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Article ; Online: Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome.

Pastorczak, Agata / Szmyd, Bartosz / Braun, Marcin / Madzio, Joanna / Wypyszczak, Kamila / Sztromwasser, Pawel / Fendler, Wojciech / Wojtaszewska, Marzena / Chrzanowski, Jedrzej / Grajkowska, Wieslawa / Gregorek, Hanna / Wakulinska, Anna / Kazanowska, Bernarda / Krenova, Zdenka / Weijers, Dilys D / Kuiper, Roland P / Mlynarski, Wojciech

Haematologica

2023 Volume 108, Issue 10, Page(s) 2808–2813

MeSH term(s)	Humans ; Child ; Nijmegen Breakage Syndrome ; Lymphoma, Non-Hodgkin ; Lymphoma, Large B-Cell, Diffuse/genetics
Language	English
Publishing date	2023-10-01
Publishing country	Italy
Document type	Letter
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2022.282325
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Article: Subtype-Specific Tumour Immune Microenvironment in Risk of Recurrence of Ductal Carcinoma In Situ: Prognostic Value of HER2.

Solek, Julia / Chrzanowski, Jedrzej / Cieslak, Adrianna / Zielinska, Aleksandra / Piasecka, Dominika / Braun, Marcin / Sadej, Rafal / Romanska, Hanna M

Biomedicines

2022 Volume 10, Issue 5

Abstract: Increasing evidence suggests that the significance of the tumour immune microenvironment (TIME) for disease prognostication in invasive breast carcinoma is subtype-specific but equivalent studies in ductal carcinoma in situ (DCIS) are limited. The ... ...

Abstract	Increasing evidence suggests that the significance of the tumour immune microenvironment (TIME) for disease prognostication in invasive breast carcinoma is subtype-specific but equivalent studies in ductal carcinoma in situ (DCIS) are limited. The purpose of this paper is to review the existing data on immune cell composition in DCIS in relation to the clinicopathological features and molecular subtype of the lesion. We discuss the value of infiltration by various types of immune cells and the PD-1/PD-L1 axis as potential markers of the risk of recurrence. Analysis of the literature available in PubMed and Medline databases overwhelmingly supports an association between densities of infiltrating immune cells, traits of immune exhaustion, the foci of microinvasion, and overexpression of HER2. Moreover, in several studies, the density of immune infiltration was found to be predictive of local recurrence as either in situ or invasive cancer in HER2-positive or ER-negative DCIS. In light of the recently reported first randomized DCIS trial, relating recurrence risk with overexpression of HER2, we also include a closing paragraph compiling the latest mechanistic data on a functional link between HER2 and the density/composition of TIME in relation to its potential value in the prognostication of the risk of recurrence.
Language	English
Publishing date	2022-05-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10051061
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Article ; Online: Subtype-Specific Tumour Immune Microenvironment in Risk of Recurrence of Ductal Carcinoma In Situ

Julia Solek / Jedrzej Chrzanowski / Adrianna Cieslak / Aleksandra Zielinska / Dominika Piasecka / Marcin Braun / Rafal Sadej / Hanna M. Romanska

Biomedicines, Vol 10, Iss 1061, p

Prognostic Value of HER2

2022 Volume 1061

Abstract	Increasing evidence suggests that the significance of the tumour immune microenvironment (TIME) for disease prognostication in invasive breast carcinoma is subtype-specific but equivalent studies in ductal carcinoma in situ (DCIS) are limited. The purpose of this paper is to review the existing data on immune cell composition in DCIS in relation to the clinicopathological features and molecular subtype of the lesion. We discuss the value of infiltration by various types of immune cells and the PD-1/PD-L1 axis as potential markers of the risk of recurrence. Analysis of the literature available in PubMed and Medline databases overwhelmingly supports an association between densities of infiltrating immune cells, traits of immune exhaustion, the foci of microinvasion, and overexpression of HER2. Moreover, in several studies, the density of immune infiltration was found to be predictive of local recurrence as either in situ or invasive cancer in HER2-positive or ER-negative DCIS. In light of the recently reported first randomized DCIS trial, relating recurrence risk with overexpression of HER2, we also include a closing paragraph compiling the latest mechanistic data on a functional link between HER2 and the density/composition of TIME in relation to its potential value in the prognostication of the risk of recurrence.
Keywords	DCIS ; recurrence ; tumour immune microenvironment ; HER2 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction: Assessing Public Interest Based on Wikipedia's Most Visited Medical Articles During the SARS-CoV-2 Outbreak: Search Trends Analysis.

