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Article ; Online: Assessing and managing the risks of COVID-19 in the workplace: Applying industrial hygiene (IH)/occupational and environmental health and safety (OEHS) frameworks.

Zisook, Rachel E / Monnot, Andrew / Parker, Justine / Gaffney, Shannon / Dotson, Scott / Unice, Kenneth

2020 Volume 36, Issue 9, Page(s) 607–618

Abstract: ... CoV-2), specifically. Available IH/OEHS risk assessment and risk management tools (e.g. control ... selecting the best available controls, and applying other emerging tools (e.g. quantitative microbial ...

Abstract	As businesses attempt to reopen to varying degrees amid the current coronavirus disease (COVID-19) pandemic, industrial hygiene (IH) and occupational and environmental health and safety (OEHS) professionals have been challenged with assessing and managing the risks of COVID-19 in the workplace. In general, the available IH/OEHS tools were designed to control hazards originating in the workplace; however, attempts to tailor them specifically to the control of infectious disease outbreaks have been limited. This analysis evaluated the IH decision-making framework (Anticipate, Recognize, Evaluate, Control, and Confirm ("ARECC")) as it relates to biological hazards, in general, and to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically. Available IH/OEHS risk assessment and risk management tools (e.g. control banding and the hierarchy of controls) are important components of the ARECC framework. These conceptual models, however, were primarily developed for controlling chemical hazards and must be adapted to the unique characteristics of highly infectious and virulent pathogens, such as SARS-CoV-2. This assessment provides an overview of the key considerations for developing occupational infection control plans, selecting the best available controls, and applying other emerging tools (e.g. quantitative microbial risk assessment), with the ultimate goal of facilitating risk management decisions during the current global pandemic.
MeSH term(s)	COVID-19/prevention & control ; COVID-19/transmission ; Humans ; Infection Control/methods ; National Institute for Occupational Safety and Health, U.S. ; Occupational Exposure/prevention & control ; Occupational Health ; Pandemics ; Risk Assessment ; SARS-CoV-2 ; Safety Management/methods ; United States ; Workplace
Keywords	covid19
Language	English
Publishing date	2020-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/0748233720967522
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of the Safety and Efficacy of Hand Sanitizer Products Marketed to Children Available during the COVID-19 Pandemic.

Gloekler, Lauren E / de Gandiaga, Elise J / Binczewski, Natalie R / Steimel, Katie G / Massarsky, Andrey / Kozal, Jordan / Vincent, Melissa / Zisook, Rachel / LaGuardia, Mark J / Dotson, Scott / Gaffney, Shannon

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: Hand sanitizer use in the United States (U.S.) increased after the SARS-CoV-2 outbreak. The U.S. Food and Drug Administration (FDA) released temporary manufacturer guidance, changing impurity level limits for alcohol-based hand sanitizers (ABHSs). Since ... ...

Abstract	Hand sanitizer use in the United States (U.S.) increased after the SARS-CoV-2 outbreak. The U.S. Food and Drug Administration (FDA) released temporary manufacturer guidance, changing impurity level limits for alcohol-based hand sanitizers (ABHSs). Since the guidance took effect, the FDA has recommended against using these hand sanitizers due to concerns over safety, efficacy, and/or risk of incidental ingestion. To address current gaps in exposure characterization, this study describes a survey of ABHSs marketed to children available in the U.S., as defined by several inclusion criteria. A subset of ABHSs (
MeSH term(s)	Child ; Humans ; United States ; Hand Sanitizers ; COVID-19/epidemiology ; Pandemics ; SARS-CoV-2 ; Ethanol
Chemical Substances	Hand Sanitizers ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192114424
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Article: Assessing and managing the risks of COVID-19 in the workplace: Applying industrial hygiene (IH)/occupational and environmental health and safety (OEHS) frameworks

Zisook, Rachel E / Monnot, Andrew / Parker, Justine / Gaffney, Shannon / Dotson, Scott / Unice, Kenneth

Toxicol Ind Health

Abstract	As businesses attempt to reopen to varying degrees amid the current coronavirus disease (COVID-19) pandemic, industrial hygiene (IH) and occupational and environmental health and safety (OEHS) professionals have been challenged with assessing and managing the risks of COVID-19 in the workplace. In general, the available IH/OEHS tools were designed to control hazards originating in the workplace; however, attempts to tailor them specifically to the control of infectious disease outbreaks have been limited. This analysis evaluated the IH decision-making framework (Anticipate, Recognize, Evaluate, Control, and Confirm ("ARECC")) as it relates to biological hazards, in general, and to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically. Available IH/OEHS risk assessment and risk management tools (e.g. control banding and the hierarchy of controls) are important components of the ARECC framework. These conceptual models, however, were primarily developed for controlling chemical hazards and must be adapted to the unique characteristics of highly infectious and virulent pathogens, such as SARS-CoV-2. This assessment provides an overview of the key considerations for developing occupational infection control plans, selecting the best available controls, and applying other emerging tools (e.g. quantitative microbial risk assessment), with the ultimate goal of facilitating risk management decisions during the current global pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #883489
Database	COVID19

