinic or direct to procedure. The visit cancelation proportion (calculated excluding current visit) was substantially higher in the absentee group ( P <0.0001). A predictive model was developed and compared to current booking as well as a straight overbooking of 7%. Both overbooking models performed better than the current practice, but the predictive overbooking model did not outperform straight overbooking.
    Conclusions: Developing an endoscopy unit specific predictive model may not be more beneficial than straight overbooking as calculated by missed appointment percentage.
    MeSH term(s) Humans ; Endoscopy, Gastrointestinal ; Ambulatory Care Facilities ; Appointments and Schedules ; Outpatients ; Referral and Consultation
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001867
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  4. Article ; Online: Smartphone Application Versus Standard Instruction for Colonoscopic Preparation: A Randomized Controlled Trial.

    Patel, Sunil V / Yu, David / Taylor, Connie / McKay, Jackie / Hookey, Lawrence

    Journal of clinical gastroenterology

    2024  

    Abstract: Objective: To compare smartphone application (Colonoscopic Preparation) instructions versus paper instructions for bowel preparation for colonoscopy.: Background: Adhering to bowel preparation instructions is important to ensure a high-quality ... ...

    Abstract Objective: To compare smartphone application (Colonoscopic Preparation) instructions versus paper instructions for bowel preparation for colonoscopy.
    Background: Adhering to bowel preparation instructions is important to ensure a high-quality colonoscopy.
    Patients and methods: This randomized controlled trial included individuals undergoing colonoscopy at a tertiary care hospital. Individuals were randomized (1:1) to receive instructions through a smartphone application or traditional paper instructions. The primary outcome was the quality of the bowel preparation as measured by the Boston Bowel Preparation Score. Secondary outcomes included cecal intubation and polyp detection. Patient satisfaction was assessed using a previously developed questionnaire.
    Results: A total of 238 individuals were randomized (n = 119 in each group), with 202 available for the intention-to-treat analysis (N = 97 in the app group and 105 in the paper group). The groups had similar demographics, indications for colonoscopy, and type of bowel preparation. The primary outcome (Boston Bowel Preparation Score) demonstrated no difference between groups (Colonoscopic Preparation app mean: 7.26 vs paper mean: 7.28, P = 0.91). There was no difference in cecal intubation (P = 0.37), at least one polyp detected (P = 0.43), or the mean number of polyps removed (P = 0.11). A higher proportion strongly agreed or agreed that they would use the smartphone app compared with paper instructions (89.4% vs 70.1%, P = 0.001).
    Conclusions: Smartphone instructions performed similarly to traditional paper instructions for those willing to use the application. Local patient preferences need to be considered before making changes in the method of delivery of medical instructions.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001988
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  5. Article: Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis.

    Youssef, Michael / Sedarous, Mary / Grin, Andrea / Chung, Andrew / Hookey, Lawrence

    ACG case reports journal

    2023  Volume 10, Issue 2, Page(s) e00986

    Abstract: Granulomatosis with polyangiitis (GPA) is a rare necrotizing antineutrophil cytoplasmic antibody-associated vasculitis characterized by inflammation in small-sized arteries. Gastrointestinal involvement is exceedingly rare in GPA. Here, we present a case ...

    Abstract Granulomatosis with polyangiitis (GPA) is a rare necrotizing antineutrophil cytoplasmic antibody-associated vasculitis characterized by inflammation in small-sized arteries. Gastrointestinal involvement is exceedingly rare in GPA. Here, we present a case of recurrent acute pancreatitis as the initial presentation of GPA. The diagnosis was made based on radiological and pathological findings of acute pancreatitis in conjunction with positive anti-PR3 antibody which is strongly associated with GPA. Systemic vasculitides are rare but important to consider in cases of idiopathic acute pancreatitis. Early diagnosis and therapy allow for high rates of remission and improved survival rates.
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000986
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  6. Article ; Online: Fistulotomy versus standard cannulation as the primary technique for all patients undergoing ERCP with a native papilla: a protocol for a single center randomized controlled trial.