Chrzanowski, Jędrzej / Sołek, Julia / Fendler, Wojciech / Jemielniak, Dariusz

Journal of medical Internet research

2021 Volume 23, Issue 4, Page(s) e29598

Abstract: This corrects the article DOI: 10.2196/26331.]. ...

Abstract	[This corrects the article DOI: 10.2196/26331.].
Language	English
Publishing date	2021-04-15
Publishing country	Canada
Document type	Published Erratum
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/29598
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessing Public Interest Based on Wikipedia's Most Visited Medical Articles During the SARS-CoV-2 Outbreak: Search Trends Analysis.

Chrzanowski, Jędrzej / Sołek, Julia / Fendler, Wojciech / Jemielniak, Dariusz

Journal of medical Internet research

2021 Volume 23, Issue 4, Page(s) e26331

Abstract: Background: In the current era of widespread access to the internet, we can monitor public interest in a topic via information-targeted web browsing. We sought to provide direct proof of the global population's altered use of Wikipedia medical knowledge ...

Abstract	Background: In the current era of widespread access to the internet, we can monitor public interest in a topic via information-targeted web browsing. We sought to provide direct proof of the global population's altered use of Wikipedia medical knowledge resulting from the new COVID-19 pandemic and related global restrictions. Objective: We aimed to identify temporal search trends and quantify changes in access to Wikipedia Medicine Project articles that were related to the COVID-19 pandemic. Methods: We performed a retrospective analysis of medical articles across nine language versions of Wikipedia and country-specific statistics for registered COVID-19 deaths. The observed patterns were compared to a forecast model of Wikipedia use, which was trained on data from 2015 to 2019. The model comprehensively analyzed specific articles and similarities between access count data from before (ie, several years prior) and during the COVID-19 pandemic. Wikipedia articles that were linked to those directly associated with the pandemic were evaluated in terms of degrees of separation and analyzed to identify similarities in access counts. We assessed the correlation between article access counts and the number of diagnosed COVID-19 cases and deaths to identify factors that drove interest in these articles and shifts in public interest during the subsequent phases of the pandemic. Results: We observed a significant (P<.001) increase in the number of entries on Wikipedia medical articles during the pandemic period. The increased interest in COVID-19-related articles temporally correlated with the number of global COVID-19 deaths and consistently correlated with the number of region-specific COVID-19 deaths. Articles with low degrees of separation were significantly similar (P<.001) in terms of access patterns that were indicative of information-seeking patterns. Conclusions: The analysis of Wikipedia medical article popularity could be a viable method for epidemiologic surveillance, as it provides important information about the reasons behind public attention and factors that sustain public interest in the long term. Moreover, Wikipedia users can potentially be directed to credible and valuable information sources that are linked with the most prominent articles.
MeSH term(s)	COVID-19/mortality ; Disease Outbreaks ; Health Behavior ; Health Education/statistics & numerical data ; Humans ; Internet/statistics & numerical data ; Language ; Medicine ; Pandemics ; Public Opinion ; Retrospective Studies
Language	English
Publishing date	2021-04-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/26331
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reduced Carbohydrate Diet Influence on Postprandial Glycemia-Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 Diabetes.