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Article ; Online: Assessing and managing the risks of COVID-19 in the workplace

Zisook, Rachel E / Monnot, Andrew / Parker, Justine / Gaffney, Shannon / Dotson, Scott / Unice, Kenneth

Toxicology and Industrial Health

Applying industrial hygiene (IH)/occupational and environmental health and safety (OEHS) frameworks

2020 , Page(s) 74823372096752

Abstract	As businesses attempt to reopen to varying degrees amid the current coronavirus disease (COVID-19) pandemic, industrial hygiene (IH) and occupational and environmental health and safety (OEHS) professionals have been challenged with assessing and managing the risks of COVID-19 in the workplace. In general, the available IH/OEHS tools were designed to control hazards originating in the workplace; however, attempts to tailor them specifically to the control of infectious disease outbreaks have been limited. This analysis evaluated the IH decision-making framework (Anticipate, Recognize, Evaluate, Control, and Confirm (“ARECC”)) as it relates to biological hazards, in general, and to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically. Available IH/OEHS risk assessment and risk management tools (e.g. control banding and the hierarchy of controls) are important components of the ARECC framework. These conceptual models, however, were primarily developed for controlling chemical hazards and must be adapted to the unique characteristics of highly infectious and virulent pathogens, such as SARS-CoV-2. This assessment provides an overview of the key considerations for developing occupational infection control plans, selecting the best available controls, and applying other emerging tools (e.g. quantitative microbial risk assessment), with the ultimate goal of facilitating risk management decisions during the current global pandemic.
Keywords	Toxicology ; Public Health, Environmental and Occupational Health ; Health, Toxicology and Mutagenesis ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	56831-4
ISSN	0748-2337
ISSN	0748-2337
DOI	10.1177/0748233720967522
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of the Safety and Efficacy of Hand Sanitizer Products Marketed to Children Available during the COVID-19 Pandemic

Lauren E. Gloekler / Elise J. de Gandiaga / Natalie R. Binczewski / Katie G. Steimel / Andrey Massarsky / Jordan Kozal / Melissa Vincent / Rachel Zisook / Mark J. LaGuardia / Scott Dotson / Shannon Gaffney

International Journal of Environmental Research and Public Health, Vol 19, Iss 14424, p

2022 Volume 14424

Abstract	Hand sanitizer use in the United States (U.S.) increased after the SARS-CoV-2 outbreak. The U.S. Food and Drug Administration (FDA) released temporary manufacturer guidance, changing impurity level limits for alcohol-based hand sanitizers (ABHSs). Since the guidance took effect, the FDA has recommended against using these hand sanitizers due to concerns over safety, efficacy, and/or risk of incidental ingestion. To address current gaps in exposure characterization, this study describes a survey of ABHSs marketed to children available in the U.S., as defined by several inclusion criteria. A subset of ABHSs ( n = 31) were evaluated for ethanol and organic impurities using a modified FDA method. Products with detectable impurity levels were compared to the FDA’s established interim limits. Seven children’s products had impurity levels exceeding the FDA’s recommended interim limits, including benzene (up to 9.14 ppm), acetaldehyde (up to 134.12 ppm), and acetal (up to 75.60 ppm). The total measured alcohol content ranged from 52% to 98% in all hand sanitizers tested, ranging from 39% below, and up to 31% above, the labeled concentration. Future studies should confirm impurity contamination sources. A risk assessment could determine whether dermal application or incidental ingestion of impurity-containing hand sanitizers pose any consumer risk.
Keywords	hand sanitizer ; consumer products ; children ; impurities ; ethanol ; COVID-19 ; Medicine ; R
Subject code	330
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Setting occupational exposure limits for antimicrobial agents: A case study based on a quaternary ammonium compound-based disinfectant.

Dotson, G Scott / Lotter, Jason T / Zisook, Rachel E / Gaffney, Shannon H / Maier, Andrew / Colvin, Jonathan

Toxicology and industrial health

2020 Volume 36, Issue 9, Page(s) 619–633

Abstract: Antimicrobial agents have become an essential tool in controlling the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and guidelines on their use have been issued by various public health agencies. Through ... ...

Abstract	Antimicrobial agents have become an essential tool in controlling the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and guidelines on their use have been issued by various public health agencies. Through its
MeSH term(s)	Anti-Infective Agents/standards ; Anti-Infective Agents/therapeutic use ; COVID-19/prevention & control ; Disinfectants/standards ; Disinfectants/therapeutic use ; Humans ; Occupational Exposure/prevention & control ; Occupational Exposure/standards ; Occupational Health ; Organizational Case Studies ; Pandemics ; Quaternary Ammonium Compounds/standards ; Quaternary Ammonium Compounds/therapeutic use ; Risk Assessment ; SARS-CoV-2
Chemical Substances	Anti-Infective Agents ; Disinfectants ; Quaternary Ammonium Compounds
Language	English
Publishing date	2020-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/0748233720970438
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Emissions associated with operations of four different additive manufacturing or 3D printing technologies.