    Hookey, Lawrence / Rai, Mandip / Bechara, Robert

    Trials

    2022  Volume 23, Issue 1, Page(s) 153

    Abstract: Background: Endoscopic retrograde cholangiopancreatography (ERCP) is an indispensable procedure for the management of pancreaticobiliary diseases. Post-ERCP pancreatitis (PEP) is the most common serious adverse event. One risk factor of PEP is ... ...

    Abstract Background: Endoscopic retrograde cholangiopancreatography (ERCP) is an indispensable procedure for the management of pancreaticobiliary diseases. Post-ERCP pancreatitis (PEP) is the most common serious adverse event. One risk factor of PEP is difficulty achieving biliary access. The conventional ERCP technique involves the cannulation of the bile duct via the ampulla of Vater, followed by sphincter incision using electrocautery. Conventionally, if the standard method fails then, precut techniques have been utilized as an alternative means of gaining biliary access. The needle-knife fistulotomy (NKF) technique involves identifying the intra-duodenal segment of the bile duct and uses a needle knife to incise directly into the bile duct. This is done above and away from the natural office, thus minimizing thermal damage which may result in PEP. Our recent prospective study of 50 patients demonstrated the safety and feasibility of the NKF precut technique as a primary means of gaining biliary access. The next step is to conduct a randomized controlled trial to compare the efficacy and safety of initial NKF to the standard cannulation in a non-selective patient population undergoing ERCP.
    Methods: A randomized control trial of 538 consecutive, non-selective patients with pancreaticobiliary disease undergoing ERCP at a tertiary care center in Kingston, Ontario, Canada, will be conducted. Patients will be randomized to one of two treatment groups, standard cannulation or NKF. The primary outcome of the study will be the incidence of PEP. Secondary outcomes will include rate of successful cannulation of the common bile duct (CBD), time to successful cannulation, total procedure time, difficulty of cannulation, and incidence of complications.
    Discussion: This RCT will yield important answers regarding the efficacy and safety of initial NKF to the standard cannulation in a non-selective patient population undergoing ERCP. The results of our study could alter ERCP practices and outcomes if NKF is shown to reduce PEP risk.
    Trial registration: ClinicalTrials.gov NCT04559867 . Registered on September 23, 2020.
    MeSH term(s) Catheterization/adverse effects ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Common Bile Duct ; Humans ; Ontario ; Randomized Controlled Trials as Topic ; Sphincterotomy, Endoscopic/adverse effects ; Sphincterotomy, Endoscopic/methods
    Language English
    Publishing date 2022-02-16
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06084-4
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  7. Article ; Online: Preparation, Timing, Prokinetics, and Surface Agents in Video Capsule Endoscopy.

    Squirell, Elizabeth / Ricci, Michelle / Hookey, Lawrence

    Gastrointestinal endoscopy clinics of North America

    2021  Volume 31, Issue 2, Page(s) 251–265

    Abstract: There is a trend in data to support active preparation for video capsule endoscopy (VCE), but the timing of this remains unclear. Split dosing may be the most efficacious preparation. Study methodology continues to evolve, with increased use of ... ...

    Abstract There is a trend in data to support active preparation for video capsule endoscopy (VCE), but the timing of this remains unclear. Split dosing may be the most efficacious preparation. Study methodology continues to evolve, with increased use of standardized scales, with the addition of diagnostic yield as an outcome. The use of adjuncts has not been detrimental, but their value has not been proved to improve outcomes of VCE.
    MeSH term(s) Capsule Endoscopy ; Humans
    Language English
    Publishing date 2021-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313994-0
    ISSN 1558-1950 ; 1052-5157
    ISSN (online) 1558-1950
    ISSN 1052-5157
    DOI 10.1016/j.giec.2020.12.012
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  8. Article ; Online: An Unusual Case of Lumen-Apposing Metal Stent-Related Splenic Capsule Hemorrhage.