Lejk, Agnieszka / Chrzanowski, Jędrzej / Cieślak, Adrianna / Fendler, Wojciech / Myśliwiec, Małgorzata

Nutrients

2022 Volume 14, Issue 21

Abstract: Therapy for type 1 diabetes (T1DM) focuses on maintaining optimal blood glucose levels, achieved with intensive insulin treatment, proper nutrition, and physical activity. The aim of this study was to investigate postprandial glycemic changes under low ( ... ...

Abstract	Therapy for type 1 diabetes (T1DM) focuses on maintaining optimal blood glucose levels, achieved with intensive insulin treatment, proper nutrition, and physical activity. The aim of this study was to investigate postprandial glycemic changes under low (30%) and standard (50%) carbohydrate diets in adolescents with T1DM. A single-center cross-over nutritional study was conducted, during which 26 adolescent patients provided 220 continuous glucose-monitored (CGM) meals data from the two consecutive 3-day nutritional plans. Overall, the 50% carbohydrate diet was associated with higher postprandial glucose variability in the small meals (afternoon snacks, second breakfast) and greater postprandial peaks for other meals (breakfast, dinner, supper). Nevertheless, after the adjustment of a patient's individual clinical variables (age, Tanner classification, glucose disposal rate), we observed that mean postprandial glucose was higher for afternoon snacks and lower for suppers in the 30% carbohydrate diet. Although a 30% carbohydrate diet seems to offer better postprandial glycemia, it requires additional attention from the physician and patient when it comes to modifying daily carbohydrate intake. Increased fat/protein content and size of the main meal lead to a prolonged postprandial glycemic response, which may affect the insulin treatment and result in suboptimal glycemic control.
MeSH term(s)	Adolescent ; Humans ; Blood Glucose ; Diabetes Mellitus, Type 1/drug therapy ; Dietary Carbohydrates ; Postprandial Period ; Meals ; Diet, Carbohydrate-Restricted ; Cross-Over Studies ; Insulins ; Insulin
Chemical Substances	Blood Glucose ; Dietary Carbohydrates ; Insulins ; Insulin
Language	English
Publishing date	2022-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14214689
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Article ; Online: Effect of Nutritional Habits on the Glycemic Response to Different Carbohydrate Diet in Children with Type 1 Diabetes Mellitus.

Lejk, Agnieszka / Chrzanowski, Jędrzej / Cieślak, Adrianna / Fendler, Wojciech / Myśliwiec, Małgorzata

Nutrients

2021 Volume 13, Issue 11

Abstract: Unhealthy eating habits are associated with obesity, metabolic syndrome, and increased insulin resistance in young patients with type 1 diabetes mellitus (T1DM), and may impact the possible benefit from dietary interventions on glycaemic control. This ... ...

Abstract	Unhealthy eating habits are associated with obesity, metabolic syndrome, and increased insulin resistance in young patients with type 1 diabetes mellitus (T1DM), and may impact the possible benefit from dietary interventions on glycaemic control. This study determines how nutritional patterns influence the quality of dietary intervention with a 30% or 50% carbohydrate diet in terms of glycaemic control measured with continuous glucose monitoring (CGM). Eating habits were obtained with a frequency-of-consumption questionnaire (FFQ-6) before the diet assessment. Altogether, we collected CGM and FFQ-6 data from 30 children (16 boys and 14 girls aged 10-17 years) with T1DM subjected to two consecutive 3-day nutritional plans. From these, 23 patients met the CGM data quality criteria for further analysis. Furthermore, high accuracy achieved in training (95.65%) and V-fold cross-validation (81.67%) suggest a significant impact of food habits in response to introduced nutritional changes. Patients who consumed more vegetables or grains (>4 times per day), more wheat products (>once per day), fewer fats (<1.5 times per day), and ranked fruit juice as the most common selection in the drinks category achieved glycaemic control more often after the introduction of a 30% carbohydrate diet, as opposed to those with different dietary patterns, whose glycaemic control was negatively impacted after switching to this diet. Additionally, the 50% carbohydrate diet was safe for all patients in the context of glycaemic control.
MeSH term(s)	Adolescent ; Blood Glucose/metabolism ; Blood Glucose Self-Monitoring ; Child ; Cross-Over Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/diet therapy ; Diet Surveys ; Diet, Carbohydrate-Restricted/methods ; Dietary Carbohydrates/administration & dosage ; Feeding Behavior/physiology ; Female ; Glycemic Control/statistics & numerical data ; Humans ; Male
Chemical Substances	Blood Glucose ; Dietary Carbohydrates
Language	English
Publishing date	2021-10-27
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13113815
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessing Public Interest Based on Wikipedia’s Most Visited Medical Articles During the SARS-CoV-2 Outbreak

