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  1. Article ; Online: Towards a marketplace for Vi polysaccharide-conjugate typhoid vaccines.

    Gibani, Malick M

    The Lancet. Infectious diseases

    2021  Volume 22, Issue 4, Page(s) 435–436

    MeSH term(s) Humans ; Polysaccharides ; Salmonella typhi/immunology ; Typhoid Fever/prevention & control ; Typhoid-Paratyphoid Vaccines/immunology ; Vaccines, Conjugate/immunology
    Chemical Substances Polysaccharides ; Typhoid-Paratyphoid Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00560-0
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  2. Article ; Online: Cohorting inpatients with Omicron and Delta variants of Sars-CoV-2 does not increase rates of mixed infection.

    Davies, Jessica / Gibani, Malick M / Portone, Greta / McGregor, Alastair

    The Journal of infection

    2022  Volume 85, Issue 1, Page(s) e18–e20

    MeSH term(s) COVID-19 ; Coinfection ; Humans ; Inpatients ; SARS-CoV-2/genetics
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.04.021
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  3. Article ; Online: The effect of ciprofloxacin prophylaxis during haematopoietic cell transplantation on infection episodes, exposure to treatment antimicrobials and antimicrobial resistance: a single-centre retrospective cohort study.

    Baltas, Ioannis / Kavallieros, Konstantinos / Konstantinou, Giannis / Koutoumanou, Eirini / Gibani, Malick M / Gilchrist, Mark / Davies, Frances / Pavlu, Jiri

    JAC-antimicrobial resistance

    2024  Volume 6, Issue 1, Page(s) dlae010

    Abstract: Objectives: Fluroquinolone prophylaxis during haematopoietic cell transplantation (HCT) remains contentious. We aimed to determine its effectiveness and association with exposure to treatment antimicrobials and antimicrobial resistance.: Methods: All ...

    Abstract Objectives: Fluroquinolone prophylaxis during haematopoietic cell transplantation (HCT) remains contentious. We aimed to determine its effectiveness and association with exposure to treatment antimicrobials and antimicrobial resistance.
    Methods: All admission episodes for HCT (
    Results: Allo-HCT was performed for 43.3% (173/400) of patients, auto-HCT for 56.7% (227/400). Allo-HCT was associated with an average of 1.01 fewer infection episodes per 100 admission days (95% CI 0.62-1.40,
    Conclusions: Ciprofloxacin prophylaxis in allo-HCT was associated with fewer infection episodes and reduced exposure to treatment antimicrobials. Mortality in auto-HCT remained low. A significant burden of antimicrobial resistance was detected in allo-HCT recipients.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlae010
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  4. Article ; Online: Typhoid fever control in the 21st century: where are we now?

    Carey, Megan E / McCann, Naina S / Gibani, Malick M

    Current opinion in infectious diseases

    2022  Volume 35, Issue 5, Page(s) 424–430

    Abstract: Purpose of review: Momentum for achieving widespread control of typhoid fever has been growing over the past decade. Typhoid conjugate vaccines represent a potentially effective tool to reduce the burden of disease in the foreseeable future and new data ...

    Abstract Purpose of review: Momentum for achieving widespread control of typhoid fever has been growing over the past decade. Typhoid conjugate vaccines represent a potentially effective tool to reduce the burden of disease in the foreseeable future and new data have recently emerged to better frame their use-case.
    Recent findings: We describe how antibiotic resistance continues to pose a major challenge in the treatment of typhoid fever, as exemplified by the emergence of azithromycin resistance and the spread of Salmonella Typhi strains resistant to third-generation cephalosporins. We review efficacy and effectiveness data for TCVs, which have been shown to have high-level efficacy (≥80%) against typhoid fever in diverse field settings. Data from randomized controlled trials and observational studies of TCVs are reviewed herein. Finally, we review data from multicountry blood culture surveillance studies that have provided granular insights into typhoid fever epidemiology. These data are becoming increasingly important as countries decide how best to introduce TCVs into routine immunization schedules and determine the optimal delivery strategy.
    Summary: Continued advocacy is needed to address the ongoing challenge of typhoid fever to improve child health and tackle the rising challenge of antimicrobial resistance.
    MeSH term(s) Azithromycin/therapeutic use ; Child ; Humans ; Salmonella typhi ; Typhoid Fever/drug therapy ; Typhoid Fever/epidemiology ; Typhoid Fever/prevention & control ; Typhoid-Paratyphoid Vaccines ; Vaccines, Conjugate
    Chemical Substances Typhoid-Paratyphoid Vaccines ; Vaccines, Conjugate ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000879
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    Zs.A 2462: Show issues Location:
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  5. Article ; Online: Protocol for the challenge non-typhoidal