    Budhram, Dalton R / Nasirzadeh, Reza / Hookey, Lawrence

    Journal of the Canadian Association of Gastroenterology

    2020  Volume 5, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2020-12-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2940642-0
    ISSN 2515-2092 ; 2515-2084
    ISSN (online) 2515-2092
    ISSN 2515-2084
    DOI 10.1093/jcag/gwaa038
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  9. Article ; Online: Gastroscopy Should Come Before Colonoscopy Using CO

    Jowhari, Fahd / Hookey, Lawrence

    Journal of the Canadian Association of Gastroenterology

    2019  Volume 3, Issue 3, Page(s) 120–126

    Abstract: Background and aims: Same day bidirectional endoscopies (esophagogastroduodenoscopies [EGD]s and colonoscopies) are routinely performed. However, the best sequence of procedures is unknown, as is whether the use of carbon dioxide (CO: Methods: Two ... ...

    Abstract Background and aims: Same day bidirectional endoscopies (esophagogastroduodenoscopies [EGD]s and colonoscopies) are routinely performed. However, the best sequence of procedures is unknown, as is whether the use of carbon dioxide (CO
    Methods: Two hundred adults with a clinical indication for same day bidirectional endoscopies were randomized equally into four groups: A1 (EGD first, CO
    Results: Two hundred patients were randomized, with data available for 186. Mean Midazolam dose between groups was significantly less in the EGD first groups (
    Conclusions: This randomized controlled trial using validated patient comfort scoring assessments for same day bidirectional endoscopies demonstrated that the sequence of procedures affects the sedation used but does not affect overall patient comfort or satisfaction. Lesser sedation is needed in the EGD first group, and less postprocedural abdominal pain/discomfort and bloating is seen with CO
    Language English
    Publishing date 2019-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2940642-0
    ISSN 2515-2092 ; 2515-2084
    ISSN (online) 2515-2092
    ISSN 2515-2084
    DOI 10.1093/jcag/gwy074
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  10. Article ; Online: Alcohol-associated Liver Disease Is Now the Most Common Indication for Liver Transplant Waitlisting Among Young American Adults.

    Philip, George / Hookey, Lawrence / Richardson, Harriet / Flemming, Jennifer A

    Transplantation

    2022  Volume 106, Issue 10, Page(s) 2000–2005

    Abstract: Background: Mortality from cirrhosis is increasing and is the highest among young adults with alcohol-associated liver disease (ALD). The aim of this study was to describe rates of liver transplant (LT) waitlisting stratified by age, sex, and cirrhosis ... ...

    Abstract Background: Mortality from cirrhosis is increasing and is the highest among young adults with alcohol-associated liver disease (ALD). The aim of this study was to describe rates of liver transplant (LT) waitlisting stratified by age, sex, and cirrhosis etiology.
    Methods: Retrospective population-based study from 2003 to 2018 using the Scientific Registry of Transplant Recipients database. Adults newly registered on the LT waitlist were included, and age at listing was dichotomized to ±40 y. Annual standardized incidence proportions of LT waitlisting by age group, sex, and etiology were calculated using census data. Changes in annual rates were described with Poisson regression.
    Results: A total of 209 399 unique individuals were included, 10 326 (5%) <40 y at listing. In those <40 y of age, listing increased most for ALD (4-fold increase) followed by nonalcoholic fatty liver disease (NAFLD; 2-fold increase). Compared to young adult males, young females were more likely to be listed for ALD and less likely to be listed for NAFLD. In those ≥40 y of age, listings increased most for ALD (2-fold increase) and NAFLD (2-fold increase). Hepatitis C virus increased from 2003 to 2013 and declined post-2014 in the ≥40-y age group.
    Conclusions: LT waitlisting is increasing substantially in young Americans, driven primarily by ALD. These data support ongoing efforts to identify adolescents and young adults with early stages of ALD where interventions can be implemented to prevent the development of cirrhosis and liver-related complications.
    MeSH term(s) Adolescent ; Female ; Humans ; Liver Cirrhosis/epidemiology ; Liver Diseases, Alcoholic/epidemiology ; Liver Diseases, Alcoholic/surgery ; Liver Transplantation/adverse effects ; Male ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/surgery ; Retrospective Studies ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004202
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