Chrzanowski, Jędrzej / Sołek, Julia / Fendler, Wojciech / Jemielniak, Dariusz

Journal of Medical Internet Research, Vol 23, Iss 4, p e

Search Trends Analysis

2021 Volume 26331

Abstract: BackgroundIn the current era of widespread access to the internet, we can monitor public interest in a topic via information-targeted web browsing. We sought to provide direct proof of the global population’s altered use of Wikipedia medical knowledge ... ...

Abstract	BackgroundIn the current era of widespread access to the internet, we can monitor public interest in a topic via information-targeted web browsing. We sought to provide direct proof of the global population’s altered use of Wikipedia medical knowledge resulting from the new COVID-19 pandemic and related global restrictions. ObjectiveWe aimed to identify temporal search trends and quantify changes in access to Wikipedia Medicine Project articles that were related to the COVID-19 pandemic. MethodsWe performed a retrospective analysis of medical articles across nine language versions of Wikipedia and country-specific statistics for registered COVID-19 deaths. The observed patterns were compared to a forecast model of Wikipedia use, which was trained on data from 2015 to 2019. The model comprehensively analyzed specific articles and similarities between access count data from before (ie, several years prior) and during the COVID-19 pandemic. Wikipedia articles that were linked to those directly associated with the pandemic were evaluated in terms of degrees of separation and analyzed to identify similarities in access counts. We assessed the correlation between article access counts and the number of diagnosed COVID-19 cases and deaths to identify factors that drove interest in these articles and shifts in public interest during the subsequent phases of the pandemic. ResultsWe observed a significant (P<.001) increase in the number of entries on Wikipedia medical articles during the pandemic period. The increased interest in COVID-19–related articles temporally correlated with the number of global COVID-19 deaths and consistently correlated with the number of region-specific COVID-19 deaths. Articles with low degrees of separation were significantly similar (P<.001) in terms of access patterns that were indicative of information-seeking patterns. ConclusionsThe analysis of Wikipedia medical article popularity could be a viable method for epidemiologic surveillance, as it provides important information about the ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Public aspects of medicine ; RA1-1270
Subject code	028
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Chrzanowski, Jędrzej / Sołek, Julia / Fendler, Wojciech / Jemielniak, Dariusz

Journal of Medical Internet Research, Vol 23, Iss 4, p e

Assessing Public Interest Based on Wikipedia’s Most Visited Medical Articles During the SARS-CoV-2 Outbreak: Search Trends Analysis

2021 Volume 29598

Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improved Estimation of Glycated Hemoglobin from Continuous Glucose Monitoring and Past Glycated Hemoglobin Data.

Chrzanowski, Jędrzej / Michalak, Arkadiusz / Łosiewicz, Aleksandra / Kuśmierczyk, Hanna / Mianowska, Beata / Szadkowska, Agnieszka / Fendler, Wojciech

Diabetes technology & therapeutics

2021 Volume 23, Issue 4, Page(s) 293–305

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Blood Glucose ; Blood Glucose Self-Monitoring ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/drug therapy ; Glucose ; Glycated Hemoglobin A/analysis ; Humans ; Infant
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1452816-2
ISSN	1557-8593 ; 1520-9156
ISSN (online)	1557-8593
ISSN	1520-9156
DOI	10.1089/dia.2020.0433
Database	MEDical Literature Analysis and Retrieval System OnLINE

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