    Smith, Christopher / Smith, Emma / Rydlova, Anna / Varro, Robert / Hinton, Jay C D / Gordon, Melita A / Choy, Robert K M / Liu, Xinxue / Pollard, Andrew J / Chiu, Christopher / Cooke, Graham S / Gibani, Malick M

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e076477

    Abstract: Introduction: Invasive non-typhoidal : Methods and analysis: This double-blind, safety and dose-escalation study will randomise 40-80 healthy UK participants aged 18-50 to receive oral challenge with one of two strains of : Ethics and dissemination! ...

    Abstract Introduction: Invasive non-typhoidal
    Methods and analysis: This double-blind, safety and dose-escalation study will randomise 40-80 healthy UK participants aged 18-50 to receive oral challenge with one of two strains of
    Ethics and dissemination: Ethical approval has been obtained from the NHS Health Research Authority (London-Fulham Research Ethics Committee 21/PR/0051; IRAS Project ID 301659). The study findings will be disseminated in international peer-reviewed journals and presented at national/international stakeholder meetings. Study outcome summaries will be provided to both funders and participants.
    Trial registration number: NCT05870150.
    MeSH term(s) Humans ; Singing ; Salmonella ; Typhoid Fever ; London ; Vaccines ; Randomized Controlled Trials as Topic
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-076477
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  6. Article: The Challenge Non-Typhoidal

    Smith, Christopher / Smith, Emma / Chiu, Christopher / Hinton, Jay / Perez Sepulveda, Blanca / Gordon, Melita / Choy, Robert K M / Hill, Peter W S / Meiring, James E / Darton, Thomas C / Carey, Megan E / Cooke, Graham / Gibani, Malick M

    Wellcome open research

    2023  Volume 8, Page(s) 111

    Abstract: Invasive non- ... ...

    Abstract Invasive non-typhoidal
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.19012.2
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  7. Article ; Online: Early transcriptional responses to human enteric fever challenge.

    Barton, Amber / Hill, Jennifer / O'Connor, Daniel / Jones, Claire / Jones, Elizabeth / Camara, Susana / Shrestha, Sonu / Jin, Celina / Gibani, Malick M / Dobinson, Hazel C / Waddington, Claire / Darton, Thomas C / Blohmke, Christoph J / Pollard, Andrew J

    Infection and immunity

    2023  Volume 91, Issue 10, Page(s) e0010823

    Abstract: Enteric fever, caused by oral infection with ... ...

    Abstract Enteric fever, caused by oral infection with typhoidal
    MeSH term(s) Humans ; Typhoid Fever/prevention & control ; Salmonella typhi/genetics ; Typhoid-Paratyphoid Vaccines ; Vaccines, Attenuated ; Vaccination
    Chemical Substances Typhoid-Paratyphoid Vaccines ; Vaccines, Attenuated
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00108-23
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    Zs.A 684: Show issues Location:
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  8. Article ; Online: Protocol for the challenge non-typhoidal Salmonella (CHANTS) study

    Melita A Gordon / Christopher Smith / Xinxue Liu / Andrew J Pollard / Emma Smith / Graham S Cooke / Robert K M Choy / Anna Rydlova / Robert Varro / Jay C D Hinton / Christopher Chiu / Malick M Gibani

    BMJ Open, Vol 14, Iss

    a first-in-human, in-patient, double-blind, randomised, safety and dose-escalation controlled human infection model in the UK

    2024  Volume 1

    Abstract: Introduction Invasive non-typhoidal Salmonella (iNTS) serovars are a major cause of community-acquired bloodstream infections in sub-Saharan Africa (SSA). In this setting, Salmonella enterica serovar Typhimurium accounts for two-thirds of infections and ... ...