Zisook, Rachel E / Simmons, Brooke D / Vater, Mark / Perez, Angela / Donovan, Ellen P / Paustenbach, Dennis J / Cyrs, William D

Journal of occupational and environmental hygiene

2020 Volume 17, Issue 10, Page(s) 464–479

Abstract: In this pilot-scale study, a wide range of potential emissions were evaluated for four types of additive manufacturing (AM) machines. These included material extrusion (using acrylonitrile-butadiene-styrene [ABS]); material jetting (using liquid ... ...

Abstract	In this pilot-scale study, a wide range of potential emissions were evaluated for four types of additive manufacturing (AM) machines. These included material extrusion (using acrylonitrile-butadiene-styrene [ABS]); material jetting (using liquid photopolymer); powder bed fusion (using nylon); and vat photopolymerization (using liquid photopolymer) in an industrial laboratory setting. During isolated operation of AM machines, adjacent area samples were collected for compounds of potential concern (COPCs), including total and individual volatile organic compounds (VOCs), nano- and micron-sized particulate matter, and inorganic gases. A total of 61 compounds were also sampled using a canister followed by gas chromatography and mass spectrometry analysis. Most COPCs were not detected or were measured at concentrations far below relevant occupational exposure limits (OELs) during AM machine operations. Submicron particles, predominantly nanoparticles, were produced during material extrusion printing using ABS at approximately 12,000 particles per cubic centimeter (p cm
MeSH term(s)	Air Pollution, Indoor/analysis ; Gases/analysis ; Nanoparticles/analysis ; Particle Size ; Particulate Matter/analysis ; Pilot Projects ; Printing, Three-Dimensional ; Volatile Organic Compounds/analysis
Chemical Substances	Gases ; Particulate Matter ; Volatile Organic Compounds
Language	English
Publishing date	2020-08-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131820-7
ISSN	1545-9632 ; 1545-9624
ISSN (online)	1545-9632
ISSN	1545-9624
DOI	10.1080/15459624.2020.1798012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Single-dose psilocybin for a treatment-resistant episode of major depression: Impact on patient-reported depression severity, anxiety, function, and quality of life.

Goodwin, Guy M / Aaronson, Scott T / Alvarez, Oscar / Atli, Merve / Bennett, James C / Croal, Megan / DeBattista, Charles / Dunlop, Boadie W / Feifel, David / Hellerstein, David J / Husain, Muhammad Ishrat / Kelly, John R / Lennard-Jones, Molly R / Licht, Rasmus W / Marwood, Lindsey / Mistry, Sunil / Páleníček, Tomáš / Redjep, Ozlem / Repantis, Dimitris /

Schoevers, Robert A / Septimus, Batya / Simmons, Hollie J / Soares, Jair C / Somers, Metten / Stansfield, Susan C / Stuart, Jessica R / Tadley, Hannah H / Thiara, Nisha K / Tsai, Joyce / Wahba, Mourad / Williams, Sam / Winzer, Rachel I / Young, Allan H / Young, Matthew B / Zisook, Sid / Malievskaia, Ekaterina

Journal of affective disorders

2023 Volume 327, Page(s) 120–127

Abstract: Background: COMP360 is a proprietary, synthetic formulation of psilocybin being developed for treatment-resistant depression (TRD), a burdensome, life-threatening illness with high global impact. Here, we expand upon the previous report of primary ... ...

Abstract	Background: COMP360 is a proprietary, synthetic formulation of psilocybin being developed for treatment-resistant depression (TRD), a burdensome, life-threatening illness with high global impact. Here, we expand upon the previous report of primary outcomes from a phase 2 study of COMP360 in individuals with TRD-the largest randomised controlled clinical trial of psilocybin-to discuss findings of the exploratory efficacy endpoints. Methods: In this phase 2, double-blind trial, 233 participants with TRD were randomised to receive a single dose of psilocybin 25 mg, 10 mg, or 1 mg (control), administered alongside psychological support from trained therapists. Efficacy measures assessed patient-reported depression severity, anxiety, positive and negative affect, functioning and associated disability, quality of life, and cognitive function. Results: At Week 3, psilocybin 25 mg, compared with 1 mg, was associated with greater improvements from Baseline total scores in all measures. The 10 mg dose produced smaller effects across these measures. Limitations: Interpretation of this trial is limited by the absence of an active comparator and the possibility of functional unblinding in participants who received a low dose of psilocybin. Conclusions: Three weeks after dosing, psilocybin 25 mg and, to a lesser degree, 10 mg improved measures of patient-reported depression severity, anxiety, affect, and functioning. These results extend the primary findings from the largest randomised clinical trial of psilocybin for TRD to examine other outcomes that are of importance to patients.
MeSH term(s)	Humans ; Psilocybin ; Depression ; Depressive Disorder, Major ; Quality of Life ; Anxiety ; Patient Reported Outcome Measures
Chemical Substances	Psilocybin (2RV7212BP0)
Language	English
Publishing date	2023-02-04
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.01.108
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