    Abstract Introduction Invasive non-typhoidal Salmonella (iNTS) serovars are a major cause of community-acquired bloodstream infections in sub-Saharan Africa (SSA). In this setting, Salmonella enterica serovar Typhimurium accounts for two-thirds of infections and is associated with an estimated case fatality rate of 15%–20%. Several iNTS vaccine candidates are in early-stage assessment which—if found effective—would provide a valuable public health tool to reduce iNTS disease burden. The CHANTS study aims to develop a first-in-human Salmonella Typhimurium controlled human infection model, which can act as a platform for future vaccine evaluation, in addition to providing novel insights into iNTS disease pathogenesis.Methods and analysis This double-blind, safety and dose-escalation study will randomise 40–80 healthy UK participants aged 18–50 to receive oral challenge with one of two strains of S. Typhimurium belonging to the ST19 (strain 4/74) or ST313 (strain D23580) lineages. 4/74 is a global strain often associated with diarrhoeal illness predominantly in high-income settings, while D23580 is an archetypal strain representing invasive disease-causing isolates found in SSA. The primary objective is to determine the minimum infectious dose (colony-forming unit) required for 60%–75% of participants to develop clinical or microbiological features of systemic salmonellosis. Secondary endpoints are to describe and compare the clinical, microbiological and immunological responses following challenge. Dose escalation or de-escalation will be undertaken by continual-reassessment methodology and limited within prespecified safety thresholds. Exploratory objectives are to describe mechanisms of iNTS virulence, identify putative immune correlates of protection and describe host–pathogen interactions in response to infection.Ethics and dissemination Ethical approval has been obtained from the NHS Health Research Authority (London—Fulham Research Ethics Committee 21/PR/0051; IRAS Project ID 301659). The study findings will be ...
    Keywords Medicine ; R
    Subject code 170
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Short-course Antibiotic Therapy: A Bespoke Approach Is Required.

    Hughes, Stephen / Kamranpour, Pegah / Gibani, Malick M / Mughal, Nabeela / Moore, Luke S P

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 70, Issue 8, Page(s) 1793–1794

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Drug Administration Schedule ; Humans ; Physicians ; Time Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-04-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz711
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  10. Article ; Online: Typhoid and paratyphoid fever: a call to action.

    Gibani, Malick M / Britto, Carl / Pollard, Andrew J

    Current opinion in infectious diseases

    2018  Volume 31, Issue 5, Page(s) 440–448

    Abstract: Purpose of review: Enteric fever remains a major global-health concern, estimated to be responsible for between 11.9 and 26.9 million cases annually. Long-term prevention of enteric fever will require improved access to safe drinking water combined with ...

    Abstract Purpose of review: Enteric fever remains a major global-health concern, estimated to be responsible for between 11.9 and 26.9 million cases annually. Long-term prevention of enteric fever will require improved access to safe drinking water combined with investment in sanitation and hygiene interventions. In the short-to-medium term, new control strategies for typhoid fever have arrived in the form of typhoid Vi-conjugate vaccines (TCVs), offering hope that disease control can be achieved in the near future.
    Recent findings: The diagnosis of enteric fever is complicated by its nonspecific clinical presentation, coupled with the low sensitivity of commonly used diagnostics. Investment in diagnostics has the potential to improve management, to refine estimates of disease burden and to facilitate vaccine impact studies. A new generation of reliable, diagnostic tests is needed that are simultaneously accessible, cost-effective, sensitive, and specific. The emergence and global dissemination of multidrug-resistant, fluoroquinolone-resistant, and extensively drug-resistant (XDR) strains of Salmonella Typhi emphasizes the importance of continued surveillance and appropriate antibiotic stewardship, integrated into a global strategy to address antimicrobial resistance (AMR). Current empirical treatment guidelines are out of date and should be updated to respond to local trends in AMR, so as to guide treatment choices in the absence of robust diagnostics and laboratory facilities. In September 2017, the WHO Strategic Advisory Group of Experts (SAGE) immunization recommended the programmatic use of TCVs in high burden countries. Ongoing and future studies should aim to study the impact of these vaccines in a diverse range of setting and to support the deployment of TCVs in high-burden countries.
    Summary: The advent of new generation TCVs offers us a practical and affordable public-health tool that - for the first time - can be integrated into routine childhood immunization programmes. In this review, we advocate for the deployment of TCVs in line with WHO recommendations, to improve child health and limit the spread of antibiotic-resistant S. Typhi.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Communicable Disease Control/methods ; Diagnostic Tests, Routine/methods ; Disease Transmission, Infectious/prevention & control ; Drug Resistance, Bacterial ; Epidemiological Monitoring ; Global Health ; Humans ; Paratyphoid Fever/diagnosis ; Paratyphoid Fever/drug therapy ; Paratyphoid Fever/epidemiology ; Paratyphoid Fever/prevention & control ; Typhoid Fever/diagnosis ; Typhoid Fever/drug therapy ; Typhoid Fever/epidemiology ; Typhoid Fever/prevention & control ; Typhoid-Paratyphoid Vaccines/immunology ; Typhoid-Paratyphoid Vaccines/isolation & purification
    Chemical Substances Anti-Bacterial Agents ; Typhoid-Paratyphoid Vaccines
    Language English
    Publishing date 2018-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000479
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